RU2010113974A - Применение противовоспалительного пептида-1 в качестве терапевтического средства - Google Patents
Применение противовоспалительного пептида-1 в качестве терапевтического средства Download PDFInfo
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- RU2010113974A RU2010113974A RU2010113974/15A RU2010113974A RU2010113974A RU 2010113974 A RU2010113974 A RU 2010113974A RU 2010113974/15 A RU2010113974/15 A RU 2010113974/15A RU 2010113974 A RU2010113974 A RU 2010113974A RU 2010113974 A RU2010113974 A RU 2010113974A
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- diseases
- pharmaceutical composition
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- peptide
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- XVZUZGWPOCVGGZ-NETRMLAPSA-N (3s)-3-[[(2s)-2-[[(2s)-2-[[(2s)-6-amino-2-[[(2s)-6-amino-2-[[(2s)-2-[[(2s)-5-amino-2-[[(2s)-2-amino-4-methylsulfanylbutanoyl]amino]-5-oxopentanoyl]amino]-4-methylsulfanylbutanoyl]amino]hexanoyl]amino]hexanoyl]amino]-3-methylbutanoyl]amino]-4-methylpentano Chemical compound CSCC[C@H](N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CO)C(O)=O XVZUZGWPOCVGGZ-NETRMLAPSA-N 0.000 title 1
- 230000001225 therapeutic effect Effects 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract 11
- 108090000765 processed proteins & peptides Proteins 0.000 claims abstract 10
- 208000035473 Communicable disease Diseases 0.000 claims abstract 9
- 239000000203 mixture Substances 0.000 claims abstract 8
- 208000015181 infectious disease Diseases 0.000 claims abstract 7
- 241000187479 Mycobacterium tuberculosis Species 0.000 claims abstract 4
- 210000004251 human milk Anatomy 0.000 claims abstract 4
- 235000020256 human milk Nutrition 0.000 claims abstract 4
- 239000007788 liquid Substances 0.000 claims abstract 4
- 208000023275 Autoimmune disease Diseases 0.000 claims abstract 3
- 206010016654 Fibrosis Diseases 0.000 claims abstract 3
- 208000019693 Lung disease Diseases 0.000 claims abstract 3
- 210000004204 blood vessel Anatomy 0.000 claims abstract 3
- 201000011510 cancer Diseases 0.000 claims abstract 3
- 201000010099 disease Diseases 0.000 claims abstract 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract 3
- 230000004761 fibrosis Effects 0.000 claims abstract 3
- 208000027866 inflammatory disease Diseases 0.000 claims abstract 3
- 208000030159 metabolic disease Diseases 0.000 claims abstract 3
- 230000004770 neurodegeneration Effects 0.000 claims abstract 3
- 208000015122 neurodegenerative disease Diseases 0.000 claims abstract 3
- 230000002265 prevention Effects 0.000 claims abstract 3
- 210000000988 bone and bone Anatomy 0.000 claims abstract 2
- 239000000872 buffer Substances 0.000 claims abstract 2
- 239000007853 buffer solution Substances 0.000 claims abstract 2
- 210000003169 central nervous system Anatomy 0.000 claims abstract 2
- 239000002577 cryoprotective agent Substances 0.000 claims abstract 2
- 239000003085 diluting agent Substances 0.000 claims abstract 2
- 239000003937 drug carrier Substances 0.000 claims abstract 2
- 238000001990 intravenous administration Methods 0.000 claims abstract 2
- 210000001503 joint Anatomy 0.000 claims abstract 2
- 210000004072 lung Anatomy 0.000 claims abstract 2
- 210000004324 lymphatic system Anatomy 0.000 claims abstract 2
- -1 lyoprotector Substances 0.000 claims abstract 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims abstract 2
- 210000003491 skin Anatomy 0.000 claims abstract 2
- 210000002229 urogenital system Anatomy 0.000 claims abstract 2
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Abstract
1. Применение пептида Met-Gln-Met-Lys-Lys-Val-Leu-Asp-Ser-OH для получения фармацевтической композиции для лечения и/или профилактики злокачественной опухоли, аутоиммунных заболеваний, фиброзов, воспалительных заболеваний, нейродегенеративных заболеваний, инфекционных заболеваний, заболеваний легких, заболеваний сердца и сосудов и болезней обмена веществ. ! 2. Применение пептида по п.1, где инфекционное заболевание выбрано из инфекции Mycobacterium tuberculosis и инфекционных заболеваний, вызванных инфекцией Mycobacterium tuberculosis, выбранных из инфекционных заболеваний легкого, центральной нервной системы, лимфатической системы, системы кровообращения, мочеполовой системы, костей, суставов и кожи. ! 3. Применение пептида по п.1 или 2 для получения состава для перорального введения новорожденным, детям ясельного возраста и/или детям дошкольного возраста. ! 4. Применение пептида по п.1 или 2 для получения лиофилизированного состава или буферного жидкого состава. ! 5. Фармацевтическая композиция, содержащая пептид Met-Gln-Met-Lys-Lys-Val-Leu-Asp-Ser-OH, по меньшей мере, совместно с одним фармацевтически приемлемым носителем, криопротектором, лиопротектором, эксципиентом и/или разбавителем. ! 6. Фармацевтическая композиция по п.5 в форме лиофилизата или жидкого буферного раствора. ! 7. Фармацевтическая композиция по п.5 или 6, пригодная для внутривенного введения, перорального введения или для введения посредством ингаляции. ! 8. Фармацевтическая композиция по п.5 или 6 в форме состава искусственного материнского молока или заменителя материнского молока, пригодная для пероральной доставки новорожденным, детям ясельного возраста и/или детям дошкольного возраста. ! 9. �
Claims (9)
1. Применение пептида Met-Gln-Met-Lys-Lys-Val-Leu-Asp-Ser-OH для получения фармацевтической композиции для лечения и/или профилактики злокачественной опухоли, аутоиммунных заболеваний, фиброзов, воспалительных заболеваний, нейродегенеративных заболеваний, инфекционных заболеваний, заболеваний легких, заболеваний сердца и сосудов и болезней обмена веществ.
2. Применение пептида по п.1, где инфекционное заболевание выбрано из инфекции Mycobacterium tuberculosis и инфекционных заболеваний, вызванных инфекцией Mycobacterium tuberculosis, выбранных из инфекционных заболеваний легкого, центральной нервной системы, лимфатической системы, системы кровообращения, мочеполовой системы, костей, суставов и кожи.
3. Применение пептида по п.1 или 2 для получения состава для перорального введения новорожденным, детям ясельного возраста и/или детям дошкольного возраста.
4. Применение пептида по п.1 или 2 для получения лиофилизированного состава или буферного жидкого состава.
5. Фармацевтическая композиция, содержащая пептид Met-Gln-Met-Lys-Lys-Val-Leu-Asp-Ser-OH, по меньшей мере, совместно с одним фармацевтически приемлемым носителем, криопротектором, лиопротектором, эксципиентом и/или разбавителем.
6. Фармацевтическая композиция по п.5 в форме лиофилизата или жидкого буферного раствора.
7. Фармацевтическая композиция по п.5 или 6, пригодная для внутривенного введения, перорального введения или для введения посредством ингаляции.
8. Фармацевтическая композиция по п.5 или 6 в форме состава искусственного материнского молока или заменителя материнского молока, пригодная для пероральной доставки новорожденным, детям ясельного возраста и/или детям дошкольного возраста.
9. Фармацевтическая композиция по п.5 или 6, пригодная для лечения и/или профилактики злокачественной опухоли, аутоиммунного заболевания, фиброза, воспалительного заболевания, нейродегенеративного заболевания, инфекционного заболевания, заболевания легких, заболевания сердца и сосудов или болезней обмена веществ.
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