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RU2006104891A - METHOD FOR PRODUCING A HEPTAPEPTIDE HAVING A PSYCHOSTIMULATING ACTIVITY, TRIPEPTID FOR ITS PREPARATION AND TETRAPEPTID FOR ITS PREPARATION - Google Patents

METHOD FOR PRODUCING A HEPTAPEPTIDE HAVING A PSYCHOSTIMULATING ACTIVITY, TRIPEPTID FOR ITS PREPARATION AND TETRAPEPTID FOR ITS PREPARATION Download PDF

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Publication number
RU2006104891A
RU2006104891A RU2006104891/04A RU2006104891A RU2006104891A RU 2006104891 A RU2006104891 A RU 2006104891A RU 2006104891/04 A RU2006104891/04 A RU 2006104891/04A RU 2006104891 A RU2006104891 A RU 2006104891A RU 2006104891 A RU2006104891 A RU 2006104891A
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Russia
Prior art keywords
formula
heptapeptide
preparation
producing
synthesis
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RU2006104891/04A
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Russian (ru)
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RU2303603C2 (en
Inventor
Жанна Дмитриевна Беспалова (RU)
Жанна Дмитриевна Беспалова
Александр Сергеевич Молокоедов (RU)
Александр Сергеевич Молокоедов
Михаил Владимирович Овчинников (RU)
Михаил Владимирович Овчинников
Марина Евгеньевна Палькеева (RU)
Марина Евгеньевна Палькеева
Мари Владимировна Сидорова (RU)
Мария Владимировна Сидорова
Original Assignee
Закрытое акционерное общество "Синтез пептидов" (RU)
Закрытое акционерное общество "Синтез пептидов"
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Priority to RU2006104891/04A priority Critical patent/RU2303603C2/en
Publication of RU2006104891A publication Critical patent/RU2006104891A/en
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    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

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  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Claims (6)

1. Способ получения гептапептида формулы1. The method of producing heptapeptide of the formula
Figure 00000001
Figure 00000001
 обладающего психостимулирующей активностью в растворе, отличающийся тем, что синтез осуществляют путем конденсации С-концевого защищенного трипептида формулыpossessing psychostimulating activity in solution, characterized in that the synthesis is carried out by condensation of the C-terminal protected tripeptide of the formula
Figure 00000002
Figure 00000002
 Х - защитная группа с N-концевым защищенным тетрапептидом формулыX is a protective group with an N-terminal protected tetrapeptide of the formula
Figure 00000003
Figure 00000003
 где Y и Y1 - защитные группыwhere Y and Y 1 are protective groups и полученный защищенный гептапептид формулыand the resulting protected heptapeptide of the formula
Figure 00000004
Figure 00000004
 обрабатывают деблокирующими агентами для удаления защитных групп и выделяют конечный продукт с помощью хроматографии.treated with deblocking agents to remove the protective groups and the final product is isolated by chromatography. 2. Способ по п.1, отличающийся тем, что Х представляет собой бензил (Bzl), Y и Y1 третбутилокикарбонил (Boc), а деблокирование защищенного гептапептида проводят последовательно обработкой трифторуксусной кислотой и каталитическим гидрированием в присутствии 5% Pd/C.2. The method according to claim 1, characterized in that X represents benzyl (Bzl), Y and Y 1 tert-butylcarbonyl (Boc), and the release of the protected heptapeptide is carried out sequentially by treatment with trifluoroacetic acid and catalytic hydrogenation in the presence of 5% Pd / C. 3. Трипептид формулы3. The tripeptide of the formula
Figure 00000005
Figure 00000005
 где Х - защитная группа, в качестве промежуточного соединения для синтеза гептапептида формулы
Figure 00000006
.where X is a protective group, as an intermediate for the synthesis of a heptapeptide of the formula
Figure 00000006
. 4. Трипептид по п.3, отличающийся тем, что Х - бензил (Bzl).4. The tripeptide according to claim 3, characterized in that X is benzyl (Bzl). 5. Тетрапептид формулы5. The tetrapeptide of the formula
Figure 00000007
Figure 00000007
 где Y и Y1 - защитные группы, в качестве промежуточного соединения для синтеза гептапептида формулы
Figure 00000008
.where Y and Y 1 are protective groups, as an intermediate for the synthesis of a heptapeptide of the formula
Figure 00000008
. 6. Тетрапептид по п.5, отличающийся тем, что Y и Y1 представляют собой третбутилокикарбонил (Вос).6. The tetrapeptide according to claim 5, characterized in that Y and Y 1 are tert-butylcarbonyl (Boc).
RU2006104891/04A 2006-02-17 2006-02-17 Method and intermediates for heptapeptide production RU2303603C2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
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Application Number Priority Date Filing Date Title
RU2006104891/04A RU2303603C2 (en) 2006-02-17 2006-02-17 Method and intermediates for heptapeptide production

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RU2006104891A true RU2006104891A (en) 2006-06-27
RU2303603C2 RU2303603C2 (en) 2007-07-27

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Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU1124544C (en) * 1983-06-30 1995-01-09 Институт молекулярной генетики РАН Heptapeptide possessing properties of psychostimulator of prolonged action with immunotropic activity
RU2206573C1 (en) * 2001-12-27 2003-06-20 Институт молекулярной генетики РАН Peptide family eliciting neurotropic property

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