RU2008110349A - METHOD FOR PRODUCING 4- (2-HYDROXYETHYL) PHENOL OF HIGH PURITY OF PURITY - Google Patents
METHOD FOR PRODUCING 4- (2-HYDROXYETHYL) PHENOL OF HIGH PURITY OF PURITY Download PDFInfo
- Publication number
- RU2008110349A RU2008110349A RU2008110349/04A RU2008110349A RU2008110349A RU 2008110349 A RU2008110349 A RU 2008110349A RU 2008110349/04 A RU2008110349/04 A RU 2008110349/04A RU 2008110349 A RU2008110349 A RU 2008110349A RU 2008110349 A RU2008110349 A RU 2008110349A
- Authority
- RU
- Russia
- Prior art keywords
- hydroxyethyl
- tert
- phenol
- oxyalkylation
- butylphenol
- Prior art date
Links
- YCCILVSKPBXVIP-UHFFFAOYSA-N 2-(4-hydroxyphenyl)ethanol Chemical compound OCCC1=CC=C(O)C=C1 YCCILVSKPBXVIP-UHFFFAOYSA-N 0.000 title claims abstract 6
- 238000004519 manufacturing process Methods 0.000 title 1
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims abstract 6
- 239000003054 catalyst Substances 0.000 claims abstract 4
- 238000006243 chemical reaction Methods 0.000 claims abstract 4
- 230000020335 dealkylation Effects 0.000 claims abstract 4
- 238000006900 dealkylation reaction Methods 0.000 claims abstract 4
- DKCPKDPYUFEZCP-UHFFFAOYSA-N 2,6-di-tert-butylphenol Chemical compound CC(C)(C)C1=CC=CC(C(C)(C)C)=C1O DKCPKDPYUFEZCP-UHFFFAOYSA-N 0.000 claims abstract 2
- BRZPJNCKIKTYBE-UHFFFAOYSA-N 2,6-ditert-butyl-4-(2-hydroxyethyl)phenol Chemical compound CC(C)(C)C1=CC(CCO)=CC(C(C)(C)C)=C1O BRZPJNCKIKTYBE-UHFFFAOYSA-N 0.000 claims abstract 2
- IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 claims abstract 2
- VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 claims abstract 2
- 150000001875 compounds Chemical class 0.000 claims abstract 2
- 238000000034 method Methods 0.000 claims abstract 2
- 239000001632 sodium acetate Substances 0.000 claims abstract 2
- 235000017281 sodium acetate Nutrition 0.000 claims abstract 2
- RKSOPLXZQNSWAS-UHFFFAOYSA-N tert-butyl bromide Chemical compound CC(C)(C)Br RKSOPLXZQNSWAS-UHFFFAOYSA-N 0.000 claims abstract 2
- HPGGPRDJHPYFRM-UHFFFAOYSA-J tin(iv) chloride Chemical compound Cl[Sn](Cl)(Cl)Cl HPGGPRDJHPYFRM-UHFFFAOYSA-J 0.000 claims abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract 2
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
Способ получения 4-(2-гидроксиэтил)фенола путем оксиалкилирования 2,6-ди-трет-бутилфенола этиленоксидом в присутствии катализатора и последующего деалкилирования полученного 4-(2-гидроксиэтил)-2,6-ди-трет-бутилфенола, отличающийся тем, что оксиалкилирование проводят в присутствии безводного четыреххлористого олова в качестве катализатора при низкой скорости реакции, деалкилирование проводят с использованием водной НВr при температуре 120-130°С с одновременным удалением из реакционной массы воды и трет-бутилбромида, полученное соединение обрабатывают последовательно ацетатом натрия и гидроокисью натрия.The method of producing 4- (2-hydroxyethyl) phenol by oxyalkylation of 2,6-di-tert-butylphenol with ethylene oxide in the presence of a catalyst and subsequent dealkylation of the obtained 4- (2-hydroxyethyl) -2,6-di-tert-butylphenol, characterized in that oxyalkylation is carried out in the presence of anhydrous tin tetrachloride as a catalyst at a low reaction rate, dealkylation is carried out using aqueous HBr at a temperature of 120-130 ° C while removing water and tert-butyl bromide from the reaction mass, the obtained compound Work successively with sodium acetate and sodium hydroxide.
Claims (1)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU2008110349/04A RU2385858C2 (en) | 2008-03-20 | 2008-03-20 | Method of producing high-purity 4-(2-hydroxyethyl)phenol |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU2008110349/04A RU2385858C2 (en) | 2008-03-20 | 2008-03-20 | Method of producing high-purity 4-(2-hydroxyethyl)phenol |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2008110349A true RU2008110349A (en) | 2009-09-27 |
| RU2385858C2 RU2385858C2 (en) | 2010-04-10 |
Family
ID=41168935
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2008110349/04A RU2385858C2 (en) | 2008-03-20 | 2008-03-20 | Method of producing high-purity 4-(2-hydroxyethyl)phenol |
Country Status (1)
| Country | Link |
|---|---|
| RU (1) | RU2385858C2 (en) |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2558329C1 (en) * | 2014-05-13 | 2015-07-27 | Федеральное государственное бюджетное учреждение науки Институт проблем химико-энергетических технологий Сибирского отделения Российской академии наук (ИПХЭТ СО РАН) | METHOD OF PRODUCING 2-(4-HYDROXYPHENYL)ETHANOL (n-THYROZOL) |
| CN106748716B (en) * | 2016-11-14 | 2018-04-03 | 江苏汉阔生物有限公司 | A kind of new method for preparing 2,4,5 trifluoro benzene acetic acids |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2151137C1 (en) * | 1998-07-20 | 2000-06-20 | Иркутский институт химии СО РАН | Method of preparing 2-(4-hydroxyphenyl)ethanol |
| JP3275074B2 (en) * | 1999-05-26 | 2002-04-15 | 大塚化学株式会社 | Method for producing 4-hydroxyphenethyl alcohol compound |
| CN100432035C (en) * | 2006-07-19 | 2008-11-12 | 沈阳理工大学 | Technical method for synthesizing beta p-hydroxy phenethyl alcohol |
-
2008
- 2008-03-20 RU RU2008110349/04A patent/RU2385858C2/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| RU2385858C2 (en) | 2010-04-10 |
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| MM4A | The patent is invalid due to non-payment of fees |
Effective date: 20160321 |
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| PD4A | Correction of name of patent owner |