RU2004111357A - Комбинированные агенты для лечения глаукомы - Google Patents
Комбинированные агенты для лечения глаукомы Download PDFInfo
- Publication number
- RU2004111357A RU2004111357A RU2004111357/15A RU2004111357A RU2004111357A RU 2004111357 A RU2004111357 A RU 2004111357A RU 2004111357/15 A RU2004111357/15 A RU 2004111357/15A RU 2004111357 A RU2004111357 A RU 2004111357A RU 2004111357 A RU2004111357 A RU 2004111357A
- Authority
- RU
- Russia
- Prior art keywords
- treatment
- prevention
- combination
- glaucoma
- glaucoma according
- Prior art date
Links
- 208000010412 Glaucoma Diseases 0.000 title claims abstract 13
- 238000011282 treatment Methods 0.000 title claims abstract 13
- 239000004480 active ingredient Substances 0.000 claims abstract 4
- 150000001875 compounds Chemical class 0.000 claims abstract 4
- 150000003180 prostaglandins Chemical class 0.000 claims abstract 4
- 229940123413 Angiotensin II antagonist Drugs 0.000 claims abstract 3
- 239000002333 angiotensin II receptor antagonist Substances 0.000 claims abstract 3
- 229940094443 oxytocics prostaglandins Drugs 0.000 claims abstract 2
- 230000002265 prevention Effects 0.000 claims 11
- XXUPXHKCPIKWLR-JHUOEJJVSA-N isopropyl unoprostone Chemical compound CCCCCCCC(=O)CC[C@H]1[C@H](O)C[C@H](O)[C@@H]1C\C=C/CCCC(=O)OC(C)C XXUPXHKCPIKWLR-JHUOEJJVSA-N 0.000 claims 3
- 229960001160 latanoprost Drugs 0.000 claims 3
- GGXICVAJURFBLW-CEYXHVGTSA-N latanoprost Chemical compound CC(C)OC(=O)CCC\C=C/C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1CC[C@@H](O)CCC1=CC=CC=C1 GGXICVAJURFBLW-CEYXHVGTSA-N 0.000 claims 3
- 230000000699 topical effect Effects 0.000 claims 3
- 229950008081 unoprostone isopropyl Drugs 0.000 claims 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 238000000034 method Methods 0.000 claims 1
- UCTWMZQNUQWSLP-UHFFFAOYSA-N Adrenaline Natural products CNCC(O)C1=CC=C(O)C(O)=C1 UCTWMZQNUQWSLP-UHFFFAOYSA-N 0.000 abstract 1
- 229940006133 antiglaucoma drug and miotics carbonic anhydrase inhibitors Drugs 0.000 abstract 1
- 239000003489 carbonate dehydratase inhibitor Substances 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 0 *Cc(cc1)ccc1-c(cccc1)c1-c1nnn[n]1 Chemical compound *Cc(cc1)ccc1-c(cccc1)c1-c1nnn[n]1 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/557—Eicosanoids, e.g. leukotrienes or prostaglandins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Ophthalmology & Optometry (AREA)
- Heart & Thoracic Surgery (AREA)
- Cardiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Saccharide Compounds (AREA)
Claims (10)
1. Комбинация для профилактики или лечения глаукомы, которая включает антагонист ангиотензина II и простагландинов в качестве активных ингредиентов, для одновременного, раздельного или последовательного использования указанных активных ингредиентов, где антагонист ангиотензина II представляет собой соединение формулы (I) или его фармакологически приемлемую соль, сложный эфир или другое производное:
где R1 представляет группу, имеющую структурную формулу (Ia), (Ib), (Ic), (Id), (Ie) или (If):
2. Комбинация для профилактики или лечения глаукомы по п. 1, в которой R1 представляет группу, имеющую формулу (Ia), (Ib) или (Ic).
3. Комбинация для профилактики или лечения глаукомы по п. 1, в которой R1 представляет группу, имеющую формулу (Ia).
4. Комбинация для профилактики или лечения глаукомы по любому из пп. 1-3, в которой простагландин представляет собой изопропил унопростон или латанопрост или их фармацевтически приемлемую соль.
5. Комбинация для профилактики или лечения глаукомы по любому из пп. 1-3, в которой простагландин представляет собой изопропил унопростон или латанопрост.
6. Комбинация для профилактики или лечения глаукомы по любому из пп. 1-3, которая находится в форме, удобной для местного нанесения в глаза.
7. Комбинация для профилактики или лечения глаукомы по любому из п. 4, которая находится в форме, удобной для местного нанесения в глаза.
8. Комбинация для профилактики или лечения глаукомы по любому из п. 5, которая находится в форме, удобной для местного нанесения в глаза.
9. Комбинация для профилактики или лечения глаукомы по п. 1, содержащая соединение (А)
и, по меньшей мере, одно соединение, выбранное из изопропила унопростона и латанопроста.
10. Способ профилактики или лечения глаукомы, который включает введение пациенту комбинации для профилактики или лечения глаукомы по любому из пп. 1-9.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP11/341524 | 1999-12-01 | ||
| JP34152499 | 1999-12-01 | ||
| JP2000-78769 | 2000-03-21 | ||
| JP2000078769 | 2000-03-21 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2002114335/15A Division RU2002114335A (ru) | 1999-12-01 | 2000-12-01 | Комбинированные агенты для лечения глаукомы |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2004111357A true RU2004111357A (ru) | 2005-09-20 |
| RU2299067C2 RU2299067C2 (ru) | 2007-05-20 |
Family
ID=26576988
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2002114335/15A RU2002114335A (ru) | 1999-12-01 | 2000-12-01 | Комбинированные агенты для лечения глаукомы |
| RU2004111359/15A RU2004111359A (ru) | 1999-12-01 | 2004-04-13 | Комбинированные агенты для лечения глаукомы |
| RU2004111358/15A RU2004111358A (ru) | 1999-12-01 | 2004-04-13 | Комбинированные агенты для лечения глаукомы |
| RU2004111357/15A RU2299067C2 (ru) | 1999-12-01 | 2004-04-13 | Комбинированные агенты для лечения глаукомы |
Family Applications Before (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2002114335/15A RU2002114335A (ru) | 1999-12-01 | 2000-12-01 | Комбинированные агенты для лечения глаукомы |
| RU2004111359/15A RU2004111359A (ru) | 1999-12-01 | 2004-04-13 | Комбинированные агенты для лечения глаукомы |
| RU2004111358/15A RU2004111358A (ru) | 1999-12-01 | 2004-04-13 | Комбинированные агенты для лечения глаукомы |
Country Status (22)
| Country | Link |
|---|---|
| US (4) | US7307096B2 (ru) |
| EP (3) | EP1344535A3 (ru) |
| JP (1) | JP4000505B2 (ru) |
| KR (3) | KR20040045028A (ru) |
| CN (3) | CN1263512C (ru) |
| AT (1) | ATE332145T1 (ru) |
| AU (1) | AU773110B2 (ru) |
| BR (1) | BR0015980A (ru) |
| CA (1) | CA2392804C (ru) |
| CZ (1) | CZ20021829A3 (ru) |
| DE (1) | DE60029242T2 (ru) |
| ES (1) | ES2267586T3 (ru) |
| HK (1) | HK1047239B (ru) |
| HU (1) | HUP0204049A3 (ru) |
| IL (2) | IL149444A0 (ru) |
| MX (1) | MXPA02005505A (ru) |
| NO (1) | NO20022584L (ru) |
| NZ (1) | NZ518930A (ru) |
| PL (1) | PL201783B1 (ru) |
| RU (4) | RU2002114335A (ru) |
| TW (1) | TWI290470B (ru) |
| WO (1) | WO2001039805A1 (ru) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1386611A4 (en) * | 2001-04-19 | 2009-05-13 | Teika Pharmaceutical Co Ltd | MEDICAL DEVICES AND MEDICAL SETS |
| TW200305424A (en) * | 2002-01-29 | 2003-11-01 | Santen Pharmaceutical Co Ltd | Glaucoma-treating agent comprising bunazosin and prostaglandin |
| US20050119299A1 (en) * | 2002-03-08 | 2005-06-02 | Sankyo Company, Limited | Ophthalmic solutions containing tetrazole derivatives |
| US8580851B2 (en) | 2002-08-21 | 2013-11-12 | Sucampo Ag | Ophthalmic solution |
| US7074827B2 (en) * | 2002-10-24 | 2006-07-11 | Sucampo Ag (Usa) Inc. | Method for treating ocular hypertension and glaucoma |
| EP2404606A1 (en) * | 2003-08-21 | 2012-01-11 | Sucampo AG | Ophthalmic compositions comprising a prostaglandin and a viscosity agent |
| JP2005263792A (ja) * | 2004-02-19 | 2005-09-29 | Santen Pharmaceut Co Ltd | 澄明なラタノプロスト点眼液 |
| WO2005079809A1 (ja) * | 2004-02-19 | 2005-09-01 | Santen Pharmaceutical Co., Ltd. | 澄明なラタノプロスト点眼液 |
| AU2007225798B2 (en) * | 2006-03-13 | 2012-09-06 | R-Tech Ueno, Ltd. | Aqueous composition |
| RU2339384C1 (ru) * | 2007-10-18 | 2008-11-27 | Государственное учреждение "УФИМСКИЙ НАУЧНО-ИССЛЕДОВАТЕЛЬСКИЙ ИНСТИТУТ ГЛАЗНЫХ БОЛЕЗНЕЙ" Академии наук Республики Башкортостан (УфНИИ ГБ АН РБ) | Вискоэластик для защиты интраокулярных тканей |
| US12478503B2 (en) | 2009-05-18 | 2025-11-25 | Glaukos Corporation | Implants with controlled drug delivery features and methods of using same |
| US10206813B2 (en) | 2009-05-18 | 2019-02-19 | Dose Medical Corporation | Implants with controlled drug delivery features and methods of using same |
| RU2411946C1 (ru) * | 2009-07-06 | 2011-02-20 | Государственное учреждение "УФИМСКИЙ НАУЧНО-ИССЛЕДОВАТЕЛЬСКИЙ ИНСТИТУТ ГЛАЗНЫХ БОЛЕЗНЕЙ" Академии наук Республики Башкортостан (УфНИИ ГБ АН РБ) | Вископротектор для защиты интраокулярных тканей |
| MX2012012941A (es) * | 2010-05-07 | 2013-07-29 | Sun Pharma Advanced Res Co Ltd | Nuevas composiciones oftalmicas. |
| RU2443416C2 (ru) * | 2010-05-17 | 2012-02-27 | Республиканское Унитарное производственное предприятие "Белмедпрепараты" | Капли глазные |
| JP6023082B2 (ja) | 2011-01-24 | 2016-11-09 | インセプタム リサーチ アンド セラピューティクス，インク． | 精神神経性の疾病を処置するためのプロスタグランジンを含む組成物 |
| KR101327267B1 (ko) | 2012-04-26 | 2013-11-11 | 한양대학교 에리카산학협력단 | 엔드이펙터용 구동력 전달장치 |
| CN107645951B (zh) | 2014-11-25 | 2021-05-04 | 艾克思摩尔有限公司 | 用于递送一种或多种生物活性剂的组合物和方法 |
| WO2016093346A1 (ja) * | 2014-12-12 | 2016-06-16 | 興和株式会社 | 水性組成物 |
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| US3619370A (en) | 1969-04-21 | 1971-11-09 | Frosst & Co Charles E | Microbial reduction of thiadiazoles |
| JPS4966691A (ru) | 1972-10-30 | 1974-06-27 | ||
| IE50901B1 (en) * | 1980-03-04 | 1986-08-06 | Merck & Co Inc | Ophthalmic compositions of carbonic anhydrase inhibitors for topical application in the treatment of elevated intraocular pressure |
| US4394382A (en) | 1980-06-17 | 1983-07-19 | Kowa Company, Ltd. | Dihydrobenzopyran compounds and pharmaceutical composition comprising said compounds |
| ATE41002T1 (de) * | 1984-12-12 | 1989-03-15 | Merck & Co Inc | Substituierte aromatische sulfonamide, ihre herstellung und diese enthaltende ophthalmische zubereitungen. |
| US4863922A (en) | 1984-12-12 | 1989-09-05 | Merck & Co., Inc. | Substituted aromatic sulfonamides as antiglaucoma agents, compositions and use |
| US5182264A (en) * | 1986-03-07 | 1993-01-26 | Schering Corporation | Angiotensin II receptor blockers as antiglaucoma agents |
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| ATE186456T1 (de) | 1988-09-09 | 1999-11-15 | Draenert Klaus | Hüftgelenksprothese |
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| WO1991015206A1 (en) * | 1990-04-05 | 1991-10-17 | E.I. Du Pont De Nemours And Company | Treatment of glaucoma and ocular hypertension with imidazole angiotensin-ii receptor antagonists |
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| CA2057089A1 (en) * | 1990-12-07 | 1992-06-08 | Eric E. Allen | Substituted pyrazolopyrimidines and imidazopyridazines as angiotensin ii antagonists |
| NZ242724A (en) * | 1991-05-15 | 1994-09-27 | Du Pont | Synergistic composition comprising an angiotensin-ii receptor antagonist and a calcium channel blocker |
| IL104648A0 (en) | 1992-02-13 | 1993-06-10 | Merck & Co Inc | Ophthalmic compositions comprising combinations of a carbonic anhydrase inhibitor and a prostaglandin or prostaglandin derivative |
| JP2965267B2 (ja) * | 1992-02-21 | 1999-10-18 | アルコン ラボラトリーズ，インコーポレイテッド | 局所用抗緑内障組成物 |
| CA2125251C (en) * | 1993-06-07 | 2005-04-26 | Yoshiyuki Inada | A pharmaceutical composition for angiotensin ii-mediated diseases |
| CZ154994A3 (en) * | 1993-07-02 | 1995-09-13 | Senju Pharma Co | Visual hypotensive agent |
| US5510383A (en) * | 1993-08-03 | 1996-04-23 | Alcon Laboratories, Inc. | Use of cloprostenol, fluprostenol and their salts and esters to treat glaucoma and ocular hypertension |
| DK0743852T3 (da) * | 1994-02-08 | 2005-10-17 | Novartis Ag | Behandling af glaukom med normalt tryk med valsartan |
| AU684916B2 (en) * | 1994-03-16 | 1998-01-08 | Sankyo Company Limited | Ocular tension depressant |
| CA2185524C (en) * | 1994-03-16 | 2006-12-05 | Tomihisa Yokoyama | Ocular tension depressant |
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| EP1007028A4 (en) | 1997-05-09 | 2002-06-05 | TREATING GLAUCOMA WITH 8 ISO PROSTAGLANDINE | |
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-
2000
- 2000-11-30 JP JP2000363933A patent/JP4000505B2/ja not_active Expired - Fee Related
- 2000-11-30 TW TW089125460A patent/TWI290470B/zh not_active IP Right Cessation
- 2000-12-01 HU HU0204049A patent/HUP0204049A3/hu unknown
- 2000-12-01 PL PL355431A patent/PL201783B1/pl not_active IP Right Cessation
- 2000-12-01 NZ NZ518930A patent/NZ518930A/en unknown
- 2000-12-01 CZ CZ20021829A patent/CZ20021829A3/cs unknown
- 2000-12-01 CN CNB008166668A patent/CN1263512C/zh not_active Expired - Fee Related
- 2000-12-01 KR KR10-2004-7004651A patent/KR20040045028A/ko not_active Ceased
- 2000-12-01 RU RU2002114335/15A patent/RU2002114335A/ru unknown
- 2000-12-01 EP EP03013533A patent/EP1344535A3/en not_active Withdrawn
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Effective date: 20091202 |