RU2008101513A - Пленки, растворяющиеся в полости рта - Google Patents
Пленки, растворяющиеся в полости рта Download PDFInfo
- Publication number
- RU2008101513A RU2008101513A RU2008101513/15A RU2008101513A RU2008101513A RU 2008101513 A RU2008101513 A RU 2008101513A RU 2008101513/15 A RU2008101513/15 A RU 2008101513/15A RU 2008101513 A RU2008101513 A RU 2008101513A RU 2008101513 A RU2008101513 A RU 2008101513A
- Authority
- RU
- Russia
- Prior art keywords
- agent
- dosage form
- nicotine
- active agent
- sensory impulse
- Prior art date
Links
- 210000000214 mouth Anatomy 0.000 title claims 2
- 239000003795 chemical substances by application Substances 0.000 claims abstract 14
- 230000001953 sensory effect Effects 0.000 claims abstract 12
- 239000013543 active substance Substances 0.000 claims abstract 9
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims abstract 9
- 239000002552 dosage form Substances 0.000 claims abstract 8
- 239000000779 smoke Substances 0.000 claims abstract 7
- SNICXCGAKADSCV-JTQLQIEISA-N (-)-Nicotine Chemical compound CN1CCC[C@H]1C1=CC=CN=C1 SNICXCGAKADSCV-JTQLQIEISA-N 0.000 claims abstract 6
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims abstract 6
- 235000019788 craving Nutrition 0.000 claims abstract 6
- 229960002715 nicotine Drugs 0.000 claims abstract 6
- SNICXCGAKADSCV-UHFFFAOYSA-N nicotine Natural products CN1CCCC1C1=CC=CN=C1 SNICXCGAKADSCV-UHFFFAOYSA-N 0.000 claims abstract 6
- 240000003291 Armoracia rusticana Species 0.000 claims abstract 4
- 235000011330 Armoracia rusticana Nutrition 0.000 claims abstract 4
- 244000056139 Brassica cretica Species 0.000 claims abstract 4
- 235000003351 Brassica cretica Nutrition 0.000 claims abstract 4
- 235000003343 Brassica rupestris Nutrition 0.000 claims abstract 4
- 244000203593 Piper nigrum Species 0.000 claims abstract 4
- 235000008184 Piper nigrum Nutrition 0.000 claims abstract 4
- 244000195452 Wasabia japonica Species 0.000 claims abstract 4
- 235000000760 Wasabia japonica Nutrition 0.000 claims abstract 4
- 244000273928 Zingiber officinale Species 0.000 claims abstract 4
- 235000006886 Zingiber officinale Nutrition 0.000 claims abstract 4
- 239000000227 bioadhesive Substances 0.000 claims abstract 4
- QKSKPIVNLNLAAV-UHFFFAOYSA-N bis(2-chloroethyl) sulfide Chemical compound ClCCSCCCl QKSKPIVNLNLAAV-UHFFFAOYSA-N 0.000 claims abstract 4
- 235000013614 black pepper Nutrition 0.000 claims abstract 4
- 235000008397 ginger Nutrition 0.000 claims abstract 4
- 230000002045 lasting effect Effects 0.000 claims abstract 4
- 231100000067 mild irritant Toxicity 0.000 claims abstract 4
- 239000000203 mixture Substances 0.000 claims abstract 4
- 235000010460 mustard Nutrition 0.000 claims abstract 4
- 239000006186 oral dosage form Substances 0.000 claims abstract 4
- 239000011668 ascorbic acid Substances 0.000 claims abstract 3
- 229960005070 ascorbic acid Drugs 0.000 claims abstract 3
- 235000010323 ascorbic acid Nutrition 0.000 claims abstract 3
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract 2
- 239000001257 hydrogen Substances 0.000 claims abstract 2
- 239000000463 material Substances 0.000 claims abstract 2
- 239000004014 plasticizer Substances 0.000 claims abstract 2
- 239000002537 cosmetic Substances 0.000 claims 2
- 239000002202 Polyethylene glycol Substances 0.000 claims 1
- 229920001223 polyethylene glycol Polymers 0.000 claims 1
- 230000001225 therapeutic effect Effects 0.000 claims 1
- 229920002554 vinyl polymer Polymers 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/465—Nicotine; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
- A61K31/724—Cyclodextrins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/006—Oral mucosa, e.g. mucoadhesive forms, sublingual droplets; Buccal patches or films; Buccal sprays
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7007—Drug-containing films, membranes or sheets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
- A61P39/02—Antidotes
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Addiction (AREA)
- Neurology (AREA)
- Inorganic Chemistry (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Psychiatry (AREA)
- Toxicology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Plant Substances (AREA)
- Cosmetics (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
1. Пероральная дозированная форма, содержащая ! a) по меньшей мере, один никотиновый активный агент; ! b) по меньшей мере, один биоадгезивный материал, способный образовывать водородную связь с никотиновым активным агентом, и ! c) по меньшей мере, один быстро высвобождающийся сенсорный импульсный агент; ! в которой быстро высвобождающийся сенсорный импульсный агент присутствует в количестве, эффективном для быстрого ослабления тяги к никотину, при этом дозированная форма обеспечивает быстрое и продолжительное ослабление тяги к никотину у нуждающегося в этом человека. ! 2. Дозированная форма по п.1, в которой сенсорный импульсный агент выбран из группы, включающей капсиацин, горчицу, хрен, имбирь, васаби, дым и черный перец; мягкие раздражители, например освобожденный от никотина дым, лимонную кислоту, аскорбиновую кислоту и их смеси. ! 3. Дозированная форма по п.1, дополнительно содержащая щелочной буферный агент. ! 4. Дозированная форма по п.1, дополнительно содержащая пластификатор. ! 5. Способ обеспечения быстрого и продолжительного облегчения тяги к никотину посредством введения нуждающемуся в этом человеку перорально дозированной формы, содержащей, по меньшей мере, один никотиновый активный агент, по меньшей мере, один биоадгезивный компонент и, по меньшей мере, один быстро высвобождающийся сенсорный импульсный агент, где сенсорный импульсный агент присутствует в количестве, эффективном для быстрого облегчения тяги у указанного человека. ! 6. Способ по п.5, в котором сенсорный импульсный агент выбран из группы, состоящей из капсиацина, горчицы, хрена, имбиря, васаби, дыма и черного перца; мягких раздражителей, наприме�
Claims (8)
1. Пероральная дозированная форма, содержащая
a) по меньшей мере, один никотиновый активный агент;
b) по меньшей мере, один биоадгезивный материал, способный образовывать водородную связь с никотиновым активным агентом, и
c) по меньшей мере, один быстро высвобождающийся сенсорный импульсный агент;
в которой быстро высвобождающийся сенсорный импульсный агент присутствует в количестве, эффективном для быстрого ослабления тяги к никотину, при этом дозированная форма обеспечивает быстрое и продолжительное ослабление тяги к никотину у нуждающегося в этом человека.
2. Дозированная форма по п.1, в которой сенсорный импульсный агент выбран из группы, включающей капсиацин, горчицу, хрен, имбирь, васаби, дым и черный перец; мягкие раздражители, например освобожденный от никотина дым, лимонную кислоту, аскорбиновую кислоту и их смеси.
3. Дозированная форма по п.1, дополнительно содержащая щелочной буферный агент.
4. Дозированная форма по п.1, дополнительно содержащая пластификатор.
5. Способ обеспечения быстрого и продолжительного облегчения тяги к никотину посредством введения нуждающемуся в этом человеку перорально дозированной формы, содержащей, по меньшей мере, один никотиновый активный агент, по меньшей мере, один биоадгезивный компонент и, по меньшей мере, один быстро высвобождающийся сенсорный импульсный агент, где сенсорный импульсный агент присутствует в количестве, эффективном для быстрого облегчения тяги у указанного человека.
6. Способ по п.5, в котором сенсорный импульсный агент выбран из группы, состоящей из капсиацина, горчицы, хрена, имбиря, васаби, дыма и черного перца; мягких раздражителей, например освобожденного от никотина дыма, лимонной кислоты, аскорбиновой кислоты и их смесей.
7. Растворяющаяся в полости рта пленка, содержащая
a) косметический или фармацевтический активный агент и
b) привитой сополимер поливиниловый спирт-полиэтиленгликоль общей формулы:
8. Растворяющаяся в полости рта композиция пленки по п.7, в которой косметический или терапевтический активный агент представляет собой никотиновый активный агент.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US48985503P | 2003-07-24 | 2003-07-24 | |
| US60/489,855 | 2003-07-24 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2006105630/15A Division RU2351315C2 (ru) | 2003-07-24 | 2004-07-22 | Пленки, растворяющиеся в полости рта |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2008101513A true RU2008101513A (ru) | 2009-07-20 |
Family
ID=34102944
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2006105630/15A RU2351315C2 (ru) | 2003-07-24 | 2004-07-22 | Пленки, растворяющиеся в полости рта |
| RU2008101513/15A RU2008101513A (ru) | 2003-07-24 | 2008-01-14 | Пленки, растворяющиеся в полости рта |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2006105630/15A RU2351315C2 (ru) | 2003-07-24 | 2004-07-22 | Пленки, растворяющиеся в полости рта |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US9675548B2 (ru) |
| EP (2) | EP1648421B1 (ru) |
| JP (4) | JP2006528636A (ru) |
| CN (1) | CN100508976C (ru) |
| AR (1) | AR045076A1 (ru) |
| AU (2) | AU2004259006B2 (ru) |
| BR (1) | BRPI0412752B8 (ru) |
| CA (1) | CA2533577C (ru) |
| CL (2) | CL2008002406A1 (ru) |
| DK (2) | DK1648421T3 (ru) |
| ES (2) | ES2466943T3 (ru) |
| HR (1) | HRP20171944T1 (ru) |
| HU (1) | HUE037508T2 (ru) |
| LT (1) | LT1648421T (ru) |
| MX (1) | MXPA06000852A (ru) |
| PE (1) | PE20050496A1 (ru) |
| PL (2) | PL1648421T3 (ru) |
| PT (2) | PT1648421T (ru) |
| RU (2) | RU2351315C2 (ru) |
| SI (1) | SI1648421T1 (ru) |
| TW (1) | TW200514579A (ru) |
| UY (1) | UY28431A1 (ru) |
| WO (1) | WO2005009386A2 (ru) |
Families Citing this family (114)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005046363A2 (en) | 2003-11-07 | 2005-05-26 | U.S. Smokeless Tobacco Company | Tobacco compositions |
| US8627828B2 (en) | 2003-11-07 | 2014-01-14 | U.S. Smokeless Tobacco Company Llc | Tobacco compositions |
| DE102005033943A1 (de) * | 2005-07-20 | 2007-02-22 | Hexal Ag | Nicht-ausspuckbarer, oraler, schnell-zerfallender Film für ein Neuroleptikum |
| DE102005058569B4 (de) * | 2005-12-08 | 2010-07-15 | Lts Lohmann Therapie-Systeme Ag | Schaumwafer mit Polyvinylalkohol-Polyethylenglycol-Pfropfcopolymer |
| US7810507B2 (en) | 2006-02-10 | 2010-10-12 | R. J. Reynolds Tobacco Company | Smokeless tobacco composition |
| EP1993509A2 (en) * | 2006-02-17 | 2008-11-26 | Novartis AG | Disintegrable oral films |
| WO2008005509A2 (en) * | 2006-07-06 | 2008-01-10 | Massachusetts Institute Of Technology | Methods and compositions for altering biological surfaces |
| WO2008080773A1 (de) * | 2006-12-29 | 2008-07-10 | Basf Se | Verfahren zur herstellung von festen dosierungsformen enthaltend pfropfcopolymere |
| FR2912915B1 (fr) * | 2007-02-28 | 2012-11-16 | Pf Medicament | Film a desintegration rapide pour l'administration buccale de substances actives. |
| WO2008112124A2 (en) * | 2007-03-07 | 2008-09-18 | Novartis Ag | Orally administrable films |
| PT2152250T (pt) * | 2007-05-07 | 2019-12-12 | Evonik Operations Gmbh | Formas farmacêuticas sólidas que compreendem um revestimento entérico com libertação acelerada do fármaco |
| DK2377413T3 (en) | 2007-07-23 | 2017-05-01 | Reynolds Tobacco Co R | Smokeless tobacco compositions and methods of treating tobacco for use therein |
| WO2009043588A2 (en) * | 2007-10-02 | 2009-04-09 | LABTEC Gesellschaft für technologische Forschung und Entwicklung mbH | Ph regulating antibacterial films for the oral or vaginal cavity |
| US9125434B2 (en) | 2007-10-11 | 2015-09-08 | Philip Morris Products S.A. | Smokeless tobacco product, smokeless tobacco product in the form of a sheet, extrudable tobacco composition, method for manufacturing a smokeless tobacco product, method for delivering super bioavailable nicotine contained in tobacco to a user, and packaged smokeless tobacco product sheet |
| EA021392B1 (ru) * | 2007-10-11 | 2015-06-30 | Филип Моррис Продактс С.А. | Бездымный табачный продукт |
| JP2009102287A (ja) * | 2007-10-19 | 2009-05-14 | Seiji Sakao | 禁煙用の辛い唐辛子 |
| US20090253754A1 (en) * | 2007-12-04 | 2009-10-08 | Francesca Selmin | Fast dissolving films and coatings for controlled release of flavors, active pharmaceutical ingredients, food substances, and nicotine |
| AU2008334684A1 (en) * | 2007-12-11 | 2009-06-18 | Novartis Ag | Multi-zone films |
| WO2009080021A1 (en) | 2007-12-20 | 2009-07-02 | Fertin Pharma A/S | Compressed chewing gum tablet |
| DK2229158T3 (en) * | 2007-12-20 | 2016-12-12 | Fertin Pharma As | Compressed chewing gum tablet |
| CN102014882A (zh) * | 2008-01-31 | 2011-04-13 | 麦克内尔-Ppc股份有限公司 | 即刻释放活性成分的可食用膜条片 |
| CA2711974A1 (en) * | 2008-01-31 | 2009-08-13 | Mcneil-Ppc, Inc. | Edible film-strips with modified release active ingredients |
| EP2252261A2 (en) * | 2008-02-13 | 2010-11-24 | Bayer Schering Pharma Aktiengesellschaft | Drug delivery system with stabilising effect |
| US20110054043A1 (en) * | 2008-04-15 | 2011-03-03 | Takeshi Funaki | Film composition |
| SMT201700346T1 (it) * | 2008-11-13 | 2017-09-07 | Nogra Pharma Ltd | Composizioni antisenso e metodi per la loro preparazione e loro uso |
| EP2210595A1 (en) * | 2009-01-14 | 2010-07-28 | LEK Pharmaceuticals d.d. | Active coating of pharmaceutical dosage forms |
| US20100256215A1 (en) * | 2009-04-02 | 2010-10-07 | Silver Eagle Labs Nv, Llc | Menthol-Melatonin Dissolving Film |
| US20100256197A1 (en) * | 2009-04-02 | 2010-10-07 | Silver Eagle Labs Nv, Llc | Nicotine Dissolving Film With Or Without Menthol |
| CN102421423B (zh) * | 2009-05-12 | 2014-11-05 | Bpsi控股有限责任公司 | 增强型防潮即释薄膜包衣系统和覆有该包衣的基体 |
| US9017718B2 (en) * | 2009-05-21 | 2015-04-28 | Bionex Pharmaceuticals Llc | Dual and single layer dosage forms |
| US8944072B2 (en) | 2009-06-02 | 2015-02-03 | R.J. Reynolds Tobacco Company | Thermal treatment process for tobacco materials |
| US8434496B2 (en) | 2009-06-02 | 2013-05-07 | R. J. Reynolds Tobacco Company | Thermal treatment process for tobacco materials |
| HUE028121T2 (en) * | 2009-06-12 | 2016-11-28 | Cynapsus Therapeutics Inc | Sublingual apomorphine |
| WO2010146601A1 (en) * | 2009-06-15 | 2010-12-23 | Unijules Life Sciences Ltd | Rapid dissolvable oral film for delivering herbal extract/s with or without other pharmaceutically active agents |
| CA2771403C (en) | 2009-08-19 | 2015-02-24 | Eisai R&D Management Co. Ltd. | Quinoline derivative-containing pharmaceutical composition |
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| US20080292683A1 (en) * | 2007-05-24 | 2008-11-27 | Monosolrx, Llc. | Film shreds and delivery system incorporating same |
| KR101405930B1 (ko) * | 2007-07-05 | 2014-06-12 | 엘지전자 주식회사 | 식기 세척기의 제어방법 |
| US20090081294A1 (en) * | 2007-09-26 | 2009-03-26 | Gin Jerry B | Sustained release dosage form for lubricating an oral cavity |
| KR100905027B1 (ko) * | 2007-10-03 | 2009-06-30 | (주)씨엘팜 | 식용 필름 |
| WO2009045022A2 (en) | 2007-10-03 | 2009-04-09 | C.L. Pharm | Edible film |
| US20090253754A1 (en) | 2007-12-04 | 2009-10-08 | Francesca Selmin | Fast dissolving films and coatings for controlled release of flavors, active pharmaceutical ingredients, food substances, and nicotine |
| AU2008334684A1 (en) | 2007-12-11 | 2009-06-18 | Novartis Ag | Multi-zone films |
| CA2737307A1 (en) | 2008-10-14 | 2010-04-22 | Mcneil Ab | Multi portion intra-oral dosage form and use thereof |
| US20100247586A1 (en) * | 2009-03-27 | 2010-09-30 | Andreas Hugerth | Multi-Portion Intra-Oral Dosage Form With Organoleptic Properties |
| KR101074271B1 (ko) * | 2009-06-25 | 2011-10-17 | (주)차바이오앤디오스텍 | 불쾌한 맛을 효과적으로 은폐한 경구용 속용 필름 |
| PT2519225E (pt) * | 2009-12-30 | 2015-07-27 | Novartis Ag | Tiras finas de nicotina extrudidas por fusão |
| CA2795304A1 (en) * | 2010-04-27 | 2011-11-03 | Novartis Ag | Oral dosage forms |
| BR112013006632A2 (pt) | 2010-09-24 | 2017-07-18 | Nexmed Holdings Inc | composições e sistema de liberação de distribuição de droga aprimorados |
-
2004
- 2004-07-22 HU HUE04778981A patent/HUE037508T2/hu unknown
- 2004-07-22 EP EP04778981.3A patent/EP1648421B1/en not_active Expired - Lifetime
- 2004-07-22 US US10/565,706 patent/US9675548B2/en active Active
- 2004-07-22 AU AU2004259006A patent/AU2004259006B2/en not_active Expired
- 2004-07-22 PE PE2004000696A patent/PE20050496A1/es active IP Right Grant
- 2004-07-22 TW TW093121830A patent/TW200514579A/zh unknown
- 2004-07-22 BR BRPI0412752A patent/BRPI0412752B8/pt not_active IP Right Cessation
- 2004-07-22 ES ES12152301.3T patent/ES2466943T3/es not_active Expired - Lifetime
- 2004-07-22 UY UY28431A patent/UY28431A1/es unknown
- 2004-07-22 HR HRP20171944TT patent/HRP20171944T1/hr unknown
- 2004-07-22 JP JP2006521266A patent/JP2006528636A/ja active Pending
- 2004-07-22 ES ES04778981.3T patent/ES2654062T3/es not_active Expired - Lifetime
- 2004-07-22 MX MXPA06000852A patent/MXPA06000852A/es unknown
- 2004-07-22 RU RU2006105630/15A patent/RU2351315C2/ru active
- 2004-07-22 CA CA2533577A patent/CA2533577C/en not_active Expired - Lifetime
- 2004-07-22 DK DK04778981.3T patent/DK1648421T3/en active
- 2004-07-22 EP EP12152301.3A patent/EP2446881B1/en not_active Expired - Lifetime
- 2004-07-22 CN CNB2004800213483A patent/CN100508976C/zh not_active Expired - Lifetime
- 2004-07-22 PT PT47789813T patent/PT1648421T/pt unknown
- 2004-07-22 WO PCT/US2004/023719 patent/WO2005009386A2/en not_active Ceased
- 2004-07-22 DK DK12152301.3T patent/DK2446881T3/da active
- 2004-07-22 SI SI200432422T patent/SI1648421T1/en unknown
- 2004-07-22 PL PL04778981T patent/PL1648421T3/pl unknown
- 2004-07-22 PT PT121523013T patent/PT2446881E/pt unknown
- 2004-07-22 AR ARP040102603A patent/AR045076A1/es unknown
- 2004-07-22 PL PL12152301T patent/PL2446881T3/pl unknown
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2008
- 2008-01-14 RU RU2008101513/15A patent/RU2008101513A/ru not_active Application Discontinuation
- 2008-08-14 CL CL2008002406A patent/CL2008002406A1/es unknown
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2010
- 2010-02-25 JP JP2010040716A patent/JP5378270B2/ja not_active Expired - Lifetime
- 2010-09-28 AU AU2010224456A patent/AU2010224456B9/en not_active Expired
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| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
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