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RU2007148908A - COMPOSITIONS FOR REDUCING THE RISK OF ARCTHYME CAUSED BY MEDICINES - Google Patents

COMPOSITIONS FOR REDUCING THE RISK OF ARCTHYME CAUSED BY MEDICINES Download PDF

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Publication number
RU2007148908A
RU2007148908A RU2007148908/15A RU2007148908A RU2007148908A RU 2007148908 A RU2007148908 A RU 2007148908A RU 2007148908/15 A RU2007148908/15 A RU 2007148908/15A RU 2007148908 A RU2007148908 A RU 2007148908A RU 2007148908 A RU2007148908 A RU 2007148908A
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Russia
Prior art keywords
drug
statin
aspirin
kit
azimilide
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RU2007148908/15A
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Russian (ru)
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RU2376994C2 (en
Inventor
Джозеф Майкл II СПРАФКА (US)
Джозеф Майкл II СПРАФКА
Хосе Мауро ГУЛАРТ-БРУМ (US)
Хосе Мауро ГУЛАРТ-БРУМ
Original Assignee
Дзе Проктер Энд Гэмбл Компани (US)
Дзе Проктер Энд Гэмбл Компани
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Publication of RU2007148908A publication Critical patent/RU2007148908A/en
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A61K31/22—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acyclic acids, e.g. pravastatin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/401—Proline; Derivatives thereof, e.g. captopril
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/60—Salicylic acid; Derivatives thereof
    • A61K31/612—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid
    • A61K31/616—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid by carboxylic acids, e.g. acetylsalicylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A61K31/724—Cyclodextrins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Emergency Medicine (AREA)
  • Biomedical Technology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Toxicology (AREA)
  • Cardiology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

1. Способ снижения риска возникновения вызванного лекарственными средствами трепетания-мерцания, содержащий введение пациенту, нуждающемуся в таком лечении, комбинации, содержащей по меньшей мере одно лекарство и по меньшей мере один аспирин или статин. ! 2. Способ по п.1, в котором упомянутый по меньшей мере один статин содержит симвастатин, флувастатин, правастатин, церивастатин, ловастатин или аторвастатин. ! 3. Способ по п.2, в котором упомянутое активное вещество представляет собой противоаритмическое средство класса III. ! 4. Способ по п.3, в котором противоаритмическое средство класса III выбрано из группы, состоящей из соталола, амиодарона, дофетилида, азимилида, цибензолина и бунафитидина. ! 5. Способ по п.4, в котором противоаритмическое средство представляет собой азимилид. ! 6. Способ по п.5, в котором азимилид вводят ежедневно в количествах от примерно 50 до примерно 300 мг. ! 7. Способ по п.6, в котором вводят как аспирин, так и статин. ! 8. Набор для снижения риска возникновения вызванного лекарственными средствами трепетания-мерцания, содержащий единичные дозы лекарства и единичные дозы аспирина или статина. ! 9. Набор по п.8, в котором лекарство является противоаритмическим средством класса III. ! 10. Набор по п.9, в котором лекарством является азимилид. ! 11. Набор по п.8, содержащий далее средство для содействия памяти. ! 12. Набор по п.9, в котором содержатся как аспирин, так и статин. ! 13. Фармацевтический состав, содержащий комбинацию из лекарства, вызывающего трепетания-мерцания, и аспирина или статина.1. A method of reducing the risk of drug-induced flutter-flicker, comprising administering to a patient in need of such treatment a combination comprising at least one drug and at least one aspirin or statin. ! 2. The method according to claim 1, wherein said at least one statin comprises simvastatin, fluvastatin, pravastatin, cerivastatin, lovastatin or atorvastatin. ! 3. The method according to claim 2, in which said active substance is an antiarrhythmic agent of class III. ! 4. The method according to claim 3, in which the class III antiarrhythmic agent is selected from the group consisting of sotalol, amiodarone, dofetilide, azimilide, cybenzoline and bunafitidine. ! 5. The method according to claim 4, in which the antiarrhythmic agent is azimilide. ! 6. The method according to claim 5, in which azimilide is administered daily in amounts of from about 50 to about 300 mg. ! 7. The method according to claim 6, in which both aspirin and statin are administered. ! 8. A kit to reduce the risk of drug-induced flutter-flicker, containing unit doses of the drug and unit doses of aspirin or statin. ! 9. The kit of claim 8, in which the drug is a class III antiarrhythmic drug. ! 10. The kit according to claim 9, in which the drug is azimilide. ! 11. The kit of claim 8, further containing a means to promote memory. ! 12. The kit according to claim 9, which contains both aspirin and statin. ! 13. A pharmaceutical composition comprising a combination of a flutter-flickering drug and aspirin or statin.

Claims (13)

1. Способ снижения риска возникновения вызванного лекарственными средствами трепетания-мерцания, содержащий введение пациенту, нуждающемуся в таком лечении, комбинации, содержащей по меньшей мере одно лекарство и по меньшей мере один аспирин или статин.1. A method of reducing the risk of drug-induced flutter-flicker, comprising administering to a patient in need of such treatment a combination comprising at least one drug and at least one aspirin or statin. 2. Способ по п.1, в котором упомянутый по меньшей мере один статин содержит симвастатин, флувастатин, правастатин, церивастатин, ловастатин или аторвастатин.2. The method according to claim 1, wherein said at least one statin comprises simvastatin, fluvastatin, pravastatin, cerivastatin, lovastatin or atorvastatin. 3. Способ по п.2, в котором упомянутое активное вещество представляет собой противоаритмическое средство класса III.3. The method according to claim 2, in which said active substance is an antiarrhythmic agent of class III. 4. Способ по п.3, в котором противоаритмическое средство класса III выбрано из группы, состоящей из соталола, амиодарона, дофетилида, азимилида, цибензолина и бунафитидина.4. The method according to claim 3, in which the class III antiarrhythmic agent is selected from the group consisting of sotalol, amiodarone, dofetilide, azimilide, cybenzoline and bunafitidine. 5. Способ по п.4, в котором противоаритмическое средство представляет собой азимилид.5. The method according to claim 4, in which the antiarrhythmic agent is azimilide. 6. Способ по п.5, в котором азимилид вводят ежедневно в количествах от примерно 50 до примерно 300 мг.6. The method according to claim 5, in which azimilide is administered daily in amounts of from about 50 to about 300 mg. 7. Способ по п.6, в котором вводят как аспирин, так и статин.7. The method according to claim 6, in which both aspirin and statin are administered. 8. Набор для снижения риска возникновения вызванного лекарственными средствами трепетания-мерцания, содержащий единичные дозы лекарства и единичные дозы аспирина или статина.8. A kit to reduce the risk of drug-induced flutter-flicker, containing unit doses of the drug and unit doses of aspirin or statin. 9. Набор по п.8, в котором лекарство является противоаритмическим средством класса III.9. The kit of claim 8, in which the drug is a class III antiarrhythmic drug. 10. Набор по п.9, в котором лекарством является азимилид.10. The kit according to claim 9, in which the drug is azimilide. 11. Набор по п.8, содержащий далее средство для содействия памяти.11. The kit of claim 8, further containing a means to promote memory. 12. Набор по п.9, в котором содержатся как аспирин, так и статин.12. The kit according to claim 9, which contains both aspirin and statin. 13. Фармацевтический состав, содержащий комбинацию из лекарства, вызывающего трепетания-мерцания, и аспирина или статина. 13. A pharmaceutical composition comprising a combination of a flutter-flickering drug and aspirin or statin.
RU2007148908/15A 2005-07-22 2006-07-20 Compounds for reducing risk of drug-caused arrhythmia RU2376994C2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US70155505P 2005-07-22 2005-07-22
US60/701,555 2005-07-22

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RU2007148908A true RU2007148908A (en) 2009-08-27
RU2376994C2 RU2376994C2 (en) 2009-12-27

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US (2) US8183284B2 (en)
EP (1) EP1906966A2 (en)
JP (1) JP4880685B2 (en)
KR (1) KR20080017489A (en)
CN (1) CN101227908A (en)
AR (1) AR055091A1 (en)
AU (1) AU2006271230A1 (en)
BR (1) BRPI0613670A2 (en)
CA (1) CA2615975C (en)
IL (1) IL188831A0 (en)
MA (1) MA29622B1 (en)
MX (1) MX2008001063A (en)
NO (1) NO20080890L (en)
PE (1) PE20070369A1 (en)
RU (1) RU2376994C2 (en)
SM (1) SMAP200800012A (en)
TW (1) TW200744613A (en)
WO (1) WO2007010498A2 (en)
ZA (1) ZA200800564B (en)

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CA2615975A1 (en) 2007-01-25
MX2008001063A (en) 2008-03-19
US20120178724A1 (en) 2012-07-12
US8183284B2 (en) 2012-05-22
CA2615975C (en) 2012-11-27
SMP200800012B (en) 2008-02-27
SMAP200800012A (en) 2008-02-27
ZA200800564B (en) 2008-12-31
CN101227908A (en) 2008-07-23
RU2376994C2 (en) 2009-12-27
AR055091A1 (en) 2007-08-08
IL188831A0 (en) 2008-08-07
MA29622B1 (en) 2008-07-01
KR20080017489A (en) 2008-02-26
JP2009502773A (en) 2009-01-29
NO20080890L (en) 2008-03-03
PE20070369A1 (en) 2007-05-16
TW200744613A (en) 2007-12-16
BRPI0613670A2 (en) 2011-01-25
WO2007010498A2 (en) 2007-01-25
EP1906966A2 (en) 2008-04-09
WO2007010498A3 (en) 2007-05-31
JP4880685B2 (en) 2012-02-22
US20070021395A1 (en) 2007-01-25
AU2006271230A1 (en) 2007-01-25

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