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RO82519B1 - Process for preparing some macrolid antibiotics - Google Patents

Process for preparing some macrolid antibiotics

Info

Publication number
RO82519B1
RO82519B1 RO105755A RO10575581A RO82519B1 RO 82519 B1 RO82519 B1 RO 82519B1 RO 105755 A RO105755 A RO 105755A RO 10575581 A RO10575581 A RO 10575581A RO 82519 B1 RO82519 B1 RO 82519B1
Authority
RO
Romania
Prior art keywords
sources selected
salts
preparing
submersible
dextrin
Prior art date
Application number
RO105755A
Other languages
Romanian (ro)
Inventor
Henry Baltz Richard
Andrew Kirst Herbert
Muriel Wild Gene
Thomas Seno Eugene
Original Assignee
Eli Lilly And Co.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Eli Lilly And Co. filed Critical Eli Lilly And Co.
Priority to RO105755A priority Critical patent/RO82519B1/en
Publication of RO82519B1 publication Critical patent/RO82519B1/en

Links

Classifications

    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A40/00—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production
    • Y02A40/80—Adaptation technologies in agriculture, forestry, livestock or agroalimentary production in fisheries management

Landscapes

  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Saccharide Compounds (AREA)

Abstract

Inventia se refera la un procedeu de preparare a unor antibiotice macrolide cu formula generala I: (vezi formula) si care consta în aceea ca microorganismul Streptomyces fradiae ATCC 31733 se cultiva pe un mediu de cultura continînd surse asimilabile de carbon alese dintre dextrina, glucoza, amidon, surse de azot alese dintre aminoacizi, faina de peste, uleiuri nutritive ca ulei de soia, saruri anorganice nutritive, în conditii de fermentatie aeroba submersibila, la temperaturi între 10 si 40 degree C, de preferinta 28 degree C, la pH=7,2, pîna la obtinerea unei cantitati substantiale de produs dupa care antibioticul se izoleaza dupa metode în sine cunoscute si daca se doreste se trece sub forma de esteri sau saruri prin procedee cunoscute.The invention relates to a process for the preparation of macrolide antibiotics of the general formula I (see formula) which consists in that the microorganism Streptomyces fradiae ATCC 31733 is cultured on a culture medium containing assimilable carbon sources selected from dextrin, glucose, starch, nitrogen sources selected from amino acids, fish flour, nutritive oils such as soybean oil, inorganic salts, under conditions of submersible aerobic fermentation, at temperatures between 10 and 40 ° C, preferably 28 ° C, at pH = 7 , 2, until a substantial amount of product is obtained after which the antibiotic is isolated according to methods known per se and, if desired, is converted into the esters or salts by known methods.

RO105755A 1981-11-09 1981-11-09 Process for preparing some macrolid antibiotics RO82519B1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
RO105755A RO82519B1 (en) 1981-11-09 1981-11-09 Process for preparing some macrolid antibiotics

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
RO105755A RO82519B1 (en) 1981-11-09 1981-11-09 Process for preparing some macrolid antibiotics

Publications (1)

Publication Number Publication Date
RO82519B1 true RO82519B1 (en) 1983-08-30

Family

ID=40903287

Family Applications (1)

Application Number Title Priority Date Filing Date
RO105755A RO82519B1 (en) 1981-11-09 1981-11-09 Process for preparing some macrolid antibiotics

Country Status (1)

Country Link
RO (1) RO82519B1 (en)

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