RO98498B1 - Process for preparing propylene circular dihydripiridine-5-phosphoric acid esters derivatives - Google Patents
Process for preparing propylene circular dihydripiridine-5-phosphoric acid esters derivativesInfo
- Publication number
- RO98498B1 RO98498B1 RO129352A RO12935287A RO98498B1 RO 98498 B1 RO98498 B1 RO 98498B1 RO 129352 A RO129352 A RO 129352A RO 12935287 A RO12935287 A RO 12935287A RO 98498 B1 RO98498 B1 RO 98498B1
- Authority
- RO
- Romania
- Prior art keywords
- radical
- compound
- radicals
- acid esters
- carbon atoms
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title 1
- QQONPFPTGQHPMA-UHFFFAOYSA-N propylene Natural products CC=C QQONPFPTGQHPMA-UHFFFAOYSA-N 0.000 title 1
- 125000004805 propylene group Chemical group [H]C([H])([H])C([H])([*:1])C([H])([H])[*:2] 0.000 title 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 3
- 229910052801 chlorine Inorganic materials 0.000 abstract 3
- 239000000460 chlorine Substances 0.000 abstract 3
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 2
- 125000001309 chloro group Chemical group Cl* 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 229910052739 hydrogen Inorganic materials 0.000 abstract 2
- 239000001257 hydrogen Substances 0.000 abstract 2
- HTSGKJQDMSTCGS-UHFFFAOYSA-N 1,4-bis(4-chlorophenyl)-2-(4-methylphenyl)sulfonylbutane-1,4-dione Chemical compound C1=CC(C)=CC=C1S(=O)(=O)C(C(=O)C=1C=CC(Cl)=CC=1)CC(=O)C1=CC=C(Cl)C=C1 HTSGKJQDMSTCGS-UHFFFAOYSA-N 0.000 abstract 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical group FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- CIUQDSCDWFSTQR-UHFFFAOYSA-N [C]1=CC=CC=C1 Chemical compound [C]1=CC=CC=C1 CIUQDSCDWFSTQR-UHFFFAOYSA-N 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- -1 chloro, difluoromethoxy Chemical group 0.000 abstract 1
- NLFBCYMMUAKCPC-KQQUZDAGSA-N ethyl (e)-3-[3-amino-2-cyano-1-[(e)-3-ethoxy-3-oxoprop-1-enyl]sulfanyl-3-oxoprop-1-enyl]sulfanylprop-2-enoate Chemical compound CCOC(=O)\C=C\SC(=C(C#N)C(N)=O)S\C=C\C(=O)OCC NLFBCYMMUAKCPC-KQQUZDAGSA-N 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 239000011737 fluorine Chemical group 0.000 abstract 1
- 125000001153 fluoro group Chemical group F* 0.000 abstract 1
- 239000012442 inert solvent Substances 0.000 abstract 1
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Abstract
Inventia de fata se refera la un procedeu de obtinere a derivatilor de esteri propilenici ciclici ai acidului dihidropiridinic-5-fosfonic, cu formula generala I: (vezi descriere), în care R1, R2, R3, R4, R5, R6, x1 si x2 pot fi identici sau diferiti si reprezinta hidrogen sau un radical alchil cu 1...4 atomi de carbon, unul din radicalii x1 si x2 reprezinta nitro, fluor, clor, difluormetoxi sau trifluormetil si celalalt radical hidrogen sau ambii radicali x1 si x2 reprezinta clor si y reprezinta radicalul: (vezi descriere), în care A este un radical alchilen cu 2...6 atomi de carbon, fiecare, din radicalii Ar1 si Ar2 sunt identici sau diferiti si reprezinta un radical fenil care poate fi substituit cu clor, fluor sau alcoxi cu 1...3 atomi de carbon si m este un numar întreg cuprins între 0 si 4 sau y reprezinta radicalul: (vezi descriere), în care A, Ar1 si Ar2 au semnificatiile de mai sus când ambii radicali x1 si x2, reprezinta clor, se supune reactiei un compus cu formula generala II: (vezi descriere), în care radicalii R1, R2, R3, R4, R5, R6, x1 si x2 au semnificatiile de mai sus, cu un compus cu formula generala III: (vezi descriere), în care Y are semnificatiile de mai sus, în mediu de solvent inert, la o temperatura cuprinsa între temperatura camerei si 200 degree C, la un raport molar compus III/compus II, 0,5...2,0.The present invention relates to a process for the preparation of dihydropyridine-5-phosphonic acid esters of cyclic propylene esters of the general formula I: (see description) wherein R1, R2, R3, R4, R5, R6, x1 and x2 may be the same or different and represent hydrogen or an alkyl radical of 1-4 carbon atoms, one of the radicals x1 and x2 represents nitro, fluoro, chloro, difluoromethoxy or trifluoromethyl and the other radical hydrogen or both radicals x1 and x2 represent chlorine and y represents the radical: wherein A is an alkylene radical of 2 to 6 carbon atoms, each of the radicals Ar1 and Ar2 being the same or different and represents a phenyl radical which may be substituted by chlorine , fluorine or alkoxy of 1 to 3 carbon atoms and m is an integer ranging from 0 to 4 or y represents the radical: wherein A, Ar 1 and Ar 2 are as defined above when both x 1 and x2 represents chlorine, a compound of formula (I) is reacted wherein R 1, R 2, R 3, R 4, R 5, R 6, x 1 and x 2 are as defined above, with a compound of the general formula III: wherein Y has the meanings above, in an inert solvent medium, at a temperature comprised between room temperature and 200 ° C, at a compound III / compound II molar ratio of 0.5 ... 2.0.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RO129352A RO98498B1 (en) | 1987-08-06 | 1987-08-06 | Process for preparing propylene circular dihydripiridine-5-phosphoric acid esters derivatives |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| RO129352A RO98498B1 (en) | 1987-08-06 | 1987-08-06 | Process for preparing propylene circular dihydripiridine-5-phosphoric acid esters derivatives |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RO98498B1 true RO98498B1 (en) | 1990-03-30 |
Family
ID=40906597
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RO129352A RO98498B1 (en) | 1987-08-06 | 1987-08-06 | Process for preparing propylene circular dihydripiridine-5-phosphoric acid esters derivatives |
Country Status (1)
| Country | Link |
|---|---|
| RO (1) | RO98498B1 (en) |
-
1987
- 1987-08-06 RO RO129352A patent/RO98498B1/en unknown
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