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RU2008143545A - Применение антагониста рецептора ат-1 или модулятора рецептора ат-2 для лечения болезней, связанных с увеличением содержания рецепторов ат-1 или ат-2 - Google Patents

Применение антагониста рецептора ат-1 или модулятора рецептора ат-2 для лечения болезней, связанных с увеличением содержания рецепторов ат-1 или ат-2 Download PDF

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Publication number
RU2008143545A
RU2008143545A RU2008143545/15A RU2008143545A RU2008143545A RU 2008143545 A RU2008143545 A RU 2008143545A RU 2008143545/15 A RU2008143545/15 A RU 2008143545/15A RU 2008143545 A RU2008143545 A RU 2008143545A RU 2008143545 A RU2008143545 A RU 2008143545A
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RU
Russia
Prior art keywords
compressed tablet
tablet according
microcrystalline cellulose
receptors
increasing
Prior art date
Application number
RU2008143545/15A
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English (en)
Inventor
Джиллиан Роузмари БАЛЛОК (GB)
Джиллиан Роузмари БАЛЛОК
Марк ДЕ-ГАСПАРО (CH)
Марк ДЕ-ГАСПАРО
Забине Мария ГАНТЕР (DE)
Забине Мария ГАНТЕР
Original Assignee
Новартис АГ (CH)
Новартис Аг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26152118&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=RU2008143545(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from EP98811258A external-priority patent/EP1013273A1/en
Application filed by Новартис АГ (CH), Новартис Аг filed Critical Новартис АГ (CH)
Publication of RU2008143545A publication Critical patent/RU2008143545A/ru

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/455Nicotinic acids, e.g. niacin; Derivatives thereof, e.g. esters, amides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4151,2-Diazoles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44Non condensed pyridines; Hydrogenated derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/2027Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/2004Excipients; Inactive ingredients
    • A61K9/2022Organic macromolecular compounds
    • A61K9/205Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/08Bronchodilators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/16Central respiratory analeptics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/02Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/04Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • A61K9/28Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806Coating materials
    • A61K9/2833Organic macromolecular compounds
    • A61K9/286Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Dermatology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

1. Спрессованная таблетка, включающая валсартан в качестве действующего вещества и от 31 до 65% микрокристаллической целлюлозы в пересчете на общую массу компонентов ядра этой спрессованной таблетки. ! 2. Спрессованная таблетка по п.1, включающая от 50 до 65% микрокристаллической целлюлозы в пересчете на общую массу. ! 3. Спрессованная таблетка по п.1, включающая 50% микрокристаллической целлюлозы в пересчете на общую массу. ! 4. Спрессованная таблетка по любому из пп.1-3, включающая менее 13 мас.% кросповидона. ! 5. Спрессованная таблетка по любому из пп.1-3, в которой массовое отношение валсартана к микрокристаллической целлюлозе составляет от 2:1 до 1:1. ! 6. Спрессованная таблетка по любому из пп.1-3, которая включает более чем 250 и вплоть до 360 мг валсартана в качестве действующего вещества.

Claims (6)

1. Спрессованная таблетка, включающая валсартан в качестве действующего вещества и от 31 до 65% микрокристаллической целлюлозы в пересчете на общую массу компонентов ядра этой спрессованной таблетки.
2. Спрессованная таблетка по п.1, включающая от 50 до 65% микрокристаллической целлюлозы в пересчете на общую массу.
3. Спрессованная таблетка по п.1, включающая 50% микрокристаллической целлюлозы в пересчете на общую массу.
4. Спрессованная таблетка по любому из пп.1-3, включающая менее 13 мас.% кросповидона.
5. Спрессованная таблетка по любому из пп.1-3, в которой массовое отношение валсартана к микрокристаллической целлюлозе составляет от 2:1 до 1:1.
6. Спрессованная таблетка по любому из пп.1-3, которая включает более чем 250 и вплоть до 360 мг валсартана в качестве действующего вещества.
RU2008143545/15A 1998-12-23 2008-11-05 Применение антагониста рецептора ат-1 или модулятора рецептора ат-2 для лечения болезней, связанных с увеличением содержания рецепторов ат-1 или ат-2 RU2008143545A (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP98811258A EP1013273A1 (en) 1998-12-23 1998-12-23 Use of AT-1 receptor antagonist or AT-2 receptor modulator for treating diseases associated with an increase of AT-1 or AT-2 receptors
EP98811257 1998-12-23
EP98811257.9 1998-12-23
EP98811258.7 1998-12-23

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
RU2005124363/15A Division RU2361575C2 (ru) 1998-12-23 2005-08-01 Твердые пероральные дозируемые формы валсартана

Related Child Applications (1)

Application Number Title Priority Date Filing Date
RU2012157622/15A Division RU2012157622A (ru) 2012-12-27 2012-12-27 Применение антагониста рецептора ат-1 или модулятора рецептора ат-2 для лечения болезней, связанных с увеличением содержания рецепторов ат-1 или ат-2

Publications (1)

Publication Number Publication Date
RU2008143545A true RU2008143545A (ru) 2010-05-10

Family

ID=26152118

Family Applications (3)

Application Number Title Priority Date Filing Date
RU2001119990/15A RU2271809C2 (ru) 1998-12-23 1999-12-22 Применение антагониста рецептора at-1 или модулятора рецептора ат-2 для лечения болезней, связанных с увеличением содержания рецепторов ат-1 или ат-2
RU2005124363/15A RU2361575C2 (ru) 1998-12-23 2005-08-01 Твердые пероральные дозируемые формы валсартана
RU2008143545/15A RU2008143545A (ru) 1998-12-23 2008-11-05 Применение антагониста рецептора ат-1 или модулятора рецептора ат-2 для лечения болезней, связанных с увеличением содержания рецепторов ат-1 или ат-2

Family Applications Before (2)

Application Number Title Priority Date Filing Date
RU2001119990/15A RU2271809C2 (ru) 1998-12-23 1999-12-22 Применение антагониста рецептора at-1 или модулятора рецептора ат-2 для лечения болезней, связанных с увеличением содержания рецепторов ат-1 или ат-2
RU2005124363/15A RU2361575C2 (ru) 1998-12-23 2005-08-01 Твердые пероральные дозируемые формы валсартана

Country Status (26)

Country Link
EP (3) EP2298298A3 (ru)
JP (2) JP2002533390A (ru)
KR (1) KR100646716B1 (ru)
CN (2) CN1304000C (ru)
AT (2) ATE354364T1 (ru)
AU (4) AU3043000A (ru)
BR (1) BR9916576A (ru)
CA (2) CA2622805C (ru)
CY (2) CY1106581T1 (ru)
CZ (2) CZ293257B6 (ru)
DE (1) DE69935249T2 (ru)
DK (2) DK1588706T3 (ru)
ES (2) ES2373556T3 (ru)
HK (1) HK1038888B (ru)
HU (1) HUP0104780A3 (ru)
ID (1) ID29856A (ru)
IL (5) IL143233A0 (ru)
NO (2) NO328775B1 (ru)
NZ (3) NZ511938A (ru)
PL (1) PL199100B1 (ru)
PT (2) PT1140071E (ru)
RU (3) RU2271809C2 (ru)
SI (2) SI1588706T1 (ru)
SK (1) SK9132001A3 (ru)
TR (7) TR200805740T1 (ru)
WO (1) WO2000038676A1 (ru)

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