[go: up one dir, main page]

RU2001132140A - Recombinant platelet collagen receptor glycoprotein VI and its use in pharmaceuticals - Google Patents

Recombinant platelet collagen receptor glycoprotein VI and its use in pharmaceuticals

Info

Publication number
RU2001132140A
RU2001132140A RU2001132140/13A RU2001132140A RU2001132140A RU 2001132140 A RU2001132140 A RU 2001132140A RU 2001132140/13 A RU2001132140/13 A RU 2001132140/13A RU 2001132140 A RU2001132140 A RU 2001132140A RU 2001132140 A RU2001132140 A RU 2001132140A
Authority
RU
Russia
Prior art keywords
sequence shown
glycoprotein
platelet
recombinant
gpvi
Prior art date
Application number
RU2001132140/13A
Other languages
Russian (ru)
Other versions
RU2287580C2 (en
Inventor
Кеннет Дж. КЛЕМЕТСОН
Original Assignee
Мерк Патент Гмбх
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Мерк Патент Гмбх filed Critical Мерк Патент Гмбх
Publication of RU2001132140A publication Critical patent/RU2001132140A/en
Application granted granted Critical
Publication of RU2287580C2 publication Critical patent/RU2287580C2/en

Links

Claims (10)

1. ДНК, кодирующая Гликопротеин VI или его биологически активные фрагменты.1. DNA encoding Glycoprotein VI or its biologically active fragments. 2. ДНК по п.1, которая частично или полностью содержит последовательность, представленную на фиг.2.2. DNA according to claim 1, which partially or completely contains the sequence shown in figure 2. 3. ДНК, которая имеет последовательность, представленную на фиг.2.3. DNA, which has the sequence shown in figure 2. 4. ДНК по пп.1-3, которая кодирует Гликопротеин VI, содержащий аминокислотную последовательность, представленную на фиг.1а и 1b.4. DNA according to claims 1 to 3, which encodes a Glycoprotein VI containing the amino acid sequence shown in figa and 1b. 5. Рекомбинантный человеческий Гликопротеин VI как медицинский препарат, содержащий аминокислотную последовательность, представленную на фиг.1b.5. Recombinant human Glycoprotein VI as a medicine containing the amino acid sequence shown in fig.1b. 6. Фармацевтическая композиция, включающая протеин по п.5 и фармацевтически приемлемые растворитель, носитель или их эксципиенты.6. A pharmaceutical composition comprising the protein of claim 5 and a pharmaceutically acceptable solvent, carrier, or excipients thereof. 7. Фармацевтическая композиция, включающая дополнительно фармакологически активное соединение.7. A pharmaceutical composition, further comprising a pharmacologically active compound. 8. Применение рекомбинантного GPVI в качестве инструмента скрининга на предмет определения специфических ингибиторов взаимодействий тромбоцитов с коллагеном.8. The use of recombinant GPVI as a screening tool for the determination of specific inhibitors of the interaction of platelets with collagen. 9. Применение рекомбинантного GPVI для производства медицинского препарата для терапии тромбозов, сердечно-сосудистых заболеваний и расстройств, связанных с тромбоцит-коллагеновыми взаимодействиями.9. The use of recombinant GPVI for the manufacture of a medicament for the treatment of thrombosis, cardiovascular diseases and disorders associated with platelet-collagen interactions. 10. Применение изменений в GPVI в качестве показателя возраста тромбоцита и воздействия тромбоцита на условия протекания тромбозов и сердечнососудистых заболеваний или приступов.10. Application of changes in GPVI as an indicator of platelet age and the effect of platelet on the course of thrombosis and cardiovascular disease or seizures.
RU2001132140/13A 1999-05-07 2000-04-25 Glycoprotein vi as collagen recombinant receptor on platelets and its using in pharmaceutics RU2287580C2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP99109094.5 1999-05-07
EP99109094 1999-05-07

Publications (2)

Publication Number Publication Date
RU2001132140A true RU2001132140A (en) 2003-08-10
RU2287580C2 RU2287580C2 (en) 2006-11-20

Family

ID=8238132

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2001132140/13A RU2287580C2 (en) 1999-05-07 2000-04-25 Glycoprotein vi as collagen recombinant receptor on platelets and its using in pharmaceutics

Country Status (26)

Country Link
US (5) US7928066B1 (en)
EP (3) EP2341141B1 (en)
JP (2) JP5480457B2 (en)
KR (1) KR100703592B1 (en)
CN (1) CN1253569C (en)
AR (1) AR023848A1 (en)
AT (1) ATE393223T1 (en)
AU (1) AU775952B2 (en)
BR (1) BRPI0010325B1 (en)
CA (1) CA2372515C (en)
CY (2) CY1108190T1 (en)
CZ (1) CZ302693B6 (en)
DE (1) DE60038675T2 (en)
DK (2) DK2341141T3 (en)
ES (2) ES2534652T3 (en)
HK (1) HK1045714B (en)
HU (1) HUP0201049A2 (en)
MX (1) MXPA01011274A (en)
NO (1) NO333408B1 (en)
PL (1) PL204449B1 (en)
PT (2) PT2341141E (en)
RU (1) RU2287580C2 (en)
SI (1) SI1177289T1 (en)
SK (1) SK15762001A3 (en)
WO (1) WO2000068377A1 (en)
ZA (1) ZA200110071B (en)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2341141B1 (en) * 1999-05-07 2015-01-14 Sanofi-Aventis Deutschland GmbH Antibodies against recombinant platelet collagen receptor glycoprotein VI
US20040001826A1 (en) 1999-06-30 2004-01-01 Millennium Pharmaceuticals, Inc. Glycoprotein VI and uses thereof
US7291714B1 (en) * 1999-06-30 2007-11-06 Millennium Pharmaceuticals, Inc. Glycoprotein VI and uses thereof
US6245527B1 (en) 1999-06-30 2001-06-12 Millennium Pharmaceuticals, Inc. Nucleic acid molecules encoding glycoprotein VI and recombinant uses thereof
AU7097400A (en) * 1999-09-01 2001-03-26 Otsuka Pharmaceutical Co., Ltd. Platelet membrane glycoprotein vi (gpvi) dna and protein sequences, and uses thereof
EP1224942A1 (en) * 2001-01-23 2002-07-24 Bernhard Dr. Nieswandt Use of JAQ1 (monoclonal antibody anti GPVI) as a medicament for the protection against thrombotic diseases
EP1406929A2 (en) 2001-07-18 2004-04-14 MERCK PATENT GmbH Glycoprotein vi fusion proteins
US7531178B2 (en) 2002-06-07 2009-05-12 Trigen Gmbh Immunoadhesin comprising a glycoprotein VI domain
US20070071744A1 (en) 2002-06-07 2007-03-29 Gotz Munch Agents which bind to epitopes of glycoprotein VI
EP1369128A1 (en) 2002-06-07 2003-12-10 Procorde GmbH Inhibitors of glycoprotein VI and their therapeutic use
CN100558895C (en) * 2003-07-18 2009-11-11 持田制药株式会社 Anti-platelet membrane glycoprotein vi monoclonal antibody
DE102004017295A1 (en) * 2004-04-05 2005-11-03 Zlb Behring Gmbh Compounds which cause or prevent the removal of receptors from cell membranes, and methods for their detection
RU2407752C2 (en) 2004-04-29 2010-12-27 Оцука Фармасьютикал Ко., Лтд. Glycoprotein vi antibodies and methods for producing and using such antibodies
US7645592B2 (en) 2004-04-29 2010-01-12 Otsuka Pharmaceutical Co., Ltd. Glycoprotein VI antibodies and methods of use thereof
US20090041783A1 (en) 2005-04-28 2009-02-12 Mochida Pharmaceutical Co., Ltd. Anti-platelet membrane glycoprotein vi monoclonal antibody
EP2212416A4 (en) * 2007-10-31 2013-01-09 Otsuka Pharma Co Ltd Uses of a glycoprotein vi (gpvi) inhibitor
WO2012139110A2 (en) 2011-04-08 2012-10-11 Prognosys Biosciences, Inc. Peptide constructs and assay systems
EP3184544A1 (en) * 2015-12-23 2017-06-28 Julius-Maximilians-Universität Würzburg Glycoprotein v inhibitors for use as coagulants
BR102020024677A2 (en) 2020-12-02 2022-06-14 Oxiteno S.A. Indústria E Comércio COMPOSITION AND METHOD TO INCREASE THE RESISTANCE OF AGROCHEMICAL FORMULATIONS AGAINST UVA/UVB RAYS, USE OF THE COMPOSITION, AND AGROCHEMICAL FORMULATION

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SK282961B6 (en) 1993-07-01 2003-01-09 Merck Patent Gesellschaft Mit Beschr�Nkter Haftung Purified protein, its production method and use and pharmaceutical preparation containing it
WO1995011259A1 (en) * 1993-10-22 1995-04-27 Ellerman Pharmaceuticals Limited Platelet-derived growth factor analogues
CA2278154A1 (en) * 1997-01-21 1998-07-23 Human Genome Sciences, Inc. Fc receptors and polypeptides
CA2250291A1 (en) * 1997-01-29 1998-07-30 Toray Industries Inc. Chimeric proteins, their heterodimer complexes, and platelet substitutes
EP2341141B1 (en) 1999-05-07 2015-01-14 Sanofi-Aventis Deutschland GmbH Antibodies against recombinant platelet collagen receptor glycoprotein VI
US20040001826A1 (en) 1999-06-30 2004-01-01 Millennium Pharmaceuticals, Inc. Glycoprotein VI and uses thereof
US6245527B1 (en) 1999-06-30 2001-06-12 Millennium Pharmaceuticals, Inc. Nucleic acid molecules encoding glycoprotein VI and recombinant uses thereof
US7291714B1 (en) 1999-06-30 2007-11-06 Millennium Pharmaceuticals, Inc. Glycoprotein VI and uses thereof
AU7097400A (en) 1999-09-01 2001-03-26 Otsuka Pharmaceutical Co., Ltd. Platelet membrane glycoprotein vi (gpvi) dna and protein sequences, and uses thereof
EP1406929A2 (en) 2001-07-18 2004-04-14 MERCK PATENT GmbH Glycoprotein vi fusion proteins
EP1538165A1 (en) 2003-12-03 2005-06-08 Procorde GmbH Inhibitors of glycoprotein VI based on monoclonal antibody hgp 5c4

Similar Documents

Publication Publication Date Title
RU2001132140A (en) Recombinant platelet collagen receptor glycoprotein VI and its use in pharmaceuticals
DE69738581D1 (en) HUMAN DNASE I HYPERACTIVE VARIANTS
ATE332138T1 (en) FLIBANSERIN FOR THE TREATMENT OF EXTRAPYRAMIDAL MOTION DISORDERS
KR20010079669A (en) Regulation of Substrate Activity
DE69129248D1 (en) Peptides with endothelin antagonistic activity, their preparation and pharmaceutical compositions
BR0311313A (en) Diaryl urea derivatives useful for the treatment of protein kinase dependent diseases
NO963568D0 (en) Pharmaceutical composition for the treatment of blood coagulation disorders, methods for the preparation thereof and its use
JP2006506942A5 (en)
RU98120519A (en) AUTOANTIGEN AND STRUCTURAL-RELATED PROTEINS FOR USE IN IMMUNOTHERAPY OF AUTOIMMUNE DISEASES
KR910700260A (en) Neutrophil-activated peptide-2
DE69531004D1 (en) p277 PEPTIDE ANALOGUE, PHARMACEUTICAL COMPOSITION THEREOF FOR THE TREATMENT AND DIAGNOSIS OF DIABETES
WO2004074486A3 (en) Fusion proteins of interferon alpha muteins with improved properties
JP2005538045A5 (en)
UA91820C2 (en) Therapeutic uses of chemokine variants
PT1079849E (en) USE OF HMG PROTEINS FOR THE PREPARATION OF MEDICINES WITH CYTOTOXIC ACTIVITY
EP1664322A4 (en) RECOMBINANT SUPPORT MOLECULE FOR THE EXPRESSION, ADMINISTRATION AND PURIFICATION OF TARGET POLYPEPTIDES
CA2311648A1 (en) Ifnar2/ifn complex
WO2004067027A3 (en) Osteogenic composition
EE200100662A (en) Anticoagulant compound, process for its preparation, pharmaceutical preparation containing it and therapeutic use thereof
EP1663201A4 (en) USE OF NEW 2-OXO-HETEROCYCLIC COMPOUNDS AND PHARMACEUTICAL PREPARATIONS CONTAINING THEREOF
KR970701724A (en) Corpuscles of stannius protein (stanniocalcin)
RU2005131578A (en) APLIDINE FOR TREATMENT OF MULTIPLE MYELOMA
DE60036199D1 (en) PROTEASERESISTENT FLINT ANALOG
BG103905A (en) New bpc peptide salts with organoprotective activity, method for their preparation and application in medicine
WO2002007676A3 (en) Compounds having affinity for the granulocyte-colony stimulating factor receptor (g-csfr)