PT946507E - Compostos de pirrolilo substituidos para o tratamento da inflamacao - Google Patents
Compostos de pirrolilo substituidos para o tratamento da inflamacaoInfo
- Publication number
- PT946507E PT946507E PT97950891T PT97950891T PT946507E PT 946507 E PT946507 E PT 946507E PT 97950891 T PT97950891 T PT 97950891T PT 97950891 T PT97950891 T PT 97950891T PT 946507 E PT946507 E PT 946507E
- Authority
- PT
- Portugal
- Prior art keywords
- inflammation
- compounds
- pyrrolylic
- substituted
- treatment
- Prior art date
Links
- 206010061218 Inflammation Diseases 0.000 title abstract 3
- 230000004054 inflammatory process Effects 0.000 title abstract 3
- 150000001875 compounds Chemical class 0.000 title abstract 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 125000000168 pyrrolyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/333—Radicals substituted by oxygen or sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D207/337—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
- C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US3268896P | 1996-12-10 | 1996-12-10 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT946507E true PT946507E (pt) | 2004-02-27 |
Family
ID=21866300
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT97950891T PT946507E (pt) | 1996-12-10 | 1997-12-09 | Compostos de pirrolilo substituidos para o tratamento da inflamacao |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US5935990A (pt) |
| EP (1) | EP0946507B1 (pt) |
| AT (1) | ATE250576T1 (pt) |
| AU (1) | AU5377698A (pt) |
| CA (1) | CA2273836A1 (pt) |
| DE (1) | DE69725171T2 (pt) |
| DK (1) | DK0946507T3 (pt) |
| ES (1) | ES2208964T3 (pt) |
| PT (1) | PT946507E (pt) |
| WO (1) | WO1998025896A1 (pt) |
Families Citing this family (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0889032A4 (en) * | 1996-03-18 | 2000-01-05 | Eisai Co Ltd | CARBOXYLIC ACID DERIVATIVES WITH FUSED CYCLES |
| US5908858A (en) | 1996-04-05 | 1999-06-01 | Sankyo Company, Limited | 1,2-diphenylpyrrole derivatives, their preparation and their therapeutic uses |
| US6887893B1 (en) | 1997-12-24 | 2005-05-03 | Sankyo Company, Limited | Methods and compositions for treatment and prevention of tumors, tumor-related disorders and cachexia |
| US6858598B1 (en) | 1998-12-23 | 2005-02-22 | G. D. Searle & Co. | Method of using a matrix metalloproteinase inhibitor and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia |
| US6833373B1 (en) | 1998-12-23 | 2004-12-21 | G.D. Searle & Co. | Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia |
| US6649645B1 (en) | 1998-12-23 | 2003-11-18 | Pharmacia Corporation | Combination therapy of radiation and a COX-2 inhibitor for treatment of neoplasia |
| DE19953025A1 (de) | 1999-11-04 | 2001-05-10 | Merck Patent Gmbh | Pyrrolderivate als Phosphodiesterase VII-Hemmer |
| EP1175214B1 (en) * | 1999-12-08 | 2004-11-24 | Pharmacia Corporation | Cyclooxygenase-2 inhibitor compositions having rapid onset of therapeutic effect |
| IL150368A0 (en) * | 1999-12-23 | 2002-12-01 | Nitromed Inc | Nitrosated and nitrosylated cyclooxygenase-2-inhibitors, compositions and methods of use |
| DE19963174A1 (de) * | 1999-12-27 | 2001-07-12 | Gruenenthal Gmbh | Substituierte Pyrrol-Mannichbasen |
| EP1253921A4 (en) | 2000-01-28 | 2004-10-13 | Merck & Co Inc | TREATMENT AND PROPHYLAXIS OF PROSTATE CANCER WITH COX-2 SELECTIVE INHIBITORS |
| JP2003531201A (ja) * | 2000-04-25 | 2003-10-21 | ファルマシア・コーポレーション | 炎症を治療するための２−フルオロベンゼンスルホニル化合物 |
| JP2004503601A (ja) * | 2000-07-13 | 2004-02-05 | ファルマシア・コーポレーション | 眼のｃｏｘ−２媒介疾患の処置及び予防におけるｃｏｘ−２阻害剤の使用法 |
| US7115565B2 (en) * | 2001-01-18 | 2006-10-03 | Pharmacia & Upjohn Company | Chemotherapeutic microemulsion compositions of paclitaxel with improved oral bioavailability |
| PE20021017A1 (es) | 2001-04-03 | 2002-11-24 | Pharmacia Corp | Composicion parenteral reconstituible |
| US6673818B2 (en) * | 2001-04-20 | 2004-01-06 | Pharmacia Corporation | Fluoro-substituted benzenesulfonyl compounds for the treatment of inflammation |
| UA80682C2 (en) * | 2001-08-06 | 2007-10-25 | Pharmacia Corp | Orally deliverable stabilized oral suspension formulation and process for the incresaing physical stability of thixotropic pharmaceutical composition |
| AR038957A1 (es) | 2001-08-15 | 2005-02-02 | Pharmacia Corp | Terapia de combinacion para el tratamiento del cancer |
| US7232821B2 (en) | 2002-04-08 | 2007-06-19 | Glaxo Group Limited | (2-((2-alkoxy)-phenyl) -cyclopent-1enyl) aromatic carbo and heterocyclic acid and derivatives |
| US7622117B2 (en) * | 2002-04-17 | 2009-11-24 | Dynamis Therapeutics, Inc. | 3-deoxyglucosone and skin |
| GB0212785D0 (en) * | 2002-05-31 | 2002-07-10 | Glaxo Group Ltd | Compounds |
| JP4601274B2 (ja) * | 2002-08-20 | 2010-12-22 | 第一三共株式会社 | γ−ケトアセタール類の製造方法 |
| WO2004018446A1 (ja) | 2002-08-20 | 2004-03-04 | Sankyo Company, Limited | γ-ケトアセタール類の製造方法 |
| GB0225548D0 (en) | 2002-11-01 | 2002-12-11 | Glaxo Group Ltd | Compounds |
| EP1560488B1 (en) | 2002-11-05 | 2010-09-01 | Glaxo Group Limited | Antibacterial agents |
| DE10261130A1 (de) * | 2002-12-20 | 2004-07-01 | Grünenthal GmbH | Arzneimittel enthaltend substituierte 2,5-Diaminomethyl-1H-pyrrole |
| PL2266585T3 (pl) * | 2003-05-07 | 2013-10-31 | Osteologix As | Rozpuszczalne w wodzie sole stronktu do stosowania w leczeniu chorób chrząstki i/lub kości |
| EP2266584B1 (en) * | 2003-05-07 | 2012-09-05 | Osteologix A/S | Composition with strontium and vitamin D for the prophylaxis and/or treatment of cartilage and/or bone conditions |
| US20050131028A1 (en) * | 2003-09-11 | 2005-06-16 | Pharmacia Corporation | Methods and compositions for the extended duration treatment of pain, inflammation and inflammation-related disorders |
| US7442805B2 (en) | 2003-09-25 | 2008-10-28 | Wyeth | Substituted sulfonamide-indoles |
| US7332521B2 (en) | 2003-09-25 | 2008-02-19 | Wyeth | Substituted indoles |
| US7268159B2 (en) | 2003-09-25 | 2007-09-11 | Wyeth | Substituted indoles |
| US7265148B2 (en) | 2003-09-25 | 2007-09-04 | Wyeth | Substituted pyrrole-indoles |
| GB0328024D0 (en) * | 2003-12-03 | 2004-01-07 | Glaxo Group Ltd | Compounds |
| MX2007008227A (es) * | 2005-01-05 | 2007-09-11 | Novacea Inc | Prevencion de trastornos tromboticos con compuestos de vitamina d activa o mimeticos de los mismos. |
| FR2887548B1 (fr) * | 2005-06-27 | 2007-09-21 | Sanofi Aventis Sa | Derives de 4,5-diarylpyrrole, leur preparation et leur application en therapeutique |
| WO2007038684A2 (en) * | 2005-09-27 | 2007-04-05 | Myriad Genetics, Inc. | Pyrrole derivatives as therapeutic compounds |
| BRPI0520806A2 (pt) * | 2005-12-27 | 2009-06-09 | Ct Nac De Investigaciones Oncologicas | derivados pirrólicos, processos para a preparação de compostos, seu uso e composição farmacêutica que os contém |
| EP2038278A2 (en) * | 2006-06-27 | 2009-03-25 | Abbott Laboratories | Thiazoline and oxazoline derivatives and their methods of use |
| US7906551B2 (en) | 2006-08-03 | 2011-03-15 | Rottapharm S.P.A. | 3-substituted-1,5-diarly-2-alkyl-pyrroles highly selective and orally effective COX-2 inhibitors |
| EP2059238A4 (en) * | 2006-09-07 | 2011-04-06 | Myriad Genetics Inc | THERAPEUTIC COMPOUNDS FOR DISEASES AND DISORDERS |
| US8247423B2 (en) | 2007-07-12 | 2012-08-21 | Tragara Pharmaceuticals, Inc. | Methods and compositions for the treatment of cancer, tumors, and tumor-related disorders |
| WO2010019905A1 (en) * | 2008-08-15 | 2010-02-18 | N30 Pharmaceuticals, Llc | Novel pyrrole inhibitors of s-nitrosoglutathione reductase as therapeutic agents |
| US8673961B2 (en) * | 2008-08-15 | 2014-03-18 | N30 Pharmaceuticals, Inc. | Pyrrole inhibitors of S-nitrosoglutathione reductase as therapeutic agents |
| WO2010019909A1 (en) * | 2008-08-15 | 2010-02-18 | N30 Pharmaceuticals, Llc | Pyrrole inhibitors of s-nitrosoglutathione reductase |
| US10500178B2 (en) | 2015-03-13 | 2019-12-10 | The Board Of Trustees Of The Leland Stanford Junior University | LTB4 inhibition to prevent and treat human lymphedema |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3168531A (en) * | 1963-06-12 | 1965-02-02 | Parke Davis & Co | 1-aryl-5-(p-lower alkoxyphenyl)-pyrrole-2-propionic acid compounds |
| BE633582A (pt) * | 1963-06-13 | |||
| US3427305A (en) * | 1966-11-01 | 1969-02-11 | Searle & Co | 5 - ((halo/alkoxy)phenyl) - 1 - (p - sulfonamido(phenyl/benzyl)) - 2 - pyrrolepropionic acids |
| US3531497A (en) * | 1967-02-21 | 1970-09-29 | Upjohn Co | 2,4,5 - triphenyl - (and substituted triphenyl) - 3 - acetonitriles of pyrrole |
| GB1263940A (en) * | 1968-08-02 | 1972-02-16 | Innothera Lab Sa | 0-phenyl-pyrroles |
| US5187185A (en) * | 1988-12-09 | 1993-02-16 | Rhone-Poulenc Ag Company | Pesticidal 1-arylpyrroles |
| DE2261965A1 (de) * | 1971-12-23 | 1973-06-28 | Continental Pharma | Derivate der pyrrolessigsaeure und deren salze sowie von pyrrolacetonitril, verfahren zur herstellung dieser verbindungen, diese verbindungen enthaltende pharmazeutische produkte und verwendung dieser verbindungen und produkte |
| US4267184A (en) * | 1979-02-08 | 1981-05-12 | E. I. Du Pont De Nemours And Company | Antiinflammatory 4,5-diaryl-2-(substituted-thio)pyrroles and their corresponding sulfoxides and sulfones |
| US4335136A (en) * | 1980-04-18 | 1982-06-15 | E. I. Du Pont De Nemours And Company | Anti-inflammatory 4,5-diaryl-α-(polyfluoroalkyl)-1H-pyrrole-2-methanamines |
| US4267190A (en) * | 1980-04-18 | 1981-05-12 | E. I. Du Pont De Nemours And Company | Antiinflammatory 4,5-diaryl-α,α-bis(polyfluoromethyl)-1H-pyrrole-2-methanethiols |
| US4652582A (en) * | 1985-01-09 | 1987-03-24 | E. I. Du Pont De Nemours And Company | Antiinflammatory-2-halo-4,5-diarylpyrroles |
| US4694018A (en) * | 1985-11-29 | 1987-09-15 | G. D. Serale & Co. | Substituted 1,5-diphenyl-2-pyrrolepropionic acids and derivatives |
| DE3739882A1 (de) * | 1987-11-25 | 1989-06-08 | Bayer Ag | Substituierte hydroxylamine |
| AU641905B2 (en) * | 1988-12-09 | 1993-10-07 | Rhone-Poulenc Agrochimie | 1-substituted-phenyl pyrrole derivatives as insecticides and methods for their production |
| US5096919A (en) * | 1989-01-05 | 1992-03-17 | Ciba-Geigy Corporation | Pyrrolylphenyl-substituted hydroxamic acid derivatives |
| DE4036706A1 (de) * | 1990-11-17 | 1992-05-21 | Hoechst Ag | Verfahren zur behandlung der cardialen sowie der vasculaeren hypertrophie und hyperplasie |
| US5128485A (en) * | 1990-12-17 | 1992-07-07 | American Cyanamid Company | Synthesis of 2-aryl-5-(trifluoromethyl)pyrroles useful as pesticidal agents and as intermediates for the preparation of said agents |
| ES2131044T3 (es) * | 1990-12-26 | 1999-07-16 | American Cyanamid Co | Procedimiento para la preparacion de compuestos 2-aril-5-(trifluorometil)pirrol 1-sustituidos utiles como agentes insecticidas, acaricidas y nematocidas y como intermedios para la fabricacion de dichos agentes. |
| US5144041A (en) * | 1990-12-26 | 1992-09-01 | American Cyanamid Company | Process for the preparation of 2-aryl-1-substituted-5-(trifluoromethyl) pyrrole compounds useful as insecticidal, acaricidal and nematocidal agents and as intermediates for the manufacture of said agents |
| US5219856A (en) * | 1992-04-06 | 1993-06-15 | E. I. Du Pont De Nemours And Company | Angiotensin-II receptor blocking, heterocycle substituted imidazoles |
| EP0759432A1 (en) * | 1993-01-15 | 1997-02-26 | G.D. Searle & Co. | Use of medicaments containing 3,4-diaryl furans and analogs thereof for treating a skin-related condition |
| US5474995A (en) * | 1993-06-24 | 1995-12-12 | Merck Frosst Canada, Inc. | Phenyl heterocycles as cox-2 inhibitors |
| US5908858A (en) * | 1996-04-05 | 1999-06-01 | Sankyo Company, Limited | 1,2-diphenylpyrrole derivatives, their preparation and their therapeutic uses |
-
1997
- 1997-12-09 US US08/987,356 patent/US5935990A/en not_active Expired - Fee Related
- 1997-12-09 AT AT97950891T patent/ATE250576T1/de not_active IP Right Cessation
- 1997-12-09 WO PCT/US1997/022488 patent/WO1998025896A1/en not_active Ceased
- 1997-12-09 ES ES97950891T patent/ES2208964T3/es not_active Expired - Lifetime
- 1997-12-09 EP EP97950891A patent/EP0946507B1/en not_active Expired - Lifetime
- 1997-12-09 DE DE69725171T patent/DE69725171T2/de not_active Expired - Fee Related
- 1997-12-09 CA CA002273836A patent/CA2273836A1/en not_active Abandoned
- 1997-12-09 AU AU53776/98A patent/AU5377698A/en not_active Abandoned
- 1997-12-09 DK DK97950891T patent/DK0946507T3/da active
- 1997-12-09 PT PT97950891T patent/PT946507E/pt unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US5935990A (en) | 1999-08-10 |
| DE69725171T2 (de) | 2004-07-15 |
| DK0946507T3 (da) | 2004-01-26 |
| AU5377698A (en) | 1998-07-03 |
| DE69725171D1 (de) | 2003-10-30 |
| ES2208964T3 (es) | 2004-06-16 |
| WO1998025896A1 (en) | 1998-06-18 |
| CA2273836A1 (en) | 1998-06-18 |
| EP0946507B1 (en) | 2003-09-24 |
| EP0946507A1 (en) | 1999-10-06 |
| ATE250576T1 (de) | 2003-10-15 |
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