RU2003129166A - Средства, подавляющие отторжение трансплантата - Google Patents
Средства, подавляющие отторжение трансплантата Download PDFInfo
- Publication number
- RU2003129166A RU2003129166A RU2003129166/15A RU2003129166A RU2003129166A RU 2003129166 A RU2003129166 A RU 2003129166A RU 2003129166/15 A RU2003129166/15 A RU 2003129166/15A RU 2003129166 A RU2003129166 A RU 2003129166A RU 2003129166 A RU2003129166 A RU 2003129166A
- Authority
- RU
- Russia
- Prior art keywords
- pharmaceutical composition
- ailim
- substance
- composition according
- transplantation
- Prior art date
Links
- 101001042104 Homo sapiens Inducible T-cell costimulator Proteins 0.000 claims abstract 7
- 102100021317 Inducible T-cell costimulator Human genes 0.000 claims abstract 7
- 238000002054 transplantation Methods 0.000 claims abstract 5
- 206010052779 Transplant rejections Diseases 0.000 claims abstract 4
- 210000000056 organ Anatomy 0.000 claims abstract 4
- 238000011316 allogeneic transplantation Methods 0.000 claims abstract 2
- 210000002216 heart Anatomy 0.000 claims abstract 2
- 210000003734 kidney Anatomy 0.000 claims abstract 2
- 210000004185 liver Anatomy 0.000 claims abstract 2
- 210000004072 lung Anatomy 0.000 claims abstract 2
- 210000000496 pancreas Anatomy 0.000 claims abstract 2
- 238000002689 xenotransplantation Methods 0.000 claims abstract 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 11
- 239000000126 substance Substances 0.000 claims 8
- 230000000694 effects Effects 0.000 claims 3
- 229920001184 polypeptide Polymers 0.000 claims 3
- 108090000765 processed proteins & peptides Proteins 0.000 claims 3
- 102000004196 processed proteins & peptides Human genes 0.000 claims 3
- 102000004169 proteins and genes Human genes 0.000 claims 3
- 108090000623 proteins and genes Proteins 0.000 claims 3
- 210000001519 tissue Anatomy 0.000 claims 3
- 239000003937 drug carrier Substances 0.000 claims 2
- 229940125721 immunosuppressive agent Drugs 0.000 claims 2
- 239000003018 immunosuppressive agent Substances 0.000 claims 2
- 230000001404 mediated effect Effects 0.000 claims 2
- 239000000203 mixture Substances 0.000 claims 2
- 230000019491 signal transduction Effects 0.000 claims 2
- PMATZTZNYRCHOR-CGLBZJNRSA-N Cyclosporin A Chemical compound CC[C@@H]1NC(=O)[C@H]([C@H](O)[C@H](C)C\C=C\C)N(C)C(=O)[C@H](C(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](CC(C)C)N(C)C(=O)[C@@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)N(C)C(=O)CN(C)C1=O PMATZTZNYRCHOR-CGLBZJNRSA-N 0.000 claims 1
- 108010036949 Cyclosporine Proteins 0.000 claims 1
- 102100039498 Cytotoxic T-lymphocyte protein 4 Human genes 0.000 claims 1
- 101000889276 Homo sapiens Cytotoxic T-lymphocyte protein 4 Proteins 0.000 claims 1
- 102000006496 Immunoglobulin Heavy Chains Human genes 0.000 claims 1
- 108010019476 Immunoglobulin Heavy Chains Proteins 0.000 claims 1
- QJJXYPPXXYFBGM-LFZNUXCKSA-N Tacrolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1\C=C(/C)[C@@H]1[C@H](C)[C@@H](O)CC(=O)[C@H](CC=C)/C=C(C)/C[C@H](C)C[C@H](OC)[C@H]([C@H](C[C@H]2C)OC)O[C@@]2(O)C(=O)C(=O)N2CCCC[C@H]2C(=O)O1 QJJXYPPXXYFBGM-LFZNUXCKSA-N 0.000 claims 1
- 239000003470 adrenal cortex hormone Substances 0.000 claims 1
- LMEKQMALGUDUQG-UHFFFAOYSA-N azathioprine Chemical compound CN1C=NC([N+]([O-])=O)=C1SC1=NC=NC2=C1NC=N2 LMEKQMALGUDUQG-UHFFFAOYSA-N 0.000 claims 1
- 229960002170 azathioprine Drugs 0.000 claims 1
- 210000000988 bone and bone Anatomy 0.000 claims 1
- 229960001265 ciclosporin Drugs 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 210000004087 cornea Anatomy 0.000 claims 1
- 229930182912 cyclosporin Natural products 0.000 claims 1
- -1 deoxyspergulin Chemical compound 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 230000002708 enhancing effect Effects 0.000 claims 1
- 229960000556 fingolimod Drugs 0.000 claims 1
- KKGQTZUTZRNORY-UHFFFAOYSA-N fingolimod Chemical compound CCCCCCCCC1=CC=C(CCC(N)(CO)CO)C=C1 KKGQTZUTZRNORY-UHFFFAOYSA-N 0.000 claims 1
- 229960000681 leflunomide Drugs 0.000 claims 1
- VHOGYURTWQBHIL-UHFFFAOYSA-N leflunomide Chemical compound O1N=CC(C(=O)NC=2C=CC(=CC=2)C(F)(F)F)=C1C VHOGYURTWQBHIL-UHFFFAOYSA-N 0.000 claims 1
- RTGDFNSFWBGLEC-SYZQJQIISA-N mycophenolate mofetil Chemical compound COC1=C(C)C=2COC(=O)C=2C(O)=C1C\C=C(/C)CCC(=O)OCCN1CCOCC1 RTGDFNSFWBGLEC-SYZQJQIISA-N 0.000 claims 1
- 229960004866 mycophenolate mofetil Drugs 0.000 claims 1
- ZAHRKKWIAAJSAO-UHFFFAOYSA-N rapamycin Natural products COCC(O)C(=C/C(C)C(=O)CC(OC(=O)C1CCCCN1C(=O)C(=O)C2(O)OC(CC(OC)C(=CC=CC=CC(C)CC(C)C(=O)C)C)CCC2C)C(C)CC3CCC(O)C(C3)OC)C ZAHRKKWIAAJSAO-UHFFFAOYSA-N 0.000 claims 1
- 229960002930 sirolimus Drugs 0.000 claims 1
- QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 claims 1
- 210000003491 skin Anatomy 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
- 206010053159 Organ failure Diseases 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 230000001629 suppression Effects 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P41/00—Drugs used in surgical methods, e.g. surgery adjuvants for preventing adhesion or for vitreum substitution
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Biochemistry (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Transplantation (AREA)
- Surgery (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Graft Or Block Polymers (AREA)
- External Artificial Organs (AREA)
- Transplanting Machines (AREA)
- Soil Working Implements (AREA)
- Cylinder Crankcases Of Internal Combustion Engines (AREA)
Claims (11)
1. Фармацевтическая композиция для подавления, лечения или профилактики отторжения трансплантата, сопровождающего трансплантацию органа, его части или ткани, причем указанная композиция включает в себя вещество, обладающее активностью модуляции трансдукции сигнала, опосредованного AILIM, и фармацевтически приемлемый носитель.
2. Фармацевтическая композиция для усиления эффекта одного или нескольких иммуносупрессорных средств для подавления, лечения или профилактики отторжения трансплантата, сопровождающего трансплантацию органа, его части или ткани, причем указанная композиция включает в себя вещество, обладающее активностью модуляции трансдукции сигнала, опосредованного AILIM, и фармацевтически приемлемый носитель.
3. Фармацевтическая композиция по п.2, в которой указанное иммуносупрессорное средство представляет собой одно или несколько терапевтических средств, выбранных из группы, состоящей из азатиоприна, адренокортикостероида, циклоспорина, мизорибина и такролимуса (FK-506), микофенолата мофетила, лефлуномида, сиролимуса, дезоксиспергулина, FTY720 и препарата CTLA4.
4. Фармацевтическая композиция по любому из пп.1-3, где указанная трансплантация представляет собой аллотрансплантацию.
5. Фармацевтическая композиция по любому из пп.1-3, где указанная трансплантация представляет собой ксенотрансплантацию.
6. Фармацевтическая композиция по любому из пп.1-5, где указанный орган представляет собой печень, сердце, почку, легкое или поджелудочную железу.
7. Фармацевтическая композиция по любому из пп.1-5, где указанная ткань представляет собой кожу, роговицу или костную ткань.
8. Фармацевтическая композиция по любому из пп.1-7, в которой указанное вещество представляет собой белковое вещество.
9. Фармацевтическая композиция по п.8, где указанное белковое вещество выбрано из группы, состоящей из
а) антитела, которое связывается с AILIM, или части указанного антитела;
b) полипептида, включающего в себя, полностью или частично, внеклеточную область AILIM;
c) гибридного полипептида, включающего в себя, полностью или частично, внеклеточную область AILIM, и полностью или частично константную область тяжелой цепи иммуноглобулина; и
d) полипептида, который связывается с AILIM.
10. Фармацевтическая композиция по любому из пп.1-7, в которой указанное вещество представляет собой небелковое вещество.
11. Фармацевтическая композиция по п.10, где указанное небелковое вещество представляет собой ДНК, РНК или химически синтезированное соединение.
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2001-56209 | 2001-03-01 | ||
| JP2001056209 | 2001-03-01 | ||
| JP2001-56216 | 2001-03-01 | ||
| JP2001056216 | 2001-03-01 | ||
| JP2002008028 | 2002-01-16 | ||
| JP2002-8028 | 2002-01-16 | ||
| PCT/JP2002/000930 WO2002070010A1 (fr) | 2001-03-01 | 2002-02-05 | Inhibiteurs de rejet du greffon |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2003129166A true RU2003129166A (ru) | 2005-03-10 |
| RU2263512C2 RU2263512C2 (ru) | 2005-11-10 |
Family
ID=27346134
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2003129166/15A RU2263512C2 (ru) | 2001-03-01 | 2002-02-05 | Средства, подавляющие отторжение трансплантата |
Country Status (24)
| Country | Link |
|---|---|
| US (2) | US7438905B2 (ru) |
| EP (2) | EP1769807B1 (ru) |
| JP (1) | JP4212278B2 (ru) |
| KR (1) | KR100609444B1 (ru) |
| CN (1) | CN1518458B (ru) |
| AT (2) | ATE352318T1 (ru) |
| AU (1) | AU2002228435B2 (ru) |
| BR (1) | BR0207787A (ru) |
| CA (1) | CA2439858C (ru) |
| CY (1) | CY1110143T1 (ru) |
| CZ (1) | CZ20032406A3 (ru) |
| DE (2) | DE60235928D1 (ru) |
| DK (1) | DK1769807T3 (ru) |
| ES (1) | ES2344219T3 (ru) |
| HU (2) | HU228108B1 (ru) |
| IL (2) | IL156845A0 (ru) |
| MX (1) | MXPA03006736A (ru) |
| NO (2) | NO331690B1 (ru) |
| NZ (1) | NZ527076A (ru) |
| PT (1) | PT1769807E (ru) |
| RU (1) | RU2263512C2 (ru) |
| SI (1) | SI1769807T1 (ru) |
| SK (1) | SK288048B6 (ru) |
| WO (1) | WO2002070010A1 (ru) |
Families Citing this family (73)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3521382B2 (ja) | 1997-02-27 | 2004-04-19 | 日本たばこ産業株式会社 | 細胞間接着及びシグナル伝達を媒介する細胞表面分子 |
| US7112655B1 (en) | 1997-02-27 | 2006-09-26 | Japan Tobacco, Inc. | JTT-1 protein and methods of inhibiting lymphocyte activation |
| DE19821060A1 (de) * | 1997-09-23 | 1999-04-15 | Bundesrepublik Deutschland Let | Ko-stimulierendes Polypeptid von T-Zellen, monoklonale Antikörper sowie die Herstellung und deren Verwendung |
| JP4210454B2 (ja) | 2001-03-27 | 2009-01-21 | 日本たばこ産業株式会社 | 炎症性腸疾患治療剤 |
| JP3871503B2 (ja) | 1999-08-30 | 2007-01-24 | 日本たばこ産業株式会社 | 免疫性疾患治療剤 |
| CZ20022000A3 (cs) * | 1999-12-16 | 2003-02-12 | Teva Pharmaceuticals Industries Ltd. | Způsoby přípravy a nová krystalická forma leflunomidu |
| JP3597140B2 (ja) | 2000-05-18 | 2004-12-02 | 日本たばこ産業株式会社 | 副刺激伝達分子ａｉｌｉｍに対するヒトモノクローナル抗体及びその医薬用途 |
| JP4212278B2 (ja) | 2001-03-01 | 2009-01-21 | 日本たばこ産業株式会社 | 移植片拒絶反応抑制剤 |
| RU2291675C2 (ru) * | 2004-07-09 | 2007-01-20 | Институт теоретической и экспериментальной биофизики РАН | Способ обработки трансплантатов для сердечно-сосудистой хирургии |
| GB0504544D0 (en) * | 2005-03-04 | 2005-04-13 | Novartis Ag | Organic compounds |
| JP2006321765A (ja) * | 2005-05-20 | 2006-11-30 | Mikiko Ueda | 肝移植における拒絶反応の予防又は治療薬、或いは拒絶反応とは断定できない肝機能異常の治療薬 |
| US20080279851A1 (en) * | 2007-05-07 | 2008-11-13 | Medlmmune, Llc | Anti-icos antibodies and their use in treatment of oncology, transplantation and autoimmune disease |
| US9931386B2 (en) * | 2008-06-16 | 2018-04-03 | Atsuo Ochi | Recombinant multiple domain fusion protein mitogens and use thereof for inducing enhancement or repression of antigen-specific immunity |
| US20120114595A1 (en) | 2009-07-16 | 2012-05-10 | Otsuka Chemical Co., Ltd. | Sugar chain-added ailim extracellular domain and method for producing same |
| US9420770B2 (en) | 2009-12-01 | 2016-08-23 | Indiana University Research & Technology Corporation | Methods of modulating thrombocytopenia and modified transgenic pigs |
| EP2558024B1 (en) * | 2010-04-12 | 2017-03-08 | The University Of Miami | Macroporous bioengineered scaffolds for cell transplantation |
| ES2612914T3 (es) * | 2011-03-31 | 2017-05-19 | Inserm - Institut National De La Santé Et De La Recherche Médicale | Anticuerpos dirigidos contra Icos y usos de los mismos |
| US20150139994A1 (en) * | 2013-11-12 | 2015-05-21 | The Regents Of The University Of California | Compositions and methods for preventing allogeneic immune rejection |
| MX378834B (es) * | 2013-11-22 | 2025-03-11 | Takeda Pharmaceuticals Co | El uso de un inhibidor de c1-esterasa para el tratamiento del rechazo mediado por anticuerpos en pacientes con trasplante de órganos. |
| GB201403775D0 (en) | 2014-03-04 | 2014-04-16 | Kymab Ltd | Antibodies, uses & methods |
| WO2015138803A1 (en) | 2014-03-12 | 2015-09-17 | Icahn School Of Medicine At Mount Sinai | Method for identifying kidney allograft recipients at risk for chronic injury |
| CN106661634B (zh) * | 2014-06-26 | 2021-03-12 | 西奈山伊坎医学院 | 用于诊断肾异体移植物纤维化和排异风险的方法 |
| CN113444783B (zh) | 2014-06-26 | 2024-04-09 | 西奈山伊坎医学院 | 通过分析预示性基因集诊断亚临床和临床的急性排异的方法 |
| MA41414A (fr) | 2015-01-28 | 2017-12-05 | Centre Nat Rech Scient | Protéines de liaison agonistes d' icos |
| ES2863225T3 (es) | 2015-12-03 | 2021-10-11 | Glaxosmithkline Ip Dev Ltd | Dinucleótidos cíclicos purinos como moduladores del sting |
| WO2017098421A1 (en) | 2015-12-08 | 2017-06-15 | Glaxosmithkline Intellectual Property Development Limited | Benzothiadiazine compounds |
| WO2017153952A1 (en) | 2016-03-10 | 2017-09-14 | Glaxosmithkline Intellectual Property Development Limited | 5-sulfamoyl-2-hydroxybenzamide derivatives |
| WO2017175156A1 (en) | 2016-04-07 | 2017-10-12 | Glaxosmithkline Intellectual Property Development Limited | Heterocyclic amides useful as protein modulators |
| CR20200045A (es) | 2016-04-07 | 2020-03-11 | Glaxosmithkline Ip Dev Ltd | AMIDAS HETEROCÍCLICAS ÚTILES COMO MODULADORES DE PROTEÍNAS (Divisional 2018-0472) |
| EP3452483B1 (en) | 2016-05-05 | 2020-04-01 | GlaxoSmithKline Intellectual Property (No. 2) Limited | Enhancer of zeste homolog 2 inhibitors |
| WO2018029474A2 (en) | 2016-08-09 | 2018-02-15 | Kymab Limited | Anti-icos antibodies |
| US9567399B1 (en) | 2016-06-20 | 2017-02-14 | Kymab Limited | Antibodies and immunocytokines |
| SG11201810509PA (en) | 2016-06-20 | 2018-12-28 | Kymab Ltd | Anti-pd-l1 antibodies |
| KR20190028540A (ko) | 2016-07-20 | 2019-03-18 | 글락소스미스클라인 인털렉츄얼 프로퍼티 디벨로프먼트 리미티드 | Perk 억제제로서의 이소퀴놀린 유도체 |
| RU2764548C2 (ru) | 2016-08-09 | 2022-01-18 | Кимаб Лимитед | Анти-icos антитела |
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