RU2003100505A

RU2003100505A - METHOD FOR PRODUCING QUINOLINE DERIVATIVES

Info

Publication number: RU2003100505A
Application number: RU2003100505/04A
Authority: RU
Inventors: Карл ШОЙЦГЕР
Original assignee: Зингента Партисипейшнс Аг
Priority date: 2000-06-28
Filing date: 2001-06-26
Publication date: 2004-06-27

Claims

1. The method of obtaining the compounds of formula I

in which R ₁ represents a hydrogen or chlorine atom, and

R ₂ represents a hydrogen atom, C ₁ -C ₈ alkyl or C ₁ -C ₈ alkyl substituted with C ₁ -C ₈ alkoxy or C ₃ -C ₆ alkenyloxy, including

a) the introduction of the main part of the amount of the compounds of formula II

which must interact in a solvent mixture comprising at least one organic solvent capable of forming an azeotrope with water and at least one aprotic bipolar solvent;

b) dosing into an aqueous strong base, taken in an amount equivalent to the main part of the total amount of this compound of formula II;

c) adding the remainder of the amount of the compound of formula II to be reacted;

g) adding a weak base in an amount that is at least equivalent to this remaining part;

d) removing water from the reaction mixture by azeotropic distillation;

e) adding a compound of formula III

in which R ₂ has the same meanings as indicated for formula I; and

g) isolation from the reaction mixture of the obtained compound of formula 1.

2. The method according to claim 1, in which the compound of formula I is isolated from the reaction mixture after completion of the reaction step e) by distilling off the solvents from the product melt, extracting the product melt with water, and then removing the aqueous phase from the product melt.