RU2012112532A - METHOD FOR INCREASING SURGERY OF THE SKIN FLAP IN THE CONDITIONS OF REDUCED BLOOD CIRCULATION BY SILDENAFIL - Google Patents
METHOD FOR INCREASING SURGERY OF THE SKIN FLAP IN THE CONDITIONS OF REDUCED BLOOD CIRCULATION BY SILDENAFIL Download PDFInfo
- Publication number
- RU2012112532A RU2012112532A RU2012112532/14A RU2012112532A RU2012112532A RU 2012112532 A RU2012112532 A RU 2012112532A RU 2012112532/14 A RU2012112532/14 A RU 2012112532/14A RU 2012112532 A RU2012112532 A RU 2012112532A RU 2012112532 A RU2012112532 A RU 2012112532A
- Authority
- RU
- Russia
- Prior art keywords
- sildenafil
- conditions
- blood circulation
- reduced blood
- skin flap
- Prior art date
Links
- BNRNXUUZRGQAQC-UHFFFAOYSA-N sildenafil Chemical compound CCCC1=NN(C)C(C(N2)=O)=C1N=C2C(C(=CC=1)OCC)=CC=1S(=O)(=O)N1CCN(C)CC1 BNRNXUUZRGQAQC-UHFFFAOYSA-N 0.000 title claims abstract 10
- 230000017531 blood circulation Effects 0.000 title claims abstract 5
- 229960003310 sildenafil Drugs 0.000 title claims abstract 5
- 238000000034 method Methods 0.000 title claims abstract 3
- 238000001356 surgical procedure Methods 0.000 title 1
- 241001465754 Metazoa Species 0.000 claims abstract 2
- 238000010171 animal model Methods 0.000 claims abstract 2
- 230000004083 survival effect Effects 0.000 claims abstract 2
Landscapes
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Способ увеличения выживаемости кожного лоскута в условиях редуцированного кровообращения силденафилом, отличающийся тем, что при моделировании кожного лоскута в условиях редуцированного кровообращения на вторые сутки эксперимента лабораторному животному внутрибрюшинно вводят силденафил в дозе 2,2 мг/кг на первые, третьи и пятые сутки эксперимента.A method for increasing the survival of a skin flap in conditions of reduced blood circulation by sildenafil, characterized in that when modeling a skin flap in conditions of reduced blood circulation on the second day of the experiment, sildenafil in a dose of 2.2 mg / kg is administered intraperitoneally to the laboratory animal on the first, third and fifth days of the experiment.
Claims (1)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU2012112532/14A RU2498414C1 (en) | 2012-03-30 | 2012-03-30 | Method for dermal flap survival growth in reduced circulation with sildenafil |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU2012112532/14A RU2498414C1 (en) | 2012-03-30 | 2012-03-30 | Method for dermal flap survival growth in reduced circulation with sildenafil |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2012112532A true RU2012112532A (en) | 2013-10-10 |
| RU2498414C1 RU2498414C1 (en) | 2013-11-10 |
Family
ID=49302594
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2012112532/14A RU2498414C1 (en) | 2012-03-30 | 2012-03-30 | Method for dermal flap survival growth in reduced circulation with sildenafil |
Country Status (1)
| Country | Link |
|---|---|
| RU (1) | RU2498414C1 (en) |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6265420B1 (en) * | 1998-06-23 | 2001-07-24 | Medinox, Inc. | Use of nitric oxide scavengers to treat side effects caused by therapeutic administration of sources of nitric oxide |
| RU2283116C2 (en) * | 2002-05-27 | 2006-09-10 | Курский государственный медицинский университет | Method for increasing survival rate of isolated skin pedicle flap in animals having reduced antioxidation background |
| RU2429547C1 (en) * | 2010-03-24 | 2011-09-20 | Государственное образовательное учреждение высшего профессионального образования "Курский государственный медицинский университет Федерального агентства по здравоохранению и социальному развитию" | Method for improving survival rate of ischemic tissues (isolated skin pedicle flap) in reduced blood circulation |
-
2012
- 2012-03-30 RU RU2012112532/14A patent/RU2498414C1/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| RU2498414C1 (en) | 2013-11-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | The patent is invalid due to non-payment of fees |
Effective date: 20140331 |