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RU2003118500A - MEANS FOR INHIBITING REPRODUCTION OF COATED VIRUSES, METHOD FOR ITS PRODUCTION, PHARMACEUTICAL COMPOSITION AND METHOD FOR INHIBITING VIRAL INFECTIONS - Google Patents

MEANS FOR INHIBITING REPRODUCTION OF COATED VIRUSES, METHOD FOR ITS PRODUCTION, PHARMACEUTICAL COMPOSITION AND METHOD FOR INHIBITING VIRAL INFECTIONS

Info

Publication number
RU2003118500A
RU2003118500A RU2003118500/15A RU2003118500A RU2003118500A RU 2003118500 A RU2003118500 A RU 2003118500A RU 2003118500/15 A RU2003118500/15 A RU 2003118500/15A RU 2003118500 A RU2003118500 A RU 2003118500A RU 2003118500 A RU2003118500 A RU 2003118500A
Authority
RU
Russia
Prior art keywords
inhibiting
reproduction
pharmaceutical composition
enveloped viruses
fullerene
Prior art date
Application number
RU2003118500/15A
Other languages
Russian (ru)
Other versions
RU2236852C1 (en
Original Assignee
Закрытое акционерное общество "Деско" (ЗАО "Деско")
Filing date
Publication date
Application filed by Закрытое акционерное общество "Деско" (ЗАО "Деско") filed Critical Закрытое акционерное общество "Деско" (ЗАО "Деско")
Priority claimed from RU2003118500/15A external-priority patent/RU2236852C1/en
Priority to RU2003118500/15A priority Critical patent/RU2236852C1/en
Priority to US10/559,681 priority patent/US20060122276A1/en
Priority to GEAP20049178A priority patent/GEP20084377B/en
Priority to PCT/RU2004/000208 priority patent/WO2004112804A1/en
Priority to UAA200600635A priority patent/UA82528C2/en
Priority to BRPI0411679-8A priority patent/BRPI0411679A/en
Priority to EP04748919A priority patent/EP1645279A4/en
Priority to CA002530004A priority patent/CA2530004A1/en
Priority to CNA2004800171673A priority patent/CN1819834A/en
Priority to JP2006517009A priority patent/JP2007522082A/en
Priority to KR1020057024813A priority patent/KR20060017887A/en
Priority to EA200600010A priority patent/EA010483B1/en
Priority to AP2006003495A priority patent/AP2006003495A0/en
Priority to AU2004249090A priority patent/AU2004249090A1/en
Publication of RU2236852C1 publication Critical patent/RU2236852C1/en
Application granted granted Critical
Publication of RU2003118500A publication Critical patent/RU2003118500A/en
Priority to IL172634A priority patent/IL172634A0/en

Links

Claims (5)

1. Средство для ингибирования репродукции оболочечных вирусов, характеризующееся тем, что оно представляет собой водорастворимое соединение фуллеренполикарбоновых анионов общей формулы1. Means for inhibiting the reproduction of enveloped viruses, characterized in that it is a water-soluble compound of fullerene polycarboxylic anions of the General formula C60Hn[NH(CH2)mC(O)O-]n,C 60 H n [NH (CH 2 ) m C (O) O - ] n , где С60 - фуллереновое ядро,where C 60 is the fullerene core, NH(CH2)mC(O)O- - аминокарбоновый анионNH (CH 2 ) m C (O) O - - aminocarboxylic anion m равно целому числу от 1 до 5, предпочтительно 3 и 5, наиболее предпочтительно 5,m is an integer from 1 to 5, preferably 3 and 5, most preferably 5, n равно целому числу от 2 до 12, предпочтительно от 4 до 6, наиболее предпочтительно 6.n is an integer from 2 to 12, preferably from 4 to 6, most preferably 6. 2. Способ получения средства для ингибирования репродукции оболочечных вирусов, характеризующийся тем, что в раствор фуллерена в о-дихлорбензоле вносят аминокислоту в виде калиевой или натриевой соли, далее добавляют солюбилизатор выбранный из группы полиалкиленоксидов: полиэтиленгликоли мол массы от 150 до 400 и выше, а также диметиловые эфиры полиэтиленгликолей, при этом соотношение фуллерена и кислоты увеличено более чем в 50 раз, а синтез проводят при температуре 60-80°С.2. A method of obtaining a tool for inhibiting the reproduction of enveloped viruses, characterized in that an amino acid in the form of potassium or sodium salt is added to the solution of fullerene in o-dichlorobenzene, then a solubilizer selected from the group of polyalkylene oxides is added: polyethylene glycols of a mass of 150 to 400 and higher, and also dimethyl ethers of polyethylene glycols, while the ratio of fullerene and acid is increased by more than 50 times, and the synthesis is carried out at a temperature of 60-80 ° C. 3. Фармацевтическая композиция для ингибирования репродукции оболочечных вирусов, характеризующаяся тем, что она содержит средство по п.1 в эффективном количестве и фармацевтически приемлемые наполнители.3. A pharmaceutical composition for inhibiting the reproduction of enveloped viruses, characterized in that it contains the agent according to claim 1 in an effective amount and pharmaceutically acceptable excipients. 4. Фармацевтическая композиция для ингибирования репродукции оболочечных вирусов по п.3, характеризующаяся тем, что она выполнена в форме таблеток, капсул, раствора для инъекций, суппозиториев, мази, крема, спрея, геля.4. The pharmaceutical composition for inhibiting the reproduction of enveloped viruses according to claim 3, characterized in that it is made in the form of tablets, capsules, injection, suppositories, ointments, cream, spray, gel. 5. Способ ингибирования репродукции оболочечных вирусов, характеризующийся тем, что используют фармацевтическую композицию по п.п.3 и 4 для подавления вирусов при лечении заболеваний ВИЧ и СПИД, герпес-инфекций, вирусного гепатита С.5. A method of inhibiting the reproduction of enveloped viruses, characterized in that they use the pharmaceutical composition according to claims 3 and 4 to suppress viruses in the treatment of HIV and AIDS, herpes infections, hepatitis C.
RU2003118500/15A 2003-06-23 2003-06-23 Agent for inhibition of reproduction of enveloped viruses, method for its preparing, pharmaceutical composition and method for inhibition of viral infections RU2236852C1 (en)

Priority Applications (15)

Application Number Priority Date Filing Date Title
RU2003118500/15A RU2236852C1 (en) 2003-06-23 2003-06-23 Agent for inhibition of reproduction of enveloped viruses, method for its preparing, pharmaceutical composition and method for inhibition of viral infections
CNA2004800171673A CN1819834A (en) 2003-06-23 2004-05-31 Drug for inhibiting membrane virus replication, production method thereof, pharmaceutical composition and method for inhibiting virus infection
KR1020057024813A KR20060017887A (en) 2003-06-23 2004-05-31 Substances that inhibit membrane virus proliferation, methods for their preparation, pharmaceutical compositions and methods for inhibiting viral infection
PCT/RU2004/000208 WO2004112804A1 (en) 2003-06-23 2004-05-31 Agent for inhibiting membrane virus reproduction, method for the production thereof, pharmaceutical composition and method for inhibiting viral infections
UAA200600635A UA82528C2 (en) 2003-06-23 2004-05-31 Agent for inhibition of membrane-enveloped viruses propagation based on fullerene water-soluble compound and process for the preparation thereof
BRPI0411679-8A BRPI0411679A (en) 2003-06-23 2004-05-31 membrane virus inhibiting agent, method for producing virus, pharmaceutical composition and method for inhibiting viral infection
EP04748919A EP1645279A4 (en) 2003-06-23 2004-05-31 Agent for inhibiting membrane virus reproduction, method for the production thereof, pharmaceutical composition and method for inhibiting viral infections
CA002530004A CA2530004A1 (en) 2003-06-23 2004-05-31 Agent for inhibiting membrane virus reproduction, method for the production thereof, pharmaceutical composition and method for inhibiting viral infections
US10/559,681 US20060122276A1 (en) 2003-06-23 2004-05-31 Agent for inhibiting membrane virus reproduction, method for the production thereof, pharmaceutical composition and method for inhibiting viral infections
JP2006517009A JP2007522082A (en) 2003-06-23 2004-05-31 Agent for inhibiting membrane virus production, method for its production, pharmaceutical composition and method for inhibiting viral infection
GEAP20049178A GEP20084377B (en) 2003-06-23 2004-05-31 Agent for inhibiting membrane virus reproduction, method for the production thereof, pharmaceutical composition and method for inhibiting viral infections
EA200600010A EA010483B1 (en) 2003-06-23 2004-05-31 Agent for inhibiting membrane virus production, method for the production thereof, pharmaceutical composition and method for inhibiting viral infections
AP2006003495A AP2006003495A0 (en) 2003-06-23 2004-05-31 Agent for inhibiting membrane virus reproduction, method for the production thereof, pharmaceutical composition and method for inhibiting viral infections.
AU2004249090A AU2004249090A1 (en) 2003-06-23 2004-05-31 Agent for inhibiting membrane virus reproduction, method for the production thereof, pharmaceutical composition and method for inhibiting viral infections
IL172634A IL172634A0 (en) 2003-06-23 2005-12-15 Agent for inhibiting membrane virus reproduction, method for the production thereof pharmaceutical composition and method for inhibiting viral infections

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
RU2003118500/15A RU2236852C1 (en) 2003-06-23 2003-06-23 Agent for inhibition of reproduction of enveloped viruses, method for its preparing, pharmaceutical composition and method for inhibition of viral infections

Publications (2)

Publication Number Publication Date
RU2236852C1 RU2236852C1 (en) 2004-09-27
RU2003118500A true RU2003118500A (en) 2004-12-20

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
RU2003118500/15A RU2236852C1 (en) 2003-06-23 2003-06-23 Agent for inhibition of reproduction of enveloped viruses, method for its preparing, pharmaceutical composition and method for inhibition of viral infections

Country Status (15)

Country Link
US (1) US20060122276A1 (en)
EP (1) EP1645279A4 (en)
JP (1) JP2007522082A (en)
KR (1) KR20060017887A (en)
CN (1) CN1819834A (en)
AP (1) AP2006003495A0 (en)
AU (1) AU2004249090A1 (en)
BR (1) BRPI0411679A (en)
CA (1) CA2530004A1 (en)
EA (1) EA010483B1 (en)
GE (1) GEP20084377B (en)
IL (1) IL172634A0 (en)
RU (1) RU2236852C1 (en)
UA (1) UA82528C2 (en)
WO (1) WO2004112804A1 (en)

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RU2458046C1 (en) * 2011-02-01 2012-08-10 Лев Давидович Раснецов Hydrated n-fullerene-amino acid derivatives, method for preparing them and based pharmaceutical compositions
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CA2810515C (en) * 2012-02-06 2018-06-05 Lev Davidovich Rasnetsov Hydrated n-fullerene amino acids, method for producing the latter, and pharmaceutical compositions on the basis thereof
CA2810507A1 (en) * 2012-02-06 2012-08-09 Lev Davidovich Rasnetsov Homo- and hetero-polyamino-acid derivatives of fullerene c60, method for producing same, and pharmaceutical compositions based on said derivatives
RU2533232C2 (en) * 2012-07-20 2014-11-20 Федеральное государственное бюджетное учреждение "Научно-исследовательский институт вирусологии им. Д.И. Ивановского" Министерства здравоохранения и социального развития Российской Федерации (ФГБУ "НИИ вирусологии им. Д.И. Ивановского" Минздравсоцразвития России Using polycarboxylic fullerene deriative as microbiocidal antiviral agent
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CN111135188A (en) * 2018-11-06 2020-05-12 海南森溪海科技有限公司 Application of fullerene and/or water-soluble derivative thereof in medicine for preventing and treating female genital tract diseases

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