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RU2005121895A - DEPIGMENTING WATER-ALCOHOL GEL - Google Patents

DEPIGMENTING WATER-ALCOHOL GEL Download PDF

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Publication number
RU2005121895A
RU2005121895A RU2005121895/15A RU2005121895A RU2005121895A RU 2005121895 A RU2005121895 A RU 2005121895A RU 2005121895/15 A RU2005121895/15 A RU 2005121895/15A RU 2005121895 A RU2005121895 A RU 2005121895A RU 2005121895 A RU2005121895 A RU 2005121895A
Authority
RU
Russia
Prior art keywords
composition according
water
retinoid
alcohol
alcohol gel
Prior art date
Application number
RU2005121895/15A
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Russian (ru)
Other versions
RU2355393C2 (en
Inventor
Фабьенн ЛУИ (FR)
Фабьенн ЛУИ
Сандрин ОРЗОНИ (FR)
Сандрин ОРЗОНИ
Лоран ФРЕДОН (FR)
Лоран ФРЕДОН
Original Assignee
Галдерма Ресерч Энд Девелопмент, Снс (Fr)
Галдерма Ресерч Энд Девелопмент, Снс
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication of RU2005121895A publication Critical patent/RU2005121895A/en
Application granted granted Critical
Publication of RU2355393C2 publication Critical patent/RU2355393C2/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/02—Preparations for care of the skin for chemically bleaching or whitening the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/04—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/05—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/07—Retinol compounds, e.g. vitamin A
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A61K8/342—Alcohols having more than seven atoms in an unbroken chain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/34—Alcohols
    • A61K8/347—Phenols
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A61K8/368—Carboxylic acids; Salts or anhydrides thereof with carboxyl groups directly bound to carbon atoms of aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/671—Vitamin A; Derivatives thereof, e.g. ester of vitamin A acid, ester of retinol, retinol, retinal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/16—Emollients or protectives, e.g. against radiation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q1/00—Make-up preparations; Body powders; Preparations for removing make-up

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Epidemiology (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Birds (AREA)
  • Emergency Medicine (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Inorganic Chemistry (AREA)
  • Toxicology (AREA)
  • Dispersion Chemistry (AREA)
  • Cosmetics (AREA)
  • Medicinal Preparation (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Claims (17)

1. Депигментирующая композиция, содержащая в физиологически приемлемой среде фенольное производное, ретиноид, в частности, диспергированный, и, в известных случаях, солнцезащитный фильтр, отличающаяся тем, что она представляет собой водно-спиртовой гель.1. A depigmenting composition containing in a physiologically acceptable medium a phenolic derivative, a retinoid, in particular dispersed, and, in known cases, a sunscreen, characterized in that it is a water-alcohol gel. 2. Композиция по п.1, отличающаяся тем, что водно-спиртовой гель содержит от 1 до 30% спирта.2. The composition according to claim 1, characterized in that the water-alcohol gel contains from 1 to 30% alcohol. 3. Композиция по п.1, отличающаяся тем, что спирт представляет собой этанол.3. The composition according to claim 1, characterized in that the alcohol is ethanol. 4. Композиция по п.1, отличающаяся тем, что водно-спиртовой гель содержит, равным образом, один или несколько из следующих ингредиентов: а) карбомер, б) другой желирующий компонент, в) антиоксидант, г) и хелатирующую добавку.4. The composition according to claim 1, characterized in that the water-alcohol gel contains, equally, one or more of the following ingredients: a) carbomer, b) another gelling component, c) an antioxidant, d) and a chelating additive. 5. Композиция по одному из пп.3 или 4, отличающаяся тем, что водно-спиртовой гель содержит 4,00% фенольного производного, 0,10% ретиноида, 20,00% этанола, 0,40% карбомера, 0,60% другого желирующего компонента, 0,40% солей сернистой кислоты, 0,10% ЭДТК (EDTA).5. The composition according to one of claims 3 or 4, characterized in that the water-alcohol gel contains 4.00% phenolic derivative, 0.10% retinoid, 20.00% ethanol, 0.40% carbomer, 0.60% another gelling component, 0.40% salts of sulphurous acid, 0.10% EDTA (EDTA). 6. Композиция по п. 1, отличающаяся тем, что фенольное производное представляет собой гидрохинон.6. The composition according to p. 1, characterized in that the phenolic derivative is a hydroquinone. 7. Композиция по п. 1, отличающаяся тем, что фенольное производное представляет собой 4-гидроксианизол.7. The composition according to p. 1, characterized in that the phenolic derivative is a 4-hydroxyanisole. 8. Композиция по п.7, отличающаяся тем, что водно-спиртовой гель содержит 4,00% 4-гидроксианизола, 0,10% ретиноида, 5,00% этанола, 0,60% карбомера, 0,40% другого желирующего компонента, 0,40% солей сернистой кислоты, 0,10% ЭДТК.8. The composition according to claim 7, characterized in that the water-alcohol gel contains 4.00% 4-hydroxyanisole, 0.10% retinoid, 5.00% ethanol, 0.60% carbomer, 0.40% of another gelling component 0.40% salts of sulphurous acid, 0.10% EDTA. 9. Композиция по п. 1, отличающаяся тем, что ретиноид представляет собой адапален.9. The composition according to p. 1, characterized in that the retinoid is an adaptal. 10. Композиция по п.1, отличающаяся тем, что она содержит химический или физический солнцезащитный фильтр.10. The composition according to claim 1, characterized in that it contains a chemical or physical sunscreen. 11. Композиция по п.1 в качестве лекарственного средства.11. The composition according to claim 1 as a medicine. 12. Способ получения композиции по любому из предыдущих пунктов, отличающийся тем, что он содержит, последовательно, следующие стадии, осуществляемые при комнатной температуре а) получение базовой фазы, содержащей воду и хелатирующую добавку и желирующие компоненты, поддерживаемые при перемешивании вплоть до гомогенности; b) введение в базовую фазу раствора нейтрализующего компонента; c) получение в дополнительном химическом стакане первой активной фазы, содержащей фенольное производное и спирт, перемешиваемые магнитной мешалкой до полной солюбилизации; d) получение в дополнительном химическом стакане второй активной фазы, содержащей ретиноид и увлажняющий компонент, перемешиваемые до получения ровной и гомогенной дисперсии; e) смешивание различных предыдущих активных фаз, независимо, в базовой фазе при перемешивании вплоть до полного совмещения.12. A method of obtaining a composition according to any one of the preceding paragraphs, characterized in that it contains, sequentially, the following steps carried out at room temperature a) obtaining a base phase containing water and a chelating additive and gelling components, maintained with stirring up to homogeneity; b) introducing into the base phase a solution of a neutralizing component; c) obtaining, in an additional beaker, the first active phase containing the phenolic derivative and alcohol, mixed with a magnetic stirrer until complete solubilization; d) obtaining in an additional beaker a second active phase containing a retinoid and a moisturizing component, mixed until an even and homogeneous dispersion is obtained; e) mixing the various previous active phases, independently, in the base phase with stirring until completely combined. 13. Способ по п.12, отличающийся тем, что антиоксиданты, предварительно солюбилизированные в воде, вводят в базовую фазу вслед за стадией (b).13. The method according to p. 12, characterized in that the antioxidants previously solubilized in water are introduced into the base phase after stage (b). 14. Способ по любому из пп.12, 13, отличающийся тем, что в гель, полученный в результате стадии (e), вводят жирную фазу.14. The method according to any one of paragraphs.12, 13, characterized in that the fatty phase is introduced into the gel obtained as a result of step (e). 15. Применение композиции по любому из пп.1-10 для изготовления фармацевтического препарата, предназначенного для лечения и/или профилактики дерматологических заболеваний, связанных с нарушениями пигментации.15. The use of a composition according to any one of claims 1 to 10 for the manufacture of a pharmaceutical preparation intended for the treatment and / or prevention of dermatological diseases associated with pigmentation disorders. 16. Косметическое применение композиции по любому из пп.1-10 для предупреждения и/или для борьбы с пагубными воздействиями солнца и/или с фотоиндуцированным или возрастным старением.16. Cosmetic use of the composition according to any one of claims 1 to 10 for the prevention and / or for combating the harmful effects of the sun and / or photo-induced or age-related aging. 17. Способ нетерапевтической косметической обработки кожи и/или улучшения ее внешнего вида, отличающийся тем, что на кожу и/или на ее защитные покровы наносят водно-спиртовой гель, содержащий фенольное производное, ретиноид, в частности, диспергированный, и, в известных случаях, солнцезащитный фильтр.17. A method of non-therapeutic cosmetic treatment of the skin and / or improving its appearance, characterized in that a water-alcohol gel containing a phenolic derivative, a retinoid, in particular dispersed, and, in known cases, is applied to the skin and / or its protective integument sunscreen filter.
RU2005121895/15A 2002-12-12 2003-12-03 Depigmenting water-alcohol gel RU2355393C2 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
FR0215750 2002-12-12
FR0215750 2002-12-12
US43443302P 2002-12-19 2002-12-19
US60/434,433 2002-12-19

Publications (2)

Publication Number Publication Date
RU2005121895A true RU2005121895A (en) 2006-01-20
RU2355393C2 RU2355393C2 (en) 2009-05-20

Family

ID=32510293

Family Applications (1)

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RU2005121895/15A RU2355393C2 (en) 2002-12-12 2003-12-03 Depigmenting water-alcohol gel

Country Status (11)

Country Link
US (1) US20060029556A1 (en)
EP (1) EP1572176A2 (en)
JP (2) JP2006510652A (en)
KR (1) KR20050084267A (en)
AU (1) AU2003294030B2 (en)
BR (1) BR0315953A (en)
CA (1) CA2505407A1 (en)
MX (1) MXPA05005170A (en)
PL (1) PL374779A1 (en)
RU (1) RU2355393C2 (en)
WO (1) WO2004052353A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2476203C2 (en) * 2007-11-27 2013-02-27 Галдерма Ресерч Энд Девелопмент Method for preparing adapalene gels

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2871377B1 (en) * 2004-06-11 2007-08-24 Galderma Res & Dev HYDRO-ALCOHOLIC DEPIGMENTING GEL COMPRISING MEQUINOL AND ADAPALENE
US20070025937A1 (en) * 2005-07-29 2007-02-01 L'oreal S.A. Cosmetic compositions containing hydroquinone
US20070025939A1 (en) * 2005-07-29 2007-02-01 L'oreal S.A. cosmetic compositions containing hydroquinone and various sunscreen agents
FR2894474B1 (en) * 2005-12-12 2008-04-11 Galderma Res & Dev HYDRO-ALCOHOLIC DEPIGMENTING GEL
DE102005059742A1 (en) 2005-12-13 2007-06-14 Beiersdorf Ag Transparent sunscreen
FR2901701B1 (en) * 2006-05-31 2010-10-29 Galderma Res & Dev COMPOSITIONS COMPRISING AT LEAST ONE NAPHTHOIC ACID DERIVATIVE AND AT LEAST ONE FILMOGENIC AGENT, PROCESSES FOR THEIR PREPARATION, AND USES THEREOF
MXPA06008988A (en) * 2006-08-08 2008-02-07 Fernando Ahumada Ayala Topical antiacne preparations containing retinoid (tazarotene or adapalene), antibiotic (clindamycin phosphate) and/or keratolytic (miscrosponged benzoyl peroxide).
FR2915682B1 (en) * 2007-05-04 2009-07-03 Galderma Res & Dev DERMATOLOGICAL AND COSMETIC DEPIGMENTING COMPOSITIONS, PROCESSES FOR THEIR PREPARATION, AND USES THEREOF
WO2010087983A1 (en) * 2009-01-29 2010-08-05 Kambiz Thomas Moazed Method and system for effecting changes in pigmented tissue
US20100215700A1 (en) 2009-02-25 2010-08-26 Conopco, Inc., D/B/A Unilever Shear Gels and Compositions Comprising Shear Gels
RU2450836C1 (en) * 2011-03-15 2012-05-20 Закрытое акционерное общество Фармацевтическое научно-производственное предприятие "Ретиноиды" Combined ointment composition for reducing intensity of local skin hyperpigmentation
WO2012158405A2 (en) * 2011-05-16 2012-11-22 Pearlman Dale L Compositions and methods for the treatment of skin diseases

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3856934A (en) * 1970-06-24 1974-12-24 A Kligman Skin depigmentation
IN142640B (en) * 1975-01-17 1977-08-06 Johnson & Johnson
US4966773A (en) * 1986-11-25 1990-10-30 Alcon Laboratories, Inc. Topical ophthalmic compositions containing microfine retinoid particles
LU87843A1 (en) * 1990-11-15 1992-08-25 Cird Galderma AQUEOUS GEL BASED ON RETINOIC ACID AND HYDROXYPROPYL-BETA-CYCLODEXTRIN AND ITS USE IN HUMAN MEDICINE AND COSMETICS
AU670777B2 (en) * 1992-04-16 1996-08-01 Ortho Pharmaceutical Corporation Aqueous gel vehicles for retinoids
DE19609538A1 (en) * 1996-03-11 1997-09-18 Basf Ag Finely divided carotenoid and retinoid suspensions and process for their preparation
FR2704753B1 (en) * 1993-05-06 1995-06-30 Oreal USE OF DERIVATIVES OF 4-THIO RESORCIN OR 4-THIO 1-3-DIHYDROXYBENZENE, IN COSMETIC OR DERMOPHARMACEUTICAL COMPOSITIONS WITH DEPIGMENTING ACTION.
US5976555A (en) * 1994-09-07 1999-11-02 Johnson & Johnson Consumer Products, Inc. Topical oil-in-water emulsions containing retinoids
US6461622B2 (en) * 1994-09-07 2002-10-08 Johnson & Johnson Consumer Companies, Inc. Topical compositions
PL322624A1 (en) * 1995-04-03 1998-02-02 Johnson & Johnson Consumer Skin care composition containing retinoides and liposomes
FR2750326B1 (en) * 1996-06-28 1998-07-31 Oreal ACID COSMETIC AND / OR DERMATOLOGICAL COMPOSITION CONTAINING A POLY (2-ACRYLAMIDO 2-METHYLPROPANE SULFONIC ACID) CROSSLINKED AND NEUTRALIZED AT LEAST 90%
US6462064B1 (en) * 1996-07-08 2002-10-08 Galderma Research & Development S.N.C. Apoptosis inducing adamantyl derivatives and their usage as anti-cancer agents, especially for cervical cancers and dysplasias
US6160021A (en) * 1997-02-04 2000-12-12 The General Hospital Corporation Method for treating epidermal or dermal conditions
US6353029B1 (en) * 2000-08-24 2002-03-05 Bristol-Myers Squibb Company Storage stable tretinoin and 4-hydroxyanisole containing topical composition
DK1536763T3 (en) * 2002-09-05 2007-11-05 Galderma Res & Dev Depigmenting composition for the skin comprising the adapal and at least one depigmenting agent

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2476203C2 (en) * 2007-11-27 2013-02-27 Галдерма Ресерч Энд Девелопмент Method for preparing adapalene gels

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US20060029556A1 (en) 2006-02-09
CA2505407A1 (en) 2004-06-24
WO2004052353A2 (en) 2004-06-24
AU2003294030A1 (en) 2004-06-30
WO2004052353A3 (en) 2004-07-15
MXPA05005170A (en) 2005-10-05
RU2355393C2 (en) 2009-05-20
BR0315953A (en) 2005-09-13
AU2003294030B2 (en) 2009-06-04
PL374779A1 (en) 2005-10-31
EP1572176A2 (en) 2005-09-14
KR20050084267A (en) 2005-08-26
JP2006510652A (en) 2006-03-30
JP2010095534A (en) 2010-04-30

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