RU2000128647A - INTEGRATED PLATINUM CONNECTION, METHODS FOR PRODUCING THEM, PHARMACEUTICAL COMPOSITION - Google Patents
INTEGRATED PLATINUM CONNECTION, METHODS FOR PRODUCING THEM, PHARMACEUTICAL COMPOSITIONInfo
- Publication number
- RU2000128647A RU2000128647A RU2000128647/04A RU2000128647A RU2000128647A RU 2000128647 A RU2000128647 A RU 2000128647A RU 2000128647/04 A RU2000128647/04 A RU 2000128647/04A RU 2000128647 A RU2000128647 A RU 2000128647A RU 2000128647 A RU2000128647 A RU 2000128647A
- Authority
- RU
- Russia
- Prior art keywords
- carbon atoms
- general formula
- substituted
- optionally
- group
- Prior art date
Links
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 title claims 20
- 229910052697 platinum Inorganic materials 0.000 title claims 10
- 239000008194 pharmaceutical composition Substances 0.000 title claims 2
- 229920000858 Cyclodextrin Polymers 0.000 claims 9
- 125000004432 carbon atom Chemical group C* 0.000 claims 9
- 150000001875 compounds Chemical class 0.000 claims 7
- WHGYBXFWUBPSRW-FOUAGVGXSA-N beta-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO WHGYBXFWUBPSRW-FOUAGVGXSA-N 0.000 claims 5
- 229960004853 betadex Drugs 0.000 claims 5
- GDSRMADSINPKSL-HSEONFRVSA-N gamma-cyclodextrin Chemical compound OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO GDSRMADSINPKSL-HSEONFRVSA-N 0.000 claims 4
- 229940080345 gamma-cyclodextrin Drugs 0.000 claims 4
- 125000000217 alkyl group Chemical group 0.000 claims 3
- 125000001183 hydrocarbyl group Chemical group 0.000 claims 3
- 125000002768 hydroxyalkyl group Chemical group 0.000 claims 3
- 239000000243 solution Substances 0.000 claims 3
- 125000005843 halogen group Chemical group 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 230000003647 oxidation Effects 0.000 claims 2
- 238000007254 oxidation reaction Methods 0.000 claims 2
- -1 3,5-dimethyladamantylamino group Chemical group 0.000 claims 1
- 239000001116 FEMA 4028 Substances 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 150000001412 amines Chemical class 0.000 claims 1
- 239000007864 aqueous solution Substances 0.000 claims 1
- 235000011175 beta-cyclodextrine Nutrition 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 229910052751 metal Inorganic materials 0.000 claims 1
- 239000002184 metal Substances 0.000 claims 1
- 239000003960 organic solvent Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 229940124531 pharmaceutical excipient Drugs 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
- HRGDZIGMBDGFTC-UHFFFAOYSA-N platinum(2+) Chemical compound [Pt+2] HRGDZIGMBDGFTC-UHFFFAOYSA-N 0.000 claims 1
- 239000003495 polar organic solvent Substances 0.000 claims 1
- 150000003141 primary amines Chemical class 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Claims (8)
где Х представляет атом галогена и
А представляет группу -NH2R, где R представляет трициклический углеводородный фрагмент, содержащий 10-14 атомов углерода, которая может быть необязательно замещена в трициклическом кольце одной или двумя алкильной группой(ами) из 1-4 атомов углерода.1. The complex compound of platinum with oxidation state II of the formula I
where X represents a halogen atom and
A represents a —NH 2 R group, where R represents a tricyclic hydrocarbon moiety containing 10-14 carbon atoms, which may optionally be substituted on the tricyclic ring with one or two alkyl group (s) of 1-4 carbon atoms.
где Х представляет атом галогена,
А представляет группу -NH2R, где R представляет трициклический углеводородный фрагмент, содержащий 10-14 атомов углерода, которая может быть необязательно замещена в трициклическом кольце одной или двумя алкильной группой(ами) из 1-4 атомов углерода, с бета- или гамма-циклодекстрином, который может быть необязательно замещен гидроксиалкильной группой из 1-6 атомов углерода.2. The inclusion complex of the platinum complex with the oxidation state II of formula I
where X represents a halogen atom,
A represents a —NH 2 R group, where R represents a tricyclic hydrocarbon moiety containing 10-14 carbon atoms, which may optionally be substituted on the tricyclic ring with one or two alkyl group (s) of 1-4 carbon atoms, with beta or gamma β-cyclodextrin, which may optionally be substituted with a hydroxyalkyl group of 1-6 carbon atoms.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CZ19981627A CZ288406B6 (en) | 1998-05-27 | 1998-05-27 | Platinum complex of oxidation number II, process for preparing such complex, the complex functioning as medicament and pharmaceutical composition in which the complex is comprised |
| CZPV1627-98 | 1998-05-27 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2000128647A true RU2000128647A (en) | 2003-01-20 |
| RU2203901C2 RU2203901C2 (en) | 2003-05-10 |
Family
ID=5463561
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2000128647/04A RU2203901C2 (en) | 1998-05-27 | 1999-05-24 | Platinum complex compounds, methods of their synthesis, pharmaceutical composition |
Country Status (21)
| Country | Link |
|---|---|
| US (1) | US6350737B1 (en) |
| EP (1) | EP1082329B1 (en) |
| JP (1) | JP3647748B2 (en) |
| CN (1) | CN1124278C (en) |
| AU (1) | AU741381B2 (en) |
| BG (1) | BG64598B1 (en) |
| BR (1) | BR9910668A (en) |
| CA (1) | CA2331464C (en) |
| CZ (1) | CZ288406B6 (en) |
| DE (1) | DE69905714T2 (en) |
| ES (1) | ES2194457T3 (en) |
| HR (1) | HRP20000792B1 (en) |
| HU (1) | HU228940B1 (en) |
| IL (1) | IL139528A (en) |
| NO (1) | NO328940B1 (en) |
| PL (1) | PL191131B1 (en) |
| RS (1) | RS49739B (en) |
| RU (1) | RU2203901C2 (en) |
| SK (1) | SK284398B6 (en) |
| UA (1) | UA56314C2 (en) |
| WO (1) | WO1999061450A1 (en) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005102312A1 (en) * | 2004-04-27 | 2005-11-03 | Mayne Pharma Limited | Concentrated oxaliplatin solutions |
| EP2027853A3 (en) | 2004-06-18 | 2011-01-05 | Agennix USA Inc. | Kinase inhibitors for treating cancers |
| JP2008506463A (en) * | 2004-07-14 | 2008-03-06 | ゲーペーツェー ビオテック アーゲー | Variable dose package system |
| CZ2004964A3 (en) * | 2004-09-14 | 2006-03-15 | Pliva-Lachema A. S. | Peroral pharmaceutical composition for targeted transport of platinum complex into colorectal region, process for its preparation and the composition for use as medicament |
| CZ300120B6 (en) * | 2006-06-20 | 2009-02-11 | Pliva - Lachema A. S. | Pharmaceutical composition intended for administration by injection |
| US20120238488A1 (en) | 2009-09-08 | 2012-09-20 | Konstantinos Alevizopoulos | Compounds and methods for treating neoplasia |
| SMT202100639T1 (en) * | 2014-04-04 | 2022-01-10 | Taiho Pharmaceutical Co Ltd | Anti-tumor drug containing anti-tumor platinum complex, and anti-tumor effect enhancer |
| CN104922688A (en) * | 2015-02-10 | 2015-09-23 | 昆明贵研药业有限公司 | Cyclodextrin compound of oxaliplatin and preparation method |
| CN104984356A (en) * | 2015-05-14 | 2015-10-21 | 昆明贵研药业有限公司 | Satraplatin cyclodextrin compound and preparation method |
| RU2613513C2 (en) * | 2015-07-17 | 2017-03-16 | Федеральное государственное бюджетное учреждение науки Институт проблем химической физики Российской академии наук (ИПХФ РАН) | Method for producing platinum complexes (iv) with aminonitroxyle radicals |
| RU2726826C2 (en) * | 2016-12-27 | 2020-07-15 | Общество с ограниченной ответственностью "Плат-АН" (ООО "Плат-АН") | Composition based on amino-nitroxyl complex of platinum and doxorubicin and method of treating tumors |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4329299A (en) * | 1979-08-23 | 1982-05-11 | Johnson, Matthey & Co., Limited | Composition of matter containing platinum |
| ATE73814T1 (en) * | 1986-12-18 | 1992-04-15 | Shionogi & Co | AMMINE-N-HETEROCYCLIC PLATINUM COMPLEXES AND ANTITUMOR AGENTS. |
| US5225207A (en) * | 1989-03-17 | 1993-07-06 | Laboratoire Roger Bellon | Complexes derived from platinum, their preparation and the pharmaceutical compositions which contain them |
| GB9105037D0 (en) * | 1991-03-09 | 1991-04-24 | Johnson Matthey Plc | Improvements in chemical compounds |
-
1998
- 1998-05-27 CZ CZ19981627A patent/CZ288406B6/en not_active IP Right Cessation
-
1999
- 1999-05-24 WO PCT/CZ1999/000014 patent/WO1999061450A1/en not_active Ceased
- 1999-05-24 PL PL344345A patent/PL191131B1/en not_active IP Right Cessation
- 1999-05-24 RS YUP-720/00A patent/RS49739B/en unknown
- 1999-05-24 JP JP2000550854A patent/JP3647748B2/en not_active Expired - Fee Related
- 1999-05-24 DE DE69905714T patent/DE69905714T2/en not_active Expired - Lifetime
- 1999-05-24 IL IL13952899A patent/IL139528A/en not_active IP Right Cessation
- 1999-05-24 ES ES99920540T patent/ES2194457T3/en not_active Expired - Lifetime
- 1999-05-24 SK SK1774-2000A patent/SK284398B6/en not_active IP Right Cessation
- 1999-05-24 HU HU0201762A patent/HU228940B1/en not_active IP Right Cessation
- 1999-05-24 UA UA2000116683A patent/UA56314C2/en unknown
- 1999-05-24 CA CA002331464A patent/CA2331464C/en not_active Expired - Fee Related
- 1999-05-24 CN CN99806647A patent/CN1124278C/en not_active Expired - Fee Related
- 1999-05-24 BR BR9910668-0A patent/BR9910668A/en not_active Application Discontinuation
- 1999-05-24 HR HR20000792A patent/HRP20000792B1/en not_active IP Right Cessation
- 1999-05-24 AU AU38092/99A patent/AU741381B2/en not_active Ceased
- 1999-05-24 US US09/700,513 patent/US6350737B1/en not_active Expired - Fee Related
- 1999-05-24 RU RU2000128647/04A patent/RU2203901C2/en not_active IP Right Cessation
- 1999-05-24 EP EP99920540A patent/EP1082329B1/en not_active Expired - Lifetime
-
2000
- 2000-11-21 BG BG104971A patent/BG64598B1/en unknown
- 2000-11-23 NO NO20005919A patent/NO328940B1/en not_active IP Right Cessation
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