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RU2001123126A - Derivatives of pyridopyranoazepines, their preparation and therapeutic use - Google Patents

Derivatives of pyridopyranoazepines, their preparation and therapeutic use

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Publication number
RU2001123126A
RU2001123126A RU2001123126/04A RU2001123126A RU2001123126A RU 2001123126 A RU2001123126 A RU 2001123126A RU 2001123126/04 A RU2001123126/04 A RU 2001123126/04A RU 2001123126 A RU2001123126 A RU 2001123126A RU 2001123126 A RU2001123126 A RU 2001123126A
Authority
RU
Russia
Prior art keywords
alkyl group
group
alkyl
general formula
phenyl
Prior art date
Application number
RU2001123126/04A
Other languages
Russian (ru)
Other versions
RU2238273C2 (en
Inventor
Фредерик Галли
Самир Жегам
Алистер Локхид
Аксель САМСОН
Original Assignee
Санофи-Синтелябо
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR9902784A external-priority patent/FR2790474B1/en
Application filed by Санофи-Синтелябо filed Critical Санофи-Синтелябо
Publication of RU2001123126A publication Critical patent/RU2001123126A/en
Application granted granted Critical
Publication of RU2238273C2 publication Critical patent/RU2238273C2/en

Links

Claims (4)

1. Соединение, в форме чистого геометрического или оптического изомера или смеси таких изомеров, общей формулы (I)1. The compound, in the form of a pure geometric or optical isomer or a mixture of such isomers, of the general formula (I)
Figure 00000001
Figure 00000001
 в которой R1 представляет собой атом водорода, (С1-С4)алкильную группу, фенил(С1-С4)алкильную группу, фенилгидрокси(С1-С4)алкильную группу, фуранил(С1-С4)-алкильную группу или фуранилгидрокси(С1-С4)алкильную группу;in which R 1 represents a hydrogen atom, (C 1 -C 4 ) alkyl group, phenyl (C 1 -C 4 ) alkyl group, phenylhydroxy (C 1 -C 4 ) alkyl group, furanyl (C 1 -C 4 ) - an alkyl group or furanylhydroxy (C 1 -C 4 ) alkyl group; R2 является либо атомом водорода или галогена, или трифторметильной, циано, гидроксильной, нитро, ацетильной, (С1-С6)алкильной, (C1-C6) алкоксигруппой, или группой общей формулы NR4R5, в которой R4 представляет собой атом водорода или (С1-С4)алкильную или (С1-С4)алканоильную группу, и R5 представляет собой атом водорода или (С1-С4)алкильную группу, или же R4 и R5 образуют с атомом азота, который их несет, С4-С7кольцо, либо фенильной или нафтильной группой, возможно замещенной атомом галогена или трифторметильной, трифторметокси, циано, гидроксильной, нитро, ацетильной, (С1-С6)алкильной, (С1-С6)алкокси, метилендиоксигруппой, присоединенной по положениям 2 и 3 или 3 и 4 фенильного кольца, или фенилом;R 2 is either a hydrogen or halogen atom, or a trifluoromethyl, cyano, hydroxyl, nitro, acetyl, (C 1 -C 6 ) alkyl, (C 1 -C 6 ) alkoxy group, or a group of the general formula NR 4 R 5 in which R 4 represents a hydrogen atom or a (C 1 -C 4 ) alkyl or (C 1 -C 4 ) alkanoyl group, and R 5 represents a hydrogen atom or a (C 1 -C 4 ) alkyl group, or R 4 and R 5 form with the nitrogen atom that carries them a C 4 -C 7 ring, or a phenyl or naphthyl group, possibly substituted by a halogen atom or a trifluoromethyl, trifluoromethoxy, cyano, hydroxyl a yl, nitro, acetyl, (C 1 -C 6 ) alkyl, (C 1 -C 6 ) alkoxy, methylenedioxy group attached at the positions 2 and 3 or 3 and 4 of the phenyl ring, or phenyl; R3 представляет собой атом водорода или галогена или (С1-С4)алкильную группу,R 3 represents a hydrogen or halogen atom or a (C 1 -C 4 ) alkyl group, в форме основания или соли присоединения кислоты.in the form of a base or an acid addition salt. 2. Способ получения соединений по п.1, отличающийся тем, что соединение общей формулы (IV)2. A method of producing compounds according to claim 1, characterized in that the compound of general formula (IV)
Figure 00000002
Figure 00000002
 в которой R2 и R3 такие, как определено в п.1,in which R 2 and R 3 are as defined in claim 1, подвергают дегидратации в кислой среде с последующей перегруппировкой при высокой температуре с получением соединения общей формулы (Ia)subjected to dehydration in an acidic medium, followed by rearrangement at high temperature to obtain a compound of General formula (Ia)
Figure 00000003
Figure 00000003
 в которой, если желательно, модифицируют заместители R2 и R3 и/или вводят заместитель R1, такой, как определено в п.1.in which, if desired, the substituents R 2 and R 3 are modified and / or the substituent R 1 is introduced, as defined in claim 1. 3. Лекарство, отличающееся тем, что оно состоит из соединения по п.1.3. A medicine, characterized in that it consists of a compound according to claim 1. 4. Фармацевтическая композиция, отличающаяся тем, что она содержит соединение по п.1, объединенное с эксципиентом.4. A pharmaceutical composition, characterized in that it contains a compound according to claim 1, combined with an excipient.
RU2001123126/04A 1999-03-05 2000-03-01 Derivatives of pyridopyranoazepines, method for their preparing, remedy and pharmaceutical composition based on thereof RU2238273C2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR99/02784 1999-03-05
FR9902784A FR2790474B1 (en) 1999-03-05 1999-03-05 PYRIDOPYRANOAZEPINE DERIVATIVES, THEIR PREPARATION AND THEIR THERAPEUTIC APPLICATION

Publications (2)

Publication Number Publication Date
RU2001123126A true RU2001123126A (en) 2003-06-20
RU2238273C2 RU2238273C2 (en) 2004-10-20

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Country Status (37)

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US (2) US6538003B1 (en)
EP (1) EP1161434B1 (en)
JP (1) JP4806123B2 (en)
KR (2) KR100768355B1 (en)
CN (1) CN1137894C (en)
AR (1) AR022820A1 (en)
AT (1) ATE231869T1 (en)
AU (1) AU764625B2 (en)
BG (1) BG65211B1 (en)
BR (1) BR0008763A (en)
CA (1) CA2372063C (en)
CO (1) CO5160250A1 (en)
CZ (1) CZ302259B6 (en)
DE (1) DE60001307T2 (en)
DK (1) DK1161434T3 (en)
EE (1) EE04497B1 (en)
ES (1) ES2191611T3 (en)
FR (1) FR2790474B1 (en)
HK (1) HK1040398B (en)
HR (1) HRP20010655B1 (en)
HU (1) HU228671B1 (en)
ID (1) ID30116A (en)
IL (2) IL145150A0 (en)
MX (1) MXPA01008972A (en)
NO (1) NO327119B1 (en)
NZ (1) NZ513561A (en)
PE (1) PE20001543A1 (en)
PL (1) PL201683B1 (en)
RS (1) RS49997B (en)
RU (1) RU2238273C2 (en)
SK (1) SK284339B6 (en)
TR (1) TR200102403T2 (en)
TW (1) TWI222975B (en)
UA (1) UA61164C2 (en)
UY (1) UY26048A1 (en)
WO (1) WO2000053608A1 (en)
ZA (1) ZA200106811B (en)

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