PT973546E - Formulacoes estabilizadas de virus de papiloma humano - Google Patents
Formulacoes estabilizadas de virus de papiloma humanoInfo
- Publication number
- PT973546E PT973546E PT98915319T PT98915319T PT973546E PT 973546 E PT973546 E PT 973546E PT 98915319 T PT98915319 T PT 98915319T PT 98915319 T PT98915319 T PT 98915319T PT 973546 E PT973546 E PT 973546E
- Authority
- PT
- Portugal
- Prior art keywords
- stabilized formulations
- papiloma virus
- human papiloma
- formulations
- human
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 3
- 241000700605 Viruses Species 0.000 title 1
- 241000701806 Human papillomavirus Species 0.000 abstract 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 abstract 2
- 238000009472 formulation Methods 0.000 abstract 2
- 239000000427 antigen Substances 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 239000007864 aqueous solution Substances 0.000 abstract 1
- 239000002736 nonionic surfactant Substances 0.000 abstract 1
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 abstract 1
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 abstract 1
- 229920000136 polysorbate Polymers 0.000 abstract 1
- 229920000053 polysorbate 80 Polymers 0.000 abstract 1
- 229940068968 polysorbate 80 Drugs 0.000 abstract 1
- 230000002035 prolonged effect Effects 0.000 abstract 1
- 230000004845 protein aggregation Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000011780 sodium chloride Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5258—Virus-like particles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55511—Organic adjuvants
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/20011—Papillomaviridae
- C12N2710/20022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/20011—Papillomaviridae
- C12N2710/20023—Virus like particles [VLP]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/20011—Papillomaviridae
- C12N2710/20034—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Virology (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Microbiology (AREA)
- Genetics & Genomics (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Epidemiology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Mycology (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- General Engineering & Computer Science (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Biophysics (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Plant Substances (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4280897P | 1997-04-08 | 1997-04-08 | |
| GBGB9709351.2A GB9709351D0 (en) | 1997-05-07 | 1997-05-07 | Stabilized human papillomavirus formulations |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT973546E true PT973546E (pt) | 2004-06-30 |
Family
ID=26311501
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT98915319T PT973546E (pt) | 1997-04-08 | 1998-04-07 | Formulacoes estabilizadas de virus de papiloma humano |
Country Status (18)
| Country | Link |
|---|---|
| EP (1) | EP0973546B1 (pt) |
| JP (1) | JP4598201B2 (pt) |
| KR (1) | KR20010006169A (pt) |
| CN (1) | CN1259051A (pt) |
| AT (1) | ATE261734T1 (pt) |
| AU (1) | AU739829B2 (pt) |
| CA (1) | CA2286294A1 (pt) |
| DE (1) | DE69822452T2 (pt) |
| DK (1) | DK0973546T3 (pt) |
| EE (1) | EE9900612A (pt) |
| ES (1) | ES2216280T3 (pt) |
| IL (1) | IL132201A0 (pt) |
| NO (1) | NO994879L (pt) |
| NZ (1) | NZ500028A (pt) |
| PL (1) | PL336715A1 (pt) |
| PT (1) | PT973546E (pt) |
| SK (1) | SK138199A3 (pt) |
| WO (1) | WO1998044944A2 (pt) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AUPP765398A0 (en) | 1998-12-11 | 1999-01-14 | University Of Queensland, The | Treatment of papillomavirus infections |
| ES2313881T3 (es) * | 1999-02-05 | 2009-03-16 | MERCK & CO., INC. | Formulaciones de vacunas frente al papilomavirus humano. |
| US6245568B1 (en) * | 1999-03-26 | 2001-06-12 | Merck & Co., Inc. | Human papilloma virus vaccine with disassembled and reassembled virus-like particles |
| DE10137102A1 (de) | 2001-07-30 | 2003-02-27 | Deutsches Krebsforsch | Polyvalente Vakzine gegen durch Papillomaviren verursachte Erkrankungen, Verfahren zu deren Herstellung und deren Verwendung |
| GB0206360D0 (en) | 2002-03-18 | 2002-05-01 | Glaxosmithkline Biolog Sa | Viral antigens |
| TW200806315A (en) * | 2006-04-26 | 2008-02-01 | Wyeth Corp | Novel formulations which stabilize and inhibit precipitation of immunogenic compositions |
| DK2066354T3 (da) | 2006-09-29 | 2013-05-27 | Ligocyte Pharmaceuticals Inc | Norovirus vaccine formuleringer |
| CN104740624B (zh) | 2007-09-18 | 2018-04-24 | 武田疫苗股份有限公司 | 赋予针对诺如病毒的保护性免疫应答的疫苗 |
| WO2009092113A2 (en) * | 2008-01-19 | 2009-07-23 | Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Methods and compositions for the delivery of vaccines to disrupted epithelium |
| CN103249431B (zh) * | 2010-12-14 | 2016-11-02 | 葛兰素史密丝克莱恩生物有限公司 | 分枝杆菌抗原组合物 |
| CN102085354A (zh) * | 2010-12-30 | 2011-06-08 | 重庆大学 | 一种治疗人乳头瘤病毒16型引发的肿瘤的多肽药物 |
| MY170746A (en) | 2011-07-11 | 2019-08-27 | Takeda Vaccines Inc | Parenteral norovirus vaccine formulations |
| CN105177025B (zh) * | 2013-12-03 | 2022-11-01 | 北京康乐卫士生物技术股份有限公司 | 18型重组人乳头瘤病毒病毒样颗粒及其制备方法 |
| WO2016038625A2 (en) * | 2014-09-11 | 2016-03-17 | Cadila Healthcare Limited | Superior human papilloma virus antigens with superior immunological properties and vaccine containing it |
| CN106701797B (zh) * | 2015-08-12 | 2021-06-15 | 北京康乐卫士生物技术股份有限公司 | 31型重组人乳头瘤病毒病毒样颗粒及其制备方法 |
| CN106399329B (zh) * | 2015-08-12 | 2021-06-11 | 北京康乐卫士生物技术股份有限公司 | 33型重组人乳头瘤病毒病毒样颗粒及其制备方法 |
| CN108201623A (zh) * | 2016-12-19 | 2018-06-26 | 无锡鑫连鑫生物医药科技有限公司 | 人乳头瘤病毒重组四价疫苗、其制备方法及其应用 |
| CN113347987A (zh) * | 2018-11-28 | 2021-09-03 | 总医院公司 | 针对共生病毒的t细胞导向的抗癌疫苗 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2949031A1 (de) * | 1978-12-15 | 1980-07-17 | Sandoz Ag | Vakzine |
| US4606918A (en) * | 1983-08-22 | 1986-08-19 | Syntex (U.S.A.) Inc. | Polyoxypropylene-polyoxyethylene block polymer based adjuvants |
| JPS63239234A (ja) * | 1988-01-14 | 1988-10-05 | Green Cross Corp:The | ワクチン製剤 |
| JPH085803B2 (ja) * | 1988-11-10 | 1996-01-24 | 武田薬品工業株式会社 | 日本脳炎ワクチンの製造法 |
| US5904925A (en) * | 1993-12-09 | 1999-05-18 | Exner; Heinrich | Adjuvant for antigens, and process for making |
| AUPM566794A0 (en) * | 1994-05-17 | 1994-06-09 | University Of Queensland, The | Process and product |
| AR004464A1 (es) * | 1994-11-14 | 1998-12-16 | Merck Sharp & Dohme | Un metodo para producir una proteina de capside de papilomavirus |
| IL117459A (en) * | 1995-03-22 | 2005-11-20 | Merck & Co Inc | Dna encoding human papillomavirus type 18 |
| IL117591A0 (en) * | 1995-03-30 | 1996-07-23 | Merck & Co Inc | Synthetic DNA encoding human papillomavirus type 11 L1 protein |
| US5718904A (en) * | 1995-06-02 | 1998-02-17 | American Home Products Corporation | Adjuvants for viral vaccines |
-
1998
- 1998-04-07 CN CN98805728A patent/CN1259051A/zh active Pending
- 1998-04-07 NZ NZ500028A patent/NZ500028A/en unknown
- 1998-04-07 ES ES98915319T patent/ES2216280T3/es not_active Expired - Lifetime
- 1998-04-07 AU AU69533/98A patent/AU739829B2/en not_active Ceased
- 1998-04-07 SK SK1381-99A patent/SK138199A3/sk unknown
- 1998-04-07 EP EP98915319A patent/EP0973546B1/en not_active Expired - Lifetime
- 1998-04-07 PT PT98915319T patent/PT973546E/pt unknown
- 1998-04-07 IL IL13220198A patent/IL132201A0/xx unknown
- 1998-04-07 PL PL98336715A patent/PL336715A1/xx unknown
- 1998-04-07 DE DE69822452T patent/DE69822452T2/de not_active Expired - Lifetime
- 1998-04-07 WO PCT/US1998/006825 patent/WO1998044944A2/en not_active Ceased
- 1998-04-07 DK DK98915319T patent/DK0973546T3/da active
- 1998-04-07 CA CA002286294A patent/CA2286294A1/en not_active Abandoned
- 1998-04-07 EE EEP199900612A patent/EE9900612A/xx unknown
- 1998-04-07 KR KR1019997009248A patent/KR20010006169A/ko not_active Withdrawn
- 1998-04-07 AT AT98915319T patent/ATE261734T1/de not_active IP Right Cessation
- 1998-04-07 JP JP54301498A patent/JP4598201B2/ja not_active Expired - Fee Related
-
1999
- 1999-10-07 NO NO994879A patent/NO994879L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| JP4598201B2 (ja) | 2010-12-15 |
| IL132201A0 (en) | 2001-03-19 |
| ES2216280T3 (es) | 2004-10-16 |
| NZ500028A (en) | 2001-08-31 |
| WO1998044944A2 (en) | 1998-10-15 |
| NO994879L (no) | 1999-12-07 |
| ATE261734T1 (de) | 2004-04-15 |
| EE9900612A (et) | 2000-08-15 |
| SK138199A3 (en) | 2000-06-12 |
| PL336715A1 (en) | 2000-07-03 |
| AU739829B2 (en) | 2001-10-18 |
| DE69822452T2 (de) | 2006-04-20 |
| EP0973546B1 (en) | 2004-03-17 |
| CA2286294A1 (en) | 1998-10-15 |
| KR20010006169A (ko) | 2001-01-26 |
| DE69822452D1 (de) | 2004-04-22 |
| JP2001519814A (ja) | 2001-10-23 |
| AU6953398A (en) | 1998-10-30 |
| NO994879D0 (no) | 1999-10-07 |
| EP0973546A2 (en) | 2000-01-26 |
| DK0973546T3 (da) | 2004-06-28 |
| WO1998044944A3 (en) | 1998-12-30 |
| CN1259051A (zh) | 2000-07-05 |
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