RU2008130365A - Питательные композиции для младенцев, предназначенные для предупреждения ожирения - Google Patents
Питательные композиции для младенцев, предназначенные для предупреждения ожирения Download PDFInfo
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- RU2008130365A RU2008130365A RU2008130365/13A RU2008130365A RU2008130365A RU 2008130365 A RU2008130365 A RU 2008130365A RU 2008130365/13 A RU2008130365/13 A RU 2008130365/13A RU 2008130365 A RU2008130365 A RU 2008130365A RU 2008130365 A RU2008130365 A RU 2008130365A
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- 239000000203 mixture Substances 0.000 title claims abstract 26
- 208000008589 Obesity Diseases 0.000 title claims abstract 6
- 235000020824 obesity Nutrition 0.000 title claims abstract 6
- 230000002265 prevention Effects 0.000 title claims abstract 6
- 235000016709 nutrition Nutrition 0.000 title claims abstract 4
- OYHQOLUKZRVURQ-HZJYTTRNSA-N Linoleic acid Chemical compound CCCCC\C=C/C\C=C/CCCCCCCC(O)=O OYHQOLUKZRVURQ-HZJYTTRNSA-N 0.000 claims abstract 14
- 235000020778 linoleic acid Nutrition 0.000 claims abstract 14
- OYHQOLUKZRVURQ-IXWMQOLASA-N linoleic acid Natural products CCCCC\C=C/C\C=C\CCCCCCCC(O)=O OYHQOLUKZRVURQ-IXWMQOLASA-N 0.000 claims abstract 14
- DTOSIQBPPRVQHS-PDBXOOCHSA-N alpha-linolenic acid Chemical compound CC\C=C/C\C=C/C\C=C/CCCCCCCC(O)=O DTOSIQBPPRVQHS-PDBXOOCHSA-N 0.000 claims abstract 12
- 229920001542 oligosaccharide Polymers 0.000 claims abstract 11
- 235000020661 alpha-linolenic acid Nutrition 0.000 claims abstract 10
- 235000014113 dietary fatty acids Nutrition 0.000 claims abstract 10
- 229930195729 fatty acid Natural products 0.000 claims abstract 10
- 239000000194 fatty acid Substances 0.000 claims abstract 10
- 150000004665 fatty acids Chemical class 0.000 claims abstract 10
- 235000020978 long-chain polyunsaturated fatty acids Nutrition 0.000 claims abstract 10
- 229960004488 linolenic acid Drugs 0.000 claims abstract 6
- 150000002632 lipids Chemical class 0.000 claims abstract 5
- 150000002482 oligosaccharides Chemical class 0.000 claims abstract 5
- 150000004667 medium chain fatty acids Chemical class 0.000 claims abstract 4
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical class OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 claims abstract 3
- 150000001720 carbohydrates Chemical class 0.000 claims abstract 3
- 235000014633 carbohydrates Nutrition 0.000 claims abstract 3
- 235000021255 galacto-oligosaccharides Nutrition 0.000 claims abstract 3
- 150000003271 galactooligosaccharides Chemical class 0.000 claims abstract 3
- 235000004252 protein component Nutrition 0.000 claims abstract 3
- 229920001202 Inulin Polymers 0.000 claims abstract 2
- JYJIGFIDKWBXDU-MNNPPOADSA-N inulin Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)OC[C@]1(OC[C@]2(OC[C@]3(OC[C@]4(OC[C@]5(OC[C@]6(OC[C@]7(OC[C@]8(OC[C@]9(OC[C@]%10(OC[C@]%11(OC[C@]%12(OC[C@]%13(OC[C@]%14(OC[C@]%15(OC[C@]%16(OC[C@]%17(OC[C@]%18(OC[C@]%19(OC[C@]%20(OC[C@]%21(OC[C@]%22(OC[C@]%23(OC[C@]%24(OC[C@]%25(OC[C@]%26(OC[C@]%27(OC[C@]%28(OC[C@]%29(OC[C@]%30(OC[C@]%31(OC[C@]%32(OC[C@]%33(OC[C@]%34(OC[C@]%35(OC[C@]%36(O[C@@H]%37[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O%37)O)[C@H]([C@H](O)[C@@H](CO)O%36)O)[C@H]([C@H](O)[C@@H](CO)O%35)O)[C@H]([C@H](O)[C@@H](CO)O%34)O)[C@H]([C@H](O)[C@@H](CO)O%33)O)[C@H]([C@H](O)[C@@H](CO)O%32)O)[C@H]([C@H](O)[C@@H](CO)O%31)O)[C@H]([C@H](O)[C@@H](CO)O%30)O)[C@H]([C@H](O)[C@@H](CO)O%29)O)[C@H]([C@H](O)[C@@H](CO)O%28)O)[C@H]([C@H](O)[C@@H](CO)O%27)O)[C@H]([C@H](O)[C@@H](CO)O%26)O)[C@H]([C@H](O)[C@@H](CO)O%25)O)[C@H]([C@H](O)[C@@H](CO)O%24)O)[C@H]([C@H](O)[C@@H](CO)O%23)O)[C@H]([C@H](O)[C@@H](CO)O%22)O)[C@H]([C@H](O)[C@@H](CO)O%21)O)[C@H]([C@H](O)[C@@H](CO)O%20)O)[C@H]([C@H](O)[C@@H](CO)O%19)O)[C@H]([C@H](O)[C@@H](CO)O%18)O)[C@H]([C@H](O)[C@@H](CO)O%17)O)[C@H]([C@H](O)[C@@H](CO)O%16)O)[C@H]([C@H](O)[C@@H](CO)O%15)O)[C@H]([C@H](O)[C@@H](CO)O%14)O)[C@H]([C@H](O)[C@@H](CO)O%13)O)[C@H]([C@H](O)[C@@H](CO)O%12)O)[C@H]([C@H](O)[C@@H](CO)O%11)O)[C@H]([C@H](O)[C@@H](CO)O%10)O)[C@H]([C@H](O)[C@@H](CO)O9)O)[C@H]([C@H](O)[C@@H](CO)O8)O)[C@H]([C@H](O)[C@@H](CO)O7)O)[C@H]([C@H](O)[C@@H](CO)O6)O)[C@H]([C@H](O)[C@@H](CO)O5)O)[C@H]([C@H](O)[C@@H](CO)O4)O)[C@H]([C@H](O)[C@@H](CO)O3)O)[C@H]([C@H](O)[C@@H](CO)O2)O)[C@@H](O)[C@H](O)[C@@H](CO)O1 JYJIGFIDKWBXDU-MNNPPOADSA-N 0.000 claims abstract 2
- 229940029339 inulin Drugs 0.000 claims abstract 2
- -1 inulin) Chemical class 0.000 claims abstract 2
- 235000019197 fats Nutrition 0.000 claims 3
- DRTQHJPVMGBUCF-XVFCMESISA-N Uridine Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C(=O)NC(=O)C=C1 DRTQHJPVMGBUCF-XVFCMESISA-N 0.000 claims 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 claims 2
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- DRTQHJPVMGBUCF-PSQAKQOGSA-N beta-L-uridine Natural products O[C@H]1[C@@H](O)[C@H](CO)O[C@@H]1N1C(=O)NC(=O)C=C1 DRTQHJPVMGBUCF-PSQAKQOGSA-N 0.000 claims 1
- SQVRNKJHWKZAKO-UHFFFAOYSA-N beta-N-Acetyl-D-neuraminic acid Natural products CC(=O)NC1C(O)CC(O)(C(O)=O)OC1C(O)C(O)CO SQVRNKJHWKZAKO-UHFFFAOYSA-N 0.000 claims 1
- 229910052791 calcium Inorganic materials 0.000 claims 1
- 239000011575 calcium Substances 0.000 claims 1
- 235000012000 cholesterol Nutrition 0.000 claims 1
- OEYIOHPDSNJKLS-UHFFFAOYSA-N choline Chemical compound C[N+](C)(C)CCO OEYIOHPDSNJKLS-UHFFFAOYSA-N 0.000 claims 1
- 229960001231 choline Drugs 0.000 claims 1
- 150000003272 mannan oligosaccharides Chemical class 0.000 claims 1
- 150000003904 phospholipids Chemical class 0.000 claims 1
- SQVRNKJHWKZAKO-OQPLDHBCSA-N sialic acid Chemical compound CC(=O)N[C@@H]1[C@@H](O)C[C@@](O)(C(O)=O)OC1[C@H](O)[C@H](O)CO SQVRNKJHWKZAKO-OQPLDHBCSA-N 0.000 claims 1
- 150000003408 sphingolipids Chemical class 0.000 claims 1
- DRTQHJPVMGBUCF-UHFFFAOYSA-N uracil arabinoside Natural products OC1C(O)C(CO)OC1N1C(=O)NC(=O)C=C1 DRTQHJPVMGBUCF-UHFFFAOYSA-N 0.000 claims 1
- 229940045145 uridine Drugs 0.000 claims 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
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- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/115—Fatty acids or derivatives thereof; Fats or oils
- A23L33/12—Fatty acids or derivatives thereof
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- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
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- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
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- A61K31/201—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having one or two double bonds, e.g. oleic, linoleic acids
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- A61K31/202—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids having three or more double bonds, e.g. linolenic
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Abstract
1. Применение композиции, содержащей липидный компонент, белковый компонент и компонент, состоящий из усваиваемых углеводов, где липидный компонент включает: ! (i) линолевую кислоту (LA) и альфа-линоленовую кислоту (ALA) в массовом соотношении LA/ALA от 2 до 7; ! (ii) менее чем 15 мас.% LA в пересчете на общую массу жирных кислот; и ! (iii) по меньшей мере, 1 мас.% ALA в пересчете на общую массу жирных кислот, ! и где композиция дополнительно содержит n-6 длинноцепочечные полиненасыщенные жирные кислоты (LC-PUFA) и n-3 LC-PUFA в массовом соотношении менее 1,5; от 0,02 до 0,8 мас.% n-6 LC-PUFA в пересчете на общую массу жирных кислот и, по меньшей мере, 0,2 мас.% n-3 LC-PUFA в пересчете на общую массу жирных кислот, для получения питательной композиции, предназначенной для введения не страдающему ожирением младенцу в возрасте менее 36 месяцев для профилактики ожирения. ! 2. Применение по п.1, где композиция содержит ! (i) от 3 до 50 мас.% среднецепочечных жирных кислот (MCFA) в пересчете на общую массу жирных кислот. ! 3. Применение по п.1 или 2, где композиция включает линолевую кислоту (LA) и альфа-линоленовую кислоту (ALA) в массовом соотношении LA/ALA от 2 до 5. ! 4. Применение по п.1 или 2, где композиция дополнительно содержит, по меньшей мере, 0,5 мас.% по меньшей мере, одного растворимого, не усваиваемого олигосахарида, в пересчете на общую массу сухого вещества композиции. ! 5. Применение по п.1 или 2, где композиция содержит, по меньшей мере, 0,5 мас.%, по меньшей мере, одного растворимого, не усваиваемого олигосахарида, выбранного из группы, состоящей из фруктоолигосахаридов (включая инулин), галактоолигосахаридов (включая трансгалактоолигосахариды), глюкоолигосахаридов (включая гентио-, нигеро- и
Claims (14)
1. Применение композиции, содержащей липидный компонент, белковый компонент и компонент, состоящий из усваиваемых углеводов, где липидный компонент включает:
(i) линолевую кислоту (LA) и альфа-линоленовую кислоту (ALA) в массовом соотношении LA/ALA от 2 до 7;
(ii) менее чем 15 мас.% LA в пересчете на общую массу жирных кислот; и
(iii) по меньшей мере, 1 мас.% ALA в пересчете на общую массу жирных кислот,
и где композиция дополнительно содержит n-6 длинноцепочечные полиненасыщенные жирные кислоты (LC-PUFA) и n-3 LC-PUFA в массовом соотношении менее 1,5; от 0,02 до 0,8 мас.% n-6 LC-PUFA в пересчете на общую массу жирных кислот и, по меньшей мере, 0,2 мас.% n-3 LC-PUFA в пересчете на общую массу жирных кислот, для получения питательной композиции, предназначенной для введения не страдающему ожирением младенцу в возрасте менее 36 месяцев для профилактики ожирения.
2. Применение по п.1, где композиция содержит
(i) от 3 до 50 мас.% среднецепочечных жирных кислот (MCFA) в пересчете на общую массу жирных кислот.
3. Применение по п.1 или 2, где композиция включает линолевую кислоту (LA) и альфа-линоленовую кислоту (ALA) в массовом соотношении LA/ALA от 2 до 5.
4. Применение по п.1 или 2, где композиция дополнительно содержит, по меньшей мере, 0,5 мас.% по меньшей мере, одного растворимого, не усваиваемого олигосахарида, в пересчете на общую массу сухого вещества композиции.
5. Применение по п.1 или 2, где композиция содержит, по меньшей мере, 0,5 мас.%, по меньшей мере, одного растворимого, не усваиваемого олигосахарида, выбранного из группы, состоящей из фруктоолигосахаридов (включая инулин), галактоолигосахаридов (включая трансгалактоолигосахариды), глюкоолигосахаридов (включая гентио-, нигеро- и циклодекстринолигосахариды), арабиноолигосахаридов, маннанолигосахаридов, ксилоолигосахаридов, фукоолигосахаридов, арабиногалактоолигосахаридов, глюкоманноолигосахаридов, галактоманноолигосахаридов, олигосахаридов, включающих сиаловую кислоту, и олигосахаридов, включающих уроновую кислоту.
6. Применение по п.1 или 2, где композиция содержит галактоолигосахариды.
7. Применение по п.1 или 2, где композиция дополнительно содержит фруктоолигосахариды.
8. Применение по п.1 или 2 для профилактики развития ожирения на более позднем этапе жизни и/или для профилактики развития ожирения, когда возраст указанного младенца составляет более 36 месяцев.
9. Применение по п.1 или 2, где композиция дополнительно содержит:
(a) от 0,5 до 20 мас.% фосфолипидов в пересчете на общую массу жира;
(b) от 0,5 до 20 мас.% сфинголипидов в пересчете на общую массу жира;
(c) от 0,005 до 10 мас.% холестерина в пересчете на общую массу жира; и/или
(d) от 0,035 до 1 мас.% холина в пересчете на общую массу сухого вещества композиции и
от 0,001 до 0,1 мас.% уридина в пересчете на общую массу сухого вещества композиции.
10. Применение по п.1 или 2, где липидный компонент обеспечивает от 35 до 55% общего количества калорий, белковый компонент обеспечивает от 5 до 15% общего количества калорий и компонент, состоящий из усваиваемых углеводов обеспечивает от 30 до 60% общего количества калорий.
11. Применение по п.1 или 2, где композиция обеспечивает 60-90 ккал/100 мл.
12. Применение по п.1 или 2 для профилактики развития ожирения у людей в возрасте старше 12 лет.
13. Применение по п.1 или 2, где питательную композицию вводят младенцам в возрасте менее 12 месяцев.
14. Применение по п.1 или 2, где композиция содержит, по меньшей мере, 0,3 мас.% кальция в пересчете на общую массу сухого вещества композиции.
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| EP20050077972 EP1800675B1 (en) | 2005-12-23 | 2005-12-23 | Composition comprising polyunsaturated fatty acids, proteins, manganese and/or molybden and nucleosides/nucleotides for treating dementia |
| PCT/NL2006/050274 WO2008054192A1 (en) | 2006-11-02 | 2006-11-02 | Use of nutritional compositions for preventing disorders |
| NLPCT/NL2006/050274 | 2006-11-02 |
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| RU2008130367/15A RU2414905C2 (ru) | 2005-12-23 | 2006-12-22 | Применение питательных композиций с фосфолипидами, сфинголипидами и холестерином |
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