RU2006101589A - Композиция для белкового фармацевтического препарата без добавления человеческого альбумина (hsa) - Google Patents
Композиция для белкового фармацевтического препарата без добавления человеческого альбумина (hsa) Download PDFInfo
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- RU2006101589A RU2006101589A RU2006101589/15A RU2006101589A RU2006101589A RU 2006101589 A RU2006101589 A RU 2006101589A RU 2006101589/15 A RU2006101589/15 A RU 2006101589/15A RU 2006101589 A RU2006101589 A RU 2006101589A RU 2006101589 A RU2006101589 A RU 2006101589A
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- asparagine
- glutamine
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- 239000000203 mixture Substances 0.000 title claims abstract 18
- 102000004169 proteins and genes Human genes 0.000 title claims abstract 5
- 108090000623 proteins and genes Proteins 0.000 title claims abstract 5
- 102000008100 Human Serum Albumin Human genes 0.000 title claims 2
- 108091006905 Human Serum Albumin Proteins 0.000 title claims 2
- 229940079593 drug Drugs 0.000 title 1
- 150000001413 amino acids Chemical class 0.000 claims abstract 6
- 239000003795 chemical substances by application Substances 0.000 claims abstract 4
- 239000003599 detergent Substances 0.000 claims abstract 4
- 239000004094 surface-active agent Substances 0.000 claims abstract 4
- 230000006641 stabilisation Effects 0.000 claims abstract 3
- 238000011105 stabilization Methods 0.000 claims abstract 3
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims 6
- DCXYFEDJOCDNAF-REOHCLBHSA-N L-asparagine Chemical compound OC(=O)[C@@H](N)CC(N)=O DCXYFEDJOCDNAF-REOHCLBHSA-N 0.000 claims 6
- DCXYFEDJOCDNAF-UHFFFAOYSA-N Asparagine Natural products OC(=O)C(N)CC(N)=O DCXYFEDJOCDNAF-UHFFFAOYSA-N 0.000 claims 5
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims 5
- 235000009582 asparagine Nutrition 0.000 claims 5
- 229960001230 asparagine Drugs 0.000 claims 5
- 235000013922 glutamic acid Nutrition 0.000 claims 5
- 239000004220 glutamic acid Substances 0.000 claims 5
- 235000004554 glutamine Nutrition 0.000 claims 5
- ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 claims 5
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims 4
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 claims 4
- 235000001014 amino acid Nutrition 0.000 claims 4
- 229940024606 amino acid Drugs 0.000 claims 4
- 235000003704 aspartic acid Nutrition 0.000 claims 4
- OQFSQFPPLPISGP-UHFFFAOYSA-N beta-carboxyaspartic acid Natural products OC(=O)C(N)C(C(O)=O)C(O)=O OQFSQFPPLPISGP-UHFFFAOYSA-N 0.000 claims 4
- 229930006000 Sucrose Natural products 0.000 claims 3
- 235000018102 proteins Nutrition 0.000 claims 3
- 229960004793 sucrose Drugs 0.000 claims 3
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 claims 2
- GUBGYTABKSRVRQ-XLOQQCSPSA-N Alpha-Lactose Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@H](O)[C@H](O)[C@H]1O GUBGYTABKSRVRQ-XLOQQCSPSA-N 0.000 claims 2
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 claims 2
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 claims 2
- 101710138657 Neurotoxin Proteins 0.000 claims 2
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 claims 2
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 claims 2
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 claims 2
- 239000012736 aqueous medium Substances 0.000 claims 2
- 150000002016 disaccharides Chemical class 0.000 claims 2
- 239000008101 lactose Substances 0.000 claims 2
- 239000002581 neurotoxin Substances 0.000 claims 2
- 231100000618 neurotoxin Toxicity 0.000 claims 2
- 239000005720 sucrose Substances 0.000 claims 2
- CKLJMWTZIZZHCS-UHFFFAOYSA-N Aspartic acid Chemical compound OC(=O)C(N)CC(O)=O CKLJMWTZIZZHCS-UHFFFAOYSA-N 0.000 claims 1
- 241000193155 Clostridium botulinum Species 0.000 claims 1
- 102000004127 Cytokines Human genes 0.000 claims 1
- 108090000695 Cytokines Proteins 0.000 claims 1
- 108090000790 Enzymes Proteins 0.000 claims 1
- 102000004190 Enzymes Human genes 0.000 claims 1
- 102000001690 Factor VIII Human genes 0.000 claims 1
- 108010054218 Factor VIII Proteins 0.000 claims 1
- 102000006395 Globulins Human genes 0.000 claims 1
- 108010044091 Globulins Proteins 0.000 claims 1
- 102000006992 Interferon-alpha Human genes 0.000 claims 1
- 108010047761 Interferon-alpha Proteins 0.000 claims 1
- 102000003996 Interferon-beta Human genes 0.000 claims 1
- 108090000467 Interferon-beta Proteins 0.000 claims 1
- 102000008070 Interferon-gamma Human genes 0.000 claims 1
- 108010074328 Interferon-gamma Proteins 0.000 claims 1
- 102000014150 Interferons Human genes 0.000 claims 1
- 108010050904 Interferons Proteins 0.000 claims 1
- 108010001014 Plasminogen Activators Proteins 0.000 claims 1
- 102000001938 Plasminogen Activators Human genes 0.000 claims 1
- RVGRUAULSDPKGF-UHFFFAOYSA-N Poloxamer Chemical compound C1CO1.CC1CO1 RVGRUAULSDPKGF-UHFFFAOYSA-N 0.000 claims 1
- 229920001213 Polysorbate 20 Polymers 0.000 claims 1
- 108010023197 Streptokinase Proteins 0.000 claims 1
- 108090000435 Urokinase-type plasminogen activator Proteins 0.000 claims 1
- 102000003990 Urokinase-type plasminogen activator Human genes 0.000 claims 1
- 230000000603 anti-haemophilic effect Effects 0.000 claims 1
- 239000007864 aqueous solution Substances 0.000 claims 1
- 230000001112 coagulating effect Effects 0.000 claims 1
- 229940088598 enzyme Drugs 0.000 claims 1
- 229960000301 factor viii Drugs 0.000 claims 1
- 238000004108 freeze drying Methods 0.000 claims 1
- 229940079322 interferon Drugs 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- 229940127126 plasminogen activator Drugs 0.000 claims 1
- 229960000502 poloxamer Drugs 0.000 claims 1
- 229920001983 poloxamer Polymers 0.000 claims 1
- 229940116406 poloxamer 184 Drugs 0.000 claims 1
- 229940044519 poloxamer 188 Drugs 0.000 claims 1
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 claims 1
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 claims 1
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 claims 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims 1
- 229920000136 polysorbate Polymers 0.000 claims 1
- 229950008882 polysorbate Drugs 0.000 claims 1
- 229940068977 polysorbate 20 Drugs 0.000 claims 1
- 229920000053 polysorbate 80 Polymers 0.000 claims 1
- 229940068968 polysorbate 80 Drugs 0.000 claims 1
- 239000000843 powder Substances 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000000243 solution Substances 0.000 claims 1
- 230000000087 stabilizing effect Effects 0.000 claims 1
- 229960005202 streptokinase Drugs 0.000 claims 1
- 125000000185 sucrose group Chemical group 0.000 claims 1
- 229960005356 urokinase Drugs 0.000 claims 1
- 238000001291 vacuum drying Methods 0.000 claims 1
- 239000000470 constituent Substances 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/05—Dipeptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
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- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Dermatology (AREA)
- Pain & Pain Management (AREA)
- Inorganic Chemistry (AREA)
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- Biochemistry (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Physical Education & Sports Medicine (AREA)
- Orthopedic Medicine & Surgery (AREA)
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- Gastroenterology & Hepatology (AREA)
- Immunology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Claims (13)
1. Композиция, свободная от человеческого сывороточного альбумина, для стабилизации белковых агентов в фармацевтических препаратах, содержащая следующие компоненты:
а) поверхностно-активное вещество, предпочтительно неионный детергент (поверхностно-активное вещество); и
б) смесь по меньшей мере двух аминокислот, где указанные по меньшей мере две аминокислоты представляют собой либо глутаминовую кислоту (Glu) и глутамин (Gln), либо аспарагиновую кислоту (Asp) и аспарагин (Asn).
2. Композиция по п.1, дополнительно содержащая по меньшей мере один из следующих компонентов:
в) дисахарид, предпочтительно сахарозу (тростниковый сахар), трегалозу или лактозу;
г) этилендиаминтетрауксусную кислоту (ЭДТА), предпочтительно в форме одной из ее солей, такой как Na4-ЭДТА.
3. Композиция по п.1 или 2, содержащая компоненты (а), (б) и (в), компоненты (а), (б) и (г) или компоненты (а), (б), (в) и (г).
4. Композиция по п.1, где указанная композиция либо растворима в водных средах, либо представлена в виде водного раствора.
5. Фармацевтическая композиция, содержащая белковый агент и композицию для стабилизации по любому из пп.1-4.
6. Фармацевтическая композиция по п.5, где указанная фармацевтическая композиция присутствует в виде порошка сублимационной или вакуумной сушки, который растворим в водных средах.
7. Фармацевтическая композиция по п.5 или 6, где указанный белковый агент представляет собой коагулирующий фактор, такой как фактор VIII (антигемофильный глобулин), цитокин, такой как интерферон, в частности интерферон альфа, бета или гамма, фермент, такой как урокиназа или стрептокиназа, активатор плазминогена или сверхчистый нейротоксин и нейротоксиновый комплекс, соответственно, из Closthdium botulinum, в частности из Clostridium botulinum типа А или В.
8. Композиция для стабилизации по п.1 или фармацевтическая композиция по п.5, где указанные по меньшей мере две аминокислоты представляют собой (1) аспарагиновую кислоту, аспарагин, глутаминовую кислоту, (2) аспарагиновую кислоту, аспарагин, глутамин, (3) аспарагиновую кислоту, глутаминовую кислоту, глутамин, (4) аспарагин, глутаминовую кислоту, глутамин, или (5) аспарагиновую кислоту, аспарагин, глутаминовую кислоту и глутамин.
9. Композиция по п.8, где концентрации индивидуальных аминокислот составляют в каждом случае от 20 до 200 мМ, более предпочтительно от 20 до 100 мМ, в частности 50 мМ.
10. Композиция по п.8 или 9, где указанное поверхностно-активное вещество представляет собой неионный детергент.
11. Композиция по п.8, где указанный неионный детергент представляет собой полисорбат, такой как полисорбат 20 или полисорбат 80, или полоксамер, такой как полоксамер 184 или 188.
12. Композиция по п.8, где указанный дисахарид представляет собой сахарозу, трегалозу или лактозу.
13. Композиция по п.8, где рН указанной композиции в растворе имеет значение от 5,0 до 8,5, в частности от 6,0 до 8,0, предпочтительно от 6,0 до 7,0 и 6,5, соответственно.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE10333317A DE10333317A1 (de) | 2003-07-22 | 2003-07-22 | Formulierung für Proteinarzneimittel ohne Zusatz von humanem Serumalbumin (HSA) |
| DE10333317.7 | 2003-07-22 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2008147818/15A Division RU2491927C2 (ru) | 2003-07-22 | 2004-07-22 | Композиция для белкового фармацевтического препарата без добавления человеческого сывороточного альбумина (hsa) |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2006101589A true RU2006101589A (ru) | 2006-09-10 |
| RU2354366C2 RU2354366C2 (ru) | 2009-05-10 |
Family
ID=34071833
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2008147818/15A RU2491927C2 (ru) | 2003-07-22 | 2004-07-22 | Композиция для белкового фармацевтического препарата без добавления человеческого сывороточного альбумина (hsa) |
| RU2006101589/15A RU2354366C2 (ru) | 2003-07-22 | 2004-07-22 | Композиция для белкового фармацевтического препарата без добавления человеческого сывороточного альбумина (hsa) |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2008147818/15A RU2491927C2 (ru) | 2003-07-22 | 2004-07-22 | Композиция для белкового фармацевтического препарата без добавления человеческого сывороточного альбумина (hsa) |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US7829525B2 (ru) |
| EP (1) | EP1648485B2 (ru) |
| JP (1) | JP4912147B2 (ru) |
| KR (1) | KR101176579B1 (ru) |
| CN (1) | CN100450542C (ru) |
| AT (1) | ATE506071T1 (ru) |
| AU (1) | AU2004257391B2 (ru) |
| BR (1) | BRPI0412241A (ru) |
| CA (1) | CA2532475C (ru) |
| DE (2) | DE10333317A1 (ru) |
| ES (1) | ES2363600T5 (ru) |
| IL (1) | IL172835A (ru) |
| NO (1) | NO20060772L (ru) |
| RU (2) | RU2491927C2 (ru) |
| WO (1) | WO2005007185A2 (ru) |
Families Citing this family (80)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE19925739A1 (de) * | 1999-06-07 | 2000-12-21 | Biotecon Ges Fuer Biotechnologische Entwicklung & Consulting Mbh | Therapeutikum mit einem Botulinum-Neurotoxin |
| US20160279239A1 (en) | 2011-05-02 | 2016-09-29 | Immunomedics, Inc. | Subcutaneous administration of anti-cd74 antibody for systemic lupus erythematosus and autoimmune disease |
| SG150570A1 (en) | 2004-03-03 | 2009-03-30 | Revance Therapeutics Inc | Compositions and methods for topical diagnostic and therapeutic transport |
| GB2416122A (en) | 2004-07-12 | 2006-01-18 | Ipsen Ltd | Botulinum neurotoxin composition |
| SG160357A1 (en) | 2005-03-03 | 2010-04-29 | Revance Therapeutics Inc | Compositions and methods for topical application and transdermal delivery of botulinum toxins |
| US20160355591A1 (en) | 2011-05-02 | 2016-12-08 | Immunomedics, Inc. | Subcutaneous anti-hla-dr monoclonal antibody for treatment of hematologic malignancies |
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- 2004-07-22 RU RU2006101589/15A patent/RU2354366C2/ru not_active IP Right Cessation
- 2004-07-22 EP EP04762485.3A patent/EP1648485B2/de not_active Expired - Lifetime
- 2004-07-22 JP JP2006520664A patent/JP4912147B2/ja not_active Expired - Fee Related
- 2004-07-22 AT AT04762485T patent/ATE506071T1/de active
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| CA2532475A1 (en) | 2005-01-27 |
| AU2004257391B2 (en) | 2010-02-11 |
| IL172835A (en) | 2010-06-16 |
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| ATE506071T1 (de) | 2011-05-15 |
| CN100450542C (zh) | 2009-01-14 |
| RU2491927C2 (ru) | 2013-09-10 |
| CN1826132A (zh) | 2006-08-30 |
| EP1648485B2 (de) | 2014-09-24 |
| NO20060772L (no) | 2006-04-19 |
| EP1648485B1 (de) | 2011-04-20 |
| IL172835A0 (en) | 2006-06-11 |
| WO2005007185A3 (de) | 2005-05-12 |
| JP4912147B2 (ja) | 2012-04-11 |
| CA2532475C (en) | 2013-05-28 |
| JP2006528137A (ja) | 2006-12-14 |
| AU2004257391A1 (en) | 2005-01-27 |
| WO2005007185A2 (de) | 2005-01-27 |
| KR20060031697A (ko) | 2006-04-12 |
| BRPI0412241A (pt) | 2006-10-17 |
| US7829525B2 (en) | 2010-11-09 |
| ES2363600T3 (es) | 2011-08-10 |
| US20070134199A1 (en) | 2007-06-14 |
| RU2354366C2 (ru) | 2009-05-10 |
| DE502004012418D1 (de) | 2011-06-01 |
| KR101176579B1 (ko) | 2012-08-23 |
| ES2363600T5 (es) | 2014-12-05 |
| RU2008147818A (ru) | 2010-06-10 |
| DE10333317A1 (de) | 2005-02-17 |
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