RU2010125678A - METHOD FOR PRODUCING RECOMBINANT VACCINE - Google Patents
METHOD FOR PRODUCING RECOMBINANT VACCINE Download PDFInfo
- Publication number
- RU2010125678A RU2010125678A RU2010125678/10A RU2010125678A RU2010125678A RU 2010125678 A RU2010125678 A RU 2010125678A RU 2010125678/10 A RU2010125678/10 A RU 2010125678/10A RU 2010125678 A RU2010125678 A RU 2010125678A RU 2010125678 A RU2010125678 A RU 2010125678A
- Authority
- RU
- Russia
- Prior art keywords
- ligand
- conducts
- vaccine
- sequence
- signal
- Prior art date
Links
- 108010008038 Synthetic Vaccines Proteins 0.000 title claims abstract 3
- 238000004519 manufacturing process Methods 0.000 title claims abstract 3
- 229940124551 recombinant vaccine Drugs 0.000 title claims abstract 3
- 239000003446 ligand Substances 0.000 claims abstract 6
- 108020001507 fusion proteins Proteins 0.000 claims abstract 4
- 102000037865 fusion proteins Human genes 0.000 claims abstract 4
- 101000607306 Homo sapiens UL16-binding protein 1 Proteins 0.000 claims abstract 2
- 102000018071 Immunoglobulin Fc Fragments Human genes 0.000 claims abstract 2
- 108010091135 Immunoglobulin Fc Fragments Proteins 0.000 claims abstract 2
- 102000002689 Toll-like receptor Human genes 0.000 claims abstract 2
- 102100040012 UL16-binding protein 1 Human genes 0.000 claims abstract 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims abstract 2
- 239000000427 antigen Substances 0.000 claims abstract 2
- 102000036639 antigens Human genes 0.000 claims abstract 2
- 108091007433 antigens Proteins 0.000 claims abstract 2
- 239000010445 mica Substances 0.000 claims abstract 2
- 229910052618 mica group Inorganic materials 0.000 claims abstract 2
- 239000002773 nucleotide Substances 0.000 claims abstract 2
- 125000003729 nucleotide group Chemical group 0.000 claims abstract 2
- 239000002245 particle Substances 0.000 claims abstract 2
- 244000052769 pathogen Species 0.000 claims abstract 2
- 239000013612 plasmid Substances 0.000 claims abstract 2
- 108090000623 proteins and genes Proteins 0.000 claims abstract 2
- 102000004169 proteins and genes Human genes 0.000 claims abstract 2
- 102000005962 receptors Human genes 0.000 claims abstract 2
- 108020003175 receptors Proteins 0.000 claims abstract 2
- 229960005486 vaccine Drugs 0.000 claims abstract 2
Landscapes
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Abstract
Способ получения рекомбинантной вакцины, включающий конструирование нуклеотидной или аминокислотной последовательности, кодирующей химерные белки, состоящие из антигена патогенного организма, лиганда к рецепторам, проводящим сигнал через ITAM-мотив - Fc-фрагмента антител, отличающийся тем, что в составе химерного белка содержится последовательность, кодирующая лиганд к TLR-рецепторам, в качестве лиганда, проводящего сигнал через ITAM-мотив, используют последовательность доменов MICA или ULBP1, вакцину в организм вводят в виде белка, или в виде нуклеотидной последовательности в составе носителя, в качестве которого используют плазмидную ДНК или рекомбинантную аденовирусную частицу. A method for producing a recombinant vaccine, comprising constructing a nucleotide or amino acid sequence encoding chimeric proteins consisting of an antigen of a pathogenic organism, a ligand to receptors that conducts a signal through an ITAM motif — an Fc fragment of antibodies, characterized in that the chimeric protein contains a sequence encoding the ligand to TLR receptors, as the ligand that conducts the signal through the ITAM motif, use the sequence of MICA or ULBP1 domains, the vaccine is introduced into the body as a protein, or as well the cleotid sequence in the composition of the carrier, which is used as plasmid DNA or a recombinant adenoviral particle.
Claims (1)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU2010125678/10A RU2444570C1 (en) | 2010-06-23 | 2010-06-23 | Method of producing recombinant vaccine |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU2010125678/10A RU2444570C1 (en) | 2010-06-23 | 2010-06-23 | Method of producing recombinant vaccine |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2010125678A true RU2010125678A (en) | 2011-12-27 |
| RU2444570C1 RU2444570C1 (en) | 2012-03-10 |
Family
ID=45782310
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2010125678/10A RU2444570C1 (en) | 2010-06-23 | 2010-06-23 | Method of producing recombinant vaccine |
Country Status (1)
| Country | Link |
|---|---|
| RU (1) | RU2444570C1 (en) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2836239A1 (en) * | 2012-04-11 | 2015-02-18 | The United States of America, as Represented By the Secretary, Department of Health and Human Services | Chimeric antigen receptors targeting b-cell maturation antigen |
| CA2963274C (en) | 2014-12-05 | 2024-01-30 | Avidbiotics Corp. | Insertable variable fragments of antibodies and modified a1-a2 domains of nkg2d ligands |
| US11117969B2 (en) | 2014-12-05 | 2021-09-14 | Xyphos Biosciences Inc. | Insertable variable fragments of antibodies and modified α1-α2 domains of NKG2D ligands |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7067110B1 (en) * | 1999-07-21 | 2006-06-27 | Emd Lexigen Research Center Corp. | Fc fusion proteins for enhancing the immunogenicity of protein and peptide antigens |
-
2010
- 2010-06-23 RU RU2010125678/10A patent/RU2444570C1/en active
Also Published As
| Publication number | Publication date |
|---|---|
| RU2444570C1 (en) | 2012-03-10 |
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