RU2010116271A - Ангиогенные клетки из плацентарного перфузата человека - Google Patents
Ангиогенные клетки из плацентарного перфузата человека Download PDFInfo
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- 230000003169 placental effect Effects 0.000 title claims abstract 28
- 230000002491 angiogenic effect Effects 0.000 title 1
- 238000000034 method Methods 0.000 claims abstract 40
- 102100031573 Hematopoietic progenitor cell antigen CD34 Human genes 0.000 claims abstract 34
- 101000777663 Homo sapiens Hematopoietic progenitor cell antigen CD34 Proteins 0.000 claims abstract 34
- 210000004700 fetal blood Anatomy 0.000 claims abstract 8
- 230000010412 perfusion Effects 0.000 claims abstract 7
- 210000002826 placenta Anatomy 0.000 claims abstract 6
- 102100031650 C-X-C chemokine receptor type 4 Human genes 0.000 claims abstract 5
- 101000922348 Homo sapiens C-X-C chemokine receptor type 4 Proteins 0.000 claims abstract 5
- 102100024616 Platelet endothelial cell adhesion molecule Human genes 0.000 claims abstract 5
- 108091008605 VEGF receptors Proteins 0.000 claims abstract 5
- 102100033177 Vascular endothelial growth factor receptor 2 Human genes 0.000 claims abstract 5
- 210000004369 blood Anatomy 0.000 claims abstract 3
- 239000008280 blood Substances 0.000 claims abstract 3
- 210000001185 bone marrow Anatomy 0.000 claims abstract 3
- 239000011159 matrix material Substances 0.000 claims abstract 3
- 210000005259 peripheral blood Anatomy 0.000 claims abstract 3
- 239000011886 peripheral blood Substances 0.000 claims abstract 3
- 102000005741 Metalloproteases Human genes 0.000 claims abstract 2
- 108010006035 Metalloproteases Proteins 0.000 claims abstract 2
- 102000004887 Transforming Growth Factor beta Human genes 0.000 claims abstract 2
- 108090001012 Transforming Growth Factor beta Proteins 0.000 claims abstract 2
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 claims abstract 2
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 claims abstract 2
- 230000015572 biosynthetic process Effects 0.000 claims abstract 2
- 210000004204 blood vessel Anatomy 0.000 claims abstract 2
- 238000000338 in vitro Methods 0.000 claims abstract 2
- 238000001727 in vivo Methods 0.000 claims abstract 2
- ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C([C@H](NC(=O)[C@H](C(C)C)NC(=O)CNC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H]([C@@H](C)O)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCSC)C(C)C)[C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](C)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N1[C@@H](CCC1)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(O)=O)C1=CC=C(O)C=C1 ZRKFYGHZFMAOKI-QMGMOQQFSA-N 0.000 claims abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 6
- 101000738771 Homo sapiens Receptor-type tyrosine-protein phosphatase C Proteins 0.000 claims 5
- 102100037422 Receptor-type tyrosine-protein phosphatase C Human genes 0.000 claims 5
- 201000010099 disease Diseases 0.000 claims 3
- 208000035475 disorder Diseases 0.000 claims 3
- 230000001575 pathological effect Effects 0.000 claims 3
- 208000020446 Cardiac disease Diseases 0.000 claims 1
- 206010007558 Cardiac failure chronic Diseases 0.000 claims 1
- 206010007559 Cardiac failure congestive Diseases 0.000 claims 1
- 208000031229 Cardiomyopathies Diseases 0.000 claims 1
- 206010019280 Heart failures Diseases 0.000 claims 1
- 208000018262 Peripheral vascular disease Diseases 0.000 claims 1
- 208000014888 Vascular hypertensive disease Diseases 0.000 claims 1
- 230000001154 acute effect Effects 0.000 claims 1
- 210000001367 artery Anatomy 0.000 claims 1
- 230000000747 cardiac effect Effects 0.000 claims 1
- 230000001684 chronic effect Effects 0.000 claims 1
- 230000002526 effect on cardiovascular system Effects 0.000 claims 1
- 208000019622 heart disease Diseases 0.000 claims 1
- 208000028867 ischemia Diseases 0.000 claims 1
- 208000010125 myocardial infarction Diseases 0.000 claims 1
- 230000002093 peripheral effect Effects 0.000 claims 1
- 230000002685 pulmonary effect Effects 0.000 claims 1
- 208000004124 rheumatic heart disease Diseases 0.000 claims 1
- 208000019553 vascular disease Diseases 0.000 claims 1
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/48—Reproductive organs
- A61K35/50—Placenta; Placental stem cells; Amniotic fluid; Amnion; Amniotic stem cells
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- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/069—Vascular Endothelial cells
- C12N5/0692—Stem cells; Progenitor cells; Precursor cells
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Abstract
1. Способ формирования сосудов из популяции клеток плацентарного перфузата, включающий приведение в контакт указанной популяции клеток в условиях, которые способствуют формированию сосудов. ! 2. Способ по п.1, где указанная популяция клеток плацентарного перфузата представляет собой все нуклеарные клетки плацентарного перфузата. ! 3. Способ по п.1, где указанное приведение в контакт включает приведение в контакт указанных клеток с VEGF (50-200 нг/мл), TGF-β (1-5 нг/мл), FGF (10-50 нг/мл), а также одной или нескольких матриксных металлопротеаз (1-3 единицы/мл каждая). ! 4. Способ по п.1, где указанное приведение в контакт осуществляют in vitro. ! 5. Способ по п.1, где указанное приведение в контакт осуществляют in vivo. ! 6. Способ по п.1, где указанная популяция клеток плацентарного перфузата включает клетки плацентарного перфузата, выделенные при перфузии одной плаценты. ! 7. Способ по п.6, где указанные клетки плацентарного перфузата представляют собой клетки CD34+. ! 8. Способ по п.7, где указанные клетки CD34+ представляют собой клетки CD34+CD45-. ! 9. Способ по п.6 или 7, где указанные клетки CD34+ или клетки CD34+CD45- экспрессируют более высокий уровень по меньшей мере одного из CD31, CXCR4 или VEGFR по сравнению с эквивалентным числом клеток CD34+ пуповинной крови. ! 10. Способ по п.1, где указанная популяция клеток плацентарного перфузата включает выделенные клетки CD34+, выделенные не из указанного перфузата. ! 11. Способ по п.10, где указанные клетки CD34+ выделяют из плаценты. ! 12. Способ по п.10, где указанные клетки CD34+ выделяют из пуповинной крови, плацентарной крови, периферической крови или костного мозга. ! 13. Способ по п.10, где указанные клетки CD34+ экспрессируют более высокий ур�
Claims (27)
1. Способ формирования сосудов из популяции клеток плацентарного перфузата, включающий приведение в контакт указанной популяции клеток в условиях, которые способствуют формированию сосудов.
2. Способ по п.1, где указанная популяция клеток плацентарного перфузата представляет собой все нуклеарные клетки плацентарного перфузата.
3. Способ по п.1, где указанное приведение в контакт включает приведение в контакт указанных клеток с VEGF (50-200 нг/мл), TGF-β (1-5 нг/мл), FGF (10-50 нг/мл), а также одной или нескольких матриксных металлопротеаз (1-3 единицы/мл каждая).
4. Способ по п.1, где указанное приведение в контакт осуществляют in vitro.
5. Способ по п.1, где указанное приведение в контакт осуществляют in vivo.
6. Способ по п.1, где указанная популяция клеток плацентарного перфузата включает клетки плацентарного перфузата, выделенные при перфузии одной плаценты.
7. Способ по п.6, где указанные клетки плацентарного перфузата представляют собой клетки CD34+.
8. Способ по п.7, где указанные клетки CD34+ представляют собой клетки CD34+CD45-.
9. Способ по п.6 или 7, где указанные клетки CD34+ или клетки CD34+CD45- экспрессируют более высокий уровень по меньшей мере одного из CD31, CXCR4 или VEGFR по сравнению с эквивалентным числом клеток CD34+ пуповинной крови.
10. Способ по п.1, где указанная популяция клеток плацентарного перфузата включает выделенные клетки CD34+, выделенные не из указанного перфузата.
11. Способ по п.10, где указанные клетки CD34+ выделяют из плаценты.
12. Способ по п.10, где указанные клетки CD34+ выделяют из пуповинной крови, плацентарной крови, периферической крови или костного мозга.
13. Способ по п.10, где указанные клетки CD34+ экспрессируют более высокий уровень CD31, CXCR4 или VEGFR по сравнению с эквивалентным числом клеток CD34+ пуповинной крови.
14. Способ по п.10, где указанные клетки CD34+ представляют собой клетки CD34+CD45-.
15. Способ лечения индивидуума, страдающего сердечным или сосудистым заболеванием, нарушением, патологическим состоянием или недостаточностью, включающий введение плацентарного перфузата человека или клеток плацентарного перфузата человека указанному индивидууму в количестве, достаточном для лечения указанного заболевания, нарушения, патологического состояния или недостаточности.
16. Способ по п.15, где указанное заболевание, нарушение, патологическое состояние или недостаточность представляет собой заболевание периферических сосудов, острый или хронический инфаркт миокарда, кардиомиопатию, застойную или хроническую сердечную недостаточность, сердечно-сосудистую ишемию, легочное сосудистое гипертензивное заболевание, заболевание периферических артерий или ревматический порок сердца.
17. Способ по п.15, где указанные клетки плацентарного перфузата представляют собой все нуклеарные клетки плацентарного перфузата.
18. Способ по п.15, где указанная популяция клеток плацентарного перфузата включает клетки плацентарного перфузата, выделенные при перфузии одной плаценты.
19. Способ по п.18, где указанные клетки плацентарного перфузата представляют собой клетки CD34+.
20. Способ по п.19, где указанные клетки CD34+ представляют собой клетки CD34+CD45-.
21. Способ по п.19 или 20, где указанные клетки CD34+ или клетки CD34+CD45- экспрессируют более высокий уровень по меньшей мере одного из CD31, CXCR4 или VEGFR по сравнению с эквивалентным числом клеток CD34+ пуповинной крови.
22. Способ по п.15, где указанная популяция клеток плацентарного перфузата включает выделенные клетки CD34+, выделенные не из указанного перфузата.
23. Способ по п.22, где указанные клетки CD34+ выделяют из плаценты.
24. Способ по п.22, где указанные клетки CD34+ выделяют из пуповинной крови, плацентарной крови, периферической крови или костного мозга.
25. Способ по п.22, где указанные клетки CD34+ экспрессируют более высокий уровень CD31, CXCR4 или VEGFR по сравнению с эквивалентным числом клеток CD34+ пуповинной крови.
26. Способ по п.15, где указанные клетки плацентарного перфузата вводят на клеточном каркасе или матрице.
27. Способ по п.15, где указанные клетки плацентарного перфузата вводят внутривенно.
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| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US99567907P | 2007-09-26 | 2007-09-26 | |
| US60/995,679 | 2007-09-26 |
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| RU2010116271A true RU2010116271A (ru) | 2011-11-10 |
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| Application Number | Title | Priority Date | Filing Date |
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| RU2010116271/10A RU2010116271A (ru) | 2007-09-26 | 2008-09-26 | Ангиогенные клетки из плацентарного перфузата человека |
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| Country | Link |
|---|---|
| US (1) | US20090104164A1 (ru) |
| EP (1) | EP2205719A1 (ru) |
| JP (6) | JP5703493B2 (ru) |
| KR (9) | KR101644659B1 (ru) |
| CN (1) | CN101978045A (ru) |
| AU (1) | AU2008305516A1 (ru) |
| BR (1) | BRPI0818191A8 (ru) |
| CA (1) | CA2700613C (ru) |
| IL (4) | IL204762A0 (ru) |
| MX (1) | MX2010003217A (ru) |
| RU (1) | RU2010116271A (ru) |
| WO (1) | WO2009042201A1 (ru) |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2206772A3 (en) | 2000-12-06 | 2010-08-04 | Robert J. Hariri | Method of collecting placental stem cells |
| US7311905B2 (en) * | 2002-02-13 | 2007-12-25 | Anthrogenesis Corporation | Embryonic-like stem cells derived from post-partum mammalian placenta, and uses and methods of treatment using said cells |
| US20080152629A1 (en) * | 2000-12-06 | 2008-06-26 | James Edinger | Placental stem cell populations |
| WO2002063962A1 (en) | 2001-02-14 | 2002-08-22 | Hariri Robert J | Renovation and repopulation of decellularized tissues and cadaveric organs by stem cells |
| US7700090B2 (en) * | 2002-02-13 | 2010-04-20 | Anthrogenesis Corporation | Co-culture of placental stem cells and stem cells from a second source |
| US7498171B2 (en) * | 2002-04-12 | 2009-03-03 | Anthrogenesis Corporation | Modulation of stem and progenitor cell differentiation, assays, and uses thereof |
| CN1717177A (zh) * | 2002-11-26 | 2006-01-04 | 人类起源公司 | 细胞治疗剂、细胞治疗单元及其用于治疗的方法 |
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| MX353489B (es) * | 2009-07-02 | 2018-01-16 | Anthrogenesis Corp | Metodo para producir eritrocitos sin celulas alimentadoras. |
| TWI395125B (zh) * | 2009-07-14 | 2013-05-01 | Sonix Technology Co Ltd | 電容式觸控感應電路 |
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