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RU2010151952A - WATER-SOLUBLE ANALOGUES OF ACETAMINOPHEN - Google Patents

WATER-SOLUBLE ANALOGUES OF ACETAMINOPHEN Download PDF

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RU2010151952A
RU2010151952A RU2010151952/04A RU2010151952A RU2010151952A RU 2010151952 A RU2010151952 A RU 2010151952A RU 2010151952/04 A RU2010151952/04 A RU 2010151952/04A RU 2010151952 A RU2010151952 A RU 2010151952A RU 2010151952 A RU2010151952 A RU 2010151952A
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compound
composition
pharmaceutically acceptable
dose
acceptable carrier
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Навид МУХАММАД (US)
Навид Мухаммад
Кейт Р. БЛЕЙ (US)
Кейт Р. Блей
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Ньюроджесэкс, Инк. (Us)
Ньюроджесэкс, Инк.
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    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/094—Esters of phosphoric acids with arylalkanols
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/661—Phosphorus acids or esters thereof not having P—C bonds, e.g. fosfosal, dichlorvos, malathion or mevinphos
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
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    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/091—Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl

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  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Biochemistry (AREA)
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  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Vascular Medicine (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Urology & Nephrology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)

Abstract

1. Соединение формулы (I): ! (I) ! или его фармацевтически приемлемая соль или сольват вышеуказанного соединения. ! 2. Соединение по п.1, где соединение представляет собой динатриевую соль формулы (II): ! (II) ! 3. Композиция, содержащая соединение по п.1 или 2, и фармацевтически приемлемый носитель. ! 4. Композиция по п.3, в которой носитель представляет собой физиологический раствор. ! 5. Композиция по п.3, дополнительно содержащая соединение, выбранное из группы, состоящей из опиоидов, нестероидных противовоспалительных лекарственных средств (НПВС), бензодиазепинов и барбитуратов. ! 6. Композиция по п.3, дополнительно содержащая соединение, выбранное из группы, состоящей из кодеина, морфина, гидрокодона, гидроморфона, леворфанола, аспирина, кеторолака, ибупрофена, напроксена, кофеина, трамадола, декстропропоксифена, метилгекситала, диазепама, лоразепама, мидазолама, пропоксифена, кетопрофена, флурбипрофена, этодолака, диклофенака, мизопростола, мелоксикама, пироксикама, доксиламина, памаброма, карисопродола и буталбитала. ! 7. Способ лечения заболевания или состояния, которые чувствительны к ацетаминофену, включающий введение пациенту эффективного количества соединения по п.1 или 2. ! 8. Способ по п.7, включающий введение пациенту композиции, содержащей эффективное количество соединения и фармацевтически приемлемый носитель. ! 9. Способ по п.7, отличающийся тем, что заболевание или состояние выбраны из группы, состоящей из боли, лихорадки, воспаления, ишемического повреждения и нейронального повреждения. ! 10. Способ по п.7, отличающийся тем, что соединение вводят парентерально. ! 11. Способ по п.7, отличающийся тем, ч 1. The compound of formula (I):! (I)! or a pharmaceutically acceptable salt or solvate thereof of the aforementioned compound. ! 2. The compound according to claim 1, where the compound is a disodium salt of the formula (II):! (II)! 3. A composition comprising a compound according to claim 1 or 2, and a pharmaceutically acceptable carrier. ! 4. The composition according to claim 3, in which the carrier is a saline solution. ! 5. The composition according to claim 3, additionally containing a compound selected from the group consisting of opioids, non-steroidal anti-inflammatory drugs (NSAIDs), benzodiazepines and barbiturates. ! 6. The composition according to claim 3, additionally containing a compound selected from the group consisting of codeine, morphine, hydrocodone, hydromorphone, levorphanol, aspirin, ketorolac, ibuprofen, naproxen, caffeine, tramadol, dextropropoxyphene, methylhexital, diazepam, lorazepam, midazole propoxyphene, ketoprofen, flurbiprofen, etodolac, diclofenac, misoprostol, meloxicam, piroxicam, doxylamine, pamabrom, carisoprodol and butalbital. ! 7. A method of treating a disease or condition that is sensitive to acetaminophen, comprising administering to the patient an effective amount of a compound according to claim 1 or 2.! 8. The method according to claim 7, comprising administering to the patient a composition comprising an effective amount of a compound and a pharmaceutically acceptable carrier. ! 9. The method according to claim 7, characterized in that the disease or condition is selected from the group consisting of pain, fever, inflammation, ischemic damage and neuronal damage. ! 10. The method according to claim 7, characterized in that the compound is administered parenterally. ! 11. The method according to claim 7, characterized in that

Claims (21)

1. Соединение формулы (I):1. The compound of formula (I):
Figure 00000001
Figure 00000001
 (I)(I)
или его фармацевтически приемлемая соль или сольват вышеуказанного соединения.or a pharmaceutically acceptable salt or solvate thereof of the aforementioned compound. 2. Соединение по п.1, где соединение представляет собой динатриевую соль формулы (II):2. The compound according to claim 1, where the compound is a disodium salt of the formula (II):
Figure 00000002
Figure 00000002
 (II)(Ii)
3. Композиция, содержащая соединение по п.1 или 2, и фармацевтически приемлемый носитель.3. A composition comprising a compound according to claim 1 or 2, and a pharmaceutically acceptable carrier. 4. Композиция по п.3, в которой носитель представляет собой физиологический раствор.4. The composition according to claim 3, in which the carrier is a saline solution. 5. Композиция по п.3, дополнительно содержащая соединение, выбранное из группы, состоящей из опиоидов, нестероидных противовоспалительных лекарственных средств (НПВС), бензодиазепинов и барбитуратов.5. The composition according to claim 3, additionally containing a compound selected from the group consisting of opioids, non-steroidal anti-inflammatory drugs (NSAIDs), benzodiazepines and barbiturates. 6. Композиция по п.3, дополнительно содержащая соединение, выбранное из группы, состоящей из кодеина, морфина, гидрокодона, гидроморфона, леворфанола, аспирина, кеторолака, ибупрофена, напроксена, кофеина, трамадола, декстропропоксифена, метилгекситала, диазепама, лоразепама, мидазолама, пропоксифена, кетопрофена, флурбипрофена, этодолака, диклофенака, мизопростола, мелоксикама, пироксикама, доксиламина, памаброма, карисопродола и буталбитала.6. The composition according to claim 3, additionally containing a compound selected from the group consisting of codeine, morphine, hydrocodone, hydromorphone, levorphanol, aspirin, ketorolac, ibuprofen, naproxen, caffeine, tramadol, dextropropoxyphene, methylhexital, diazepam, lorazepam, midazole propoxyphene, ketoprofen, flurbiprofen, etodolac, diclofenac, misoprostol, meloxicam, piroxicam, doxylamine, pamabrom, carisoprodol and butalbital. 7. Способ лечения заболевания или состояния, которые чувствительны к ацетаминофену, включающий введение пациенту эффективного количества соединения по п.1 или 2.7. A method of treating a disease or condition that is sensitive to acetaminophen, comprising administering to the patient an effective amount of a compound according to claim 1 or 2. 8. Способ по п.7, включающий введение пациенту композиции, содержащей эффективное количество соединения и фармацевтически приемлемый носитель.8. The method according to claim 7, comprising administering to the patient a composition comprising an effective amount of a compound and a pharmaceutically acceptable carrier. 9. Способ по п.7, отличающийся тем, что заболевание или состояние выбраны из группы, состоящей из боли, лихорадки, воспаления, ишемического повреждения и нейронального повреждения.9. The method according to claim 7 , characterized in that the disease or condition is selected from the group consisting of pain, fever, inflammation, ischemic damage and neuronal damage. 10. Способ по п.7, отличающийся тем, что соединение вводят парентерально.10. The method according to claim 7, characterized in that the compound is administered parenterally. 11. Способ по п.7, отличающийся тем, что доза соединения составляет от около 300 мг до около 2,6 г.11. The method according to claim 7, characterized in that the dose of the compound is from about 300 mg to about 2.6 g. 12. Способ по п.11, отличающийся тем, что доза соединения составляет от около 1,3 г до около 1,9 г.12. The method according to claim 11, characterized in that the dose of the compound is from about 1.3 g to about 1.9 g. 13. Способ по п.11, отличающийся тем, что объем дозы составляет от около 1 мл до около 25 мл.13. The method according to claim 11, characterized in that the dose volume is from about 1 ml to about 25 ml. 14. Способ по п.13, отличающийся тем, что объем дозы составляет от около 10 мл до около 20 мл.14. The method according to item 13, wherein the dose volume is from about 10 ml to about 20 ml. 15. Способ по п.13, отличающийся тем, что объем дозы составляет от около 1 мл до около 10 мл.15. The method according to item 13, wherein the dose volume is from about 1 ml to about 10 ml. 16. Способ по п.13, отличающийся тем, что объем дозы составляет от около 5 мл до около 10 мл.16. The method according to item 13, wherein the dose volume is from about 5 ml to about 10 ml. 17. Способ по п.11, отличающийся тем, что дозу вводят более одного раза в день.17. The method according to claim 11, characterized in that the dose is administered more than once a day. 18. Способ по п.11, отличающийся тем, что дозу вводят один раз в два дня или менее часто.18. The method according to claim 11, characterized in that the dose is administered once every two days or less frequently. 19. Набор для лечения или профилактики боли, лихорадки, воспаления, ишемического повреждения или нейронального повреждения, включающий соединение по п.1 или 2; и инструкции по применению в лечении или профилактике боли, лихорадки, воспаления, ишемического повреждения или нейронального повреждения.19. A kit for treating or preventing pain, fever, inflammation, ischemic damage or neuronal damage, comprising a compound according to claim 1 or 2; and instructions for use in the treatment or prevention of pain, fever, inflammation, ischemic damage, or neuronal damage. 20. Набор по п.19, включающий композицию, содержащую эффективное количество соединения и фармацевтически приемлемый носитель.20. The kit according to claim 19, comprising a composition comprising an effective amount of a compound and a pharmaceutically acceptable carrier. 21. Композиция со сниженным объемом/высокой концентрацией, включающая соединение по п.1 или 2 и фармацевтически приемлемый носитель. 21. A composition with a reduced volume / high concentration, comprising the compound according to claim 1 or 2 and a pharmaceutically acceptable carrier.
RU2010151952/04A 2008-05-20 2009-05-20 WATER-SOLUBLE ANALOGUES OF ACETAMINOPHEN RU2010151952A (en)

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Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2010012649A (en) 2008-05-20 2010-12-21 Neurogesx Inc Carbonate prodrugs and methods of using the same.
BRPI0912326A2 (en) 2008-05-20 2015-10-06 Neurogesx Inc water soluble acetaminophen analogs
KR101717145B1 (en) 2008-05-20 2017-03-16 노이로제스엑스, 인코포레이티드 Hepatoprotectant acetaminophen mutual prodrugs
EP2177215A1 (en) 2008-10-17 2010-04-21 Laboratorios Del. Dr. Esteve, S.A. Co-crystals of tramadol and NSAIDs
CN109608436B (en) * 2011-04-08 2022-10-11 斯法尔制药私人有限公司 Substituted methyl formyl reagents and methods of using same to improve physicochemical and/or pharmacokinetic properties of compounds
HK1200392A1 (en) 2011-09-22 2015-08-07 Acorda Therapeutics, Inc. Acetaminophen conjugates, compositions and methods of use thereof
JP6539274B2 (en) 2013-08-12 2019-07-03 ファーマシューティカル マニュファクチュアリング リサーチ サービシズ，インコーポレーテッド Extruded immediate release abuse deterrent pills
WO2015095391A1 (en) 2013-12-17 2015-06-25 Pharmaceutical Manufacturing Research Services, Inc. Extruded extended release abuse deterrent pill
US9492444B2 (en) 2013-12-17 2016-11-15 Pharmaceutical Manufacturing Research Services, Inc. Extruded extended release abuse deterrent pill
EP3169315B1 (en) 2014-07-17 2020-06-24 Pharmaceutical Manufacturing Research Services, Inc. Immediate release abuse deterrent liquid fill dosage form
WO2016023082A1 (en) 2014-08-12 2016-02-18 Monash University Lymph directing prodrugs
US20160106737A1 (en) 2014-10-20 2016-04-21 Pharmaceutical Manufacturing Research Services, Inc. Extended Release Abuse Deterrent Liquid Fill Dosage Form
KR20240113982A (en) 2014-10-21 2024-07-23 애브비 인코포레이티드 Carbidopa and l-dopa prodrugs and their use to treat parkinson's disease
EP3265097A4 (en) * 2015-03-03 2018-11-07 Kindred Biosciences Inc. Compositions and methods for treatment and prevention of pyrexia in horses
JP7118888B2 (en) 2015-09-08 2022-08-16 モナッシュ ユニバーシティ lymphotropic prodrug
JP2019515908A (en) * 2016-04-20 2019-06-13 アッヴィ・インコーポレイテッド Carbidopa and L-dopa prodrugs and methods of use
EP4306524A3 (en) 2017-08-29 2024-09-11 PureTech LYT, Inc. Lymphatic system-directing lipid prodrugs
US11883497B2 (en) 2017-08-29 2024-01-30 Puretech Lyt, Inc. Lymphatic system-directing lipid prodrugs
EP3727362A4 (en) 2017-12-19 2021-10-06 PureTech LYT, Inc. MYCOPHENOLIC ACID LIPID MEDICINAL PRODUCTS AND THEIR USES
US11304954B2 (en) 2017-12-19 2022-04-19 Puretech Lyt, Inc. Lipid prodrugs of mycophenolic acid and uses thereof
US11608345B1 (en) 2017-12-19 2023-03-21 Puretech Lyt, Inc. Lipid prodrugs of rapamycin and its analogs and uses thereof
TW202031265A (en) 2018-11-15 2020-09-01 美商艾伯維有限公司 Pharmaceutical formulations for subcutaneous administration
EP4021427A4 (en) 2019-08-30 2023-09-20 Remedy Diagnostics LLC TRANSDERMAL DEVICE CONTAINING PAIN MOLECULES
WO2021159021A1 (en) 2020-02-05 2021-08-12 Puretech Lyt, Inc. Lipid prodrugs of neurosteroids

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2444043A1 (en) * 1978-12-15 1980-07-11 Bottu NEW PARACETAMOL DERIVATIVE, PREPARATION METHOD THEREOF AND THERAPEUTIC USE THEREOF
DK406686D0 (en) * 1986-08-26 1986-08-26 Hans Bundgaard carboxylic acid derivatives
US5001115A (en) * 1989-05-17 1991-03-19 University Of Florida Prodrugs of biologically active hydroxyaromatic compounds
WO1991009831A1 (en) * 1989-12-26 1991-07-11 Nova Pharmaceutical Corporation Prodrug anhydrides of asprin, indomethacin and ibuprofen, their preparation, compositions, and anti-inflammatory method of use
US5627165A (en) * 1990-06-13 1997-05-06 Drug Innovation & Design, Inc. Phosphorous prodrugs and therapeutic delivery systems using same
US5272171A (en) * 1992-02-13 1993-12-21 Bristol-Myers Squibb Company Phosphonooxy and carbonate derivatives of taxol
US6750216B2 (en) * 1996-03-08 2004-06-15 Adolor Corporation Kappa agonist compounds and pharmaceutical formulations thereof
IT1282736B1 (en) * 1996-05-21 1998-03-31 Angelini Ricerche Spa USE OF P-AMINOPHENOL DERIVATIVES TO PREPARE PHARMACEUTICAL COMPOSITIONS USEFUL IN THE TREATMENT OF NEURODEGENERATIVE DISEASES
EP0981532B1 (en) * 1997-05-15 2002-08-28 Drug Innovation & Design, Inc. Acyclovir diester derivatives
EP1051181B1 (en) 1997-12-31 2004-03-17 The University Of Kansas Water soluble prodrugs of tertiary amine containing drugs and methods of making thereof
PT1056754E (en) * 1998-01-29 2004-03-31 Bristol Myers Squibb Co DIARILO 1,3,4-OXADIAZOLONE PHOSPHATE DERIVATIVES
US6204257B1 (en) 1998-08-07 2001-03-20 Universtiy Of Kansas Water soluble prodrugs of hindered alcohols
US8231899B2 (en) * 1998-09-10 2012-07-31 Nycomed Danmark Aps Quick release pharmaceutical compositions of drug substances
PT1109534E (en) * 1998-09-10 2003-06-30 Nycomed Danmark As PHARMACEUTICAL COMPOUNDS FOR QUICK RELEASE PHARMACOSES
US6461631B1 (en) * 1999-11-16 2002-10-08 Atrix Laboratories, Inc. Biodegradable polymer composition
US6362172B2 (en) * 2000-01-20 2002-03-26 Bristol-Myers Squibb Company Water soluble prodrugs of azole compounds
BR0109542A (en) * 2000-03-29 2003-06-10 Altana Pharma Ag Alkylated imidazopyrine derivatives
JP4814486B2 (en) * 2001-06-05 2011-11-16 シヴィダ・インコーポレイテッド Sustained release analgesic compounds
US6825204B2 (en) * 2002-02-05 2004-11-30 Bristol-Myers Squibb Company N-substituted 3-hydroxy-4-pyridinones and pharmaceuticals containing thereof
US20040058946A1 (en) * 2002-07-05 2004-03-25 Buchwald Stephen L. Abuse-resistant prodrugs of oxycodone and other pharmaceuticals
AU2003282624A1 (en) * 2002-11-14 2004-06-03 Syntarga B.V. Prodrugs built as multiple self-elimination-release spacers
WO2004078180A2 (en) * 2003-03-03 2004-09-16 Guilford Pharmaceuticals Inc. Naaladase inhibitors for treating opioid tolerance
JP2006520392A (en) * 2003-03-13 2006-09-07 コントロールド・ケミカルズ・インコーポレーテッド Compounds and methods for reducing drug abuse potential and extending duration of action
AU2003901813A0 (en) * 2003-04-15 2003-05-01 Vital Health Sciences Pty Ltd Pharmaceutical derivatives
US20050080260A1 (en) * 2003-04-22 2005-04-14 Mills Randell L. Preparation of prodrugs for selective drug delivery
US6992090B2 (en) * 2003-06-16 2006-01-31 Adolor Corporation Substituted piperidine compounds and methods of their use
US20050026879A1 (en) * 2003-07-31 2005-02-03 Robinson Cynthia B. Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with a tyrosine kinase inhibitor, delta opioid receptor antagonist, neurokinin receptor antagonist, or VCAM inhibitor for treatment of asthma or chronic obstructive pulmonary disease
WO2005077394A1 (en) * 2004-02-11 2005-08-25 Ramot At Tel-Aviv University Ltd Compositions for treatment of cancer and inflammation with curcumin and at least one nsaid
AU2005270124B2 (en) 2004-07-06 2011-09-08 Abbvie Inc. Prodrugs of HIV protease inhibitors
CN101678120A (en) 2006-12-05 2010-03-24 纽罗吉斯克斯公司 Prodrugs and methods of making and using the same
BRPI0912326A2 (en) 2008-05-20 2015-10-06 Neurogesx Inc water soluble acetaminophen analogs
MX2010012649A (en) 2008-05-20 2010-12-21 Neurogesx Inc Carbonate prodrugs and methods of using the same.
KR101717145B1 (en) 2008-05-20 2017-03-16 노이로제스엑스, 인코포레이티드 Hepatoprotectant acetaminophen mutual prodrugs
WO2010030781A2 (en) 2008-09-10 2010-03-18 Numed International, Inc. Aromatic carboxylic acid derivatives for treatment and prophylaxis of gastrointestinal diseases including colon cancer
EP2408443A1 (en) 2009-03-16 2012-01-25 Genmedica Therapeutics SL Anti-inflammatory and antioxidant conjugates useful for treating metabolic disorders
HK1200392A1 (en) 2011-09-22 2015-08-07 Acorda Therapeutics, Inc. Acetaminophen conjugates, compositions and methods of use thereof

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