RU2011106357A - HETEROCYCLIC ANTI-VIRAL COMPOUNDS - Google Patents

Abstract

 1. The compound of formula I:! ! where R1 represents hydrogen, C1-6 alkyl, C1-6 haloalkyl, halogen, hydroxy group, C1-6 alkoxy group, C1-6 haloalkoxy group, cyano group, NRaRb, carboxy group, C1-3 alkoxycarbonyl, carboxamide group, amino C1-3 alkyl, C1 -3 acylamino C1-3 alkyl, C1-6 hydroxyalkoxy; ! R2 is selected from the group consisting of: (a) - [C (R8) 2] p-Ar1, (b) - [C (R8) 2] p-OAr1, (c) - (CH2) mC (= O) X, (d) -NR7C (= O) Ar4, (e) -C1-6 alkyl, (f) -C1-6 haloalkyl, (g) C1-6 alkoxy groups, (h) C1-6 haloalkoxy groups, (i) C1-6 hydroxyalkyl, (j) hydroxy group, (k) halogen, (l) hydrogen, (m) phenoxy sulfonyl, (n) -O (CH2) mAr1, (o) - [C (R8) 2] p-NReRf ( p) (E) - or (Z) -R10C = CR10Ar1, (q) -C≡CAr1, where R8 independently in each case represents hydrogen, carboxyl, C1-3 alkoxycarbonyl, carboxamido group, C1-3 hydroxyalkyl, C1-3 alkyl, - (CH2) rNRgRh or a cyano group, R10 independently in each case is hydrogen, C1-6 alkyl, C1-6 hydroxyalkyl, c anogruppu, C1-3 alkoxycarbonyl, carboxamido or S1-3alkoksi-C1-6 alkyl, p is from 0 to 4, and r has a value from 1 to 3; ! Ar1 is phenyl, naphthyl, pyridinyl, pyrimidinide, pyrazinyl, pyridazinyl, quinolinyl, optionally independently substituted by 1-3 substituents selected from the group consisting of (a) hydroxy group, (b) C1-6 alkoxy group, (c) C1-6 alkyl, (d) C1-10 hydroxyalkyl, where one or two carbon atoms may optionally be substituted with oxygen, provided that the substitution does not form an oxygen-oxygen bond, (e) C1-3 alkoxy-C1-6 alkyl, ( f) halogen, (g) cyano, (h) C1-6 alkoxycarbonyl, (i) C1-6 alkylsulfonyl, (j) X1 (CH2) 1-6CO2H, (k) C1-3 acylamino-C1-6 alk sludge, (l) (CH2) nNRaRb, (m) (CH2) nCONRaRb, (n) -O (CH2) nCONRaRb, (o) X2 (CH2) 2-6NRgRh (p) X1-C1-6 hydroxyalkyl, (q ) C1-6 haloalkyl or (r) carboxyl; ! Ra and Rb represent

Claims (25)

1. The compound of formula I:

where R ¹ represents hydrogen, C _1-6 alkyl, C _1-6 haloalkyl, halogen, hydroxy group, C _1-6 alkoxy group, C _1-6 haloalkoxy group, cyano group, NR ^a R ^b , carboxy group, C _1-3 alkoxycarbonyl, carboxamido group, amino C _1-3 alkyl, C _1-3 acylamino C _1-3 alkyl, C _1-6 hydroxyalkoxy; R ^{2 is} selected from the group consisting of: (a) - [C (R ⁸ ) ₂ ] _p -Ar ¹ , (b) - [C (R ⁸ ) ₂ ] _p -OAr ¹ , (c) - (CH ₂ ) _m C (= O) X, (d) -NR ⁷ C (= O) Ar ⁴ , (e) -C _1-6 alkyl, (f) -C _1-6 halogenated, (g) C _1-6 alkoxy groups, (h) C _1-6 haloalkoxy groups, (i) C _1-6 hydroxyalkyl, (j) hydroxy groups, (k) halogen, (l) hydrogen, (m) phenoxy sulfonyl, (n) -O (CH ₂ ) _m Ar ¹ , (o) - [C (R ⁸ ) ₂ ] _p -NR ^e R ^f (p) (E) - or (Z) -R ¹⁰ C = CR ¹⁰ Ar ¹ , (q) -C≡CAr ¹ where r ⁸ in each case independently represents hydrogen, carboxyl, C _1-3 alkoxycarbonyl, carboxamido, C _1-3 hydroxyalkyl, C _1-3 alkyl, - (CH _{2) r} NR ^g _r ^h or a cyano group, r ¹⁰ is independently in each case represents Orod, C _1-6 alkyl, C _1-6 hydroxyalkyl, cyano, C _1-3 alkoxycarbonyl, carboxamido or C _1-3 alkoxy-C _1-6 alkyl, p is from 0 to 4, and r has a value of 1 until 3; Ar ¹ represents phenyl, naphthyl, pyridinyl, pyrimidinide, pyrazinyl, pyridazinyl, quinolinyl, optionally independently substituted by 1-3 substituents selected from the group consisting of (a) hydroxy group, (b) C _1-6 alkoxy group, (c) C _1-6 alkyl, (d) C _1-10 hydroxyalkyl, where one or two carbon atoms may optionally be substituted with oxygen, provided that the substitution does not lead to the formation of an oxygen-oxygen bond, (e) C _1-3 alkoxy-C _1-6 alkyl, (f) halogen, (g) cyano, (h) C _1-6 alkoxycarbonyl, (i) C _1-6 alkylsulfonyl, (j) X ¹ (CH ₂ ) _1-6 CO ₂ H, ( k) C _1-3 acyl but-C _1-6 alkyl, (l) (CH ₂ ) _n NR ^a R ^b , (m) (CH ₂ ) _n CONR ^a R ^b , (n) -O (CH ₂ ) _n CONR ^a R ^b , ( o) X ² (CH ₂ ) _2-6 NR ^g R ^h (p) X ¹ -C _1-6 hydroxyalkyl, (q) C _1-6 haloalkyl or (r) carboxyl; R ^a and R ^b are (i) independently in each case (a) hydrogen, (b) C _1-6 alkyl, (c) C _1-3 haloalkyl, (d) C _1-6 acyl, (e) C _1-6 alkylsulfonyl, (f) C _1-6 haloalkylsulfonyl, (g) C _3-7 cycloalkylsulfonyl, (h) C _3-7 cycloalkyl-C _1-3 alkylsulfonyl, (i) C _1-6 alkoxy-C _{1- 6} alkylsulfonyl, (J) (CH ₂ ) _1-3 NR ^g R ^h , (k) SO ₂ (CH ₂ ) _1-6 NR ^g R ^h , where R ^g and R ^h are as defined above, (l ) sulfamoyl, (m) C _1-3 alkylsulfamoyl, (n) C _1-3 dialkylsulfamoyl, (o) carbamoyl, (p) C _1-3 alkylcarbamoyl, (q) C _1-3 dialkylcarbamoyl, (r) benzoyl said benzoyl is optionally independently substituted with one or two mja groups selected from the group consisting of amino, halogen, C _1-6 alkyl or C _1-3 alkilsulfonilamidogruppy, (s) C _1-6 karboksialkilsulfonila, (t) C _2-6 gidroksialkilsulfonila, or (ii) R ^a and R ^b together with the nitrogen atom to which they are attached represent (a) an optionally substituted cyclic amine, (b) (CH ₂ ) _2-3 OC (O) or (c) 2-oxooxazolidine; R ^e and R ^f (i) are independently selected from (a) hydrogen, (b) C _1-3 alkyl, (c) C _4-7 cycloalkyl, (d) C _3-7 cycloalkylcarbonyl, (e) phenyl, cycloalkyl and said phenyl groups are optionally independently substituted by 1-3 groups selected from C _1-3 alkylsulfonylamido groups, C _1-3 alkyl, C _1-3 alkoxy groups or halogen, or (ii) together with the nitrogen atom to which they are attached, represent a cyclic amine independently substituted by 1-3 groups selected from a C _1-3 alkylsulfonylamido group, a C _1-3 alkyl group, a C _1-3 alkoxy group or a halogen; X represents OH, a C _1-6 alkoxy group, NR ^c R ^d or Ar ³ ; Ar ³ is phenyl optionally substituted with 1-3 substituents selected from the group consisting of: (a) halogen, (b) hydroxy group, (c) C _1-3 hydroxyalkyl, (d) amino group, (e) amino-C _1-3 alkyl, (f) C _1-3 alkylamino, (g) C _1-3 alkylamino C _1-3 alkyl, (h) C _1-3 dialkylamino, (i) C _1-3 dialkylamino-C _{1- 3} alkyl, (j) carboxamido groups, (k) C _1-6 alkylsulfonylamido groups, (l) C _1-6 alkylsulfonylamido-C _1-3 alkyls, (m) NR ⁷ -C _1-3 alkyl-C _1-6 alkylsulfonamido groups. (n) C _1-6 alkyl; (o) C _1-6 alkoxycarbonyl; and (p) carboxyl; R ^c and R ^d are (i) independently in each case: (a) hydrogen, (b) Ar ² , (c) Ar ² -C _1-6 alkyl, (d) C _3-6 cycloalkyl optionally substituted with C _1-3 dialkylamino group, C _1-6 alkylsulfonamido group or C _1-3 hydroxyalkyl, (e) C _1-6 alkyl-C _3-7 cycloalkyl, (f) C _1-3 alkoxy-C _1-3 alkyl, (g) pyridinyl or pyridinyl C _1-6 alkyl, wherein said pyridinyl is optionally substituted with an amino group, C _1-3 alkylamino group, C _1-3 dialkylamino group, C _1-6 alkylsulfonylamido group, sulfamoyl, C _1-3 alkylsulfamoyl, C _1-3 dialkylsulfamoyl, (h ) thienyl optionally substituted nd C _1-3 alkyl, (i) heterocyclyl or heterocyclyl C _1-6 alkyl, wherein the heterocyclyl group is pyrrolidine or piperidine said heterocyclyl group being optionally substituted by C _1-3 alkyl or oxo, (j) C _1-3 alkylimidazole -4-yl or (k) (CH ₂ ) _2-4 NR ^g R ^h ; or (ii) R ^c and R ^d together with the nitrogen atom to which they are attached are pyrrolidinyl or piperidinyl, both of which are optionally substituted with C _1-3 alkyl, hydroxy or hydroxy-C _1-3 alkyl; Ar ² is phenyl optionally substituted with 1-3 substituents independently selected from the group consisting of (a) C _1-3 alkyl, (b) amino group, (c) amino C _1-3 alkyl, (d) C _{1- 3} alkylamino, (e) C _1-3 alkylamino-C _1-3 alkyl, (f) C _1-3 dialkylamino, (g) CO OCH ₂ NR ^g R ^{h, (h)} C _1-3 alkilsulfonilamidogruppy, (i) C _1-3 alkylsulfonamido-C _1-3 alkyl, (j) NC _1-3 alkyl-C _1-6 alkylsulfonamido, (k) C _1-3 hydroxyalkyl and (l) hydroxy; Ar ⁴ represents phenyl, pyridinyl, pyrazinyl, pyridazinyl or pyrimidinyl, each optionally substituted with 1-3 substituents, independently selected in each case from the group consisting of (a) amino group, (b) C _1-3 alkylamino group, (c) di -C _1-3 alkylamino groups, (d) C _1-3 haloalkylamino groups, (e) C _1-6 alkylsulfonylamido groups, (f) sulfamoyl, (g) C _1-3 alkylsulfamoyl, (h) C _1-3 dialkylsulfamoyl, (i ) C _1-6 alkylsulfonylamido-C _1-3 alkyl, (j) NR ⁷ -C _1-3 alkyl-C _1-6 alkylsulfonamido groups, (k) halogen, (l) C _1-3 alkyl, (m) C _{1 -3} alkoxy groups, (n) C _1-6 acylamino groups, ( o) hydroxy groups, (p) (CH ₂ ) _n CONR ^a R ^b , (q) -O (CH ₂ ) _n CONR ^a R ^b , (r) -O (CH ₂ ) _n NR ⁱ R ^j , where R ⁱ and R ^j independently represent hydrogen or C _1-3 alkyl, (s) -NR ⁱ (CH ₂ ) _n OR ^j , where R ⁱ and R ^j independently represent hydrogen or C _1-3 alkyl, (t) C _{1 -3-} haloalkyl, (u) C _1-3 alkoxy-C _1-6 alkoxy groups, (v) C _3-6 cycloalkylamine; R ³ represents hydrogen, C _1-6 alkyl, C _1-6 haloalkyl, C _1-6 alkoxy, C _1-6 haloalkoxy, C _1-3 alkoxy-C _1-6 alkoxy, halogen, O (CH ₂ ) _{2 -6} X ³ , where X ³ represents OH or N (R ⁷ ) ₂ , or R ³ and R ^4a together represent CH ₂ -O and together with the atoms to which they are attached form 2,3-dihydrobenzofuran or indane ; R ^4a , R ^4b and R ^4c (a) are independently selected from (i) C _1-3 alkyl, (ii) C _1-2 alkoxy groups, (iii) C _1-2 fluoroalkyl, (iv) C _{1- 3} hydroxyalkyls, (v) hydroxy groups, (vi) CO ₂ H, (vii) C _1-6 alkoxycarbonyl, (viii) cyano groups or (ix) N (R ⁷ ) ₂ , or (b) together (i) R ^4a and R ^4b together represents C _2-4 methylene and R ^4c represents hydrogen, C _1-3 alkyl, C _1-3 hydroxyalkyl, C _1-2 alkoxy, halogen, cyano or C _1-2 fluoroalkyl, or (ii) R ^4a and R ^4b together with the carbon atom to which they are attached represent 3-oxetanyl, R ^4c represents hydrogen, C _1-3 alkyl, or (c) (i) R ⁵ and R ^4a and whether (ii) R ³ and R ^4a together represent CH ₂ —O or (CH ₂ ) ₂ and with the atoms to which they are attached form 2,3-dihydrobenzofuran or indan, and R ^4b and R ^4c are C _{1 -3} alkyl, or (d) R ^4a , R ^4b , R ^4c together with the carbon atom to which they are attached are cyclopropyl, trifluoromethyl or 2,2,2-trifluoroethyl; R ⁵ represents hydrogen, halogen, C _1-6 alkyl, hydroxy, or R ⁵ and R ^4a together represent CH ₂ -O and together with the atoms to which they are attached form 2,3-dihydrobenzofuran or indan; R ⁶ represents (a) halogen, (b) C _1-6 alkyl, where one or two non-adjacent carbon atoms may optionally be substituted with an oxygen atom, (c) C _1-3 haloalkyl, (d) C _1-3 alkoxy group, (f) X ¹ -C _2-6 hydroxyalkyl, where one or two non-adjacent carbon atoms may optionally be substituted by an oxygen atom, (f) cyano-C _1-3 alkyl, (g) X ¹ (CH ₂ ) _1-6 CO ₂ N or (h) X ¹ - (CH ₂ ) _2-6 NR ^g R ^h ; R ⁷ independently in each case represents hydrogen or C _1-3 alkyl; R ⁹ represents hydrogen, CH ₂ OH, CH (Me) OH, CH (Me) R ^9a or CH ₂ OR ^9a , where R ^9a represents (a) CO (CH ₂ ) _s CO ₂ H, where s is 1 to 4, (b) C (O) CHR ^9b NHR ^9c , where R ^9b is hydrogen, methyl, isopropyl, isobutyl, sec-butyl, phenyl or 4-hydroxyphenyl, and R ^9c is hydrogen or C _1-6 alkoxycarbonyl, or R ^9b and R ^9c together represent (CH ₂ ) ₃ , (c) -P (O) (OH) ₂ or (d) COR ¹¹ , where R ¹¹ represents C _1-6 alkyl, piperidin-4-ylmethyl or optionally substituted aryl; X ¹ represents O, NR ⁷ or a bond; X ² represents O or NR ⁷ ; R ^g and R ^h independently represent hydrogen or C _1-6 alkyl, or R ^g and R ^h together with the nitrogen atom to which they are attached represent an optionally substituted cyclic amine; m has a value from 0 to 3; n independently in each case has a value from 0 to 2; or its pharmaceutically acceptable salts. 2. The compound according to claim 1, where: R ² represents (E) -R ¹⁰ C = CR ¹⁰ Ar ¹ ; Ar ¹ represents phenyl, pyridinyl, pyrimidinyl, pyrazinyl, pyridazinyl; R ³ represents hydrogen or a C _1-6 alkoxy group; R ⁹ represents hydrogen; and p is 2. 3. The compound according to claim 1 or claim 2, where R ¹⁰ represents hydrogen. 4. The compound according to claim 1, where: R ² represents - [C (R ⁸ ) ₂ ] _p -Ar ¹ ; Ar ¹ represents phenyl, pyridinyl, pyrimidinyl, pyrazinyl, pyridazinyl; R ³ represents hydrogen or a C _1-6 alkoxy group; R ⁹ represents hydrogen; and p is 2. 5. The compound according to claim 1, where R ⁸ represents hydrogen. 6. The compound according to claim 1, where: R ² represents - [C (R ⁸ ) ₂ ] _p -Ar ¹ ; p is 0; Ar ¹ is naphthyl or quinolinyl substituted with at least (CH ₂ ) _n NR ^a R ^b , where n is 0 or 1, R ^a is hydrogen and R ^b is C _1-6 alkylsulfonyl, C _1-6 haloalkylsulfonyl C _3-7 cycloalkylsulfonyl; C _3-7 cycloalkyl-C _1-3 alkylsulfonyl; or C _1-6 alkoxy-C _1-6 alkylsulfonyl; R ³ represents hydrogen or a C _1-6 alkoxy group. 7. The compound according to claim 1, where Ar ¹ represents phenyl or pyridinyl substituted with at least (CH ₂ ) _n NR ^a R ^b , where n is 0 or 1, R ^a is hydrogen and R ^b is C _{1 -6} alkylsulfonyl, C _1-6 haloalkylsulfonyl, C _3-7 cycloalkylsulfonyl, C _3-7 cycloalkyl-C _1-3 alkylsulfonyl or C _1-6 alkoxy-C _1-6 alkylsulfonyl. 8. The compound of claim 7, wherein Ar ¹ is optionally substituted 4-methanesulfonylaminophenyl, 5-methanesulfonylaminopyridin-2-yl or 2-methanesulfonylaminopyridin-5-yl. 9. The compound according to claim 1, where R ⁸ represents hydrogen and p represents 1 or 2. 10. The compound according to claim 1, where R ² represents - (CH ₂ ) _m C (= O) X, m is 0 and X is NR ^c R ^d . 11. The compound of claim 10, where R ¹ and R ⁵ are hydrogen, R ³ is a C _1-6 alkoxy group, R ² is - (CH ₂ ) _m C (= O) X, m is 0 and X represents NR ^c R ^d where R ^c represents hydrogen and R ^d represents Ar ² , wherein said Ar ² phenyl is optionally substituted with 1-3 groups independently selected from hydroxy, C _1-6 alkyl, C _1-6 hydroxyalkyl, halogen, (CH ₂ ) NR ^a R ^b and where n is 1 or 2, R ^a is hydrogen or C _1-3 alkyl, and R ^b is hydrogen, C _1-3 alkyl, C _1-3 acyl, C _1-3 alkylsulfonyl, C _1-6 haloalkyls ulphonyl, C _3-7 cycloalkylsulfonyl, C _3-7 cycloalkyl-C _1-3 alkylsulfonyl or C _1-6 alkoxy-C _1-6 alkylsulfonyl. 12. The compound according to claim 1, where R ² represents NR ⁷ C (= O) Ar ⁴ . 13. The compound of claim 12, wherein R ¹ and R ⁵ are hydrogen and R ³ is a C _1-6 alkoxy group. 14. The compound according to any one of paragraphs.12 or 13, where Ar ⁴ is phenyl substituted by 1-3 groups independently selected from C _1-3 alkyl, halogen, (CH ₂ ) _n NR ^a R ^b and (CH ₂ ) _n CO ₂ NR ^a R ^b , n is 0, 1 or 2, R ^a is hydrogen or C _1-3 alkyl, and R ^b is hydrogen, C _1-3 alkyl, C _1-3 acyl, C _{1- 6} alkylsulfonyl, C _1-6 haloalkylsulfonyl, C _3-7 cycloalkylsulfonyl, C _3-7 cycloalkyl-C _1-3 alkylsulfonyl or C _1-6 alkoxy-C _1-6 alkylsulfonyl. 15. The compound according to claim 1, where R ² represents - [C (R ⁸ ) ₂ ] _p -NR ^e R ^f . 16. The compound according to claim 1 or 15, where R ^e and R ^f together with the nitrogen atom to which they are attached represent a pyrrolidine, piperidine or azepinyl ring, optionally independently substituted by 1-3 groups selected from C _1-3 alkylsulfonylamido groups , C _1-3 alkyl, C _1-3 alkoxygroup or halogen. 17. The compound according to claim 1, where R ¹ represents hydrogen or a hydroxy group; R ⁵ is hydrogen, R ³ is hydrogen or a methoxy group, and R ⁶ is halogen, C _1-6 alkyl or C _1-6 alkoxy. 18. The compound according to claim 1, where (a) R ^4a and R ^4b are C _1-3 alkyl, and R ^4c selected from (i) C _1-2 alkoxygroup, (ii) C _1-2 fluoroalkyl, (iii ) C _1-3 hydroxyalkyl or (iv) hydroxy groups, or (b) R ^4a and R ^4b together represent C _2-4 methylene and R ^4c represents C _1-3 alkyl, C _1-2 alkoxy, halogen, cyano or C _1-2 fluoroalkyl, or (c) R ^4a and R ^4b together with the carbon atom to which they are attached represent 3-oxetanyl, and R ^4c represents hydrogen or C _1-3 alkyl, or (c) (i ) R ⁵ and R ^4a, or (ii) R ³ and R ^4a together represent CH ₂ -O or (CH _{2) 2} and with atoms to which nor are attached form 2,3-dihydrobenzofuran, or indan, and R ^4b and R ^4c represent C _1-3 alkyl. 19. The compound of claim 18, wherein R ^4a , R ^4b and R ^4c are methyl. 20. The compound according to claim 1, where R ⁹ represents CH ₂ OH, CH ₂ OR ^9a , where R ^9a represents (CH ₂ ) _s CO ₂ H, where s has a value from 1 to 4, C (O) CHR ^9b NHR ^9c , where R ^9b represents hydrogen, methyl, iso-propyl, iso-butyl, sec-butyl, phenyl or 4-hydroxyphenyl, and R ^9c represents hydrogen or C _1-6 alkoxycarbonyl. 21. The compound according to claim 1, selected from the group consisting of the following compounds: 3- (3-tert-butylphenyl) -1H-pyridin-2-one; 3- (5-tert-butyl-2-hydroxyphenyl) -1H-pyridin-2-one; 3- (3-tert-butyl-5-methylphenyl) -1H-pyridin-2-one; 3- (3-tert-butyl-4-methoxyphenyl) -1H-pyridin-2-one; 3- (3-tert-butyl-4-ethoxyphenyl) -1H-pyridin-2-one; 3- (3-tert-butyl-4-difluoromethoxyphenyl) -1H-pyridin-2-one; 3- (3-tert-butyl-5-methylphenyl) -5-methyl-1H-pyridin-2-one; 3- (3-tert-butyl-5-methylphenyl) -5-chloro-1H-pyridin-2-one; 3- [3-bromo-5- (1,1-dimethylpropyl) -2-hydroxyphenyl] -1H-pyridin-2-one; 3- (5-tert-butyl-2-hydroxy-3-hydroxymethylphenyl) -1H-pyridin-2-one; 3- (5-tert-butyl-2-hydroxy-3-methylphenyl) -1H-pyridin-2-one; 3- (3-tert-butyl-5-methylphenyl) -6-hydroxymethyl-1H-pyridin-2-one; 3- (3-bromo-5-tert-butyl-2-hydroxyphenyl) -1H-pyridin-2-one; 3- (5-tert-butyl-3-ethyl-2-hydroxyphenyl) -1H-pyridin-2-one; 3- (5-tert-butyl-2-hydroxybiphenyl-3-yl) -1H-pyridin-2-one; 3- (5-tert-butyl-3-chloro-2-hydroxyphenyl) -1H-pyridin-2-one; 3- (3-benzyl-5-tert-butyl-2-hydroxyphenyl) -1H-pyridin-2-one; 3- [5-tert-butyl-2-hydroxy-3- (2-oxo-1,2-dihydropyridin-3-yl) phenyl] propionic acid; 3-tert-butyl-N-cyclopropyl-2-methoxy-5- (2-oxo-1,2-dihydropyridin-3-yl) benzamide; 3- {5-tert-butyl-3- [2- (4-fluorophenyl) ethyl] -2-hydroxyphenyl} -1H-pyridin-2-one; 3- {3-tert-butyl-5- [2- (4-fluorophenyl) ethyl] -4-methoxyphenyl} -1H-pyridin-2-one; 3- [3-tert-butyl-2-methoxy-5- (2-oxo-1,2-dihydropyridin-3-yl) phenyl] propionic acid; 3- (3-tert-butyl-5-hydroxy-4-methoxyphenyl) -1H-pyridin-2-one; 3- [3-tert-butyl-5- (3-hydroxymethylpiperidin-1-carbonyl) -4-methoxyphenyl] -1H-pyridin-2-one; 4-amino-N- [3-tert-butyl-2-methoxy-5- (2-oxo-1,2-dihydropyridin-3-yl) phenyl] -2-chlorobenzamide; 3- (3-tert-butyl-4,5-dimethoxyphenyl) -1H-pyridin-2-one; 3- [3-methyl-5- (1-methylcyclopentyl) phenyl] -1H-pyridin-2-one; 3- [3-methyl-5- (1-methylcyclobutyl) phenyl] -1H-pyridin-2-one; 3- (3-tert-butyl-4-methoxy-5-methylphenyl) -1H-pyridin-2-one; 3- (3-tert-butyl-5-ethyl-4-methoxyphenyl) -1H-pyridin-2-one; 3-tert-butyl-N-cyclopropyl-2-methoxy-N- (2-methoxyethyl) -5- (2-oxo-1,2-dihydropyridin-3-yl) benzamide; N- (3- {2- [3-tert-butyl-2-methoxy-5- (2-oxo-1,2-dihydropyridin-3-yl) phenyl] ethyl} phenyl) methanesulfonamide; N- (4- {2- [3-tert-butyl-2-methoxy-5- (2-oxo-1,2-dihydropyridin-3-yl) phenyl] ethyl} phenyl) methanesulfonamide; 3-tert-butyl-2-methoxy-5- (2-oxo-1,2-dihydropyridin-3-yl) -N-phenethylbenzamide; 3-tert-butyl-2-methoxy-5- (2-oxo-1,2-dihydropopyridin-3-yl) -N- (2-phenylpropyl) benzamide; 3-tert-butyl-2-methoxy-5- (2-oxo-1,2-dihydropyridin-3-yl) -N- (2-pyridin-3-yl-ethyl) benzamide; N-benzyl-3-tert-butyl-2-methoxy-5- (2-oxo-1,2-dihydropyridin-3-yl) benzamide; 3-tert-butyl-2-methoxy-5- (2-oxo-1,2-dihydropyridin-3-yl) -N-pyridin-4-ylmethylbenzamide; 3-tert-butyl-2-methoxy-N- (3-methyl-3H-imidazol-4-ylmethyl) -5- (2-oxo-1,2-dihydropyridin-3-yl) benzamide; 3-tert-butyl-N- (4-dimethylaminobenzyl) -2-methoxy-5- (2-oxo-1,2-dihydropyridin-3-yl) benzamide; 3-tert-butyl-N- (4-dimethylaminophenyl) -2-methoxy-5- (2-oxo-1,2-dihydropyridin-3-yl) benzamide; 3-tert-butyl-2-methoxy-5- (2-oxo-1,2-dihydropyridin-3-yl) -N- (4-pyrrolidin-1-ylbutyl) benzamide; 3-tert-butyl-N- (2-dimethylaminoethyl) -2-methoxy-5- (2-oxo-1,2-dihydropyridin-3-yl) benzamide; 3-tert-butyl-2-methoxy-5- (2-oxo-1,2-dihydropyridin-3-yl) -N- [3- (2-oxopyrrolidin-1-yl) propyl] benzamide; 3- (3-tert-butyl-5-phenoxyphenyl) -1H-pyridin-2-one; 3- (3-benzyl-5-tert-butylphenyl) -1H-pyridin-2-one; 3- (3-benzoyl-5-tert-butyl-4-methoxyphenyl) -1H-pyridin-2-one; 3- (3-benzyl-5-tert-butyl-4-methoxyphenyl) -1H-pyridin-2-one; 3- [3-tert-butyl-5- (3-fluorobenzoyl) -4-methoxyphenyl] -1H-pyridin-2-one; 3- [3-tert-butyl-5- (4-fluorobenzoyl) -4-methoxyphenyl] -1H-pyridin-2-one; N- (4- {2- [5-tert-butyl-2-hydroxy-3- (2-oxo-1,2-dihydropyridin-3-yl) phenyl] ethyl} phenyl) methanesulfonamide; 3- [3-tert-butyl-5- (3,5-difluorobenzoyl) -4-methoxyphenyl] -1H-pyridin-2-one; 3- (3-tert-butyl-5-methylphenyl) -5-fluoro-1H-pyridin-2-one; 3- [3-tert-butyl-5- (3-hydroxybenzoyl) -4-methoxyphenyl] -1H-pyridin-2-one; 3- [3-tert-butyl-5- (4-hydroxybenzoyl) -4-methoxyphenyl] -1H-pyridin-2-one; 3- (3-tert-butyl-2-fluoro-4-methoxyphenyl) -1H-pyridin-2-one; 3- [3-tert-butyl-4-methoxy-5- (3-methylthiophen-2-carbonyl) phenyl] -1H-pyridin-2-one; N- [3-tert-butyl-2-methoxy-5- (2-oxo-1,2-dihydropyridin-3-yl) phenyl] benzamide; 3- [3- (3-aminobenzoyl) -5-tert-butyl-4-methoxyphenyl] -1H-pyridin-2-one; N- [3-tert-butyl-2-fluoro-5- (2-oxo-1,2-dihydropyridin-3-yl) phenyl] benzamide; 3- [4-methoxy-3- (1-methylcyclopropyl) phenyl] -1H-pyridin-2-one; 3- [4-methoxy-3- (1-methoxy-1-methylethyl) phenyl] -1H-pyridin-2-one; 3- [3-tert-butyl-2-methoxy-5- (2-oxo-1,2-dihydropyridin-3-yl) benzoyl] benzamide; N- (4- {2- [3-tert-butyl-2-methoxy-5- (6-methyl-2-oxo-1,2-dihydropyridin-3-yl) phenyl] ethyl} phenyl) methanesulfonamide; N- {3- [3-tert-butyl-2-methoxy-5- (2-oxo-1,2-dihydropyridin-3-yl) benzoyl] benzyl} methanesulfonamide; 3- [3- (4-aminomethylbenzoyl) -5-tert-butyl-4-methoxyphenyl] -1H-pyridin-2-one; N- (4- {2- [3-tert-butyl-5- (5-fluoro-2-oxo-1,2-dihydropyridin-3-yl) -2-methoxyphenyl] ethyl} phenyl) methanesulfonamide; 3-tert-butyl-2-methoxy-5- (2-oxo-1,2-dihydropyridin-3-yl) -N-phenylbenzamide; 3-tert-butyl-N- (4-methanesulfonylamino-2-methylphenyl) -2-methoxy-5- (2-oxo-1,2-dihydropyridin-3-yl) benzamide; N- [3-tert-butyl-2-methoxy-5- (2-oxo-1,2-dihydropyridin-3-yl) phenyl] -4-methanesulfonylaminobenzamide; N- {4- [3-tert-butyl-2-methoxy-5- (2-oxo-1,2-dihydropyridin-3-yl) benzyloxy] phenyl} methanesulfonamide; 4-amino-N- [3-tert-butyl-2-methoxy-5- (2-oxo-1,2-dihydropyridin-3-yl) phenyl] benzamide; N- [3-tert-butyl-2-fluoro-5- (2-oxo-1,2-dihydropopyridin-3-yl) phenyl] -4-methanesulfonylaminobenzamide; N- (4- {2- [3-tert-butyl-5- (2-oxo-1,2-dihydropyridin-3-yl) phenyl] ethyl} phenyl) methanesulfonamide; 3-tert-butyl-N- [4- (methanesulfonylmethylamino) phenyl] -2-methoxy-5- (2-oxo-1,2-dihydropyridin-3-yl) benzamide; 3-tert-butyl-N- [4- (methanesulfonylaminomethyl) phenyl] -2-methoxy-5- (2-oxo-1,2-dihydropyridin-3-yl) benzamide; 3-tert-butyl-2-methoxy-N- (1-methylpiperidin-3-yl) -5- (2-oxo-1,2-dihydropyridin-3-yl) benzamide; 3-tert-butyl-N- (3-hydroxymethyl-2-methylphenyl) -2-methoxy-5- (2-oxo-1,2-dihydropyridin-3-yl) benzamide; 3-tert-butyl-2-methoxy-5- (2-oxo-1,2-dihydropyridin-3-yl) -N-o-tolylbenzamide; N- [4-tert-butyl-2- [2- (4-methanesulfonylaminophenyl) ethyl] -6- (2-oxo-1,2-dihydropyridin-3-yl) phenyl] acetamide; N- [3-tert-butyl-5- (5-fluoro-2-oxo-1,2-dihydropyridin-3-yl) -2-methoxyphenyl] -4-methanesulfonylaminobenzamide; 4-methanesulfonylamino-N- [2-methoxy-3- (1-methylcyclopropyl) -5- (2-oxo-1,2-dihydropyridin-3-yl) phenyl] benzamide; N- (4- {2- [3-tert-butyl-5- (2-oxo-1,2-dihydropyridin-3-yl) phenyl] ethyl} phenyl) acetamide; 3- [3- (2-aminopyridin-4-carbonyl) -5-tert-butyl-4-methoxyphenyl] -1H-pyridin-2-one; 1- (4- {2- [3-tert-butyl-5- (2-oxo-1,2-dihydropyridin-3-yl) phenyl] ethyl} phenyl) -3,3-dimethyl sulfamate; 1- (4- {2- [3-tert-butyl-5- (2-oxo-1,2-dihydropyridin-3-yl) phenyl] ethyl} phenyl) -3-methylurea; N- (4- {2- [5-tert-butyl-2-cyano-3- (2-oxo-1,2-dihydropopyridin-3-yl) phenyl] ethyl} phenyl) methanesulfonamide; 3-tert-butyl-2-methoxy-5- (2-oxo-1,2-dihydropopyridin-3-yl) -N-piperidin-4-ylbenzamide; compound with formic acid; 3-tert-butyl-2-methoxy-5- (2-oxo-1,2-dihydropyridin-3-yl) -N-piperidin-3-ylbenzamide; compound with formic acid; 3-tert-butyl-2-methoxy-5- (2-oxo-1,2-dihydropyridin-3-yl) -N - ((S) -6-oxopiperidin-3-yl) benzamide; 3-tert-butyl-2-methoxy-N- (1-methylpiperidin-4-yl) -5- (2-oxo-1,2-dihydropyridin-3-yl) benzamide; 3-tert-butyl-N- (4-dimethylaminocyclohexyl) -2-methoxy-5- (2-oxo-1,2-dihydropyridin-3-yl) benzamide; 3-tert-butyl-N- (2-hydroxymethylcyclohexyl) -2-methoxy-5- (2-oxo-1,2-dihydropyridin-3-yl) benzamide; N- (4- {2- [3-tert-butyl-5- (5-fluoro-2-oxo-1,2-dihydropyridin-3-yl) phenyl] ethyl} phenyl) methanesulfonamide; N- (4- {2- [3-tert-butyl-5- (5-chloro-2-oxo-1,2-dihydropyridin-3-yl) -2-methoxyphenyl] ethyl} phenyl) methanesulfonamide; N- (4- {2- [5- (5-bromo-2-oxo-1,2-dihydropyridin-3-yl) -3-tert-butyl-2-methoxyphenyl] ethyl} phenyl) methanesulfonamide; 3-tert-butyl-N- (3-hydroxymethylphenyl) -2-methoxy-5- (2-oxo-1,2-dihydropyridin-3-yl) benzamide; N- (4- {2- [2-amino-5-tert-butyl-3- (2-oxo-1,2-dihydropyridin-3-yl) phenyl] ethyl} phenyl) methanesulfonamide; 3- [3- [2- (4-aminophenyl) ethyl] -4-methoxy-5- (1-methylcyclopropyl) phenyl] -1H-pyridin-2-one; N- {3- [3-tert-butyl-2-methoxy-5- (2-oxo-1,2-dihydropyridin-3-yl) benzoyl] phenyl} methanesulfonamide; 3-tert-butyl-N-cyclohexyl-2-methoxy-5- (2-oxo-1,2-dihydropyridin-3-yl) benzamide; N- (4- {2- [3-tert-butyl-2-methoxy-5- (2-oxo-1,2-dihydropyridin-3-yl) phenyl] ethyl} -3-fluorophenyl) methanesulfonamide; N- (4- {2- [3-tert-butyl-2-methoxy-5- (2-oxo-1,2-dihydropyridin-3-yl) phenyl] ethyl} -2-fluorophenyl) methanesulfonamide; N- [3-tert-butyl-2-methoxy-5- (2-oxo-1,2-dihydropyridin-3-yl) phenyl] -4-methanesulfonylamino-N-methylbenzamide; 3- (5-tert-butyl-2-methoxyphenyl) -6-ethyl-1H-pyridin-2-one; 3- [3- (3-aminomethylbenzoyl) -5-tert-butyl-4-methoxyphenyl] -1H-pyridin-2-one; 3- (3-benzenesulfonyl-5-tert-butylphenyl) -1H-pyridin-2-one; N- (4- {2- [2-methoxy-3- (1-methylcyclopropyl) -5- (2-oxo-1,2-dihydropyridin-3-yl) phenyl] ethyl} phenyl) methanesulfonamide; N- (4- {2- [3-tert-butyl-2-methoxy-5- (2-oxo-1,2-dihydropyridin-3-yl) phenyl] ethyl} -3-methylphenyl) methanesulfonamide; N- (4- {2- [3-tert-butyl-2-methoxy-5- (2-oxo-1,2-dihydropyridin-3-yl) phenyl] ethyl} -2-methylphenyl) methanesulfonamide; [3-tert-butyl-2-methoxy-5- (2-oxo-1,2-dihydropyridin-3-yl) phenyl] 4-methanesulfonylamino-cyclohexanecarboxylic acid amide; 3-tert-butyl-N- [3- (methanesulfonylaminomethyl) phenyl] -2-methoxy-5- (2-oxo-1,2-dihydropyridin-3-yl) benzamide; 3-tert-butyl-N- (4-carbamoylmethoxyphenyl) -2-methoxy-5- (2-oxo-1,2-dihydropyridin-3-yl) benzamide; N- (6- {2- [5-tert-butyl-2-cyano-3- (2-oxo-1,2-dihydropyridin-3-yl) phenyl] ethyl} pyridin-3-yl) methanesulfonamide; N- [3-tert-butyl-2-methoxy-5- (2-oxo-1,2-dihydropopyridin-3-yl) phenyl] -2-ethoxy-4-methanesulfonylaminobenzamide; N- [3-tert-butyl-2-methoxy-5- (2-oxo-1,2-dihydropyridin-3-yl) phenyl] -2-chloro-4-methanesulfonylaminobenzamide; N- (1- {2- [3-tert-butyl-2-methoxy-5- (2-oxo-1,2-dihydropyridin-3-yl) phenyl] ethyl} piperidin-4-yl) methanesulfonamide; N- (4- {2- [5-tert-butyl-2- (2-hydroxyethoxy) -3- (2-oxo-1,2-dihydropyridin-3-yl) phenyl] ethyl} phenyl) methanesulfonamide; N- {4- [3-tert-butyl-2-methoxy-5- (2-oxo-1,2-dihydropyridin-3-yl) benzylamino] cyclohexyl} methanesulfonamide; 4-amino-N- [3-tert-butyl-2-methoxy-5- (2-oxo-1,2-dihydropyridin-3-yl) phenyl] -3-fluorobenzamide; N- [3-tert-butyl-2-methoxy-5- (2-oxo-1,2-dihydropyridin-3-yl) phenyl] -3-fluoro-4-methanesulfonylaminobenzamide; 4-tert-butyl-2- [2- (4-methanesulfonylaminophenyl) ethyl] -6- (2-oxo-1,2-dihydropyridin-3-yl) benzamide; N- (5- {2- [3-tert-butyl-2-methoxy-5- (2-oxo-1,2-dihydropyridin-3-yl) phenyl] ethyl} pyridin-2-yl) methanesulfonamide; N- (6- {2- [3-tert-butyl-2-methoxy-5- (2-oxo-1,2-dihydropyridin-3-yl) phenyl] ethyl} pyridin-3-yl) methanesulfonamide; N- (5- {2- [3-tert-butyl-2-methoxy-5- (2-oxo-1,2-dihydropyridin-3-yl) phenyl] ethyl} pyrimidin-2-yl) methanesulfonamide; N- (4 - {(E) -2- [3-tert-butyl-2-methoxy-5- (2-oxo-1,2-dihydropyridin-3-yl) phenyl] vinyl} phenyl) methanesulfonamide; N- (6- {2- [3-tert-butyl-2-methoxy-5- (2-oxo-1,2-dihydropyridin-3-yl) phenyl] ethyl} pyridazin-3-yl) methanesulfonamide; 3- {3- [2- (6-aminopyridazin-3-yl) ethyl] -5-tert-butyl-4-methoxyphenyl} -1H-pyridin-2-one; N- [3-tert-butyl-2-methoxy-5- (2-oxo-1,2-dihydropyridin-3-yl) phenyl] -4-methanesulfonylamino-3-methylbenzamide; N- [3-tert-butyl-2-methoxy-5- (2-oxo-1,2-dihydropopyridin-3-yl) phenyl] -4-methanesulfonylamino-3-methoxybenzamide; N- [3-tert-butyl-2-methoxy-5- (2-oxo-1,2-dihydropopyridin-3-yl) phenyl] -3-chloro-4-methanesulfonylaminobenzamide; N- [3-tert-butyl-2-methoxy-5- (2-oxo-1,2-dihydropyridin-3-yl) phenyl] -4-methanesulfonylamino-2-trifluoromethylbenzamide; N- (5- {2- [3-tert-butyl-2-methoxy-5- (2-oxo-1,2-dihydropyridin-3-yl) phenyl] ethyl} pyrazin-2-yl) methanesulfonamide; 4-tert-butyl-2- [2- (4-methanesulfonylaminophenyl) ethyl] -6- (2-oxo-1,2-dihydropyridin-3-yl) benzoic acid methyl ester; 4-tert-butyl-2- [2- (4-methanesulfonylaminophenyl) ethyl] -6- (2-oxo-1,2-dihydropyridin-3-yl) benzoic acid; [3-tert-butyl-2-methoxy-5- (2-oxo-1,2-dihydropyridin-3-yl) phenyl] 5-methanesulfonylaminopyridin-2-carboxylic acid amide; N- (4 - {(E) -2- [5-tert-butyl-2-hydroxy-3- (2-oxo-1,2-dihydropyridin-3-yl) phenyl] vinyl} phenyl) methanesulfonamide; N- (4 - {(Z) -2- [3-tert-butyl-2-methoxy-5- (2-oxo-1,2-dihydropyridin-3-yl) phenyl] -1-cyanovinyl} phenyl) methanesulfonamide; N- (4 - {(E) -2- [3-tert-butyl-2-methoxy-5- (2-oxo-1,2-dihydropyridin-3-yl) phenyl] -1-methylvinyl} phenyl) methanesulfonamide; N- (4 - {(E) -2- [5-tert-butyl-2-hydroxy-3- (6-methyl-2-oxo-1,2-dihydropyridin-3-yl) phenyl] vinyl} phenyl) methanesulfonamide; N- (4 - {(E) -2- [3-tert-butyl-5- (2-oxo-1,2-dihydropyridin-3-yl) phenyl] vinyl} phenyl) methanesulfonamide; N- (4 - {(E) -2- [3-tert-butyl-5- (5-fluoro-2-oxo-1,2-dihydropyridin-3-yl) -2-methoxyphenyl] vinyl} phenyl) methanesulfonamide; N- (4 - {(E) -2- [5-tert-butyl-2-hydroxy-3- (2-oxo-1,2-dihydropyridin-3-yl) phenyl] -1-methylvinyl} phenyl) methanesulfonamide; 3- [3-tert-butyl-4-methoxy-5 - ((E) -styryl) phenyl] -1H-pyridin-2-one; N- (4 - {(E) -2- [3-tert-butyl-2-methoxy-5- (2-oxo-1,2-dihydropyridin-3-yl) phenyl] -1-hydroxymethylvinyl} phenyl) methanesulfonamide ; N- (4 - {(E) -2- [3-tert-butyl-5- (2-oxo-1,2-dihydropyridin-3-yl) phenyl] vinyl} -2-fluorophenyl) methanesulfonamide; N- (4 - {(E) -2- [3-tert-butyl-5- (2-oxo-1,2-dihydropyridin-3-yl) phenyl] vinyl} -3-cyanophenyl) methanesulfonamide; N- (4 - {(E) -2- [3-tert-butyl-5- (5-fluoro-2-oxo-1,2-dihydropyridin-3-yl) phenyl] vinyl} phenyl) methanesulfonamide; N- (4 - {(Z) -2- [3-tert-butyl-2-methoxy-5- (2-oxo-1,2-dihydropyridin-3-yl) phenyl] -1-hydroxymethylvinyl} phenyl) methanesulfonamide; N- (4 - {(E) -2- [3-tert-butyl-2-methoxy-5- (2-oxo-1,2-dihydropopyridin-3-yl) phenyl] vinyl} -3-cyanophenyl) methanesulfonamide; [3-cyclopropyl-5- (3H- [1,2,3] triazol-4-yl) -2- (4-trifluoromethoxyphenyl) -3H-imidazol-4-yl] - [4 - ((S) -3 -fluoropyrrolidin-1-yl) piperidin-1-yl] methanone; (4 - {(E) -2- [3-tert-butyl-5- (5-fluoro-2-oxo-1,2-dihydropopyridin-3-yl) -2-methoxyphenyl] vinyl} phenyl) amide 2,2, 2-trifluoroethanesulfonic acid; N- (4 - {(E) -2- [3-tert-butyl-5- (5-fluoro-2-oxo-1,2-dihydropyridin-3-yl) -2-methoxyphenyl] vinyl} phenyl) -C- cyclopropylmethanesulfonamide; N- (4 - {(E) -2- [3-tert-butyl-5- (5-fluoro-2-oxo-1,2-dihydropyridin-3-yl) -2-methoxyphenyl] vinyl} phenyl) -C, C, C-trifluoromethanesulfonamide; (4 - {(E) -2- [3-tert-butyl-5- (5-fluoro-2-oxo-1,2-dihydropyridin-3-yl) -2-methoxyphenyl] vinyl} phenyl) cyclopropanesulfonic acid amide; (4 - {(E) -2- [3-tert-butyl-5- (5-fluoro-2-oxo-1,2-dihydropyridin-3-yl) -2-methoxyphenyl] vinyl} phenyl) amide 3-methoxypropan- 1-sulfonic acid; 2 - {(E) -2- [3-tert-butyl-2-methoxy-5- (2-oxo-1,2-dihydropyridin-3-yl) phenyl] vinyl} -5-methanesulfonylaminobenzoic acid methyl ester; 2 - {(E) -2- [3-tert-butyl-5- (2-oxo-1,2-dihydropyridin-3-yl) phenyl] vinyl} -5-methanesulfonylaminobenzoic acid methyl ester; 2 - {(E) -2- [3-tert-butyl-5- (2-oxo-1,2-dihydropyridin-3-yl) phenyl] vinyl} -5-methanesulfonylaminobenzoic acid; N- (2 - {(E) -2- [3-tert-butyl-2-methoxy-5- (2-oxo-1,2-dihydropyridin-3-yl) phenyl] vinyl} -5-methanesulfonylaminobenzyl) acetamide; N- (4 - {(E) -2- [3-tert-butyl-5- (5-chloro-2-oxo-1,2-dihydropyridin-3-yl) -2-methoxyphenyl] vinyl} phenyl) methanesulfonamide; N- (4 - {(E) -2- [3- (1-hydroxymethylcyclopropyl) -5- (2-oxo-1,2-dihydropyridin-3-yl) phenyl] vinyl} phenyl) methanesulfonamide; N- (4 - {(E) -2- [3-tert-butyl-5- (6-hydroxymethyl-2-oxo-1,2-dihydropyridin-3-yl) -2-methoxyphenyl] vinyl} phenyl) methanesulfonamide; N- (4 - {(E) -2- [3-tert-butyl-2-methoxy-5- (6-methoxymethyl-2-oxo-1,2-dihydropyridin-3-yl) phenyl] vinyl} phenyl) methanesulfonamide; N- [4 - ((E) -2- {3-tert-butyl-2-methoxy-5- [6- (2-methoxyethoxymethyl) -2-oxo-1,2-dihydropyridin-3-yl] phenyl} vinyl) phenyl] methanesulfonamide; N- (6 - {(E) -2- [3-tert-butyl-2-methoxy-5- (2-oxo-1,2-dihydropopyridin-3-yl) phenyl] vinyl} pyridin-3-yl) methanesulfonamide; N- (6 - {(E) -2- [5-tert-butyl-2-hydroxy-3- (2-oxo-1,2-dihydropyridin-3-yl) phenyl] vinyl} pyridin-3-yl) methanesulfonamide; N- (6 - {(E) -2- [3-tert-butyl-5- (2-oxo-1,2-dihydropyridin-3-yl) phenyl] vinyl} pyridin-3-yl) methanesulfonamide; N- (6 - {(E) -2- [3-tert-butyl-5- (5-fluoro-2-oxo-1,2-dihydropyridin-3-yl) -2-methoxyphenyl] vinyl} pyridin-3-yl ) acetamide; N- (6 - {(E) -2- [3-tert-butyl-5- (5-fluoro-2-oxo-1,2-dihydropyridin-3-yl) -2-methoxyphenyl] vinyl} pyridin-3-yl ) methanesulfonamide; 3- {3 - [(E) -2- (6-aminopyridin-3-yl) vinyl] -5-tert-butyl-4-methoxyphenyl} -1H-pyridin-2-one; N- (5 - {(E) -2- [3-tert-butyl-2-methoxy-5- (2-oxo-1,2-dihydropyridin-3-yl) phenyl] vinyl} pyridin-2-yl) methanesulfonamide; 3- {3 - [(E) -2- (6-aminopyridin-3-yl) vinyl] -5-tert-butyl-4-methoxyphenyl} -5-fluoro-1H-pyridin-2-one; N- (5 - {(E) -2- [3-tert-butyl-5- (5-fluoro-2-oxo-1,2-dihydropyridin-3-yl) -2-methoxyphenyl] vinyl} pyridin-2-yl ) methanesulfonamide; N- (4- {2- [3-tert-butyl-2-methoxy-5- (2-oxo-1,2-dihydropyridin-3-yl) phenyl] -1-hydroxymethylethyl} phenyl) methanesulfonamide; N- (4- {2- [3-tert-butyl-2-methoxy-5- (2-oxo-1,2-dihydropyridin-3-yl) phenyl] -1-cyanoethyl} phenyl) methanesulfonamide; 3- [3-tert-butyl-2-methoxy-5- (2-oxo-1,2-dihydropyridin-3-yl) phenyl] -2- (4-methanesulfonylaminophenyl) propionamide; 3- [3-tert-butyl-2-methoxy-5- (2-oxo-1,2-dihydropyridin-3-yl) phenyl] -2- (4-methanesulfonylaminophenyl) propionic acid; N- (4 - {(E) -2- [2-methoxy-5- (2-oxo-1,2-dihydropyridin-3-yl) -3- (2,2,2-trifluoro-1-hydroxy- 1-methylethyl) phenyl] vinyl} phenyl) methanesulfonamide; 3- {3 - [(E) -2- (6-aminopyridazin-3-yl) vinyl] -5-tert-butyl-4-methoxyphenyl} -1H-pyridin-2-one; N- (6 - {(E) -2- [3-tert-butyl-2-methoxy-5- (2-oxo-1,2-dihydropopyridin-3-yl) phenyl] vinyl} pyridazin-3-yl) methanesulfonamide; 3- {3 - [(E) -2- (6-aminopyridazin-3-yl) vinyl] -5-tert-butyl-4-methoxyphenyl} -5-fluoro-1H-pyridin-2-one; N- (6 - {(E) -2- [3-tert-butyl-5- (5-fluoro-2-oxo-1,2-dihydropyridin-3-yl) -2-methoxyphenyl] vinyl} pyridazin-3-yl ) methanesulfonamide; 3-tert-butyl-N- (3-hydroxy-2-methylphenyl) -2-methoxy-5- (2-oxo-1,2-dihydropyridin-3-yl) benzamide; 2 - {(E) -2- [3-tert-butyl-5- (5-fluoro-2-oxo-1,2-dihydropyridin-3-yl) -2-methoxyphenyl] vinyl} -5-methanesulfonylaminobenzoic acid methyl ester; N- (4 - {(E) -2- [3-tert-butyl-5- (5-fluoro-2-oxo-1,2-dihydropyridin-3-yl) -2-methoxyphenyl] vinyl} -3-hydroxymethylphenyl) methanesulfonamide; 2 - {(E) -2- [3-tert-butyl-5- (5-fluoro-2-oxo-1,2-dihydropyridin-3-yl) -2-methoxyphenyl] vinyl} -5-methanesulfonylaminobenzoic acid; 2- {2- [3-tert-butyl-5- (5-fluoro-2-oxo-1,2-dihydropyridin-3-yl) -2-methoxyphenyl] ethyl} -5-methanesulfonylaminobenzoic acid methyl ester; 2- {2- [3-tert-butyl-5- (5-fluoro-2-oxo-1,2-dihydropyridin-3-yl) -2-methoxyphenyl] ethyl} -5-methanesulfonylaminobenzoic acid; N- (4- {1-aminomethyl-2- [3-tert-butyl-2-methoxy-5- (2-oxo-1,2-dihydropyridin-3-yl) phenyl] ethyl} phenyl) methanesulfonamide; N- (4- {2- [3-tert-butyl-2-methoxy-5- (2-oxo-1,2-dihydropyridin-3-yl) phenyl] -1-dimethylaminomethylethyl} phenyl) methanesulfonamide; N- (4- {2- [3-tert-butyl-2-methoxy-5- (2-oxo-1,2-dihydropyridin-3-yl) phenyl] -1-morpholin-4-ylmethylethyl} phenyl) methanesulfonamide; N- (4- {2- [3-tert-butyl-2-methoxy-5- (2-oxo-1,2-dihydropyridin-3-yl) phenyl] -1-pyrrolidin-1-ylmethylethyl} phenyl) methanesulfonamide; compound with formic acid; N- {4- [2- [3-tert-butyl-2-methoxy-5- (2-oxo-1,2-dihydropyridin-3-yl) phenyl] -1- (3,3-difluoropyrrolidin-1-ylmethyl) ethyl] phenyl} methanesulfonamide; N- (4- {2- [3-tert-butyl-2-methoxy-5- (2-oxo-1,2-dihydropyridin-3-yl) phenyl] -1-cyano-1-methylethyl} phenyl) methanesulfonamide; N- (4- {1-aminomethyl-2- [3-tert-butyl-2-methoxy-5- (2-oxo-1,2-dihydropyridin-3-yl) phenyl] -1-methylethyl} phenyl) methanesulfonamide ; N- (4- {2- [3-tert-butyl-2-methoxy-5- (2-oxo-1,2-dihydropyridin-3-yl) phenyl] -1-hydroxymethyl-1-methylethyl} phenyl) methanesulfonamide; N- (4- {2- [2-hydroxy-5- (2-hydroxy-1,1-dimethylethyl) -3- (2-oxo-1,2-dihydropyridin-3-yl) phenyl] ethyl} phenyl) methanesulfonamide; N- (4 - {(E) -2- [3-tert-butyl-5- (5-fluoro-2-oxo-1,2-dihydropyridin-3-yl) -2-methoxyphenyl] vinyl} -3-cyanophenyl) methanesulfonamide; 2 - {(E) -2- [3-tert-butyl-2-methoxy-5- (6-methyl-2-oxo-1,2-dihydropyridin-3-yl) phenyl] vinyl} -5-methanesulfonylaminobenzoic acid methyl ester ; 2 - {(E) -2- [3-tert-butyl-2-methoxy-5- (2-oxo-1,2-dihydropyridin-3-yl) phenyl] vinyl} -5-methanesulfonylamino-N, N-dimethylbenzamide; 2 - {(E) -2- [3-tert-butyl-2-methoxy-5- (2-oxo-1,2-dihydropyridin-3-yl) phenyl] vinyl} -5-methanesulfonylaminobenzoic acid; N- [4 - {(E) -2- [3-tert-butyl-2-methoxy-5- (2-oxo-1,2-dihydropyridin-3-yl) phenyl] vinyl} -3- (1-hydroxy- 1-methylethyl) phenyl] methanesulfonamide; N- (4 - {(E) -2- [3-tert-butyl-2-methoxy-5- (2-oxo-1,2-dihydropyridin-3-yl) phenyl] vinyl} -3-hydroxymethylphenyl) methanesulfonamide; N- (4 - {(E) -2- [3-tert-butyl-2-methoxy-5- (2-oxo-1,2-dihydropyridin-3-yl) phenyl] vinyl} -3-methoxymethylphenyl) methanesulfonamide; 2 - {(E) -2- [3-tert-butyl-5- (5-fluoro-2-oxo-1,2-dihydropyridin-3-yl) -2-methoxyphenyl] vinyl} -N- (2-dimethylaminoethyl) -5-methanesulfonylamino-N-methylbenzamide; N- (4 - {(E) -2- [3-tert-butyl-2-methoxy-5- (6-methyl-2-oxo-1,2-dihydropyridin-3-yl) phenyl] vinyl} -3-methoxymethylphenyl ) methanesulfonamide; N- (4 - {(E) -2- [3-tert-butyl-2-methoxy-5- (6-methoxy-2-oxo-1,2-dihydropyridin-3-yl) phenyl] vinyl} -3-methoxymethylphenyl ) methanesulfonamide; N- (4 - {(E) -2- [3-tert-butyl-2-methoxy-5- (6-methoxy-2-oxo-1,2-dihydropyridin-3-yl) phenyl] vinyl} -3-hydroxymethylphenyl ) methanesulfonamide; 2 - {(E) -2- [3-tert-butyl-2-methoxy-5- (6-methoxy-2-oxo-1,2-dihydropyridin-3-yl) phenyl] vinyl} -5-methanesulfonylaminobenzoic acid; N- (5- {2- [5-tert-butyl-2-cyano-3- (2-oxo-1,2-dihydropyridin-3-yl) phenyl] ethyl} pyridin-2-yl) methanesulfonamide; N- (6 - {(E) -2- [3-tert-butyl-2-methoxy-5- (2-oxo-1,2-dihydropyridin-3-yl) phenyl] vinyl} -5-methylpyridin-3-yl ) methanesulfonamide; N- (6- {2- [5-tert-butyl-2-hydroxy-3- (2-oxo-1,2-dihydropyridin-3-yl) phenyl] ethyl} pyridin-3-yl) methanesulfonamide; N- (5- {2- [5-tert-butyl-2-hydroxy-3- (2-oxo-1,2-dihydropyridin-3-yl) phenyl] ethyl} pyridin-2-yl) methanesulfonamide; N- (4- {2- [5-tert-butyl-2-hydroxy-3- (2-oxo-1,2-dihydropyridin-3-yl) phenyl] ethyl} -3-cyanophenyl) methanesulfonamide; N- {4- [5-tert-butyl-2-hydroxy-3- (2-oxo-1,2-dihydropyridin-3-yl) phenylethinyl] -3-fluorophenyl} methanesulfonamide; N- (4- {2- [3-tert-butyl-6-hydroxy-2-methoxy-5- (2-oxo-1,2-dihydropyridin-3-yl) phenyl] ethyl} phenyl) methanesulfonamide; N- [4 - {(E) -2- [3-tert-butyl-5- (5-fluoro-2-oxo-1,2-dihydropyridin-3-yl) -2-methoxyphenyl] vinyl} -3- (3 -hydroxy-3-methylbutoxymethyl) phenyl] methanesulfonamide; N- [4 - {(E) -2- [3-tert-butyl-5- (5-fluoro-2-oxo-1,2-dihydropyridin-3-yl) -2-methoxyphenyl] vinyl} -3- (2 -oxoxoxolidin-3-ylmethyl) phenyl] methanesulfonamide; N- (4 - {(E) -2- [3-tert-butyl-5- (5-fluoro-2-oxo-1,2-dihydropopyridin-3-yl) -2-methoxyphenyl] vinyl} -3-dimethylaminomethylphenyl) methanesulfonamide; N- (1,5,6-trimethyl-1H-benzonimidazol-4-yl) methanesulfonamide; N- [4 - ((E) -2- {3-tert-butyl-5- [6- (1-hydroxyethyl) -2-oxo-1,2-dihydropyridin-3-yl] -2-methoxyphenyl} vinyl) phenyl ] methanesulfonamide; N- (4 - {(E) -2- [3-tert-butyl-5- (6-cyano-methyl-2-oxo-1,2-dihydropopyridin-3-yl) -2-methoxyphenyl] vinyl} phenyl) methanesulfonamide; N- [4 - ((E) -2- {3-tert-butyl-5- [6- (2-hydroxyethoxymethyl) -2-oxo-1,2-dihydropyridin-3-yl] -2-methoxyphenyl} vinyl) phenyl ] methanesulfonamide; N- (4 - {(E) -2- [3-tert-butyl-2-methoxy-5- (5-methyl-2-oxo-1,2-dihydropyridin-3-yl) phenyl] vinyl} phenyl) methanesulfonamide; N- [4 - {(E) -2- [3-tert-butyl-5- (5-fluoro-2-oxo-1,2-dihydropyridin-3-yl) -2-methoxyphenyl] vinyl} -3- (2 -methoxyethyl) phenyl] methanesulfonamide; (4 - {(E) -2- [3-tert-butyl-5- (5-fluoro-2-oxo-1,2-dihydropyridin-3-yl) -2-methoxyphenyl] vinyl} phenyl) ethanesulfonic acid amide; (6 - {(E) -2- [3-tert-butyl-5- (5-fluoro-2-oxo-1,2-dihydropyridin-3-yl) -2-methoxyphenyl] vinyl} pyridin-3-yl) amide 2,2,2-trifluoroethanesulfonic acid; (4 - {(E) -2- [3-tert-butyl-5- (5-fluoro-2-oxo-1,2-dihydropyridin-3-yl) -2-methoxyphenyl] vinyl} phenyl) amide 3-pyrrolidin- 1-ylpropan-1-sulfonic acid; (4 - {(E) -2- [3-tert-butyl-5- (5-fluoro-2-oxo-1,2-dihydropyridin-3-yl) -2-methoxyphenyl] vinyl} phenyl) amide 3-morpholin- 4-ylpropan-1-sulfonic acid; (4 - {(E) -2- [3-tert-butyl-5- (5-fluoro-2-oxo-1,2-dihydropyridin-3-yl) -2-methoxyphenyl] vinyl} phenyl) amide 2-pyrrolidin- 1-yl-ethanesulfonic acid; (4 - {(E) -2- [3-tert-butyl-5- (5-fluoro-2-oxo-1,2-dihydropyridin-3-yl) -2-methoxyphenyl] vinyl} phenyl) amide 2-morpholin- 4-yl-ethanesulfonic acid; (4 - {(E) -2- [3-tert-butyl-2-methoxy-5- (2-oxo-1,2-dihydropyridin-3-yl) phenyl] vinyl} phenyl) amide 3-pyrrolidin-1-ylpropane -1-sulfonic acid; (4 - {(E) -2- [3-tert-butyl-2-methoxy-5- (6-methyl-2-oxo-1,2-dihydropyridin-3-yl) phenyl] vinyl} phenyl) amide 3-pyrrolidine -1-ylpropan-1-sulfonic acid; N- (4 - {(E) -2- [3-tert-butyl-5- (5-fluoro-2-oxo-1,2-dihydropyridin-3-yl) -2-methoxyphenyl] vinyl} -3-fluorophenyl) methanesulfonamide; 3- {3-tert-butyl-5 - [(E) -2- (2-fluoro-phenyl) vinyl] -4-methoxyphenyl} -1H-pyridin-2-one; 2 - {(E) -2- [3-tert-butyl-2-methoxy-5- (2-oxo-1,2-dihydropyridin-3-yl) phenyl] vinyl} benzonitrile; [5-amino-1- (2-methyl-1H-benzoimidazol-5-yl) -1H-pyrazol-4-yl] - [5- (4-trifluoromethylphenyl) -1H-indol-2-yl] methanone; 3- [3-tert-butyl-4-methoxy-5 - ((E) -2-pyridin-4-ylvinyl) phenyl] -1H-pyridin-2-one; 3- [3-tert-butyl-4-methoxy-5 - ((E) -2-pyridin-2-ylvinyl) phenyl] -1H-pyridin-2-one; 2 - {(E) -2- [3-tert-butyl-2-methoxy-5- (2-oxo-1,2-dihydropyridin-3-yl) phenyl] vinyl} benzoic acid methyl ester; 3- {3 - [(E) -2- (2-acetylphenyl) vinyl] -5-tert-butyl-4-methoxyphenyl} -1H-pyridin-2-one; 3- {3-tert-butyl-5 - [(E) -2- (2-methanesulfonylphenyl) vinyl] -4-methoxyphenyl} -1H-pyridin-2-one; 4 - {(E) -2- [3-tert-butyl-2-methoxy-5- (2-oxo-1,2-dihydropyridin-3-yl) phenyl] vinyl} nicotinonitrile; 2 - {(E) -2- [3-tert-butyl-2-methoxy-5- (2-oxo-1,2-dihydropyridin-3-yl) phenyl] vinyl} benzoic acid; 6-amino-N- [3-tert-butyl-2-methoxy-5- (2-oxo-1,2-dihydropyridin-3-yl) phenyl] nicotinamide; [3-tert-butyl-2-methoxy-5- (2-oxo-1,2-dihydropyridin-3-yl) phenyl] amide 6- (2,2,2-trifluoroethylamino) pyridazine-3-carboxylic acid; N- (4 - {(E) -2- [3-tert-butyl-2-ethoxy-5- (2-oxo-1,2-dihydropyridin-3-yl) phenyl] vinyl} phenyl) methanesulfonamide; N- (4 - {(E) -2- [3-tert-butyl-2- (2-methoxyethoxy) -5- (2-oxo-1,2-dihydropyridin-3-yl) phenyl] vinyl} phenyl) methanesulfonamide; N- [3-tert-butyl-2-methoxy-5- (2-oxo-1,2-dihydropyridin-3-yl) phenyl] -3-fluoro-4- (2,2,2-trifluoroethylamino) benzamide; N- [3-tert-butyl-2-methoxy-5- (2-oxo-1,2-dihydropyridin-3-yl) phenyl] -2-fluoro-4-hydroxybenzamide; N- [3-tert-butyl-2-methoxy-5- (2-oxo-1,2-dihydropyridin-3-yl) phenyl] -4- (2,2,2-trifluoroethylamino) benzamide; N- [3-tert-butyl-2-methoxy-5- (2-oxo-1,2-dihydropyridin-3-yl) phenyl] -6- (2-methoxyethylamino) nicotinamide; N- [3-tert-butyl-2-methoxy-5- (2-oxo-1,2-dihydropopyridin-3-yl) phenyl] -6-cyclopropylaminonicotinamide; N- [3-tert-butyl-2-methoxy-5- (2-oxo-1,2-dihydropopyridin-3-yl) phenyl] -4-cyclopropylaminobenzamide; {[3- (2 ′, 3′-difluoro-6′-methoxybiphenyl-4-yloxymethyl) benzoyl] methylamino} acetic acid; N- (6 - {(E) -2- [3- (1-difluoromethylcyclopropyl) -2-methoxy-5- (2-oxo-1,2-dihydropyridin-3-yl) phenyl] vinyl} pyridin-3- sludge) methanesulfonamide; 3-tert-butyl-N- (3-methanesulfonylaminophenyl) -2-methoxy-5- (2-oxo-1,2-dihydropyridin-3-yl) benzamide; 3-tert-butyl-N- (4-methanesulfonylaminocyclohexyl) -2-methoxy-5- (2-oxo-1,2-dihydropyridin-3-yl) benzamide; N- (6 - {(E) -2- [3-tert-butyl-5- (5-chloro-2-oxo-1,2-dihydropyridin-3-yl) -2-methoxyphenyl] vinyl} pyridin-3-yl ) methanesulfonamide; N- (4 - {(E) -2- [3-tert-butyl-2-methoxy-5- (6-methyl-2-oxo-1,2-dihydropyridin-3-yl) phenyl] vinyl} phenyl) methanesulfonamide; N- (4 - {(E) -2- [3- (1-chlorocyclopropyl) -5- (5-fluoro-2-oxo-1,2-dihydropyridin-3-yl) -2-methoxyphenyl] vinyl} phenyl ) methanesulfonamide; N- (4 - {(E) -2- [3- (1-chloro-cyclo-propyl) -5- (5-chloro-2-oxo-1,2-dihydropopyridin-3-yl) -2-methoxyphenyl] vinyl} phenyl ) methanesulfonamide; N- (4 - {(E) -2- [3- (1-chlorocyclopropyl) -2-methoxy-5- (6-methyl-2-oxo-1,2-dihydropyridin-3-yl) phenyl] vinyl} phenyl) methanesulfonamide; N- (4 - {(E) -2- [2-methoxy-3- (1-methoxycyclopropyl) -5- (2-oxo-1,2-dihydropyridin-3-yl) phenyl] vinyl} phenyl) methanesulfonamide; N- (4 - {(E) -2- [3- (1-chlorocyclopropyl) -2-methoxy-5- (2-oxo-1,2-dihydropyridin-3-yl) phenyl] vinyl} phenyl) methanesulfonamide; N- (4 - {(E) -2- [3- (1-cyanocyclopropyl) -2-methoxy-5- (2-oxo-1,2-dihydropyridin-3-yl) phenyl] vinyl} phenyl) methanesulfonamide; N- (4 - {(E) -2- [3- (1-difluoromethylcyclopropyl) -5- (5-fluoro-2-oxo-1,2-dihydropyridin-3-yl) -2-methoxyphenyl] vinyl} phenyl ) methanesulfonamide; N- (4 - {(E) -2- [3- (1-difluoromethylcyclopropyl) -2-methoxy-5- (2-oxo-1,2-dihydropyridin-3-yl) phenyl] vinyl} phenyl) methanesulfonamide; N- (4 - {(E) -2- [3- (1-fluorocyclobutyl) -5- (2-oxo-1,2-dihydropopyridin-3-yl) phenyl] vinyl} phenyl) methanesulfonamide; N- (4 - {(E) -2- [3- (2-hydroxy-1,1-dimethylethyl) -5- (2-oxo-1,2-dihydropyridin-3-yl) phenyl] vinyl} phenyl) methanesulfonamide; N- (4 - {(E) -2- [3- (1-chlorocyclopropyl) -5- (5-fluoro-2-oxo-1,2-dihydropyridin-3-yl) phenyl] vinyl} phenyl) methanesulfonamide; N- (4 - {(E) -2- [3- (1-chlorocyclopropyl) -5- (2-oxo-1,2-dihydropopyridin-3-yl) phenyl] vinyl} phenyl) methanesulfonamide; N- (4 - {(E) -2- [3- (1-difluoromethylcyclopropyl) -5- (2-oxo-1,2-dihydropyridin-3-yl) phenyl] vinyl} phenyl) methanesulfonamide; N- [3-tert-butyl-2-methoxy-5- (2-oxo-1,2-dihydropopyridin-3-yl) phenyl] -4-methanesulfonylamino-2- (2-methoxyethoxy) benzamide; 4-acetylamino-N- [3-tert-butyl-2-methoxy-5- (2-oxo-1,2-dihydropyridin-3-yl) phenyl] benzamide; 4-amino-N- [3-tert-butyl-2-methoxy-5- (2-oxo-1,2-dihydropyridin-3-yl) phenyl] -3-methylbenzamide; 4-amino-N- [3-tert-butyl-2-methoxy-5- (2-oxo-1,2-dihydropyridin-3-yl) phenyl] -2-trifluoromethylbenzamide; 4-amino-N- [3-tert-butyl-2-methoxy-5- (2-oxo-1,2-dihydropyridin-3-yl) phenyl] -2-fluorobenzamide; N- [3-tert-butyl-2-methoxy-5- (2-oxo-1,2-dihydropyridin-3-yl) phenyl] -2-fluoro-4-methanesulfonylaminobenzamide; N- [3-tert-butyl-2-methoxy-5- (2-oxo-1,2-dihydropyridin-3-yl) phenyl] -4-methanesulfonylamino-2-methylbenzamide; [3-tert-butyl-2-methoxy-5- (2-oxo-1,2-dihydropyridin-3-yl) phenyl] 5-aminopyridin-2-carboxylic acid amide; 1- (morpholine-4-sulfonyl) piperidine-4-carboxylic acid (4-trifluoromethoxyphenyl) amide; N- [3-tert-butyl-2-methoxy-5- (2-oxo-1,2-dihydropyridin-3-yl) phenyl] -2- (2-dimethylaminoethoxy) -4-methanesulfonylaminobenzamide; N- [3-tert-butyl-2-methoxy-5- (6-methyl-2-oxo-1,2-dihydropyridin-3-yl) phenyl] -4-methanesulfonylaminobenzamide; N- (4- {2- [3-tert-butyl-4-fluoro-2-methoxy-5- (2-oxo-1,2-dihydropopyridin-3-yl) phenyl] ethyl} phenyl) methanesulfonamide; N- (4 - {(E) -2- [3- (2-hydroxy-1,1-dimethylethyl) -2-methoxy-5- (2-oxo-1,2-dihydropyridin-3-yl) phenyl] vinyl} phenyl) methanesulfonamide; N- (4 - {(E) -2- [2-methoxy-3- (1-methoxy-1-methylethyl) -5- (2-oxo-1,2-dihydropyridin-3-yl) phenyl] vinyl} phenyl) methanesulfonamide; N- (4 - {(E) -2- [2-methoxy-3- (3-methyloxetan-3-yl) -5- (2-oxo-1,2-dihydropyridin-3-yl) phenyl] vinyl} phenyl) methanesulfonamide; N- (4 - {(E) -2- [5- (5-chlorop-2-oxo-1,2-dihydropopyridin-3-yl) -2-methoxy-3- (3-methyloxetan-3-yl) phenyl] vinyl} phenyl) methanesulfonamide; N- (4 - {(E) -2- [5- (5-chlorop-2-oxo-1,2-dihydropopyridin-3-yl) -3-cyclopropyl-2-methoxyphenyl] vinyl} phenyl) methanesulfonamide; N- [3-tert-butyl-5- (2-oxo-1,2-dihydropyridin-3-yl) phenyl] -4-methanesulfonylamino-N-methylbenzamide; N- (4 - {(E) -2- [3,3-dimethyl-5- (2-oxo-1,2-dihydropyridin-3-yl) -2,3-dihydrobenzofuran-7-yl] vinyl} phenyl ) methanesulfonamide; N- (4 - {(E) -2- [3,3-dimethyl-7- (2-oxo-1,2-dihydropyridin-3-yl) -2,3-dihydrobenzofuran-5-yl] vinyl} phenyl ) methanesulfonamide; N- (4 - {(E) -2- [7- (5-fluoro-2-oxo-1,2-dihydropyridin-3-yl) -3,3-dimethyl-2,3-dihydrobenzofuran-5-yl ] vinyl} phenyl) methanesulfonamide; N- [3,3-dimethyl-7- (2-oxo-1,2-dihydropyridin-3-yl) -2,3-dihydrobenzofuran-5-yl] -4-methanesulfonylaminobenzamide; N- (4 - {(E) -2- [4-methoxy-3,3-dimethyl-7- (2-oxo-1,2-dihydropyridin-3-yl) indan-5-yl] vinyl} phenyl) methanesulfonamide; mono- (3- {3-tert-butyl-5 - [(E) -2- (4-methanesulfonylaminophenyl) vinyl] -4-methoxyphenyl} -5-fluoro-2-oxo-2H-pyridin-1-ylmethyl) amber acids; 3- {3-tert-butyl-5 - [(E) -2- (4-methanesulfonylaminophenyl) vinyl] -4-methoxyphenyl} -5-fluoro-2-oxo-2H-pyridin-1-ylmethyl ether (S) -2 amino-3-methylbutanoic acid; mono- (3- {3-tert-butyl-5 - [(E) -2- (4-methanesulfonylaminophenyl) vinyl] -4-methoxyphenyl} -5-fluoro-2-oxo-2H-pyridin-1-ylmethyl) phosphoric ester acids; and N- {3- [3-tert-butyl-2-methoxy-5- (2-oxo-1,2-dihydropyridin-3-yl) phenyl] -1-ethoxyisoquinolin-7-yl} methanesulfonamide; N- (4 - {(E) -2- [2-methoxy-5- (2-oxo-1,2-dihydropyridin-3-yl) -3-trifluoromethylphenyl] vinyl} phenyl) methanesulfonamide; N- (4 - {(E) -2- [2-methoxy-5- (2-oxo-1,2-dihydropyridin-3-yl) -3- (2,2,2-trifluoroethyl) phenyl] vinyl} phenyl) methanesulfonamide or its pharmaceutically acceptable salt. 22. The compound according to claim 1, intended for use as a medicine. 23. The compound according to claim 1, intended for use in the treatment of diseases caused by hepatitis C virus (HCV). 24. The use of a compound according to any one of claims 1 to 21 for the manufacture of a medicament for the treatment of a disease caused by hepatitis C virus (HCV). 25. A pharmaceutical composition comprising a compound according to any one of claims 1 to 21 in a therapeutically effective amount in a mixture with at least one pharmaceutically acceptable carrier, diluent or excipient.