[go: up one dir, main page]

RU2008139612A - METHOD FOR PRODUCING A LINEZOLIDE - Google Patents

METHOD FOR PRODUCING A LINEZOLIDE Download PDF

Info

Publication number
RU2008139612A
RU2008139612A RU2008139612/04A RU2008139612A RU2008139612A RU 2008139612 A RU2008139612 A RU 2008139612A RU 2008139612/04 A RU2008139612/04 A RU 2008139612/04A RU 2008139612 A RU2008139612 A RU 2008139612A RU 2008139612 A RU2008139612 A RU 2008139612A
Authority
RU
Russia
Prior art keywords
compound
amino
chloro
propan
bromophenyl
Prior art date
Application number
RU2008139612/04A
Other languages
Russian (ru)
Inventor
Рик Джозеф ИМБОРДИНО (US)
Рик Джозеф ИМБОРДИНО
Уилльям Роланд ПЕРРО (US)
Уилльям Роланд ПЕРРО
Майкл Роберт РИДЕР (US)
Майкл Роберт РИДЕР
Original Assignee
Пфайзер Продактс Инк. (Us)
Пфайзер Продактс Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Пфайзер Продактс Инк. (Us), Пфайзер Продактс Инк. filed Critical Пфайзер Продактс Инк. (Us)
Publication of RU2008139612A publication Critical patent/RU2008139612A/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D263/18—Oxygen atoms
    • C07D263/20—Oxygen atoms attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C251/00—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton
    • C07C251/02—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups
    • C07C251/04—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups having carbon atoms of imino groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C251/06—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups having carbon atoms of imino groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of a saturated carbon skeleton
    • C07C251/08—Compounds containing nitrogen atoms doubly-bound to a carbon skeleton containing imino groups having carbon atoms of imino groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of a saturated carbon skeleton being acyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
    • C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
    • C07D251/08—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/04—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms
    • C07D295/12—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms
    • C07D295/135—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms with substituted hydrocarbon radicals attached to ring nitrogen atoms substituted by singly or doubly bound nitrogen atoms with the ring nitrogen atoms and the substituent nitrogen atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

1. Способ получения линезолида ! ! который включает: ! a) взаимодействие соединения структуры (1) ! ! где X представляет собой хлорфенил, бромфенил или 2,4-дихлорфенил, ! с соединением структуры (2) ! ! при температуре в диапазоне от температуры окружающей среды до приблизительно 65°C, где R представляет собой бензил или C1-8алкил, с получением соединения структуры (3): ! ! где X представляет собой хлорфенил, бромфенил или 2,4-дихлорфенил; ! б) гидролиз соединения структуры (3) и последующее ацилирование с получением линезолида. ! 2. Способ по п.1, где соединение структуры (1) представляет собой (S)-1-хлор-3-[(4-хлор-E-бензилиден)амино]пропан-2-ол. ! 3. Способ по п.1, где соединение структуры (1) представляет собой (S)-1-хлор-3-[(4-бром-E-бензилиден)амино]пропан-2-ол. ! 4. Способ по п.1, где соединение структуры (1) представляет собой (S)-1-хлор-3-[(2,4-дихлорбензилиден)амино]пропан-2-ол. ! 5. Способ по п.1, где соединение структуры (3) представляет собой (S)-5-{[(4-хлорбензилиден)амино]метил}-3-(3-фтор-4-морфолин-4-илфенил)оксазолидин-2-он. ! 6. Способ по п.1, где соединение структуры (3) представляет собой (S)-5-{[(4-бромбензилиден)амино]метил}-3-(3-фтор-4-морфолин-4-илфенил)оксазолидин-2-он. ! 7. Способ по п.1, где соединение структуры (3) представляет собой (S)-5-{[(2,4-дихлорбензилиден)амино]метил}-3-(3-фтор-4-морфолин-4-илфенил)оксазолидин-2-он. ! 8. Способ по п.1, где R представляет собой бензил. ! 9. Способ получения соединения структуры (3) ! ! где X представляет собой хлорфенил, бромфенил или 2,4-дихлорфенил, ! который включает ! a) взаимодействие соединения структуры (1) ! ! где X представляет собой хлорфенил, бромфенил или 2,4-дихлорфенил, ! с соединением структуры (2) ! ! при температуре в ди 1. The method of obtaining linezolid! ! which includes:! a) the interaction of the compounds of structure (1)! ! where X is chlorophenyl, bromophenyl or 2,4-dichlorophenyl! with compound structure (2)! ! at a temperature ranging from ambient to about 65 ° C, where R is benzyl or C1-8 alkyl, to give a compound of structure (3):! ! where X is chlorophenyl, bromophenyl or 2,4-dichlorophenyl; ! b) hydrolysis of the compound of structure (3) and subsequent acylation to obtain linezolid. ! 2. The method according to claim 1, where the compound of structure (1) is (S) -1-chloro-3 - [(4-chloro-E-benzylidene) amino] propan-2-ol. ! 3. The method according to claim 1, where the compound of structure (1) is (S) -1-chloro-3 - [(4-bromo-E-benzylidene) amino] propan-2-ol. ! 4. The method according to claim 1, where the compound of structure (1) is (S) -1-chloro-3 - [(2,4-dichlorobenzylidene) amino] propan-2-ol. ! 5. The method according to claim 1, where the compound of structure (3) is (S) -5 - {[(4-chlorobenzylidene) amino] methyl} -3- (3-fluoro-4-morpholin-4-ylphenyl) oxazolidine -2-he. ! 6. The method according to claim 1, where the compound of structure (3) is (S) -5 - {[(4-bromobenzylidene) amino] methyl} -3- (3-fluoro-4-morpholin-4-ylphenyl) oxazolidine -2-he. ! 7. The method according to claim 1, where the compound of structure (3) is (S) -5 - {[((2,4-dichlorobenzylidene) amino] methyl} -3- (3-fluoro-4-morpholin-4-ylphenyl ) oxazolidin-2-one. ! 8. The method according to claim 1, where R is benzyl. ! 9. A method of obtaining a compound of structure (3)! ! where X is chlorophenyl, bromophenyl or 2,4-dichlorophenyl! which includes! a) the interaction of the compounds of structure (1)! ! where X is chlorophenyl, bromophenyl or 2,4-dichlorophenyl! with compound structure (2)! ! at temperature in di

Claims (15)

1. Способ получения линезолида1. The method of obtaining linezolid
Figure 00000001
Figure 00000001
 который включает:which includes: a) взаимодействие соединения структуры (1)a) the interaction of the compounds of structure (1)
Figure 00000002
Figure 00000002
 где X представляет собой хлорфенил, бромфенил или 2,4-дихлорфенил,where X represents chlorophenyl, bromophenyl or 2,4-dichlorophenyl, с соединением структуры (2)with compound structure (2)
Figure 00000003
Figure 00000003
 при температуре в диапазоне от температуры окружающей среды до приблизительно 65°C, где R представляет собой бензил или C1-8алкил, с получением соединения структуры (3):at a temperature in the range from ambient temperature to about 65 ° C, where R is benzyl or C 1-8 alkyl, to obtain a compound of structure (3):
Figure 00000004
Figure 00000004
 где X представляет собой хлорфенил, бромфенил или 2,4-дихлорфенил;where X is chlorophenyl, bromophenyl or 2,4-dichlorophenyl; б) гидролиз соединения структуры (3) и последующее ацилирование с получением линезолида.b) hydrolysis of the compound of structure (3) and subsequent acylation to obtain linezolid. 2. Способ по п.1, где соединение структуры (1) представляет собой (S)-1-хлор-3-[(4-хлор-E-бензилиден)амино]пропан-2-ол.2. The method according to claim 1, where the compound of structure (1) is (S) -1-chloro-3 - [(4-chloro-E-benzylidene) amino] propan-2-ol. 3. Способ по п.1, где соединение структуры (1) представляет собой (S)-1-хлор-3-[(4-бром-E-бензилиден)амино]пропан-2-ол.3. The method according to claim 1, where the compound of structure (1) is (S) -1-chloro-3 - [(4-bromo-E-benzylidene) amino] propan-2-ol. 4. Способ по п.1, где соединение структуры (1) представляет собой (S)-1-хлор-3-[(2,4-дихлорбензилиден)амино]пропан-2-ол.4. The method according to claim 1, where the compound of structure (1) is (S) -1-chloro-3 - [(2,4-dichlorobenzylidene) amino] propan-2-ol. 5. Способ по п.1, где соединение структуры (3) представляет собой (S)-5-{[(4-хлорбензилиден)амино]метил}-3-(3-фтор-4-морфолин-4-илфенил)оксазолидин-2-он.5. The method according to claim 1, where the compound of structure (3) is (S) -5 - {[(4-chlorobenzylidene) amino] methyl} -3- (3-fluoro-4-morpholin-4-ylphenyl) oxazolidine -2-he. 6. Способ по п.1, где соединение структуры (3) представляет собой (S)-5-{[(4-бромбензилиден)амино]метил}-3-(3-фтор-4-морфолин-4-илфенил)оксазолидин-2-он.6. The method according to claim 1, where the compound of structure (3) is (S) -5 - {[(4-bromobenzylidene) amino] methyl} -3- (3-fluoro-4-morpholin-4-ylphenyl) oxazolidine -2-he. 7. Способ по п.1, где соединение структуры (3) представляет собой (S)-5-{[(2,4-дихлорбензилиден)амино]метил}-3-(3-фтор-4-морфолин-4-илфенил)оксазолидин-2-он.7. The method according to claim 1, where the compound of structure (3) is (S) -5 - {[(2,4-dichlorobenzylidene) amino] methyl} -3- (3-fluoro-4-morpholin-4-ylphenyl ) oxazolidin-2-one. 8. Способ по п.1, где R представляет собой бензил.8. The method according to claim 1, where R represents benzyl. 9. Способ получения соединения структуры (3)9. A method of obtaining a compound of structure (3)
Figure 00000005
Figure 00000005
 где X представляет собой хлорфенил, бромфенил или 2,4-дихлорфенил,where X represents chlorophenyl, bromophenyl or 2,4-dichlorophenyl, который включаетwhich includes a) взаимодействие соединения структуры (1)a) the interaction of the compounds of structure (1)
Figure 00000006
Figure 00000006
 где X представляет собой хлорфенил, бромфенил или 2,4-дихлорфенил,where X represents chlorophenyl, bromophenyl or 2,4-dichlorophenyl, с соединением структуры (2)with compound structure (2)
Figure 00000007
Figure 00000007
 при температуре в диапазоне от температуры окружающей среды до приблизительно 65°C, где R представляет собой бензил или C1-8алкил.at a temperature in the range of ambient temperature to about 65 ° C, where R is benzyl or C 1-8 alkyl. 10. Соединение структуры (1)10. Compound structure (1)
Figure 00000006
Figure 00000006
 где X представляет собой хлорфенил, бромфенил или 2,4-дихлорфенил.where X is chlorophenyl, bromophenyl or 2,4-dichlorophenyl. 11. Соединение по п.10, представляющее собой (S)-1-хлор-3-[(4-хлор-E-бензилиден)амино]пропан-2-ол.11. The compound of claim 10, which is (S) -1-chloro-3 - [(4-chloro-E-benzylidene) amino] propan-2-ol. 12. Соединение по п.10, представляющее собой (S)-1-хлор-3-[(4-бром-E-бензилиден)амино]пропан-2-ол.12. The compound of claim 10, which is (S) -1-chloro-3 - [(4-bromo-E-benzylidene) amino] propan-2-ol. 13. Соединение по п.10, представляющее собой (S)-1-хлор-3-[(2,4-дихлорбензилиден)амино]пропан-2-ол.13. The compound of claim 10, which is (S) -1-chloro-3 - [(2,4-dichlorobenzylidene) amino] propan-2-ol. 14. (S)-5-{[(4-хлорбензилиден)амино]метил}-3-(3-фтор-4-морфолин-4-илфенил)оксазолидин-2-он.14. (S) -5 - {[(4-chlorobenzylidene) amino] methyl} -3- (3-fluoro-4-morpholin-4-ylphenyl) oxazolidin-2-one. 15. Способ кристаллизации соединения структуры (1), как определено в п.1,15. The method of crystallization of the compounds of structure (1), as defined in claim 1,
Figure 00000006
Figure 00000006
 включающийincluding a) превращение в жидкость соединения структуры (1) в присутствии неполярного апротонного углеводородного растворителя при температуре в диапазоне от температуры окружающей среды до приблизительно 55°C, необязательно в присутствии апротонного полярного растворителя; иa) the transformation into a liquid of a compound of structure (1) in the presence of a non-polar aprotic hydrocarbon solvent at a temperature in the range from ambient temperature to about 55 ° C, optionally in the presence of an aprotic polar solvent; and б) медленное охлаждение до температуры окружающей среды или ниже. b) slow cooling to ambient temperature or lower.
RU2008139612/04A 2006-04-07 2007-03-26 METHOD FOR PRODUCING A LINEZOLIDE RU2008139612A (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US79036006P 2006-04-07 2006-04-07
US60/790,360 2006-04-07
US81698306P 2006-06-28 2006-06-28
US60/816,983 2006-06-28

Publications (1)

Publication Number Publication Date
RU2008139612A true RU2008139612A (en) 2010-04-20

Family

ID=38308763

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2008139612/04A RU2008139612A (en) 2006-04-07 2007-03-26 METHOD FOR PRODUCING A LINEZOLIDE

Country Status (11)

Country Link
EP (1) EP2007740A1 (en)
JP (1) JP2007277243A (en)
KR (1) KR20080104178A (en)
AR (1) AR060299A1 (en)
AU (1) AU2007235635A1 (en)
BR (1) BRPI0710312A2 (en)
CA (1) CA2648178A1 (en)
MX (1) MX2008012941A (en)
RU (1) RU2008139612A (en)
TW (1) TW200808782A (en)
WO (1) WO2007116284A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2792687C1 (en) * 2019-08-20 2023-03-23 Хангжоу Дике Технологиес Ко., Лтд. Method for synthesis of n-substituted phenyl-5-hydroxymethyl-2-oxazolidinone

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010084514A2 (en) * 2009-01-02 2010-07-29 Neuland Laboratories Ltd. A process for the preparation of (5s)-(n)-[[3-[3-fluoro-4-(4-morpholinyl) phenyl]-2-oxo-5-oxazolidinyl] methyl] acetamide
CN101774978B (en) 2009-01-13 2011-09-21 联化科技股份有限公司 Preparation method of linezolid and intermediate thereof
BR112012027901A2 (en) 2010-04-30 2015-09-08 Univ Indiana Res & Tech Corp processes for preparing linezolid
WO2012019632A1 (en) 2010-08-11 2012-02-16 Synthon B.V. Process for making linezolid
EP2690100A1 (en) 2010-08-11 2014-01-29 Synhton B.V. Process for making linezolid
ES2395304B1 (en) * 2011-05-20 2014-01-16 Interquim, S.A. PROCEDURE FOR OBTAINING A THIOPHEN-2-CARBOXAMIDE.
CN102827154B (en) * 2011-06-14 2015-04-22 上海科胜药物研发有限公司 New method for synthesizing rivaroxaban intermediate 4-{4-[(5S)-5-(aminomethyl)-2-oxo-1,3-oxazolidine-3-yl]phenyl}morpholine-3-ketone
WO2013072923A1 (en) 2011-09-19 2013-05-23 Cadila Healthcare Limited Process for the preparation of crystalline linezolid
CN103254148B (en) 2012-02-15 2016-04-13 浙江海正药业股份有限公司 The preparation method of linezolid intermediate
CZ2012111A3 (en) 2012-02-16 2013-08-28 Zentiva, K.S. Process for preparing rivaroxaban based on the use of (S)-epichlorohydrin
ES2603252T3 (en) 2012-11-09 2017-02-24 Synthon Bv Process to prepare linezolid
US9643939B1 (en) 2016-04-18 2017-05-09 Optimus Drugs Private Limited Process for the preparation of linezolid
USRE47606E1 (en) 2016-04-21 2019-09-17 Optimus Drugs Private Limited Process for the preparation of linezolid
CN110579556B (en) * 2018-06-08 2024-11-05 四川科伦药物研究院有限公司 Testing methods for linezolid products
CN115236236A (en) * 2022-07-26 2022-10-25 上海市食品药品检验研究院 Linezolid and separation and analysis method of enantiomers in preparation thereof

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5688792A (en) * 1994-08-16 1997-11-18 Pharmacia & Upjohn Company Substituted oxazine and thiazine oxazolidinone antimicrobials
DE69738457T2 (en) * 1996-04-11 2008-12-24 Pharmacia & Upjohn Co. Llc, Kalamazoo Process for the preparation of oxazolidinones
KR100619639B1 (en) * 1997-11-07 2006-09-06 파마시아 앤드 업존 캄파니 엘엘씨 Process to Produce Oxazolidinones

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2792687C1 (en) * 2019-08-20 2023-03-23 Хангжоу Дике Технологиес Ко., Лтд. Method for synthesis of n-substituted phenyl-5-hydroxymethyl-2-oxazolidinone

Also Published As

Publication number Publication date
EP2007740A1 (en) 2008-12-31
JP2007277243A (en) 2007-10-25
WO2007116284A1 (en) 2007-10-18
TW200808782A (en) 2008-02-16
AU2007235635A1 (en) 2007-10-18
BRPI0710312A2 (en) 2011-08-09
MX2008012941A (en) 2008-10-15
AR060299A1 (en) 2008-06-04
KR20080104178A (en) 2008-12-01
CA2648178A1 (en) 2007-10-18

Similar Documents

Publication Publication Date Title
RU2008139612A (en) METHOD FOR PRODUCING A LINEZOLIDE
PE20080169A1 (en) METHOD FOR PREPARING ALCOHOLS SUBSTITUTED WITH SULFONAMIDES AND THEIR INTERMEDIATE COMPOUNDS
DE602006020411D1 (en) SYSTEM FOR CONTROLLING AN ULTRASONIC CATHETER FOR ILLUSTRATING A HARD HEART
FR2899336B1 (en) METHOD AND DEVICE FOR IMAGING A VISCOELASTIC MEDIUM
DE602007013242D1 (en) PREPARATION OF ACETIC ACID
RU2010131168A (en) SULFENAMIDE, VOLCANIZATION ACCELERATOR OF RUBBER CONTAINING SULFENAMID AND METHOD FOR PRODUCING VULCANIZATION ACCELERATOR
RU2018106948A (en) METHOD FOR PRODUCING SUBSTITUTED 3- (2-ANILINO-1-CYCLOGEXYL-1H-BENZIMIDAZOL-5-IL) PROPANIC ACID DERIVATIVES
EP1860482A3 (en) Microscope system and method for synthesizing microscopic images
RU2010110603A (en) HIGH-CONCENTRATED DRUGS OF 1-METHYL HETTyl ETHER FLUROXIPYR, STABLE AT LOW TEMPERATURES
EA200600741A1 (en) CATALYST FOR OBTAINING COMPLEX ETHERS
RU2005127043A (en) Vulcanizing Agents Based on Bisaminophenyl and Vulcanizing Agents and Accelerators of Amidine Based on Perfluoroelastomer Compositions
PE20120223A1 (en) HETEROCYCLIC COMPOUNDS AS INHIBITORS OF THE GLYCINE-1 TRANSPORTER (GLYT-1)
PE20070814A1 (en) COMPOUNDS DERIVED FROM 2-CARBOXYTHIOPHENE AS INHIBITORS OF HEPATITIS C VIRUS POLYMERASE (HCV)
PE20040929A1 (en) SUBSTITUTED 5-AMINOMETIL-1H-PYRROL-2-CARBOXYL ACID AMIDES
DE602006021411D1 (en) PROCESS FOR PREPARING OPTIONAL 2-SUBSTITUTED 1,6-DIHYDRO-6-OXO-4-PYRIMIDINCARBOXYLIC ACIDS
EA200501321A1 (en) METHOD FOR OBTAINING GLIMEPIRIDE AND RELATED INTERMEDIATE COMPOUND
ATE475653T1 (en) METHOD FOR PRODUCING VALSARTAN
DE602004004679D1 (en) PROCESS FOR PREPARING THE HEMICALCIUM SALT OF (E) -7-A4- (4-FLUORO-PHENYL) -6-ISOPROPYL-2-EMETHYL (METHYLSULFONYL) AMINO-PYRIMIDIN-5-YLÜ (3R, 5S) -3,5-DIHYDROXY-6-HEPTIC ACID
RU2009143794A (en) METHOD OF OBTAINING DOCETAXEL
RU2009137002A (en) COMPLEX ETHERIC COMPOUND OF CYCLOPROPANOCARBOXYLIC ACID AND ITS APPLICATION FOR PEST CONTROL
JP2008520206A5 (en)
RU2015130337A (en) METHOD FOR PRODUCING FLUORACTON DERIVATIVE
RU2013106503A (en) METHOD FOR OBTAINING CONTRAST AGENTS
RU2006109543A (en) Derivatives of cycloalkylamino acids, methods for their preparation and use
DE60142931D1 (en) PROCESS FOR PREPARING ARYLETHANOL DIAMINES USED AS BETA-3-ADRENOCEPTOR AGONISTS

Legal Events

Date Code Title Description
FA93 Acknowledgement of application withdrawn (no request for examination)

Effective date: 20110216