RU2001116118A - DEVICE FOR DELIVERY OF MEDICINES, ESPECIALLY FOR DELIVERY OF ANDROGENS - Google Patents

Claims (10)

1. A device for delivering a therapeutically active agent with controlled release, in particular androgen, over an extended period of time, comprising: a core comprising the aforementioned therapeutically active agent and a membrane covering the above core, wherein the above membrane is made of siloxane-based elastomer, containing 3,3,3-trifluoropropyl groups attached to the Si atoms of the siloxane units, characterized in that from 1 to about 50% of the substituents attached to the Si atoms in the elastomer in the units of siloxane are 3,3,3-trifluoropropyl groups and that the elastomer is obtained either from i) a mixture consisting of a) a non-substituted fluorine-based siloxane polymer and b) a fluorinated siloxane-based polymer in which the above polymer contains 3, 3,3-trifluoropropyl groups attached to the Si atoms of the siloxane units, or from ii) a single siloxane-based polymer containing 3,3,3-trifluoropropyl groups attached to the Si atoms of the siloxane units, wherein the above polymer or mixture of polymers connected cross bonds with the formation of an elastomer.  2. The device according to p. 1, characterized in that it represents an implantable device intended for subcutaneous administration of the active agent.  3. The device according to claim 1, characterized in that the polymer mixture is a mixture of a) poly (dimethylsiloxane) and b) poly (dimethylsiloxane), in which the methyl groups attached to the Si atoms of the siloxane units are replaced to some extent by 3.3 , 3-trifluoropropyl groups.  4. The device according to p. 3, characterized in that approximately 50% of the methyl groups in polymer b) are replaced by 3,3,3-trifluoropropyl groups.  5. The device according to claim 1, characterized in that the core is an elastomeric matrix in which the drug is dispersed.  6. The device according to p. 5, characterized in that the core elastomer is PDMS (polydimethylsiloxane).  7. The device according to claim 5, characterized in that the core elastomer is also a siloxane-based elastomer containing 3,3,3-trifluoropropyl groups attached to the Si atoms of the siloxane units.  8. The device according to p. 1, characterized in that the therapeutically active agent is androgen.  9. The device according to p. 8, characterized in that the androgen is MENT or MENT Ac, and that the device is an implant for subcutaneous use.  10. Device according to any one of the preceding paragraphs, characterized in that the elastomer contains a filler.