RU2007144740A - PHOTOSENSIBILIZER AND METHODS OF ITS PRODUCTION - Google Patents
PHOTOSENSIBILIZER AND METHODS OF ITS PRODUCTION Download PDFInfo
- Publication number
- RU2007144740A RU2007144740A RU2007144740/04A RU2007144740A RU2007144740A RU 2007144740 A RU2007144740 A RU 2007144740A RU 2007144740/04 A RU2007144740/04 A RU 2007144740/04A RU 2007144740 A RU2007144740 A RU 2007144740A RU 2007144740 A RU2007144740 A RU 2007144740A
- Authority
- RU
- Russia
- Prior art keywords
- monoamide
- chlorin
- derivatives
- interaction
- ester
- Prior art date
Links
- OYINILBBZAQBEV-UWJYYQICSA-N (17s,18s)-18-(2-carboxyethyl)-20-(carboxymethyl)-12-ethenyl-7-ethyl-3,8,13,17-tetramethyl-17,18,22,23-tetrahydroporphyrin-2-carboxylic acid Chemical compound N1C2=C(C)C(C=C)=C1C=C(N1)C(C)=C(CC)C1=CC(C(C)=C1C(O)=O)=NC1=C(CC(O)=O)C([C@@H](CCC(O)=O)[C@@H]1C)=NC1=C2 OYINILBBZAQBEV-UWJYYQICSA-N 0.000 claims abstract 9
- 150000002148 esters Chemical class 0.000 claims abstract 6
- 230000003993 interaction Effects 0.000 claims abstract 6
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims abstract 4
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims abstract 4
- PIICEJLVQHRZGT-UHFFFAOYSA-N Ethylenediamine Chemical compound NCCN PIICEJLVQHRZGT-UHFFFAOYSA-N 0.000 claims abstract 4
- 150000007524 organic acids Chemical class 0.000 claims abstract 4
- 150000003839 salts Chemical group 0.000 claims abstract 4
- 235000016425 Arthrospira platensis Nutrition 0.000 claims abstract 2
- 240000002900 Arthrospira platensis Species 0.000 claims abstract 2
- 125000000217 alkyl group Chemical group 0.000 claims abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 claims abstract 2
- 235000005985 organic acids Nutrition 0.000 claims abstract 2
- 239000003504 photosensitizing agent Substances 0.000 claims abstract 2
- 239000002994 raw material Substances 0.000 claims abstract 2
- 229940082787 spirulina Drugs 0.000 claims abstract 2
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 claims 2
Landscapes
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
1. Производные моноамида хлорина е6 общей формулы (I), ! ! где R1 означает линейный или разветвленный алкил, имеющий от 1 до 4 атомов углерода, ! R2 означает соль фармацевтически приемлемых органических кислот. ! 2. Фотосенсибилизатор, содержащий производные моноамида хлорина е6, отличающийся тем, что данные производные образованы по п.1. ! 3. Способ получения производных по п.1, характеризующийся тем, что обеспечивают взаимодействие спирта, содержащего R1, и хлорина е6 для образования эфира феофорбида хлорина е6, содержащего R1 ! обеспечивают взаимодействие образованного эфира с этилендиамином для образования моноамида вышеуказанного эфира, ! обеспечивают взаимодействие образованного моноамида с фармацевтически приемлемой органической кислотой для образования соли вышеуказанного моноамида. ! 4. Способ по п.3, отличающийся тем, что в качестве сырья, содержащего хлорин е6, применяют спирулину. ! 5. Способ по любому из пп.3 и 4, отличающийся тем, что обеспечивают взаимодействие образованного эфира с этилендиамином в среде, содержащей спирт.1. Derivatives of monoamide chlorin e6 of the general formula (I),! ! where R1 means a linear or branched alkyl having from 1 to 4 carbon atoms,! R2 is a salt of pharmaceutically acceptable organic acids. ! 2. A photosensitizer containing derivatives of chlorin e6 monoamide, characterized in that these derivatives are formed according to claim 1. ! 3. The method of producing derivatives according to claim 1, characterized in that they provide the interaction of alcohol containing R1, and chlorin e6 to form the ester of pheophorbide chlorin e6 containing R1! provide the interaction of the formed ester with ethylenediamine to form the monoamide of the above ester,! interacting the formed monoamide with a pharmaceutically acceptable organic acid to form a salt of the above monoamide. ! 4. The method according to claim 3, characterized in that spirulina is used as the raw material containing chlorin e6. ! 5. The method according to any one of claims 3 and 4, characterized in that they provide the interaction of the formed ether with ethylenediamine in a medium containing alcohol.
Claims (5)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU2007144740/04A RU2416614C2 (en) | 2007-12-05 | 2007-12-05 | Photosensitiser and preparation method thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RU2007144740/04A RU2416614C2 (en) | 2007-12-05 | 2007-12-05 | Photosensitiser and preparation method thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2007144740A true RU2007144740A (en) | 2009-06-10 |
| RU2416614C2 RU2416614C2 (en) | 2011-04-20 |
Family
ID=41024237
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2007144740/04A RU2416614C2 (en) | 2007-12-05 | 2007-12-05 | Photosensitiser and preparation method thereof |
Country Status (1)
| Country | Link |
|---|---|
| RU (1) | RU2416614C2 (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2467777C1 (en) * | 2011-07-26 | 2012-11-27 | Федеральное государственное учреждение "Межотраслевой научно-технический комплекс "Микрохирургия глаза" имени академика С.Н. Федорова Федерального агентства по высокотехнологичной медицинской помощи" | Method of photodynamic therapy of intraocular neoplasms |
| CN103031354A (en) * | 2012-12-29 | 2013-04-10 | 西安岳达植物科技有限公司 | A method for extracting pheophorbide A from spirulina |
Families Citing this family (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2548675C9 (en) * | 2013-05-29 | 2015-11-10 | Федеральное государственное бюджетное образовательное учреждение высшего профессионального образования "Московский государственный университет тонких химических технологий имени М.В. Ломоносова" (МИТХТ им. М.В. Ломоносова) | Amino amides in bacteriochlorophyll a series, having photodynamic activity and method for production thereof |
| RU2536966C1 (en) * | 2013-12-25 | 2014-12-27 | Федеральное государственное унитарное предприятие "Государственный научный центр "Научно-исследовательский институт органических полупродуктов и красителей" (ФГУП "ГНЦ "НИОПИК") | Photosensitisers for photodynamic therapy |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5002962A (en) * | 1988-07-20 | 1991-03-26 | Health Research, Inc. | Photosensitizing agents |
| US5330741A (en) * | 1992-02-24 | 1994-07-19 | The Regents Of The University Of California | Long-wavelength water soluble chlorin photosensitizers useful for photodynamic therapy and diagnosis of tumors |
| RU2144538C1 (en) * | 1998-01-22 | 2000-01-20 | Закрытое акционерное общество "Вета" | Method of preparing water-soluble chlorines |
-
2007
- 2007-12-05 RU RU2007144740/04A patent/RU2416614C2/en not_active IP Right Cessation
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2467777C1 (en) * | 2011-07-26 | 2012-11-27 | Федеральное государственное учреждение "Межотраслевой научно-технический комплекс "Микрохирургия глаза" имени академика С.Н. Федорова Федерального агентства по высокотехнологичной медицинской помощи" | Method of photodynamic therapy of intraocular neoplasms |
| CN103031354A (en) * | 2012-12-29 | 2013-04-10 | 西安岳达植物科技有限公司 | A method for extracting pheophorbide A from spirulina |
| CN103031354B (en) * | 2012-12-29 | 2014-05-14 | 西安岳达植物科技有限公司 | Method for extracting pheophorbide A from spirulina |
Also Published As
| Publication number | Publication date |
|---|---|
| RU2416614C2 (en) | 2011-04-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2391346C2 (en) | 39-desmethoxy derivatives of rapamycin | |
| MX2013002558A (en) | Hetero ring-fused imidazole derivative having ampk activating effect. | |
| RU2009105669A (en) | METHOD FOR PRODUCING 3-SUBSTITUTED 2-AMINO-5-HALOGENBENZAMIDES | |
| EA201171387A1 (en) | DERIVATIVES 7-AZASPIRO [3,5] NONAN-7-CARBOXYLATES, THEIR RECEIVING AND THEIR APPLICATION IN THERAPY | |
| EA201070872A1 (en) | DERIVATIVES OF ABABLE CARBOXAMIDES, THEIR RECEIVING AND THEIR APPLICATION IN THERAPY | |
| IL175024A0 (en) | Method for producing 2-dihaloacyl-3-amino-acrylic acid esters and 3-dihalomethyl-pyrazole-4-carboxylic acid esters | |
| JO2643B1 (en) | 2Aryl-6- Phenylimidazo [1,2-a] Pyridine Derivatives, Preparation Thereof And Therapeutic Use Thereof | |
| CY1116885T1 (en) | Substituted cyclohexylmethyl derivatives | |
| MA29464B1 (en) | PROCESS FOR THE PREPARATION OF OPTIONALLY 2-SUBSTITUTED 1,6-DIHYDRO-6-OXO-4-PYRIMIDINECARBOXYLIC ACIDS | |
| UA98966C2 (en) | BENZAZEPIN DERIVATIVES SUITABLE FOR USE AS VASOPRESIN ANTAGONISTS | |
| ES2613753T3 (en) | Process for the preparation of sterol derivatives | |
| PH12012502363A1 (en) | Process for the preparation of dihydropyrrole derivatives | |
| RU2011139325A (en) | AMVOROUS SALT MACROCYCLIC INHIBITOR HCV | |
| RU2011108663A (en) | METHODS FOR PRODUCING METHYL ETHER 4-OXO-OCTAGHYDROINDOL-1-CARBOXYLIC ACID AND ITS DERIVATIVES | |
| RU2012116208A (en) | METHOD FOR PRODUCING N-Acylbiphenylalanine | |
| EP2665705A4 (en) | IMPROVED METHOD FOR THE PRODUCTION OF MOLYBDEN-SUCCINIMIDE COMPLEXES OF HIGH MOLECULAR WEIGHT | |
| AR078916A1 (en) | PROCEDURE FOR PURIFICATION OF PALIPERIDONA | |
| EA201001087A1 (en) | NEW DIHYDROINDOLONIC COMPOUNDS, METHOD OF THEIR PRODUCTION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | |
| RU2013118021A (en) | METHODS AND COMPOSITIONS FOR TREATMENT OF DIABETES MELLITUS AND DYSLIPIDEMIA | |
| RU2007144740A (en) | PHOTOSENSIBILIZER AND METHODS OF ITS PRODUCTION | |
| EP2581442A4 (en) | PROCESS FOR PRODUCING HEMATOPOIETIC STEM CELLS | |
| EA201001252A1 (en) | Method of producing derivatives of 3,6-dihydro-1,3,5-triazine | |
| RU2012136457A (en) | NEW COMPOSITIONS FOR REDUCING AB 42 SYNTHESIS AND THEIR APPLICATION IN TREATMENT OF ALZHEIMER'S DISEASE (AD) | |
| PE20120112A1 (en) | HETEROCYCLIC COMPOUNDS, TOPOISOMERASE INHIBITORS | |
| ATE537159T1 (en) | METHOD FOR PRODUCING GLYCIDYLE ESTERS |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | The patent is invalid due to non-payment of fees |
Effective date: 20141206 |