RU2008102641A - Вирусы prrs, их инфекционные клоны, мутантные формы и способы применения - Google Patents
Вирусы prrs, их инфекционные клоны, мутантные формы и способы применения Download PDFInfo
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- RU2008102641A RU2008102641A RU2008102641/13A RU2008102641A RU2008102641A RU 2008102641 A RU2008102641 A RU 2008102641A RU 2008102641/13 A RU2008102641/13 A RU 2008102641/13A RU 2008102641 A RU2008102641 A RU 2008102641A RU 2008102641 A RU2008102641 A RU 2008102641A
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- 208000015181 infectious disease Diseases 0.000 title claims abstract 19
- 230000002458 infectious effect Effects 0.000 title claims abstract 19
- 208000005342 Porcine Reproductive and Respiratory Syndrome Diseases 0.000 title 1
- 241000700605 Viruses Species 0.000 title 1
- 239000002773 nucleotide Substances 0.000 claims abstract 59
- 125000003729 nucleotide group Chemical group 0.000 claims abstract 59
- 239000002157 polynucleotide Substances 0.000 claims abstract 40
- 102000040430 polynucleotide Human genes 0.000 claims abstract 40
- 108091033319 polynucleotide Proteins 0.000 claims abstract 40
- 230000037430 deletion Effects 0.000 claims abstract 17
- 238000012217 deletion Methods 0.000 claims abstract 17
- 239000002245 particle Substances 0.000 claims abstract 5
- 230000003612 virological effect Effects 0.000 claims abstract 5
- 102000004163 DNA-directed RNA polymerases Human genes 0.000 claims 2
- 108090000626 DNA-directed RNA polymerases Proteins 0.000 claims 2
- 239000003550 marker Substances 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 101800000511 Non-structural protein 2 Proteins 0.000 claims 1
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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- C12N15/86—Viral vectors
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- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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- C12N2770/10011—Arteriviridae
- C12N2770/10021—Viruses as such, e.g. new isolates, mutants or their genomic sequences
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- C12N2770/00011—Details
- C12N2770/10011—Arteriviridae
- C12N2770/10022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/10011—Arteriviridae
- C12N2770/10041—Use of virus, viral particle or viral elements as a vector
- C12N2770/10043—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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- Micro-Organisms Or Cultivation Processes Thereof (AREA)
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- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Abstract
1. Выделенный инфекционный полинуклеотид, содержащий нуклеотидную последовательность, имеющую по меньшей мере 88% идентичность с SEQ ID NO:1 и делецию по меньшей мере 39 последовательно расположенных нуклеотидов, соответствующих нуклеотидам от нуклеотида 2062 до нуклеотида 3864 SEQ ID NO:1. ! 2. Выделенный полинуклеотид, содержащий нуклеотидную последовательность, имеющую по меньшей мере 88% идентичность с SEQ ID NO:1, и по меньшей мере одну делецию по меньшей мере 39 последовательно расположенных нуклеотидов, соответствующих нуклеотидам от нуклеотида 2062 до нуклеотида 3864 SEQ ID NO:1, и где полинуклеотид реплицируется и продуцирует инфекционные вирусные частицы при введении в клетку. ! 3. Инфекционный клон, содержащий полинуклеотид, обладающий нуклеотидной последовательностью, имеющей по меньшей мере 88% идентичность с SEQ ID NO:1 и по меньшей мере одну делецию по меньшей мере 39 последовательно расположенных нуклеотидов, соответствующих нуклеотидам от нуклеотида 2062 до нуклеотида 3864 SEQ ID NO:1. ! 4. Выделенный инфекционный полинуклеотид, содержащий нуклеотидную последовательность, имеющую по меньшей мере 88% идентичность с SEQ ID NO:14 и делецию по меньшей мере 39 последовательно расположенных нуклеотидов, соответствующих нуклеотидам от нуклеотида 2061 до нуклеотида 3545 SEQ ID NO:14. ! 5. Выделенный полинуклеотид, содержащий нуклеотидную последовательность, имеющую по меньшей мере 88% идентичность с SEQ ID NO:14, и по меньшей мере одну делецию по меньшей мере 39 последовательно расположенных нуклеотидов, соответствующих нуклеотидам от нуклеотида 2061 до нуклеотида 3545 SEQ ID NO:14, и где полинуклеотид реплицируется и продуцирует инфекционные вирусные частицы при введении �
Claims (21)
1. Выделенный инфекционный полинуклеотид, содержащий нуклеотидную последовательность, имеющую по меньшей мере 88% идентичность с SEQ ID NO:1 и делецию по меньшей мере 39 последовательно расположенных нуклеотидов, соответствующих нуклеотидам от нуклеотида 2062 до нуклеотида 3864 SEQ ID NO:1.
2. Выделенный полинуклеотид, содержащий нуклеотидную последовательность, имеющую по меньшей мере 88% идентичность с SEQ ID NO:1, и по меньшей мере одну делецию по меньшей мере 39 последовательно расположенных нуклеотидов, соответствующих нуклеотидам от нуклеотида 2062 до нуклеотида 3864 SEQ ID NO:1, и где полинуклеотид реплицируется и продуцирует инфекционные вирусные частицы при введении в клетку.
3. Инфекционный клон, содержащий полинуклеотид, обладающий нуклеотидной последовательностью, имеющей по меньшей мере 88% идентичность с SEQ ID NO:1 и по меньшей мере одну делецию по меньшей мере 39 последовательно расположенных нуклеотидов, соответствующих нуклеотидам от нуклеотида 2062 до нуклеотида 3864 SEQ ID NO:1.
4. Выделенный инфекционный полинуклеотид, содержащий нуклеотидную последовательность, имеющую по меньшей мере 88% идентичность с SEQ ID NO:14 и делецию по меньшей мере 39 последовательно расположенных нуклеотидов, соответствующих нуклеотидам от нуклеотида 2061 до нуклеотида 3545 SEQ ID NO:14.
5. Выделенный полинуклеотид, содержащий нуклеотидную последовательность, имеющую по меньшей мере 88% идентичность с SEQ ID NO:14, и по меньшей мере одну делецию по меньшей мере 39 последовательно расположенных нуклеотидов, соответствующих нуклеотидам от нуклеотида 2061 до нуклеотида 3545 SEQ ID NO:14, и где полинуклеотид реплицируется и продуцирует инфекционные вирусные частицы при введении в клетку.
6. Инфекционный клон, содержащий полинуклеотид, обладающий нуклеотидной последовательностью, имеющей по меньшей мере 88% идентичность с SEQ ID NO:14 и по меньшей мере одну делецию по меньшей мере 39 последовательно расположенных нуклеотидов, соответствующих нуклеотидам от нуклеотида 2061 до нуклеотида 3545 SEQ ID NO:14.
7. Выделенный полинуклеотид по п.1, 2, 4 или 5, где полинуклеотид находится в векторе.
8. Выделенный полинуклеотид по п.1, 2, 4 или 5, где полинуклеотид содержит 2 или более делеций, и где каждая делеция независимо представляет собой по меньшей мере 37 последовательно расположенных нуклеотидов.
9. Инфекционный клон по п.3 или 6, где полинуклеотид содержит 2 или более делеций, и где каждая делеция независимо представляет собой по меньшей мере 37 последовательно расположенных нуклеотидов.
10. Выделенный полинуклеотид по п.1, 2, 4 или 5, где полинуклеотид находится в выделенной вирусной частице.
11. Выделенный полинуклеотид по п.1, 2, 4 или 5, где полинуклеотид представляет собой полинуклеотид РНК.
12. Выделенный полинуклеотид по п.1, 2, 4 или 5, где полинуклеотид находится в клетке.
13. Инфекционный клон по п.3 или 6, где полинуклеотид находится в клетке.
14. Выделенный полинуклеотид по п.1, 2, 4 или 5, где с полинуклеотидом функционально связан промотор РНК-полимеразы.
15. Инфекционный клон по п.3 или 6, где с полинуклеотидом функционально связан промотор РНК-полимеразы.
16. Выделенный полинуклеотид по п.1, 2, 4 или 5, где полинуклеотид дополнительно содержит экзогенный полинуклеотид, находящийся в области делеции.
17. Выделенный полинуклеотид по п.16, где экзогенный полинуклеотид кодирует детектируемый маркер.
18. Инфекционный клон по п.3 или 6, где полинуклеотид дополнительно содержит экзогенный полинуклеотид, находящийся в области делеции.
19. Инфекционный клон по п.18, где экзогенный полинуклеотид кодирует детектируемый маркер.
20. Выделенный инфекционный полинуклеотид, содержащий нуклеотидную последовательность SEQ ID NO:1, SEQ ID NO:2, SEQ ID NO:3, SEQ ID NO:4, SEQ ID NO:5, SEQ ID NO:6, SEQ ID NO:7, SEQ ID NO:8, SEQ ID NO:9, SEQ ID NO:10, SEQ ID NO:11, SEQ ID NO:12 или SEQ ID NO:13.
21. Полипептид nsp2, кодируемый инфекционным полинуклеотидом, содержащим нуклеотидную последовательность SEQ ID NO:7, SEQ ID NO:8, SEQ ID NO:9, SEQ ID NO:10, SEQ ID NO:11, SEQ ID NO:12 или SEQ ID NO:13.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US69402105P | 2005-06-24 | 2005-06-24 | |
| US60/694,021 | 2005-06-24 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2008102641A true RU2008102641A (ru) | 2009-07-27 |
| RU2427646C2 RU2427646C2 (ru) | 2011-08-27 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2008102641/10A RU2427646C2 (ru) | 2005-06-24 | 2006-06-23 | Вирусы prrs, их инфекционные клоны, мутантные формы и способы применения |
Country Status (19)
| Country | Link |
|---|---|
| US (3) | US8110390B2 (ru) |
| EP (2) | EP1904631B1 (ru) |
| JP (1) | JP5139280B2 (ru) |
| KR (1) | KR101321153B1 (ru) |
| CN (1) | CN101258247B (ru) |
| AU (1) | AU2006262150B2 (ru) |
| BR (1) | BRPI0611594B1 (ru) |
| CA (4) | CA3128824C (ru) |
| DK (2) | DK2369001T3 (ru) |
| ES (2) | ES2386973T3 (ru) |
| HU (1) | HUE031018T2 (ru) |
| MX (1) | MX2007015849A (ru) |
| PL (2) | PL1904631T3 (ru) |
| PT (2) | PT1904631E (ru) |
| RU (1) | RU2427646C2 (ru) |
| SI (1) | SI1904631T1 (ru) |
| UA (1) | UA95778C2 (ru) |
| WO (1) | WO2007002321A2 (ru) |
| ZA (1) | ZA200711156B (ru) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7691389B2 (en) | 1998-12-22 | 2010-04-06 | Pfizer Inc | Infectious cDNA clone of north american porcine reproductive and respiratory syndrome (PRRS) virus and uses thereof |
| US7618797B2 (en) | 1998-12-22 | 2009-11-17 | Pfizer Inc | Infectious cDNA clone of North American porcine reproductive and respiratory syndrome (PRRS) virus and uses thereof |
| CA2571452A1 (en) | 2004-06-18 | 2006-01-26 | Regents Of The University Of Minnesota | Identifying virally infected and vaccinated organisms |
| UA95778C2 (ru) * | 2005-06-24 | 2011-09-12 | Риджентс Оф Зе Юниверсити Оф Миннесота | Вирусы репродуктивно-респираторного синдрома свиней, их инфекционные клоны и мутанты и способы применения |
| CN102483411A (zh) * | 2008-11-26 | 2012-05-30 | 南达科他州立大学 | 猪繁殖与呼吸综合征病毒的鉴定 |
| TWI627281B (zh) | 2009-09-02 | 2018-06-21 | 百靈佳殷格翰家畜藥品公司 | 降低ｐｃｖ－２組合物殺病毒活性之方法及具有改良免疫原性之ｐｃｖ－２組合物 |
| UA108902C2 (uk) | 2010-11-10 | 2015-06-25 | Вірус північноамериканського репродуктивного та респіраторного синдрому свиней (prrs) та його застосування | |
| US8728487B2 (en) | 2011-01-20 | 2014-05-20 | Hua Wu | Attenuated live vaccine for prevention of porcine reproductive and respiratory syndrome |
| ES2550258T3 (es) | 2011-02-17 | 2015-11-05 | Boehringer Ingelheim Vetmedica Gmbh | Nueva cepa del PRRSV europea |
| PH12013502436A1 (en) * | 2011-05-27 | 2014-01-20 | Sinovet Jiangsu Biopharm Co Ltd | Combined vaccines for prevention of porcine virus infections |
| US9187731B2 (en) | 2011-07-29 | 2015-11-17 | Boehringer Ingelheim Vetmedica Gmbh | PRRS virus inducing type I interferon in susceptible cells |
| EP2737058A1 (en) | 2011-07-29 | 2014-06-04 | Boehringer Ingelheim Vetmedica GmbH | INFECTIOUS cDNA CLONE OF EUROPEAN PRRS VIRUS AND USES THEREOF |
| JP6386999B2 (ja) | 2012-05-17 | 2018-09-05 | ゾエティス・エルエルシー | ブタ生殖および呼吸症候群（ｐｒｒｓ）ウイルスに対する離乳前の効果的なワクチン接種 |
| HK1208811A1 (en) * | 2012-07-18 | 2016-03-18 | South Dakota Board Of Regents | Novel arterivirus protein and expression mechanisms |
| CN105087506B (zh) * | 2015-03-20 | 2020-06-30 | 普莱柯生物工程股份有限公司 | 一种猪伪狂犬病病毒致弱方法、及其致弱的病毒株、疫苗组合物和应用 |
| CN106929480B (zh) * | 2015-12-29 | 2021-04-27 | 普莱柯生物工程股份有限公司 | 猪繁殖与呼吸综合征病毒株及其应用 |
| MX393666B (es) | 2016-08-05 | 2025-03-24 | Hipra Scient S L U | CLON DE ADNc DEL VIRUS DEL SÍNDROME REPRODUCTIVO Y RESPIRATORIO PORCINO Y USOS DEL MISMO. |
| UA124976C2 (uk) | 2016-12-14 | 2021-12-22 | Зоетіс Сервісіз Ллс | Вакцина для захисту тварини свині від зараження вірусом prrs |
| US10729756B2 (en) * | 2017-05-30 | 2020-08-04 | The United States Of America, As Represented By The Secretary Of Agriculture | Viable viruses with foreign tags |
| WO2025012350A1 (en) | 2023-07-11 | 2025-01-16 | Virovet Nv | Vectors expressing attenuated rna virus of the family arteriviridae and uses thereof |
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