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RU2000126790A - COMPOSITION INTENDED FOR TREATMENT OF ALCOHOL AND MEDICINAL DEPENDENCE CONTAINING OPIOID ANTAGONIST AND MODULATOR OF NMDA RECEPTOR COMPLEX - Google Patents

COMPOSITION INTENDED FOR TREATMENT OF ALCOHOL AND MEDICINAL DEPENDENCE CONTAINING OPIOID ANTAGONIST AND MODULATOR OF NMDA RECEPTOR COMPLEX

Info

Publication number
RU2000126790A
RU2000126790A RU2000126790/14A RU2000126790A RU2000126790A RU 2000126790 A RU2000126790 A RU 2000126790A RU 2000126790/14 A RU2000126790/14 A RU 2000126790/14A RU 2000126790 A RU2000126790 A RU 2000126790A RU 2000126790 A RU2000126790 A RU 2000126790A
Authority
RU
Russia
Prior art keywords
modulator
opioid antagonist
nmda receptor
receptor complex
alcohol
Prior art date
Application number
RU2000126790/14A
Other languages
Russian (ru)
Other versions
RU2226107C2 (en
Inventor
Мартин ДАУСТ
Ив БОНОММ
Филипп ДЮРБЕН
Original Assignee
Лифа
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP98400723A external-priority patent/EP0945133A1/en
Application filed by Лифа filed Critical Лифа
Publication of RU2000126790A publication Critical patent/RU2000126790A/en
Application granted granted Critical
Publication of RU2226107C2 publication Critical patent/RU2226107C2/en

Links

Claims (10)

1. Фармацевтическая композиция для лечения алкогольной и лекарственной зависимости, включающая терапевтически эффективное количество (i) опиоидного антагониста; и (ii) модулятора NMDA рецепторного комплекса.1. A pharmaceutical composition for treating alcohol and drug dependence, comprising a therapeutically effective amount of (i) an opioid antagonist; and (ii) a modulator of the NMDA receptor complex. 2. Фармацевтическая композиция по п. 1, в которой опиоидный антагонист выбирают из налтрексона и налоксона. 2. The pharmaceutical composition according to claim 1, wherein the opioid antagonist is selected from naltrexone and naloxone. 3. Фармацевтическая композиция по п. 1, в которой опиоидный антагонист представляет собой налтрексон. 3. The pharmaceutical composition according to claim 1, wherein the opioid antagonist is naltrexone. 4. Фармацевтическая композиция по п. 1, в которой модулятор NMDA рецепторного комплекса представляет собой модулятор спермидинового сайта. 4. The pharmaceutical composition of claim 1, wherein the NMDA receptor complex modulator is a spermidine site modulator. 5. Фармацевтическая композиция по п. 4, в которой модулятор спермидинового сайта представляет собой акампросат. 5. The pharmaceutical composition according to claim 4, wherein the spermidine site modulator is acamprosate. 6. Фармацевтический набор, включающий: (i) опиоидный антагонист; и (ii) модулятор NMDA рецепторного комплекса. 6. A pharmaceutical kit comprising: (i) an opioid antagonist; and (ii) a modulator of the NMDA receptor complex. 7. Фармацевтический набор по п. 6, в котором опиоидный антагонист выбирают из налтрексона и налоксона. 7. The pharmaceutical kit according to claim 6, in which the opioid antagonist is selected from naltrexone and naloxone. 8. Фармацевтический набор по п. 6, в котором опиоидный антагонист представляет собой налтрексон. 8. The pharmaceutical kit according to claim 6, in which the opioid antagonist is a naltrexone. 9. Фармацевтический набор по п. 6, в котором модулятор NMDA рецепторного комплекса представляет собой модулятор спермидинового сайта. 9. The pharmaceutical kit according to claim 6, wherein the NMDA receptor complex modulator is a spermidine site modulator. 10. Фармацевтический набор по п. 9, в котором модулятор спермидинового сайта представляет собой акампросат. 10. The pharmaceutical kit according to claim 9, wherein the spermidine site modulator is acamprosate.
RU2000126790/15A 1998-03-26 1999-03-26 Composition indicated for treating alcoholic and medicinal addiction and containing opioid antagonist and nmda modulator of receptor complex RU2226107C2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP98400723A EP0945133A1 (en) 1998-03-26 1998-03-26 Combination for the treatment of alcohol and drug dependence containing an opioid antagonist and a NMDA receptor complex modulator
EP98400723.7 1998-03-26

Publications (2)

Publication Number Publication Date
RU2000126790A true RU2000126790A (en) 2002-11-10
RU2226107C2 RU2226107C2 (en) 2004-03-27

Family

ID=8235311

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2000126790/15A RU2226107C2 (en) 1998-03-26 1999-03-26 Composition indicated for treating alcoholic and medicinal addiction and containing opioid antagonist and nmda modulator of receptor complex

Country Status (17)

Country Link
US (1) US6512009B1 (en)
EP (2) EP0945133A1 (en)
KR (1) KR20010034678A (en)
AT (1) ATE230993T1 (en)
AU (1) AU758569B2 (en)
BR (1) BR9909138A (en)
CA (1) CA2325739C (en)
CZ (1) CZ296367B6 (en)
DE (1) DE69904922T2 (en)
DK (1) DK1063995T3 (en)
ES (1) ES2190205T3 (en)
HU (1) HU226555B1 (en)
NO (1) NO319313B1 (en)
PL (1) PL193241B1 (en)
RU (1) RU2226107C2 (en)
SK (1) SK284623B6 (en)
WO (1) WO1999048500A1 (en)

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WO2001052851A1 (en) * 2000-01-22 2001-07-26 Albert Shulman Methods for the treatment of substance abuse
EP1262196A3 (en) * 2001-05-23 2002-12-18 Pfizer Products Inc. Combination of a monoamine reuptake inhibitor and an opioid antagonist for use in alcoholism and alcohol dependence
DE10129265A1 (en) * 2001-06-18 2003-01-02 Hf Arzneimittelforsch Gmbh Active ingredient combination for drug addiction or intoxicant therapy
ES2187288B1 (en) * 2001-09-24 2004-09-16 Garbil Pharma Investigacion Chile Ltda AMINAS AS ANTI-ALCOHOLISM AGENTS.
AU2003240493B2 (en) 2002-05-31 2008-06-12 L. Molteni & C. Dei Fratelli Alitti Societa' Di Esercizio S.P.A. Implantable polymeric device for sustained release of buprenorphine
CN101797221B (en) 2002-12-13 2013-06-12 杜雷科特公司 Oral drug delivery system comprising high viscosity liquid carrier materials
CA2510465A1 (en) * 2002-12-18 2004-07-08 Pain Therapeutics Oral dosage forms with therapeutically active agents in controlled release cores and immediate release gelatin capsule coats
SI1610791T1 (en) 2003-03-31 2011-05-31 Titan Pharmaceuticals Inc Implantable polymeric device for sustained release of dopamine agonist
JP2007502866A (en) * 2003-05-30 2007-02-15 タイタン ファーマシューティカルズ インコーポレイテッド Implantable polymer device for sustained release of nalmefene
US20070099947A1 (en) * 2005-11-03 2007-05-03 Alkermes, Inc. Methods and compositions for the treatment of brain reward system disorders by combination therapy
CA2673481A1 (en) * 2006-12-19 2008-06-26 University Of Virginia Patent Foundation Combined effects of topiramate and ondansetron on alcohol consumption
AU2008335809A1 (en) * 2007-12-06 2009-06-18 Durect Corporation Methods useful for the treatment of pain, arthritic conditions, or inflammation associated with a chronic condition
CA2716498C (en) 2008-02-28 2020-12-22 University Of Virginia Patent Foundation Serotonin transporter gene and treatment of alcoholism
US20100260844A1 (en) 2008-11-03 2010-10-14 Scicinski Jan J Oral pharmaceutical dosage forms
IL278149B2 (en) 2010-07-02 2024-03-01 Univ Virginia Patent Foundation A molecular genetic approach to the treatment and diagnosis of alcohol and drug dependence
WO2013036721A1 (en) 2011-09-09 2013-03-14 University Of Virginia Patent Foundation Molecular genetic approach to treatment and diagnosis of alcohol and drug dependence
RU2476209C1 (en) * 2012-02-29 2013-02-27 Станислав Анатольевич Кедик Implanted drug preparation of naltrexone for treating alcohol- or opioid-dependent patients
WO2014144975A1 (en) 2013-03-15 2014-09-18 Durect Corporation Compositions with a rheological modifier to reduce dissolution variability
GB201308440D0 (en) * 2013-05-10 2013-06-19 Dalgleish Angus Therapeutic
CA3028450A1 (en) 2016-07-06 2018-01-11 Durect Corporation Oral dosage form with drug composition, barrier layer and drug layer
WO2023023038A1 (en) * 2021-08-17 2023-02-23 Yale University Treatment compositions and methods

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US4882335A (en) * 1988-06-13 1989-11-21 Alko Limited Method for treating alcohol-drinking response
EP0828489A4 (en) * 1996-03-13 2001-04-04 Univ Yale TREATMENTS FOR QUITTING SMOKING INVOLVING THE USE OF NALTREXONE AND RELATED COMPOUNDS

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