[go: up one dir, main page]

RU2008108014A - Инъецируемый композитный материал, пригодный для использования в качестве заменителя костной ткани - Google Patents

Инъецируемый композитный материал, пригодный для использования в качестве заменителя костной ткани Download PDF

Info

Publication number
RU2008108014A
RU2008108014A RU2008108014/15A RU2008108014A RU2008108014A RU 2008108014 A RU2008108014 A RU 2008108014A RU 2008108014/15 A RU2008108014/15 A RU 2008108014/15A RU 2008108014 A RU2008108014 A RU 2008108014A RU 2008108014 A RU2008108014 A RU 2008108014A
Authority
RU
Russia
Prior art keywords
composite material
material according
weight
polyvinyl alcohol
injectable composite
Prior art date
Application number
RU2008108014/15A
Other languages
English (en)
Other versions
RU2407552C2 (ru
Inventor
Луиджи АМБРОЗИО (IT)
Луиджи АМБРОЗИО
Валерия САНДЖИНАРИО (IT)
Валерия САНДЖИНАРИО
Мария Пау ХИНЕБРА (ES)
Мария Пау ХИНЕБРА
Хосеп Антон ПЛАНЕЛЬ (ES)
Хосеп Антон ПЛАНЕЛЬ
Original Assignee
Консильо Национале Делле Ричерке (IT)
Консильо Национале Делле Ричерке
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Консильо Национале Делле Ричерке (IT), Консильо Национале Делле Ричерке filed Critical Консильо Национале Делле Ричерке (IT)
Publication of RU2008108014A publication Critical patent/RU2008108014A/ru
Application granted granted Critical
Publication of RU2407552C2 publication Critical patent/RU2407552C2/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/42—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having an inorganic matrix
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/02—Inorganic materials
    • A61L27/12—Phosphorus-containing materials, e.g. apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/40—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material
    • A61L27/44—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix
    • A61L27/46—Composite materials, i.e. containing one material dispersed in a matrix of the same or different material having a macromolecular matrix with phosphorus-containing inorganic fillers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/52—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/28—Bones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2/46—Special tools for implanting artificial joints
    • A61F2/4601—Special tools for implanting artificial joints for introducing bone substitute, for implanting bone graft implants or for compacting them in the bone cavity
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/28—Bones
    • A61F2002/2817—Bone stimulation by chemical reactions or by osteogenic or biological products for enhancing ossification, e.g. by bone morphogenetic or morphogenic proteins [BMP] or by transforming growth factors [TGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00—Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02—Prostheses implantable into the body
    • A61F2/30—Joints
    • A61F2002/30001—Additional features of subject-matter classified in A61F2/28, A61F2/30 and subgroups thereof
    • A61F2002/30667—Features concerning an interaction with the environment or a particular use of the prosthesis
    • A61F2002/30677—Means for introducing or releasing pharmaceutical products, e.g. antibiotics, into the body
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2310/00—Prostheses classified in A61F2/28 or A61F2/30 - A61F2/44 being constructed from or coated with a particular material
    • A61F2310/00005—The prosthesis being constructed from a particular material
    • A61F2310/00179—Ceramics or ceramic-like structures
    • A61F2310/00293—Ceramics or ceramic-like structures containing a phosphorus-containing compound, e.g. apatite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2400/00—Materials characterised by their function or physical properties
    • A61L2400/06—Flowable or injectable implant compositions

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Dermatology (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Inorganic Chemistry (AREA)
  • Composite Materials (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Materials Engineering (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Dispersion Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Cardiology (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Prostheses (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1. Инъецируемый композитный материал, содержащий трехзамещенный фосфат кальция в качестве керамической фазы и гидрогель поливинилового спирта в качестве жидкой фазы. ! 2. Инъецируемый композитный материал по п.1, в котором гидрогель поливинилового спирта в качестве жидкой фазы представляет собой 2-30% (по массе) водный раствор поливинилового спирта. ! 3. Инъецируемый композитный материал по любому из пп.1 и 2, в котором массовое (вес/вес) отношение полимер поливинилового спирта/трехзамещенный фосфат кальция составляет от 3/97 до 20/80. ! 4. Инъецируемый композитный материал по п.3, в котором массовое (вес/вес) отношение полимер поливинилового спирта/трехзамещенный фосфат кальция составляет 7/93. ! 5. Инъецируемый композитный материал по п.3, в котором массовое (вес/вес) отношение полимер поливинилового спирта/трехзамещенный фосфат кальция составляет 12/88. ! 6. Инъецируемый композитный материал по п.3, в котором массовое (вес/вес) отношение полимер поливинилового спирта/трехзамещенный фосфат кальция составляет 14/86. ! 7. Инъецируемый композитный материал по п.1, дополнительно содержащий биоактивный агент, выбранный из группы, содержащей лекарственные средства, клетки, ростовые факторы и комбинации вышеперечисленных агентов. ! 8. Инъецируемый композитный материал по п.1 в качестве заменителя костной ткани. ! 9. Инъецируемый композитный материал по п.1, для получения лекарственного средства, пригодного для использования в качестве заменителя костной ткани. ! 10. Способ получения инъецируемого композитного материала по любому из пп.1-7, включающий приготовление водного раствора поливинилового спирта и последующее смешивание полученного

Claims (10)

1. Инъецируемый композитный материал, содержащий трехзамещенный фосфат кальция в качестве керамической фазы и гидрогель поливинилового спирта в качестве жидкой фазы.
2. Инъецируемый композитный материал по п.1, в котором гидрогель поливинилового спирта в качестве жидкой фазы представляет собой 2-30% (по массе) водный раствор поливинилового спирта.
3. Инъецируемый композитный материал по любому из пп.1 и 2, в котором массовое (вес/вес) отношение полимер поливинилового спирта/трехзамещенный фосфат кальция составляет от 3/97 до 20/80.
4. Инъецируемый композитный материал по п.3, в котором массовое (вес/вес) отношение полимер поливинилового спирта/трехзамещенный фосфат кальция составляет 7/93.
5. Инъецируемый композитный материал по п.3, в котором массовое (вес/вес) отношение полимер поливинилового спирта/трехзамещенный фосфат кальция составляет 12/88.
6. Инъецируемый композитный материал по п.3, в котором массовое (вес/вес) отношение полимер поливинилового спирта/трехзамещенный фосфат кальция составляет 14/86.
7. Инъецируемый композитный материал по п.1, дополнительно содержащий биоактивный агент, выбранный из группы, содержащей лекарственные средства, клетки, ростовые факторы и комбинации вышеперечисленных агентов.
8. Инъецируемый композитный материал по п.1 в качестве заменителя костной ткани.
9. Инъецируемый композитный материал по п.1, для получения лекарственного средства, пригодного для использования в качестве заменителя костной ткани.
10. Способ получения инъецируемого композитного материала по любому из пп.1-7, включающий приготовление водного раствора поливинилового спирта и последующее смешивание полученного раствора с порошком трехзамещенного фосфата кальция.
RU2008108014/15A 2005-08-03 2006-08-01 Инъецируемый композитный материал, пригодный для использования в качестве заменителя костной ткани RU2407552C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT000549A ITTO20050549A1 (it) 2005-08-03 2005-08-03 Materiale composito iniettabile atto ad essere utilizzato come sostituto osseo
ITTO2005A000549 2005-08-03

Publications (2)

Publication Number Publication Date
RU2008108014A true RU2008108014A (ru) 2009-09-10
RU2407552C2 RU2407552C2 (ru) 2010-12-27

Family

ID=37667630

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2008108014/15A RU2407552C2 (ru) 2005-08-03 2006-08-01 Инъецируемый композитный материал, пригодный для использования в качестве заменителя костной ткани

Country Status (22)

Country Link
US (2) US20080220086A1 (ru)
EP (1) EP1924302B1 (ru)
JP (1) JP5180075B2 (ru)
KR (1) KR101276632B1 (ru)
CN (1) CN101257937B (ru)
AT (1) ATE465762T1 (ru)
AU (1) AU2006274594B2 (ru)
BR (1) BRPI0615994A2 (ru)
CA (1) CA2617721A1 (ru)
DE (1) DE602006014004D1 (ru)
DK (1) DK1924302T3 (ru)
ES (1) ES2345399T3 (ru)
IT (1) ITTO20050549A1 (ru)
NZ (1) NZ566086A (ru)
PL (1) PL1924302T3 (ru)
PT (1) PT1924302E (ru)
RU (1) RU2407552C2 (ru)
SI (1) SI1924302T1 (ru)
SM (1) SMAP200800013A (ru)
UA (1) UA92027C2 (ru)
WO (1) WO2007015208A2 (ru)
ZA (1) ZA200801928B (ru)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7235592B2 (en) 2004-10-12 2007-06-26 Zimmer Gmbh PVA hydrogel
US20070098799A1 (en) * 2005-10-28 2007-05-03 Zimmer, Inc. Mineralized Hydrogels and Methods of Making and Using Hydrogels
EP1957124A2 (en) 2005-12-07 2008-08-20 Zimmer Inc. Methods of bonding or modifying hydrogels using irradiation
US8110242B2 (en) 2006-03-24 2012-02-07 Zimmer, Inc. Methods of preparing hydrogel coatings
US7731988B2 (en) 2007-08-03 2010-06-08 Zimmer, Inc. Multi-polymer hydrogels
US8062739B2 (en) 2007-08-31 2011-11-22 Zimmer, Inc. Hydrogels with gradient
US7947784B2 (en) 2007-11-16 2011-05-24 Zimmer, Inc. Reactive compounding of hydrogels
US8034362B2 (en) 2008-01-04 2011-10-11 Zimmer, Inc. Chemical composition of hydrogels for use as articulating surfaces
US20100226956A1 (en) 2009-03-06 2010-09-09 Per Kjellin Production of moldable bone substitute
ES2981890T3 (es) 2015-07-24 2024-10-11 Trimph Ip Pty Ltd Polímero antiséptico y síntesis del mismo
JP2020067494A (ja) * 2018-10-22 2020-04-30 ウェトラブ株式会社 脳神経外科手術用頭部モデル

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP3635316B2 (ja) * 1996-11-25 2005-04-06 株式会社アドバンス 球状セラミックス多孔体の製造方法
PL363113A1 (en) * 2000-03-27 2004-11-15 Schott Glas New cosmetic, personal care, cleaning agent, and nutritional supplement compositions comprising bioactive glass and methods of making and using the same
US6949251B2 (en) 2001-03-02 2005-09-27 Stryker Corporation Porous β-tricalcium phosphate granules for regeneration of bone tissue
JP4403268B2 (ja) * 2001-10-21 2010-01-27 独立行政法人産業技術総合研究所 リン酸カルシウム多孔質焼結体の製造方法及びそれを用いた人工骨の製造方法
KR20060133961A (ko) * 2003-09-12 2006-12-27 와이어쓰 골형성 단백질 전달용의 주사 가능한 인산칼슘 고형 로드및 페이스트

Also Published As

Publication number Publication date
US20080220086A1 (en) 2008-09-11
SI1924302T1 (sl) 2010-09-30
WO2007015208A3 (en) 2007-05-31
PL1924302T3 (pl) 2010-10-29
DE602006014004D1 (de) 2010-06-10
KR20080041678A (ko) 2008-05-13
UA92027C2 (ru) 2010-09-27
AU2006274594A1 (en) 2007-02-08
EP1924302A2 (en) 2008-05-28
WO2007015208A2 (en) 2007-02-08
JP2009502405A (ja) 2009-01-29
KR101276632B1 (ko) 2013-06-18
DK1924302T3 (da) 2010-07-26
JP5180075B2 (ja) 2013-04-10
BRPI0615994A2 (pt) 2011-05-31
PT1924302E (pt) 2010-07-27
ATE465762T1 (de) 2010-05-15
EP1924302B1 (en) 2010-04-28
NZ566086A (en) 2011-03-31
AU2006274594B2 (en) 2011-12-22
SMP200800013B (it) 2008-02-27
ZA200801928B (en) 2009-07-29
RU2407552C2 (ru) 2010-12-27
ITTO20050549A1 (it) 2007-02-04
SMAP200800013A (it) 2008-02-27
US20110091554A1 (en) 2011-04-21
CA2617721A1 (en) 2007-02-08
ES2345399T3 (es) 2010-09-22
CN101257937B (zh) 2013-03-20
US8231909B2 (en) 2012-07-31
CN101257937A (zh) 2008-09-03

Similar Documents

Publication Publication Date Title
Ergul et al. 3D printing of chitosan/poly (vinyl alcohol) hydrogel containing synthesized hydroxyapatite scaffolds for hard-tissue engineering
Zhou et al. Hierarchically porous hydroxyapatite hybrid scaffold incorporated with reduced graphene oxide for rapid bone ingrowth and repair
Shahbazarab et al. Fabrication and characterization of nanobiocomposite scaffold of zein/chitosan/nanohydroxyapatite prepared by freeze-drying method for bone tissue engineering
Liu et al. Effects of the granularity of raw materials on the hydration and hardening process of calcium phosphate cement
Venkatesan et al. Role of alginate in bone tissue engineering
Tonda-Turo et al. Comparative analysis of gelatin scaffolds crosslinked by genipin and silane coupling agent
RU2008108014A (ru) Инъецируемый композитный материал, пригодный для использования в качестве заменителя костной ткани
CN105705171B (zh) 通过胶原蛋白和玻尿酸的天然交联强化其橡胶性质物性的生体材料物质及其制造方法和使用方法
Montufar et al. Self-hardening calcium deficient hydroxyapatite/gelatine foams for bone regeneration
Rajabi et al. 3D printing of chitooligosaccharide‐polyethylene glycol diacrylate hydrogel inks for bone tissue regeneration
Paul et al. In vivo evaluation of injectable calcium phosphate cement composed of Zn‐and Si‐incorporated β‐tricalcium phosphate and monocalcium phosphate monohydrate for a critical sized defect of the rabbit femoral condyle
Grosfeld et al. Fast dissolving glucose porogens for early calcium phosphate cement degradation and bone regeneration
Zhou et al. Hofmeister effect-assistant fabrication of all-natural protein-based porous materials templated from Pickering emulsions
John et al. Non-cytotoxic organic–inorganic hybrid bioscaffolds: An efficient bedding for rapid growth of bone-like apatite and cell proliferation
Abdal-hay et al. A novel simple in situ biomimetic and simultaneous deposition of bonelike apatite within biopolymer matrix as bone graft substitutes
Liu et al. Synthesis of bioactive poly (ethylene glycol)/SiO2-CaO-P2O5 hybrids for bone regeneration
WO2006067626A3 (en) Chitosan compositions
Zhu et al. Mechanical stimulus and metabolic responses by cryo‐printing anisotropic scaffolds for achieving promoted bone regeneration
Salagierski et al. When dynamic covalent chemistry meets bioactive glasses–Novel multi-level crosslinked, injectable, self-healing chitosan-based hydrogels
CN106693063B (zh) 一种抗溃散钙硅基复合骨水泥及其制备方法和应用
Schloegl et al. Porosity and mechanically optimized PLGA based in situ hardening systems
Ohba et al. Efficacy of platelet‐rich plasma gel and hyaluronan hydrogel as carriers of electrically polarized hydroxyapatite microgranules for accelerating bone formation
Ningrum et al. Innovative valorization of crab shells for hydroxyapatite‐based composite hydrogels in bone engineering applications
Chen et al. Enhanced rotator cuff tendon-bone interface regeneration with injectable manganese-based mesoporous silica nanoparticle-loaded dual crosslinked hydrogels
Jebahi et al. Osteoinduction and antiosteoporotic performance of hybrid biomaterial chitosan-bioactive glass graft: effects on bone remodeling

Legal Events

Date Code Title Description
MM4A The patent is invalid due to non-payment of fees

Effective date: 20140802