RU2001101529A - COMPOSITION INCLUDING CARNITINE AND GLUTATHION, SUITABLE FOR INCREASING GLUTATHION SUCTION AND ENHANCING ITS EFFECTS - Google Patents
COMPOSITION INCLUDING CARNITINE AND GLUTATHION, SUITABLE FOR INCREASING GLUTATHION SUCTION AND ENHANCING ITS EFFECTSInfo
- Publication number
- RU2001101529A RU2001101529A RU2001101529/14A RU2001101529A RU2001101529A RU 2001101529 A RU2001101529 A RU 2001101529A RU 2001101529/14 A RU2001101529/14 A RU 2001101529/14A RU 2001101529 A RU2001101529 A RU 2001101529A RU 2001101529 A RU2001101529 A RU 2001101529A
- Authority
- RU
- Russia
- Prior art keywords
- carnitine
- glutathione
- composition according
- acid
- pharmaceutically acceptable
- Prior art date
Links
- RWSXRVCMGQZWBV-WDSKDSINSA-N glutathione Chemical compound OC(=O)[C@@H](N)CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O RWSXRVCMGQZWBV-WDSKDSINSA-N 0.000 title claims 33
- 239000000203 mixture Substances 0.000 title claims 23
- 229960003180 glutathione Drugs 0.000 title claims 15
- 229960004203 carnitine Drugs 0.000 title claims 2
- 235000003969 glutathione Nutrition 0.000 title 2
- PHIQHXFUZVPYII-ZCFIWIBFSA-O (R)-carnitinium Chemical compound C[N+](C)(C)C[C@H](O)CC(O)=O PHIQHXFUZVPYII-ZCFIWIBFSA-O 0.000 title 1
- 230000000694 effects Effects 0.000 title 1
- 230000002708 enhancing effect Effects 0.000 title 1
- 108010024636 Glutathione Proteins 0.000 claims 13
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 12
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims 11
- 235000014680 Saccharomyces cerevisiae Nutrition 0.000 claims 11
- 150000003839 salts Chemical class 0.000 claims 9
- UFAHZIUFPNSHSL-MRVPVSSYSA-N O-propanoyl-L-carnitine Chemical compound CCC(=O)O[C@H](CC([O-])=O)C[N+](C)(C)C UFAHZIUFPNSHSL-MRVPVSSYSA-N 0.000 claims 7
- 239000002253 acid Substances 0.000 claims 7
- PHIQHXFUZVPYII-ZCFIWIBFSA-N (R)-carnitine Chemical compound C[N+](C)(C)C[C@H](O)CC([O-])=O PHIQHXFUZVPYII-ZCFIWIBFSA-N 0.000 claims 6
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 claims 6
- 239000004471 Glycine Substances 0.000 claims 6
- XUJNEKJLAYXESH-REOHCLBHSA-N L-Cysteine Chemical compound SC[C@H](N)C(O)=O XUJNEKJLAYXESH-REOHCLBHSA-N 0.000 claims 6
- WHUUTDBJXJRKMK-VKHMYHEASA-N L-glutamic acid Chemical compound OC(=O)[C@@H](N)CCC(O)=O WHUUTDBJXJRKMK-VKHMYHEASA-N 0.000 claims 6
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims 6
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 6
- 235000018417 cysteine Nutrition 0.000 claims 6
- 235000013922 glutamic acid Nutrition 0.000 claims 6
- 239000004220 glutamic acid Substances 0.000 claims 6
- 229910052749 magnesium Inorganic materials 0.000 claims 6
- 239000011777 magnesium Substances 0.000 claims 6
- 229940079593 drug Drugs 0.000 claims 5
- 239000003814 drug Substances 0.000 claims 5
- RDHQFKQIGNGIED-MRVPVSSYSA-N O-acetyl-L-carnitine Chemical compound CC(=O)O[C@H](CC([O-])=O)C[N+](C)(C)C RDHQFKQIGNGIED-MRVPVSSYSA-N 0.000 claims 4
- VZCYOOQTPOCHFL-UHFFFAOYSA-N trans-butenedioic acid Natural products OC(=O)C=CC(O)=O VZCYOOQTPOCHFL-UHFFFAOYSA-N 0.000 claims 4
- 208000029028 brain injury Diseases 0.000 claims 3
- 235000015872 dietary supplement Nutrition 0.000 claims 3
- 230000002526 effect on cardiovascular system Effects 0.000 claims 3
- 208000017169 kidney disease Diseases 0.000 claims 3
- 208000019423 liver disease Diseases 0.000 claims 3
- 230000004060 metabolic process Effects 0.000 claims 3
- 210000000056 organ Anatomy 0.000 claims 3
- 231100000614 poison Toxicity 0.000 claims 3
- 239000003440 toxic substance Substances 0.000 claims 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 claims 2
- VZCYOOQTPOCHFL-OWOJBTEDSA-N Fumaric acid Chemical compound OC(=O)\C=C\C(O)=O VZCYOOQTPOCHFL-OWOJBTEDSA-N 0.000 claims 2
- CKLJMWTZIZZHCS-REOHCLBHSA-N L-aspartic acid Chemical compound OC(=O)[C@@H](N)CC(O)=O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 claims 2
- MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 claims 2
- 229910019142 PO4 Inorganic materials 0.000 claims 2
- 244000253911 Saccharomyces fragilis Species 0.000 claims 2
- 235000018368 Saccharomyces fragilis Nutrition 0.000 claims 2
- QAOWNCQODCNURD-UHFFFAOYSA-L Sulfate Chemical compound [O-]S([O-])(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-L 0.000 claims 2
- 229940009098 aspartate Drugs 0.000 claims 2
- 230000015572 biosynthetic process Effects 0.000 claims 2
- 239000002775 capsule Substances 0.000 claims 2
- 235000013373 food additive Nutrition 0.000 claims 2
- 239000002778 food additive Substances 0.000 claims 2
- 239000008187 granular material Substances 0.000 claims 2
- 239000004615 ingredient Substances 0.000 claims 2
- 239000007937 lozenge Substances 0.000 claims 2
- VZCYOOQTPOCHFL-UPHRSURJSA-N maleic acid Chemical compound OC(=O)\C=C/C(O)=O VZCYOOQTPOCHFL-UPHRSURJSA-N 0.000 claims 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 claims 2
- 239000010452 phosphate Substances 0.000 claims 2
- 239000006187 pill Substances 0.000 claims 2
- 239000002243 precursor Substances 0.000 claims 2
- 230000002265 prevention Effects 0.000 claims 2
- 239000006188 syrup Substances 0.000 claims 2
- 235000020357 syrup Nutrition 0.000 claims 2
- 239000003826 tablet Substances 0.000 claims 2
- 230000001960 triggered effect Effects 0.000 claims 2
- NDVRKEKNSBMTAX-BTVCFUMJSA-N (2r,3s,4r,5r)-2,3,4,5,6-pentahydroxyhexanal;phosphoric acid Chemical compound OP(O)(O)=O.OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](O)C=O NDVRKEKNSBMTAX-BTVCFUMJSA-N 0.000 claims 1
- CPELXLSAUQHCOX-UHFFFAOYSA-M Bromide Chemical compound [Br-] CPELXLSAUQHCOX-UHFFFAOYSA-M 0.000 claims 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 claims 1
- FEWJPZIEWOKRBE-JCYAYHJZSA-N Dextrotartaric acid Chemical compound OC(=O)[C@H](O)[C@@H](O)C(O)=O FEWJPZIEWOKRBE-JCYAYHJZSA-N 0.000 claims 1
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 claims 1
- AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 claims 1
- VSNFQQXVMPSASB-SNVBAGLBSA-N O-valeroyl-L-carnitine Chemical compound CCCCC(=O)O[C@H](CC([O-])=O)C[N+](C)(C)C VSNFQQXVMPSASB-SNVBAGLBSA-N 0.000 claims 1
- DTQVDTLACAAQTR-UHFFFAOYSA-M Trifluoroacetate Chemical compound [O-]C(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-M 0.000 claims 1
- 238000010521 absorption reaction Methods 0.000 claims 1
- -1 alkanoyl L-carnitine Chemical compound 0.000 claims 1
- AWUCVROLDVIAJX-UHFFFAOYSA-N alpha-glycerophosphate Natural products OCC(O)COP(O)(O)=O AWUCVROLDVIAJX-UHFFFAOYSA-N 0.000 claims 1
- 239000003963 antioxidant agent Substances 0.000 claims 1
- 239000005515 coenzyme Substances 0.000 claims 1
- XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 claims 1
- IGQBPDJNUXPEMT-SNVBAGLBSA-N isovaleryl-L-carnitine Chemical compound CC(C)CC(=O)O[C@H](CC([O-])=O)C[N+](C)(C)C IGQBPDJNUXPEMT-SNVBAGLBSA-N 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- PXQPEWDEAKTCGB-UHFFFAOYSA-N orotic acid Chemical compound OC(=O)C1=CC(=O)NC(=O)N1 PXQPEWDEAKTCGB-UHFFFAOYSA-N 0.000 claims 1
- AWUCVROLDVIAJX-GSVOUGTGSA-N sn-glycerol 3-phosphate Chemical compound OC[C@@H](O)COP(O)(O)=O AWUCVROLDVIAJX-GSVOUGTGSA-N 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 239000000829 suppository Substances 0.000 claims 1
- 229940095064 tartrate Drugs 0.000 claims 1
- 229940066528 trichloroacetate Drugs 0.000 claims 1
- YNJBWRMUSHSURL-UHFFFAOYSA-N trichloroacetic acid Chemical compound OC(=O)C(Cl)(Cl)Cl YNJBWRMUSHSURL-UHFFFAOYSA-N 0.000 claims 1
- 239000011782 vitamin Substances 0.000 claims 1
- 229940088594 vitamin Drugs 0.000 claims 1
- 229930003231 vitamin Natural products 0.000 claims 1
- 235000013343 vitamin Nutrition 0.000 claims 1
Claims (22)
(a) пропионил L-карнитин или его фармацевтически приемлемую соль; и
(b) глутатион или глутатион-содержащие дрожжи;
(c) не содержащие глутатион дрожжи, если компонент (b) состоит из глутатиона.1. Combined composition, which includes
(a) propionyl L-carnitine or its pharmaceutically acceptable salt; and
(b) glutathione or glutathione-containing yeast;
(c) Glutathione-free yeast, if component (b) consists of glutathione.
(d) по меньшей мере один из предшественников биосинтеза глутатиона, выбранный из группы, включающей глутаминовую кислоту, глицин, цистеин и магний.6. The composition according to PP. 1-5, which additionally includes
(d) at least one of the precursors of glutathione biosynthesis, selected from the group comprising glutamic acid, glycine, cysteine and magnesium.
(a) пропионил L-карнитин или его фармацевтически приемлемую соль;
(b) глутатион;
(c) не содержащие глутатион дрожжи, выбранные из группы, включающей Saccharomyces cerevisiae и Saccharomyces fragilis;
(d) глутаминовую кислоту, глицин, цистеин и магний.8. The composition according to paragraphs. 1 and 6, which includes
(a) propionyl L-carnitine or its pharmaceutically acceptable salt;
(b) glutathione;
(c) non-glutathione-containing yeast selected from the group comprising Saccharomyces cerevisiae and Saccharomyces fragilis;
(d) glutamic acid, glycine, cysteine and magnesium.
(d) пропионил L-карнитин или его фармацевтически приемлемую соль;
(b) дрожжи, содержащие 7-10 вес. % глутатиона;
(c) глутаминовую кислоту, глицин, цистеин и магний.9. The composition according to paragraphs. 1 and 4-6, which includes
(d) Propionyl L-carnitine or its pharmaceutically acceptable salt;
(b) yeast containing 7-10 wt. % glutathione;
(c) glutamic acid, glycine, cysteine and magnesium.
(a) смесь L-карнитина, ацетил L-карнитина, пропионил L-карнитина или их фармацевтически приемлемых солей;
(b) глутатион;
(c) не содержащие глутатион дрожжи, выбранные из группы, включающей Saccharomyces cerevisiae и Saccharomyces fragilis;
(d) глутаминовую кислоту, глицин, цистеин и магний.10. The composition according to PP. 1 and 3-6, which includes
(a) a mixture of L-carnitine, acetyl L-carnitine, propionyl L-carnitine, or their pharmaceutically acceptable salts;
(b) glutathione;
(c) non-glutathione-containing yeast selected from the group comprising Saccharomyces cerevisiae and Saccharomyces fragilis;
(d) glutamic acid, glycine, cysteine and magnesium.
(а) смесь L-карнитина, ацетил L-карнитина, пропионил L-карнитина или их фармацевтически приемлемых солей;
(b) дрожжи, содержащие 7-10 вес. % глутатиона;
(c) глутаминовую кислоту, глицин, цистеин и магний.11. The composition according to paragraphs. 1 and 3-6, which includes
(a) a mixture of L-carnitine, acetyl L-carnitine, propionyl L-carnitine, or their pharmaceutically acceptable salts;
(b) yeast containing 7-10 wt. % glutathione;
(c) glutamic acid, glycine, cysteine and magnesium.
(a) пропионил L-карнитин или его фармацевтически приемлемую соль;
(b) глутатион или глутатион-содержащие дрожжи,
(c) не содержащие глутатион дрожжи, если компонент (b) состоит из глутатиона;
для изготовления пищевой добавки или лекарственного средства, пригодного для повышения усвоения и тканевых концентраций глутатиона.20. The use of the combined composition, which includes
(a) propionyl L-carnitine or its pharmaceutically acceptable salt;
(b) glutathione or glutathione-containing yeast,
(c) non-glutathione-containing yeast, if component (b) consists of glutathione;
for the manufacture of food supplements or medicines, suitable for increasing the absorption and tissue concentrations of glutathione.
(d) по меньшей мере один из предшественников биосинтеза глутатиона, выбранный из группы, включающей глутаминовую кислоту, глицин, цистеин и магний.21. The use of a composition according to claim 20, wherein the combination further includes
(d) at least one of the precursors of glutathione biosynthesis, selected from the group comprising glutamic acid, glycine, cysteine and magnesium.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ITRM99A000230 | 1999-04-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2001101529A true RU2001101529A (en) | 2002-12-20 |
Family
ID=
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2376984C2 (en) * | 2005-02-21 | 2009-12-27 | Лтс Ломанн Терапи-Зюстеме Аг | Method of combined treatment and combinations of medications applied in it |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2376984C2 (en) * | 2005-02-21 | 2009-12-27 | Лтс Ломанн Терапи-Зюстеме Аг | Method of combined treatment and combinations of medications applied in it |
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