[go: up one dir, main page]

RU2006142129A - METHOD FOR OBTAINING AN ANTIVERSITAL DRUG - Google Patents

METHOD FOR OBTAINING AN ANTIVERSITAL DRUG Download PDF

Info

Publication number
RU2006142129A
RU2006142129A RU2006142129/04A RU2006142129A RU2006142129A RU 2006142129 A RU2006142129 A RU 2006142129A RU 2006142129/04 A RU2006142129/04 A RU 2006142129/04A RU 2006142129 A RU2006142129 A RU 2006142129A RU 2006142129 A RU2006142129 A RU 2006142129A
Authority
RU
Russia
Prior art keywords
zofran
obtaining
base
treating
tartaric acid
Prior art date
Application number
RU2006142129/04A
Other languages
Russian (ru)
Other versions
RU2439057C2 (en
Inventor
Милинд Морешвар ГХАРПУРЕ (IN)
Милинд Морешвар ГХАРПУРЕ
Бабурао Маникрао БХАВАЛ (IN)
Бабурао Маникрао БХАВАЛ
Умеш Ревайи ЗОПЕ (IN)
Умеш Ревайи ЗОПЕ
Ануп Рамкришна БАРДЕ (IN)
Ануп Рамкришна БАРДЕ
Сатиш Раманлал МЕХТА (IN)
Сатиш Раманлал Мехта
Original Assignee
Эмкьюар Фармасьютикалз Лимитед (In)
Эмкьюар Фармасьютикалз Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Эмкьюар Фармасьютикалз Лимитед (In), Эмкьюар Фармасьютикалз Лимитед filed Critical Эмкьюар Фармасьютикалз Лимитед (In)
Priority to RU2006142129/04A priority Critical patent/RU2439057C2/en
Publication of RU2006142129A publication Critical patent/RU2006142129A/en
Application granted granted Critical
Publication of RU2439057C2 publication Critical patent/RU2439057C2/en

Links

Landscapes

  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Claims (7)

1. Способ получения R-(+)-зофрана, включающий стадии:1. The method of obtaining R - (+) - zofran, comprising the steps of: a) приготовление свободного основания зофрана путем обработки зофрана основанием, которое выбирают из группы, содержащей гидроксид металла, или карбонат, или бикарбонат;a) preparing a free base of zofran by treating the zofran with a base which is selected from the group consisting of metal hydroxide or carbonate or bicarbonate; b) обработка свободного основания зофрана 3-R/S-п-толуилтартаровой кислотой с получением соли 3-R/S-п-толуолилтартаровой кислоты соединения (II);b) treating the free base of Zofran with 3-R / S-p-toluyl tartaric acid to obtain the 3-R / S-p-toluolyl tartaric acid salt of compound (II); c) кристаллизация соли 3-R/S-п-толуолилтартаровой кислоты с использованием водного ДМФА в качестве растворителя и получения R-(+)-энантиомера соединения (I); иc) crystallization of a salt of 3-R / S-p-toluene tartaric acid using aqueous DMF as a solvent and obtaining the R - (+) - enantiomer of compound (I); and d) приготовление R-(+)-зофрана путем обработки свободного основания R-(+)-зофрана HCl в спирте.d) the preparation of R - (+) - zofran by treating the free base of R - (+) - zofran HCl in alcohol. 2. Способ по п.1 (с), где растворителем является диметилформамид и вода.2. The method according to claim 1 (c), where the solvent is dimethylformamide and water. 3. Способ по п.1 (а), где основание выбирают из группы, содержащей гидроксид металла, или карбонат, или бикарбонат.3. The method according to claim 1 (a), where the base is selected from the group consisting of metal hydroxide or carbonate or bicarbonate. 4. Способ по п.3, где предпочтительно используемым основанием является гидроксид.4. The method according to claim 3, where the preferred base is hydroxide. 5. Способ по п.4, где более предпочтительно используемым основанием является гидроксид натрия.5. The method according to claim 4, where the more preferably used base is sodium hydroxide. 6. Способ по п.1 (d), где используемым спиртом является изопропанол.6. The method according to claim 1 (d), where the alcohol used is isopropanol. 7. Способ получения R-(+)-зофрана, как описано в приведенных примерах.7. The method of obtaining R - (+) - zofran, as described in the above examples.
RU2006142129/04A 2006-11-28 2006-11-28 Method of obtaining antiemetic medication RU2439057C2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
RU2006142129/04A RU2439057C2 (en) 2006-11-28 2006-11-28 Method of obtaining antiemetic medication

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
RU2006142129/04A RU2439057C2 (en) 2006-11-28 2006-11-28 Method of obtaining antiemetic medication

Publications (2)

Publication Number Publication Date
RU2006142129A true RU2006142129A (en) 2008-06-10
RU2439057C2 RU2439057C2 (en) 2012-01-10

Family

ID=39581008

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2006142129/04A RU2439057C2 (en) 2006-11-28 2006-11-28 Method of obtaining antiemetic medication

Country Status (1)

Country Link
RU (1) RU2439057C2 (en)

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ301044B6 (en) * 1996-08-12 2009-10-21 Mitsubishi Tanabe Pharma Medicaments comprising Rho kinase inhibiting amide derivatives
US7199147B2 (en) * 2001-06-12 2007-04-03 Dainippon Sumitomo Pharma Co., Ltd. Rho kinase inhibitors
EP1541559A4 (en) * 2002-07-22 2007-08-22 Asahi Kasei Pharma Corp 5-substituted isoquinoline derivative

Also Published As

Publication number Publication date
RU2439057C2 (en) 2012-01-10

Similar Documents

Publication Publication Date Title
UA109774C2 (en) CRYSTAL FORMS OF SAXAGLIPTIN AND ITS PROCESS (OPTIONS)
RU2548673C3 (en) PHARMACEUTICAL COMPOSITION CONTAINING QUINOLINE DERIVATIVE
RU2008107599A (en) METHOD FOR PRODUCING ESOMEPRAZOLE AND ITS SALTS
EA200970594A1 (en) BETA-NUCLEAR AGENT FOR POLYPROPYLENE AND METHOD FOR ITS OBTAINING
RU2018106948A (en) METHOD FOR PRODUCING SUBSTITUTED 3- (2-ANILINO-1-CYCLOGEXYL-1H-BENZIMIDAZOL-5-IL) PROPANIC ACID DERIVATIVES
RU2010119926A (en) SOLID PHARMACEUTICAL MATRIX TYPE
JP2010180242A5 (en)
RU2017109814A (en) CRYSTALLINE 7- {(3S, 4S) -3 - [(CYCLOPROPYLAMINO) METHYL] -4-fluoropyrrolidin-1-yl} -6-fluorine-1- (2-fluoroethyl) -8-methoxy-4-oxo-1, 4-dihydroquinoline-3-carboxylic acid
EP2308828A3 (en) CaSR antagonist
RU2008136884A (en) METHOD FOR PRODUCING PROTEOGLYCAN
JP2017501141A5 (en)
EA201170983A1 (en) DERIVATIVES OF TIADIAZOLES AND OXADIAZOLES, THEIR RECEIVING AND THEIR APPLICATION IN THERAPY
RU2004127981A (en) METHOD FOR PRODUCING SODIUM SALT OF PRAVASTATIN IN CRYSTAL FORM AND SODIUM SALT OF PRAVASTATIN OBTAINED BY THIS METHOD
RU2019119584A (en) METHOD FOR PRODUCING TRIAZOLOPYRIDINE COMPOUND
JP2008540414A5 (en)
RU2008141949A (en) METHOD FOR PRODUCING ANION EXCHANGE MEMBRANES
RU2006142129A (en) METHOD FOR OBTAINING AN ANTIVERSITAL DRUG
AR081267A1 (en) PROCEDURE FOR OBTAINING THE CRYSTAL FORM A OF FEBUXOSTAT
CN101891686A (en) Synthesizing method of N-beta-alanyl-(tau-methyl) histidine
EA201170346A1 (en) METHOD FOR PREPARING CRYSTALLINE METAL ALUMOPHOSPHATE (MeAPO) MOLECULAR SITE FROM AMORPHOUS MATERIALS
RU2014114381A (en) Salts of Heterocyclyl Amide Substituted Imidazoles with Sulfonic Acid
RU2002108957A (en) A method of producing metal-containing carbon nanostructures from an organic compound with the addition of inorganic salts
RU2012142310A (en) METHOD FOR PRODUCING 2- (CYCLOHEXYLMETHYL) -N- {2 - [(2S) -1-METHYLPYRROLIDIN-2-YL] ETHYL} -1,2,3,4-TETHYRHOISOCHINOLIN-7-SULFONAMIDE
RU2012130348A (en) METHODS FOR PRODUCING ARGININE BICARBONATE AT LOW PRESSURE
RU2006109543A (en) Derivatives of cycloalkylamino acids, methods for their preparation and use

Legal Events

Date Code Title Description
MM4A The patent is invalid due to non-payment of fees

Effective date: 20191129