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RU2001112488A - Cross-linked hyaluronic acids and their use in medicine - Google Patents

Cross-linked hyaluronic acids and their use in medicine

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Publication number
RU2001112488A
RU2001112488A RU2001112488/04A RU2001112488A RU2001112488A RU 2001112488 A RU2001112488 A RU 2001112488A RU 2001112488/04 A RU2001112488/04 A RU 2001112488/04A RU 2001112488 A RU2001112488 A RU 2001112488A RU 2001112488 A RU2001112488 A RU 2001112488A
Authority
RU
Russia
Prior art keywords
hyaluronic acids
crosslinked hyaluronic
acids according
cross
chain
Prior art date
Application number
RU2001112488/04A
Other languages
Russian (ru)
Other versions
RU2230752C2 (en
Inventor
Роландо БАРБУЧЧИ
Роберто РАПУОЛИ
Original Assignee
Фармила-Теа Фармасьютичи, С.П.А.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from IT1998MI002440A external-priority patent/IT1303735B1/en
Application filed by Фармила-Теа Фармасьютичи, С.П.А. filed Critical Фармила-Теа Фармасьютичи, С.П.А.
Publication of RU2001112488A publication Critical patent/RU2001112488A/en
Application granted granted Critical
Publication of RU2230752C2 publication Critical patent/RU2230752C2/en

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Claims (12)

1. Поперечносшитые гиалуроновые кислоты, получаемые взаимодействием карбоксильных групп гиалуроновой кислоты и полиамина.1. Crosslinked hyaluronic acids obtained by the interaction of the carboxyl groups of hyaluronic acid and polyamine. 2. Поперечносшитые гиалуроновые кислоты по п.1, где полиамин является диамином.2. Crosslinked hyaluronic acids according to claim 1, where the polyamine is a diamine. 3. Поперечносшитые гиалуроновые кислоты по п.2, где диамин имеет формулу3. Crosslinked hyaluronic acids according to claim 2, where the diamine has the formula R1-NH-A-NHR2 R 1 -NH-A-NHR 2 где А является С2-С10 линейной или разветвленной алкиленовой цепью, предпочтительно С2-С6 цепью, необязательно замещенной гидроксильной, карбоксильной, галогеном, алкоксильной и амино группами; полиоксиалкиленовой цепью [{СН2)n-O-(СН2)n]m, где n равно 2 или 3, m равно целому числу от 2 до 10; арильной или гетероарильной группой, предпочтительно 1,4- или 1,3-двузамещенным бензолом; R1 и R2, которые являются одинаковыми или различными, представляют водород, C1-C6 алкил, фенил или бензил.where A is a C 2 -C 10 linear or branched alkylene chain, preferably a C 2 -C 6 chain, optionally substituted with hydroxyl, carboxyl, halogen, alkoxyl and amino groups; the polyoxyalkylene chain [{CH 2 ) n -O- (CH 2 ) n ] m , where n is 2 or 3, m is an integer from 2 to 10; an aryl or heteroaryl group, preferably 1,4- or 1,3-disubstituted benzene; R 1 and R 2 , which are the same or different, are hydrogen, C 1 -C 6 alkyl, phenyl or benzyl. 4. Поперечносшитые гиалуроновые кислоты по п.3, где А является линейным С2-С6 алкиленом или цепью формулы4. Crosslinked hyaluronic acids according to claim 3, where A is a linear C 2 -C 6 alkylene or a chain of the formula [СН2n-O-СН2n]m [CH 2n —O — CH 2n ] m где n равно 2, и m равно целому числу от 2 до 10.where n is 2, and m is an integer from 2 to 10. 5. Поперечносшитые гиалуроновые кислоты по одному из пп.1-4, где гидроксильные группы сульфатированы или гемисукцинилированы.5. Crosslinked hyaluronic acids according to one of claims 1 to 4, where the hydroxyl groups are sulfated or hemisuccinylated. 6. Поперечносшитые гиалуроновые кислоты по одному из предыдущих пунктов в виде геля.6. Crosslinked hyaluronic acids according to one of the preceding paragraphs in the form of a gel. 7. Поперечносшитые гиалуроновые кислоты по одному из предшествующих пунктов в твердой или полутвердой формах.7. Crosslinked hyaluronic acids according to one of the preceding paragraphs in solid or semi-solid forms. 8. Комплексы цинка, меди или железа соединений по пп.1-7.8. Complexes of zinc, copper or iron compounds according to claims 1-7. 9. Поперечносшитые гиалуроновые кислоты по п.6, применяемые в качестве заменителей синовиальной жидкости, жидкой части стекловидного тела, в качестве матриц в формах с регулируемым высвобождением, в качестве заживляющих и противосклеивающих агентов.9. Crosslinked hyaluronic acids according to claim 6, used as substitutes for synovial fluid, the liquid part of the vitreous body, as matrices in controlled release forms, as healing and anti-adhesive agents. 10. Комплексы поперечносшитых гиалуроновых кислот по п.8, применяемые в качестве заменителей синовиальной жидкости, жидкой части стекловидного тела, в качестве матриц в формах с регулируемым высвобождением, в качестве заживляющих и противосклеивающих агентов.10. The complexes of cross-linked hyaluronic acids of claim 8, used as substitutes for synovial fluid, the liquid part of the vitreous body, as matrices in controlled release forms, as healing and anti-adhesive agents. 11. Поперечносшитые гиалуроновые кислоты по п.7, применяемые для получения протеза сосудов, биогибридных органов, заживляющих устройств, офтальмологических и отиатрических композиций, протеза, имплантатов и медицинских устройств.11. Cross-linked hyaluronic acids according to claim 7, used to obtain a vascular prosthesis, biogybrid organs, healing devices, ophthalmic and otiatric compositions, prosthesis, implants and medical devices. 12. Биоматериалы, включающие поперечносшитые гиалуроновые кислоты и их комплексы по пп.1-8.12. Biomaterials, including cross-linked hyaluronic acids and their complexes according to claims 1-8.
RU2001112488/04A 1998-11-11 1999-11-08 Cross-linked hyaluronic acids and their application in medicine RU2230752C2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT1998MI002440A IT1303735B1 (en) 1998-11-11 1998-11-11 CROSS-LINKED HYALURONIC ACIDS AND THEIR MEDICAL USES.
ITMI98A002440 1998-11-11

Publications (2)

Publication Number Publication Date
RU2001112488A true RU2001112488A (en) 2003-08-20
RU2230752C2 RU2230752C2 (en) 2004-06-20

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EP (1) EP1144459B2 (en)
JP (1) JP2002529550A (en)
KR (1) KR100674177B1 (en)
CN (1) CN1131241C (en)
AT (1) ATE225371T1 (en)
AU (1) AU757102B2 (en)
BR (1) BR9915235A (en)
CA (1) CA2350667A1 (en)
CZ (1) CZ296842B6 (en)
DE (1) DE69903351T3 (en)
DK (1) DK1144459T4 (en)
ES (1) ES2184521T5 (en)
HK (1) HK1041011B (en)
HU (1) HU229668B1 (en)
IL (1) IL143063A0 (en)
IT (1) IT1303735B1 (en)
NO (1) NO20012315L (en)
NZ (1) NZ511306A (en)
PT (1) PT1144459E (en)
RU (1) RU2230752C2 (en)
TR (1) TR200101324T2 (en)
WO (1) WO2000027887A2 (en)
ZA (1) ZA200103799B (en)

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