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RU2000106749A - METHOD FOR SYNTHESIS OF TAXANS - Google Patents

METHOD FOR SYNTHESIS OF TAXANS

Info

Publication number
RU2000106749A
RU2000106749A RU2000106749/04A RU2000106749A RU2000106749A RU 2000106749 A RU2000106749 A RU 2000106749A RU 2000106749/04 A RU2000106749/04 A RU 2000106749/04A RU 2000106749 A RU2000106749 A RU 2000106749A RU 2000106749 A RU2000106749 A RU 2000106749A
Authority
RU
Russia
Prior art keywords
silylating agent
base
compound
taxans
synthesis
Prior art date
Application number
RU2000106749/04A
Other languages
Russian (ru)
Other versions
RU2219161C2 (en
Inventor
Роберт А. Холтон
Тофик ГАРБОИ
Винсент РЕБАУЛ
Original Assignee
Флорида Стейт Юниверсити
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Флорида Стейт Юниверсити filed Critical Флорида Стейт Юниверсити
Publication of RU2000106749A publication Critical patent/RU2000106749A/en
Application granted granted Critical
Publication of RU2219161C2 publication Critical patent/RU2219161C2/en

Links

Claims (6)

1. Способ получения соединения, формулы:
Figure 00000001

отличающийся тем, что включает обработку соединения формул:
Figure 00000002

основанием и силилирующим агентом.1. A method of obtaining a compound of the formula:
Figure 00000001

characterized in that it includes processing a compound of the formulas:
Figure 00000002

base and silylating agent. 2. Способ по п. 1, в котором основание выбирается из группы, состоящей из гидридных и амидных оснований. 2. The method of claim 1, wherein the base is selected from the group consisting of hydride and amide bases. 3. Способ по п. 1, в котором основание выбирается из группы, состоящей из гидрида калия и гексаметилдисилазида калия. 3. The method of claim 1, wherein the base is selected from the group consisting of potassium hydride and potassium hexamethyldisilazide. 4. Способ по п. 1, в котором силилирующим агентом является три(гидрокарбил)силилгалогенид. 4. The method of claim 1, wherein the silylating agent is tri (hydrocarbyl) silyl halide. 5. Способ по п. 1, в котором силилирующим агентом является триалкилсилилгалогенид, а указанные выше алкильные группы содержат от одного до четырех углеродных атомов. 5. The method of claim 1, wherein the silylating agent is a trialkylsilyl halide, and the above alkyl groups contain from one to four carbon atoms. 6. Способ по п. 1, в котором силилирующим агентом является триэтилсилилхлорид. 6. The method of claim 1, wherein the silylating agent is triethylsilyl chloride.
RU2000106749/04A 1997-08-21 1998-08-20 Taxane synthesis method RU2219161C2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US5621097P 1997-08-21 1997-08-21
US60/056,210 1997-08-21

Publications (2)

Publication Number Publication Date
RU2000106749A true RU2000106749A (en) 2002-02-27
RU2219161C2 RU2219161C2 (en) 2003-12-20

Family

ID=22002912

Family Applications (2)

Application Number Title Priority Date Filing Date
RU2000106749/04A RU2219161C2 (en) 1997-08-21 1998-08-20 Taxane synthesis method
RU2003119879/04A RU2003119879A (en) 1997-08-21 2003-07-01 KETONE COMPOUND, INTERMEDIATE COMPOUND AND METHOD FOR PRODUCING THEREOF

Family Applications After (1)

Application Number Title Priority Date Filing Date
RU2003119879/04A RU2003119879A (en) 1997-08-21 2003-07-01 KETONE COMPOUND, INTERMEDIATE COMPOUND AND METHOD FOR PRODUCING THEREOF

Country Status (14)

Country Link
US (3) US6111144A (en)
EP (1) EP1019347B1 (en)
CN (2) CN1150149C (en)
AT (1) ATE234800T1 (en)
AU (1) AU739303B2 (en)
CA (1) CA2302699A1 (en)
DE (1) DE69812395T2 (en)
DK (1) DK1019347T3 (en)
ES (1) ES2195378T3 (en)
NZ (1) NZ503206A (en)
PT (1) PT1019347E (en)
RU (2) RU2219161C2 (en)
WO (1) WO1999008986A1 (en)
ZA (1) ZA987609B (en)

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WO2008118754A2 (en) * 2007-03-23 2008-10-02 Elan Corporation Plc Gamma radiation sterilized nanoparticulate docetaxel compositions and methods for making the same
EP2543793B1 (en) 2011-07-05 2014-02-26 Matthias Sommer Method for producing and laying a floor strip
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