RU2012145549A - Тигибирование раздражающих ощущений при потреблении некурительных табачных продуктов - Google Patents
Тигибирование раздражающих ощущений при потреблении некурительных табачных продуктов Download PDFInfo
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- RU2012145549A RU2012145549A RU2012145549/12A RU2012145549A RU2012145549A RU 2012145549 A RU2012145549 A RU 2012145549A RU 2012145549/12 A RU2012145549/12 A RU 2012145549/12A RU 2012145549 A RU2012145549 A RU 2012145549A RU 2012145549 A RU2012145549 A RU 2012145549A
- Authority
- RU
- Russia
- Prior art keywords
- active ingredient
- tobacco product
- oral tobacco
- oral
- formate
- Prior art date
Links
- 235000019505 tobacco product Nutrition 0.000 title claims abstract 27
- 239000004480 active ingredient Substances 0.000 claims abstract 23
- 241000208125 Nicotiana Species 0.000 claims abstract 10
- 235000002637 Nicotiana tabacum Nutrition 0.000 claims abstract 10
- KGEKLUUHTZCSIP-HOSYDEDBSA-N [(1s,4s,6r)-1,7,7-trimethyl-6-bicyclo[2.2.1]heptanyl] acetate Chemical compound C1C[C@]2(C)[C@H](OC(=O)C)C[C@H]1C2(C)C KGEKLUUHTZCSIP-HOSYDEDBSA-N 0.000 claims abstract 8
- DSSYKIVIOFKYAU-XCBNKYQSSA-N (R)-camphor Chemical compound C1C[C@@]2(C)C(=O)C[C@@H]1C2(C)C DSSYKIVIOFKYAU-XCBNKYQSSA-N 0.000 claims abstract 7
- 241000723346 Cinnamomum camphora Species 0.000 claims abstract 7
- 229930008380 camphor Natural products 0.000 claims abstract 7
- 229960000846 camphor Drugs 0.000 claims abstract 7
- BDAGIHXWWSANSR-UHFFFAOYSA-M Formate Chemical compound [O-]C=O BDAGIHXWWSANSR-UHFFFAOYSA-M 0.000 claims abstract 5
- LSDPWZHWYPCBBB-UHFFFAOYSA-N Methanethiol Chemical compound SC LSDPWZHWYPCBBB-UHFFFAOYSA-N 0.000 claims abstract 5
- KDYFGRWQOYBRFD-UHFFFAOYSA-L succinate(2-) Chemical compound [O-]C(=O)CCC([O-])=O KDYFGRWQOYBRFD-UHFFFAOYSA-L 0.000 claims abstract 5
- 229940115397 bornyl acetate Drugs 0.000 claims abstract 4
- RDWUNORUTVEHJF-UHFFFAOYSA-N bornyl formate Chemical compound C1CC2(C)C(OC=O)CC1C2(C)C RDWUNORUTVEHJF-UHFFFAOYSA-N 0.000 claims abstract 4
- 239000011248 coating agent Substances 0.000 claims abstract 4
- 238000000576 coating method Methods 0.000 claims abstract 4
- FVSJVBUYVLMHIZ-UHFFFAOYSA-N 4-oxo-4-[(1,7,7-trimethyl-2-bicyclo[2.2.1]heptanyl)oxy]butanoic acid Chemical compound C1CC2(C)C(OC(=O)CCC(O)=O)CC1C2(C)C FVSJVBUYVLMHIZ-UHFFFAOYSA-N 0.000 claims abstract 3
- WWJLCYHYLZZXBE-UHFFFAOYSA-N 5-chloro-1,3-dihydroindol-2-one Chemical compound ClC1=CC=C2NC(=O)CC2=C1 WWJLCYHYLZZXBE-UHFFFAOYSA-N 0.000 claims abstract 3
- KGEKLUUHTZCSIP-UHFFFAOYSA-N Isobornyl acetate Natural products C1CC2(C)C(OC(=O)C)CC1C2(C)C KGEKLUUHTZCSIP-UHFFFAOYSA-N 0.000 claims abstract 3
- 239000001940 [(1R,4S,6R)-1,7,7-trimethyl-6-bicyclo[2.2.1]heptanyl] acetate Substances 0.000 claims abstract 3
- 230000035807 sensation Effects 0.000 claims abstract 3
- ZFFTZDQKIXPDAF-UHFFFAOYSA-N 2-Furanmethanethiol Chemical group SCC1=CC=CO1 ZFFTZDQKIXPDAF-UHFFFAOYSA-N 0.000 claims abstract 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims abstract 2
- 206010028813 Nausea Diseases 0.000 claims abstract 2
- 230000008693 nausea Effects 0.000 claims abstract 2
- 239000002245 particle Substances 0.000 claims abstract 2
- -1 isobornoleol Chemical compound 0.000 claims 3
- RDWUNORUTVEHJF-KKZNHRDASA-N isobornyl formate Chemical compound C1C[C@@]2(C)[C@H](OC=O)C[C@@H]1C2(C)C RDWUNORUTVEHJF-KKZNHRDASA-N 0.000 claims 2
- 229920000858 Cyclodextrin Polymers 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 claims 1
- DTGKSKDOIYIVQL-WEDXCCLWSA-N (+)-borneol Chemical compound C1C[C@@]2(C)[C@@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-WEDXCCLWSA-N 0.000 abstract 2
- DTGKSKDOIYIVQL-MRTMQBJTSA-N Isoborneol Natural products C1C[C@@]2(C)[C@H](O)C[C@@H]1C2(C)C DTGKSKDOIYIVQL-MRTMQBJTSA-N 0.000 abstract 2
- CKDOCTFBFTVPSN-UHFFFAOYSA-N borneol Natural products C1CC2(C)C(C)CC1C2(C)C CKDOCTFBFTVPSN-UHFFFAOYSA-N 0.000 abstract 2
- DTGKSKDOIYIVQL-UHFFFAOYSA-N dl-isoborneol Natural products C1CC2(C)C(O)CC1C2(C)C DTGKSKDOIYIVQL-UHFFFAOYSA-N 0.000 abstract 2
Classifications
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
- A24B13/00—Tobacco for pipes, for cigars, e.g. cigar inserts, or for cigarettes; Chewing tobacco; Snuff
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
- A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
- A24B15/18—Treatment of tobacco products or tobacco substitutes
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
- A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
- A24B15/18—Treatment of tobacco products or tobacco substitutes
- A24B15/28—Treatment of tobacco products or tobacco substitutes by chemical substances
- A24B15/281—Treatment of tobacco products or tobacco substitutes by chemical substances the action of the chemical substances being delayed
- A24B15/282—Treatment of tobacco products or tobacco substitutes by chemical substances the action of the chemical substances being delayed by indirect addition of the chemical substances, e.g. in the wrapper, in the case
-
- A—HUMAN NECESSITIES
- A24—TOBACCO; CIGARS; CIGARETTES; SIMULATED SMOKING DEVICES; SMOKERS' REQUISITES
- A24B—MANUFACTURE OR PREPARATION OF TOBACCO FOR SMOKING OR CHEWING; TOBACCO; SNUFF
- A24B15/00—Chemical features or treatment of tobacco; Tobacco substitutes, e.g. in liquid form
- A24B15/18—Treatment of tobacco products or tobacco substitutes
- A24B15/28—Treatment of tobacco products or tobacco substitutes by chemical substances
- A24B15/30—Treatment of tobacco products or tobacco substitutes by chemical substances by organic substances
Landscapes
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Toxicology (AREA)
- Manufacture Of Tobacco Products (AREA)
- Medicinal Preparation (AREA)
Abstract
1. Оральный табачный продукт, содержащий:порцию бездымного табака, содержащего активный ингредиент, выбранный из группы, состоящей из меркаптана, камфары, изоборнеола, борнилацетата, изобрнилацетата, сукцината моноборнила, сукцината моноизоборнила, формиата моноборнила и формиата моноизоборнила,причем активный ингредиент присутствует в количестве, эффективном для уменьшения или устранения раздражающего ощущения, возникающего от бездымного табака.2. Оральный табачный продукт по п.1, содержащий множество табачных частиц, по меньшей мере частично окруженных покрытием, содержащим водорастворимый несшитый компонент и по существу водонерастворимый сшитый компонент.3. Оральный табачный продукт по п.1, содержащий пакетик, содержащий бездымный табак, заключенный в водонепроницаемую обертку.4. Оральный табачный продукт по п.1, в котором активный ингредиент является фурфуриловым меркаптаном.5. Оральный табачный продукт по п.1, в котором активный ингредиент является не меркаптаном.6. Оральный табачный продукт по п.5, в котором активный ингредиент выбран из группы, состоящей из изоборнеола, борнилацетата, изоборнилацетата, сукцината моноборнила, сукцината моноизоборнила, формиата моноборнила и формиата моноизоборнила.7. Оральный табачный продукт по п.1, в котором количество активного ингредиента составляет от около 500 пикограмм до около 2000 пикограмм.8. Оральный табачный продукт по п.1, в котором активный ингредиент присутствует в количестве, эффективном для уменьшения или устранения тошноты, вызываемой при потреблении продукта.9. Оральный табачный продукт по п.1, в котором активный ингредиент присутствует в количестве
Claims (17)
1. Оральный табачный продукт, содержащий:
порцию бездымного табака, содержащего активный ингредиент, выбранный из группы, состоящей из меркаптана, камфары, изоборнеола, борнилацетата, изобрнилацетата, сукцината моноборнила, сукцината моноизоборнила, формиата моноборнила и формиата моноизоборнила,
причем активный ингредиент присутствует в количестве, эффективном для уменьшения или устранения раздражающего ощущения, возникающего от бездымного табака.
2. Оральный табачный продукт по п.1, содержащий множество табачных частиц, по меньшей мере частично окруженных покрытием, содержащим водорастворимый несшитый компонент и по существу водонерастворимый сшитый компонент.
3. Оральный табачный продукт по п.1, содержащий пакетик, содержащий бездымный табак, заключенный в водонепроницаемую обертку.
4. Оральный табачный продукт по п.1, в котором активный ингредиент является фурфуриловым меркаптаном.
5. Оральный табачный продукт по п.1, в котором активный ингредиент является не меркаптаном.
6. Оральный табачный продукт по п.5, в котором активный ингредиент выбран из группы, состоящей из изоборнеола, борнилацетата, изоборнилацетата, сукцината моноборнила, сукцината моноизоборнила, формиата моноборнила и формиата моноизоборнила.
7. Оральный табачный продукт по п.1, в котором количество активного ингредиента составляет от около 500 пикограмм до около 2000 пикограмм.
8. Оральный табачный продукт по п.1, в котором активный ингредиент присутствует в количестве, эффективном для уменьшения или устранения тошноты, вызываемой при потреблении продукта.
9. Оральный табачный продукт по п.1, в котором активный ингредиент присутствует в количестве, которое не проявляет ощущаемого эффекта.
10. Оральный табачный продукт по п.1, в котором активный ингредиент является камфарой, и продукт содержит от около 500 пикограмм до около 4 миллиграмм камфары.
11. Оральный табачный продукт по п.1, в котором активный ингредиент является камфарой, и продукт содержит от около 2 нанограмм до около 20 нанограмм камфары.
12. Оральный табачный продукт по п.2, в котором покрытие содержит активный ингредиент.
13. Оральный табачный продукт по п.3, в котором активный ингредиент расположен в растворимом покрытии на водопроницаемой обертке пакетика.
14. Оральный табачный продукт по п.3, в котором пакетик имеет по меньшей мере один шов между противоположными слоями водопроницаемой обертки и мягким краем снаружи от по меньшей мере одного шва, мягкий край содержит несвязанную область между по меньшей мере одним швом и свободными краями противоположных слоев.
15. Оральный табачный продукт по п.1, в котором активный ингредиент инкапсулирован.
16. Оральный табачный продукт по п.15, в котором активный ингредиент инкапсулирован в циклодекстрин.
17. Способ изготовления орального табачного продукта, включающий
объединение табака с активным ингредиентом, выбранным из группы, состоящей из меркаптана, камфары, изоборнеола, борнилацетата, изоборнилацетата, сукцината моноборнила, сукцината моноизоборнила, формиата моноборнила и формиата моноизоборнила для образования одной или более порций бездымного табака,
при этом активный ингредиент присутствует в количестве, эффективном для уменьшения или устранения раздражающего ощущения от орального применения продукта.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US31826810P | 2010-03-26 | 2010-03-26 | |
| US61/318,268 | 2010-03-26 | ||
| PCT/IB2011/001093 WO2011117740A2 (en) | 2010-03-26 | 2011-03-28 | Inhibition of sensory irritation during consumption of non-smokeable tobacco products |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2012145549A true RU2012145549A (ru) | 2014-05-10 |
| RU2573293C2 RU2573293C2 (ru) | 2016-01-20 |
Family
ID=44508509
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2012145549/12A RU2573293C2 (ru) | 2010-03-26 | 2011-03-28 | Ингибирование раздражающих ощущений при потреблении некурительных табачных продуктов |
Country Status (13)
| Country | Link |
|---|---|
| US (5) | US9038643B2 (ru) |
| EP (1) | EP2552245B1 (ru) |
| JP (1) | JP2013523092A (ru) |
| KR (1) | KR101831463B1 (ru) |
| BR (1) | BR112012024356A2 (ru) |
| CA (1) | CA2794333C (ru) |
| DK (1) | DK2552245T3 (ru) |
| EC (1) | ECSP12012252A (ru) |
| MX (1) | MX350636B (ru) |
| PL (1) | PL2552245T3 (ru) |
| RU (1) | RU2573293C2 (ru) |
| UA (1) | UA112411C2 (ru) |
| WO (1) | WO2011117740A2 (ru) |
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| US8646461B2 (en) * | 2011-12-14 | 2014-02-11 | Sentiens, Llc | Device and method for simulating chemosensation of smoking |
| SE536491C2 (sv) | 2012-03-26 | 2013-12-27 | Bionicotine Ab | Påse innehållande nikotin och en tuggummikomposition |
| JP6061508B2 (ja) * | 2012-06-13 | 2017-01-18 | 花王株式会社 | Ｔｒｐａ１活性抑制剤 |
| US20140255452A1 (en) | 2013-03-11 | 2014-09-11 | Niconovum Usa, Inc. | Method and apparatus for differentiating oral pouch products |
| US9538782B2 (en) | 2013-03-15 | 2017-01-10 | Altria Client Services Llc | Inhibition of sensory irritation during consumption of smokeless tobacco products using a combinatorial approach |
| US10130120B2 (en) | 2013-03-15 | 2018-11-20 | Altria Client Services Llc | Use of pectin or other anionic polymers in the stabilization and controlled release of nicotine in oral sensorial tobacco products or nicotine containing non-tobacco oral sensorial products |
| CN103232347B (zh) * | 2013-04-12 | 2015-09-16 | 合肥工业大学 | 一种cns药物的脑靶向前药及其制备方法以及冰片在cns药物脑靶向前药中的用途 |
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| US10959456B2 (en) | 2014-09-12 | 2021-03-30 | R.J. Reynolds Tobacco Company | Nonwoven pouch comprising heat sealable binder fiber |
| DK3199040T3 (da) | 2014-10-24 | 2021-03-29 | Japan Tobacco Inc | Oral tobakssammensætning og fremstillingsfremgangsmåde deraf |
| US20160157515A1 (en) | 2014-12-05 | 2016-06-09 | R.J. Reynolds Tobacco Company | Smokeless tobacco pouch |
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| US20170188622A1 (en) | 2016-01-05 | 2017-07-06 | R.J. Reynolds Tobacco Company | Smokeless tobacco product |
| JP6888974B2 (ja) * | 2016-01-27 | 2021-06-18 | 学校法人近畿大学 | Ｃｙｐ２ａ１３阻害活性を有する化合物及びｃｙｐ２ａ１３阻害剤 |
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| JP2023504916A (ja) | 2019-12-09 | 2023-02-07 | ニコベンチャーズ トレーディング リミテッド | ヒートシール可能な結合剤を有するパウチ製品 |
| WO2021116884A1 (en) * | 2019-12-09 | 2021-06-17 | Nicoventures Trading Limited | Layered fleece for pouched product |
| BR112022010899A2 (pt) | 2019-12-09 | 2022-09-06 | Nicoventures Trading Ltd | Produto oral com componente dissolúvel |
| BR112022010983A2 (pt) | 2019-12-09 | 2022-08-23 | Nicoventures Trading Ltd | Velo para produto oral com componente liberável |
| US11672862B2 (en) | 2019-12-09 | 2023-06-13 | Nicoventures Trading Limited | Oral products with reduced irritation |
| US12439952B2 (en) | 2019-12-09 | 2025-10-14 | Nicoventures Trading Limited | Moist oral compositions |
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-
2011
- 2011-03-28 UA UAA201211488A patent/UA112411C2/uk unknown
- 2011-03-28 PL PL11728390T patent/PL2552245T3/pl unknown
- 2011-03-28 CA CA2794333A patent/CA2794333C/en active Active
- 2011-03-28 DK DK11728390.3T patent/DK2552245T3/en active
- 2011-03-28 EP EP11728390.3A patent/EP2552245B1/en active Active
- 2011-03-28 RU RU2012145549/12A patent/RU2573293C2/ru not_active IP Right Cessation
- 2011-03-28 KR KR1020127027943A patent/KR101831463B1/ko not_active Expired - Fee Related
- 2011-03-28 JP JP2013500612A patent/JP2013523092A/ja active Pending
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- 2011-03-28 BR BR112012024356A patent/BR112012024356A2/pt not_active Application Discontinuation
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- 2011-11-07 US US13/290,768 patent/US9038643B2/en active Active
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| Publication number | Publication date |
|---|---|
| MX2012011152A (es) | 2013-03-05 |
| ECSP12012252A (es) | 2012-11-30 |
| EP2552245A2 (en) | 2013-02-06 |
| JP2013523092A (ja) | 2013-06-17 |
| RU2573293C2 (ru) | 2016-01-20 |
| KR20130009820A (ko) | 2013-01-23 |
| US10117453B2 (en) | 2018-11-06 |
| US11129405B2 (en) | 2021-09-28 |
| US20120247492A1 (en) | 2012-10-04 |
| MX350636B (es) | 2017-09-12 |
| BR112012024356A2 (pt) | 2016-05-24 |
| EP2552245B1 (en) | 2018-11-14 |
| UA112411C2 (uk) | 2016-09-12 |
| US9038643B2 (en) | 2015-05-26 |
| PL2552245T3 (pl) | 2019-05-31 |
| WO2011117740A3 (en) | 2011-12-29 |
| DK2552245T3 (en) | 2019-01-07 |
| CA2794333C (en) | 2019-02-12 |
| US20150250227A1 (en) | 2015-09-10 |
| CA2794333A1 (en) | 2011-09-29 |
| US20250082004A1 (en) | 2025-03-13 |
| US20190069595A1 (en) | 2019-03-07 |
| WO2011117740A2 (en) | 2011-09-29 |
| US12161145B2 (en) | 2024-12-10 |
| US20210378281A1 (en) | 2021-12-09 |
| WO2011117740A8 (en) | 2011-11-10 |
| KR101831463B1 (ko) | 2018-02-22 |
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