RU2006127045A - AMIDOPYRAZOLE DERIVATIVES - Google Patents

Claims (9)

1. The compound represented by General formula (I)

where Ar ₁ and Ar ₂ independently represent a 5- or 6-membered aromatic heterocyclic group optionally substituted with 1-3 substituents, or a phenyl group optionally substituted with 1-3 substituents, provided that if Ar ₁ represents a 5- or 6-membered an aromatic heterocyclic group substituted by 1-3 substituents, Ar ₂ represents a 5- or 6-membered aromatic heterocyclic group, optionally substituted by 1-3 substituents, and if Ar ₁ represents an unsubstituted 5- or 6-membered aromatic heterocyclic group, Ar ₂ represents it has a 5- or 6-membered aromatic heterocyclic group substituted with 1-3 substituents, or a phenyl group substituted with a carbamoyl group containing 1 or 2 substituents, or a lower alkyl group containing 1 or 2 substituents, and if Ar ₁ represents a phenyl group, optionally substituted with 1-3 substituents, Ar ₂ represents a 5- or 6-membered aromatic heterocyclic group substituted with 1-3 substituents; R1 represents a lower acyl group, a lower alkoxycarbonyl group, a lower alkoxy group, a lower alkyl group optionally substituted by 1 or 2 substituents, a carbamoyl group optionally substituted by 1 or 2 substituents, an oxamoyl group optionally substituted by 1 or 2 substituents, an amino group optionally substituted by 1 or 2 substituents, a 4-7 membered alicyclic heterocyclic group optionally substituted with 1 or 2 substituents, a phenyl group optionally substituted with 1-3 substituents, or a 5- or 6-member hydrochloric aromatic heterocyclic group optionally substituted with 1-3 substituents; and R2 represents a hydrogen atom or a lower alkyl group optionally substituted with 1 or 2 substituents; or its salt, or its solvate. 2. The compound, its salt or its solvate according to claim 1, where Ar ₁ represents a 5- or 6-membered aromatic heterocyclic group, substituted by 1-3 substituents, and Ar ₂ represents a 5- or 6-membered aromatic heterocyclic group, optionally substituted by 1 -3 substitutes. 3. The compound, its salt or its solvate according to claim 1, where Ar ₁ represents an unsubstituted 5- or 6-membered aromatic heterocyclic group and Ar ₂ represents an aromatic heterocyclic group substituted with 1-3 substituents. 4. The compound, its salt or its solvate according to claim 1, where Ar ₁ represents an unsubstituted 5- or 6-membered aromatic heterocyclic group and Ar ₂ represents a phenyl group substituted by a carbamoyl group containing 1 or 2 substituents, or a lower alkyl group, containing 1 or 2 substituents. 5. The compound, its salt or its solvate according to claim 1, where Ar ₁ represents a phenyl group optionally substituted by 1-3 substituents, and Ar ₂ represents a 5- or 6-membered aromatic heterocyclic group substituted by 1-3 substituents. 6. A medicament containing the compound, its salt or its solvate according to any one of claims 1 to 5. 7. A prophylactic and / or therapeutic composition for treating ischemic disease, comprising a compound, a salt thereof or a solvate thereof according to any one of claims 1 to 5. 8. The use of the compound, its salt or its solvate according to any one of claims 1 to 5 for the manufacture of a medicament. 9. A method for the prevention and / or treatment of ischemic disease, which comprises administering to the patient an effective amount of a compound, its salt or its solvate according to any one of claims 1 to 5.