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RU2004115492A - Внутриклеточный домен белка her-2/neu для предупреждения или лечения малигнизаций - Google Patents

Внутриклеточный домен белка her-2/neu для предупреждения или лечения малигнизаций Download PDF

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RU2004115492A
RU2004115492A RU2004115492/13A RU2004115492A RU2004115492A RU 2004115492 A RU2004115492 A RU 2004115492A RU 2004115492/13 A RU2004115492/13 A RU 2004115492/13A RU 2004115492 A RU2004115492 A RU 2004115492A RU 2004115492 A RU2004115492 A RU 2004115492A
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polypeptide
seq
nucleotides
dna sequence
cell response
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Мартин Э. ЧИВЕР (US)
Мартин Э. ЧИВЕР
Мэри Л. ДИСИС (US)
Мэри Л. ДИСИС
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Юниверсити Оф Вашингтон (Us)
Юниверсити Оф Вашингтон
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Claims (21)

1. Композиция для индукции или усиления Т-клеточного ответа на белок HER-2/neu, включающая фармацевтически приемлемый носитель или разбавитель в сочетании с полипептидом, кодируемым последовательностью ДНК, выбранной из
(a) нуклеотидов 2026-3765 SEQ ID NO:1; и
(b) последовательностей ДНК, которые гибридизуются с нуклеотидной последовательностью, комплементарной нуклеотидам 2026-3765 SEQ ID NO:1 в умеренно жестких условиях, причем последовательность ДНК кодирует полипептид, который вызывает Т-клеточный ответ на белок HER-2/neu.
2. Композиция для иммунизации теплокровного животного против злокачественного новообразования, ассоциированного с онкогеном HER-2/neu, включающая фармацевтически приемлемый носитель или разбавитель в сочетании с полипептидом, кодируемым последовательностью ДНК, выбранной из
(a) нуклеотидов 2026-3765 SEQ ID NO:1; и
(b) последовательностей ДНК, которые гибридизуются с нуклеотидной последовательностью, комплементарной нуклеотидам 2026-3765 SEQ ID NO:1 в умеренно жестких условиях, причем последовательность ДНК кодирует полипептид, который вызывает Т-клеточный ответ на белок HER-2/neu.
3. Полипептид, применяемый для иммунизации теплокровного животного для индукции или усиления Т-клеточного ответа на злокачественное новообразование, ассоциированное с онкогеном HER-2/neu, кодируемый последовательностью ДНК, выбранной из
(a) нуклеотидов 2026-3765 SEQ ID NO:1; и
(b) последовательностей ДНК, которые гибридизуются с нуклеотидной последовательностью, комплементарной нуклеотидам 2026-3765 SEQ ID NO:1 в умеренно жестких условиях, причем последовательность ДНК кодирует полипептид, который вызывает Т-клеточный ответ на белок HER-2/neu.
4. Полипептид по п.3, где указанный полипептид является усеченным.
5. Полипептид по п.3 или 4, дополнительно содержащий адъювант.
6. Полипептид по п.3 или 4, где указанный полипептид присоединен к пептиду или полипептиду, обладающему иммуногенными свойствами.
7. Полипептид по п.6, дополнительно содержащий адъювант.
8. Композиция для индукции или усиления Т-клеточного ответа на белок HER-2/neu, включающая молекулу нуклеиновой кислоты, кодирующую полипептид, кодируемый последовательностью ДНК, выбранной из
(a) нуклеотидов 2026-3765 SEQ ID NO:1; и
(b) последовательностей ДНК, которые гибридизуются с нуклеотидной последовательностью, комплементарной нуклеотидам 2026-3765 SEQ ID NO:1 в умеренно жестких условиях, причем последовательность ДНК кодирует полипептид, который вызывает Т-клеточный ответ на белок HER-2/neu.
9. Молекула нуклеиновой кислоты, применяемая для иммунизации для индукции или усиления Т-клеточного ответа на злокачественное новообразование, ассоциированное с онкогеном HER-2/neu, посредством трансфекции клеток теплокровного животного молекулой нуклеиновой кислоты, кодирующей полипептид, кодируемый последовательностью ДНК, выбранной из
(a) нуклеотидов 2026-3765 SEQ ID NO:1; и
(b) последовательностей ДНК, которые гибридизуются с нуклеотидной последовательностью, комплементарной нуклеотидам 2026-3765 SEQ ID NO:1 в умеренно жестких условиях, причем последовательность ДНК кодирует полипептид, который вызывает Т-клеточный ответ на белок HER-2/neu.
10. Композиция для иммунизации теплокровного животного против злокачественного новообразования, ассоциированного с онкогеном HER-2/neu, включающая молекулу нуклеиновой кислоты, кодирующую полипептид, кодируемый последовательностью ДНК, выбранной из
(a) нуклеотидов 2026-3765 SEQ ID NO:1; и
(b) последовательностей ДНК, которые гибридизуются с нуклеотидной последовательностью, комплементарной нуклеотидам 2026-3765 SEQ ID NO:1 в умеренно жестких условиях, причем последовательность ДНК кодирует полипептид, который вызывает Т-клеточный ответ на белок HER-2/neu.
11. Композиция для индукции или усиления Т-клеточного ответа на белок HER-2/neu, включающая вирусный вектор, управляющий экспрессией полипептида, кодируемого последовательностью ДНК, выбранной из
(a) нуклеотидов 2026-3765 SEQ ID NO:1; и
(b) последовательностей ДНК, которые гибридизуются с нуклеотидной последовательностью, комплементарной нуклеотидам 2026-3765 SEQ ID NO:1 в умеренно жестких условиях, причем последовательность ДНК кодирует полипептид, который вызывает Т-клеточный ответ на белок HER-2/neu.
12. Вирусный вектор, применяемый для иммунизации для индукции или усиления Т-клеточного ответа на злокачественное новообразование, ассоциированное с онкогеном HER-2/neu, посредством инфицирования клеток теплокровного животного вектором, управляющим экспрессией полипептида, кодируемого последовательностью ДНК, выбранной из
(a) нуклеотидов 2026-3765 SEQ ID NO:1; и
(b) последовательностей ДНК, которые гибридизуются с нуклеотидной последовательностью, комплементарной нуклеотидам 2026-3765 SEQ ID NO:1 в умеренно жестких условиях, причем последовательность ДНК кодирует полипептид, который вызывает Т-клеточный ответ на белок HER-2/neu.
13. Композиция для иммунизации теплокровного животного против злокачественного новообразования, ассоциированного с онкогеном HER-2/neu, включающая вектор, управляющий экспрессией полипептида, кодируемого последовательностью ДНК, выбранной из
(a) нуклеотидов 2026-3765 SEQ ID NO:1; и
(b) последовательностей ДНК, которые гибридизуются с нуклеотидной последовательностью, комплементарной нуклеотидам 2026-3765 SEQ ID NO:1 в умеренно жестких условиях, причем последовательность ДНК кодирует полипептид, который вызывает Т-клеточный ответ на белок HER-2/neu.
14. Композиция по любому из пп.1, 2, 8, 10, 11 и 13, где полипептид имеет аминокислотную последовательность из SEQ ID NO:2 от лизина в положении 676 до валина в положении 1255 включительно или ее вариант, который индуцирует, по крайней мере, эквивалентный иммунный ответ.
15. Композиция по п.14, дополнительно содержащая адъювант.
16. Композиция по любому из пп.1, 2, 8, 10, 11 и 13, где полипептид имеет аминокислотную последовательность из SEQ ID NO:2 от лизина в положении 676 до валина в положении 1255 включительно.
17. Композиция по п.16, где указанный полипептид является усеченным.
18. Композиция по п.16, дополнительно содержащая адъювант.
19. Композиция по любому из пп.1, 2, 8, 10, 11, 13 и 17, где указанный полипептид присоединен к пептиду или полипептиду, обладающему иммуногенными свойствами.
20. Композиция по п.19, дополнительно содержащая адъювант.
21. Композиция по любому из пп.1, 2, 8, 10, 11, 13 и 17, дополнительно содержащая адъювант.
RU2004115492/13A 1995-03-31 2004-05-21 Внутриклеточный домен белка her-2/neu для предупреждения или лечения малигнизаций RU2004115492A (ru)

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US08/414,417 1995-03-31
US08/414,417 US5801005A (en) 1993-03-17 1995-03-31 Immune reactivity to HER-2/neu protein for diagnosis of malignancies in which the HER-2/neu oncogene is associated

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RU97118145/13A Division RU2236461C2 (ru) 1995-03-31 1996-03-28 Внутриклеточный домен белка her-2/neu для предупреждения или лечения малигнизаций

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RU2004115492/13A RU2004115492A (ru) 1995-03-31 2004-05-21 Внутриклеточный домен белка her-2/neu для предупреждения или лечения малигнизаций

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PT817846E (pt) 2005-11-30
WO1996030514A1 (en) 1996-10-03
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US20020055614A1 (en) 2002-05-09
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AU5522296A (en) 1996-10-16
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US20100087621A1 (en) 2010-04-08
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