RU170168U1 - PACK FOR EXHAUSTED AIR SAMPLES WITH LONG-TERM STORAGE OF STABLE CARBON GAS CONCENTRATION IN THE SAMPLE - Google Patents

Abstract

The utility model relates to the field of medicine, to packages that are specifically designed for medical purposes, namely to bags for collecting exhaled air samples. The technical result is to increase the tightness of the package and as a consequence of the safety of the concentration of carbon dioxide in the package. The claimed result is achieved by the package for collecting exhaled air samples with long-term stable concentration of carbon dioxide in the sample, including a container with a fitting, the container made in the form of a three-layer package containing an outer layer of polyethylene terephthalate with a thickness of at least 12 microns, an average layer of aluminum foil with a thickness of at least 7 microns, an inner layer of polyethylene, with a thickness of 130 microns to 160 microns.

Description

The technical field to which the utility model relates.

The utility model relates to the field of medicine, to packages that are specifically designed for medical purposes, namely to bags for collecting exhaled air samples.

State of the art

Known packages (http://packnn.ru/catalogue/packs/vacuum, found 07/07/2016), containing in different combinations polyethylene terephthalate, polyethylene, oriented polypropylene, non-oriented (cast) polypropylene, polyamide, oriented polyamide, ethylene copolymer and vinyl alcohol.

The disadvantage of these analogues is the time limitations on the shelf life of exhaled air samples, since the insufficient tightness and safety of the concentration of carbon dioxide in each packet does not allow a long storage of the sample, which affects the quality of the studies after a long period of time.

Utility Model Disclosure

The technical result is to increase the tightness of the package and as a consequence of the safety of the concentration of carbon dioxide in the package. The claimed result is achieved by the package for collecting exhaled air samples with long-term stable concentration of carbon dioxide in the sample, including a container with a fitting, the container made in the form of a three-layer package containing an outer layer of polyethylene terephthalate with a thickness of at least 12 microns, an average layer of aluminum foil with a thickness of at least 7 microns, an inner layer of polyethylene, with a thickness of 130 microns to 160 microns.

According to a utility model, the fitting is made in the form of a nozzle with a cover.

According to a utility model, the cap is sealed to the nozzle by means of a threaded connection.

In addition, in a private embodiment, the fitting can be made with a valve.

Brief Description of the Drawings

The essence of the utility model is illustrated by a scheme for filling bags with exhaled air.

Utility Model Implementation

Bags can be made from a variety of film materials, such as, for example, airtight nylon, moisture resistant polypropylene, foil, LLDPE or durable polyethylene terephthalate (PET). As a rule, bags are made of two-, three- or four-layer laminated films with a thickness of 80-160 microns. Most often, a combination of lavsan or polyamide (the outer layer, convenient for applying flexographic or intaglio printing) with polyethylene of various thicknesses (inner layer, which ensures the stability of the packaging and heat sealability of the seams) is used. To increase the shelf life of the contents of the package, an intermediate 3rd layer of aluminum foil is used, which is a barrier between the environment and the product.

The outer layer of the claimed package PET12 - polyethylene terephthalate (lavsan), a thickness of 12 microns (or micrometer) and more. Polyethylene terephthalate is also intended for printing on a package of inscriptions and drawings.

The middle layer of the claimed Al7 package is aluminum foil, thickness 7 μm (or micrometer) and more. Aluminum foil is designed to preserve the concentration of carbon dioxide in the air sample.

The inner layer of the claimed package PE130 (up to 160) is polyethylene, a thickness of 130-160 microns (or micrometer). Polyethylene is designed to preserve the concentration of carbon dioxide in air samples, as well as for tightly gluing packages and tightly gluing the fitting. Together the formula: PET12 + Al7 + PE130 (up to 160).

Studies were conducted comparing the claimed package PET12 + Al7 + PE130 (up to 160) with a three-layer package, but with a smaller thickness of the inner layer of polyethylene (70 μm) with the formula PET12 + Al7 + PE70 and with a two-layer package without a layer of aluminum foil, but with a similar the inner layer of polyethylene (130 microns) with the formula PET12 + PE130. All packages were the same size (110 × 180 mm).

We studied 4 samples with each type of packet on the following days after taking exhaled air samples: 0, 1, 5, 6, 7, 11, 14 (the concentration of carbon dioxide in exhaled air is 4-4.5%).

The use of the KHELIKARB test kit involves taking samples of exhaled air by the patient before and after taking the diagnostic drug in special bags and subsequent isotope analysis of carbon, which is part of the carbon dioxide of the exhaled air on a specialized analyzer-analyzer of carbon isotopic ratio. Moreover, for various reasons, sampling and conducting their isotope analysis can be carried out with some time delay. Temporary restrictions on the shelf life of exhaled air samples are caused by a decrease in carbon dioxide content in the samples due to sorption on the surface of the materials used, as well as possible leakage of the seams of the bags or materials from which the bags are made.

The claimed package for collecting samples of exhaled air with a long-term stable concentration of carbon dioxide in the sample, ensures its tightness and the safety of the concentration of carbon dioxide at 4% for at least 14 days.

1. PREPARATION FOR TESTS

A scheme has been compiled for filling bags with exhaled air, of constant composition, namely: a “base” container with air for filling a series of bags 1; test packet 2; valve 3.

The carbon isotope ratio and carbon dioxide content in the samples were measured using an NSVT-01 infrared analyzer (Headway, China).

2. TESTING.

Before filling each row of bags with exhaled air, a “basic” 4 liter container was filled.

To fill the test packets, each of which has a volume of 200 ml, these packets were alternately connected via a valve to the “base” container. Packets were filled by displacing air from the “base” container into bags. After filling, the bags were closed with a standard lid.

After filling, the test bags were marked and sent for storage under normal conditions, taking into account measures to prevent mixing of packages belonging to different rows.

The carbon isotope ratio and carbon dioxide content in the packets were measured on an NSVT-01 IR analyzer immediately after filling and after 1, 5, 6, 7, 11, and 14 days after filling.

To take measurements, each time four packets were randomly selected from each series.

The results are listed in the table.

All values are rounded to the nearest tenth of a percent.

Thus, as a result of the tests, it was found that the claimed package up to 14 days retains the required concentration of carbon dioxide in the sample, in contrast to these analogues.

Claims (3)

1. A bag for collecting exhaled air samples with long-term stable concentration of carbon dioxide in the sample, including a container with a fitting, characterized in that the container is made in the form of a three-layer package containing an outer layer of polyethylene terephthalate with a thickness of at least 12 μm, the middle layer of aluminum foil with a thickness of at least 7 microns, an inner layer of polyethylene with a thickness of 130 microns to 160 microns. 2. A bag for collecting samples of exhaled air with a long-term stable concentration of carbon dioxide in the sample according to claim 1, characterized in that the fitting is made in the form of a nozzle with a cap. 3. A bag for collecting exhaled air samples with a long-term stable concentration of carbon dioxide in the sample according to claim 2, characterized in that the lid is sealed to the pipe by means of a threaded connection.

Images