PT881226E - Processo de preparacao de compostos de platina - Google Patents
Processo de preparacao de compostos de platinaInfo
- Publication number
- PT881226E PT881226E PT97929532T PT97929532T PT881226E PT 881226 E PT881226 E PT 881226E PT 97929532 T PT97929532 T PT 97929532T PT 97929532 T PT97929532 T PT 97929532T PT 881226 E PT881226 E PT 881226E
- Authority
- PT
- Portugal
- Prior art keywords
- cyclohexanediamine
- preparation process
- platinum
- deoxygenated water
- platinum compounds
- Prior art date
Links
- 150000003058 platinum compounds Chemical class 0.000 title abstract 2
- 238000002360 preparation method Methods 0.000 title abstract 2
- 229940045985 antineoplastic platinum compound Drugs 0.000 title 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 3
- 239000001301 oxygen Substances 0.000 abstract 3
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 2
- SSJXIUAHEKJCMH-PHDIDXHHSA-N (1r,2r)-cyclohexane-1,2-diamine Chemical compound N[C@@H]1CCCC[C@H]1N SSJXIUAHEKJCMH-PHDIDXHHSA-N 0.000 abstract 1
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 abstract 1
- 238000010521 absorption reaction Methods 0.000 abstract 1
- 230000015556 catabolic process Effects 0.000 abstract 1
- DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical class N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 abstract 1
- SSJXIUAHEKJCMH-UHFFFAOYSA-N cyclohexane-1,2-diamine Chemical class NC1CCCCC1N SSJXIUAHEKJCMH-UHFFFAOYSA-N 0.000 abstract 1
- 238000006731 degradation reaction Methods 0.000 abstract 1
- 239000012535 impurity Substances 0.000 abstract 1
- 230000003647 oxidation Effects 0.000 abstract 1
- 238000007254 oxidation reaction Methods 0.000 abstract 1
- 229910052700 potassium Inorganic materials 0.000 abstract 1
- 239000011591 potassium Substances 0.000 abstract 1
- 239000007858 starting material Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F15/00—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table
- C07F15/0006—Compounds containing elements of Groups 8, 9, 10 or 18 of the Periodic Table compounds of the platinum group
- C07F15/0086—Platinum compounds
- C07F15/0093—Platinum compounds without a metal-carbon linkage
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Catalysts (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP17478896A JP3154399B2 (ja) | 1996-07-04 | 1996-07-04 | 白金化合物の製造方法 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT881226E true PT881226E (pt) | 2004-03-31 |
Family
ID=15984689
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT97929532T PT881226E (pt) | 1996-07-04 | 1997-07-04 | Processo de preparacao de compostos de platina |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US5959133A (pt) |
| EP (1) | EP0881226B1 (pt) |
| JP (1) | JP3154399B2 (pt) |
| AT (1) | ATE255118T1 (pt) |
| DE (1) | DE69726408T2 (pt) |
| DK (1) | DK0881226T3 (pt) |
| ES (1) | ES2210543T3 (pt) |
| HK (1) | HK1055746A1 (pt) |
| PT (1) | PT881226E (pt) |
| WO (1) | WO1998001454A1 (pt) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040186172A1 (en) * | 2001-07-02 | 2004-09-23 | Houssam Ibrahim | Oxaliplatin active substance with a very low content of oxalic acid |
| US6476068B1 (en) | 2001-12-06 | 2002-11-05 | Pharmacia Italia, S.P.A. | Platinum derivative pharmaceutical formulations |
| WO2005051966A1 (en) * | 2003-11-25 | 2005-06-09 | Platco Technologies (Proprietary) Limited | Platinum(ii) complexes, preparation and use |
| WO2006024897A1 (en) | 2004-09-01 | 2006-03-09 | Platco Technologies (Proprietary) Limited | Preparation of platinum(ii) complexes |
| JP2006248978A (ja) | 2005-03-10 | 2006-09-21 | Mebiopharm Co Ltd | 新規なリポソーム製剤 |
| EP1879568B1 (en) * | 2005-03-28 | 2009-05-06 | Dabur Pharma Limited | Stable pharmaceutical compositions of platinum (ii) antitumour agents |
| CA2604862A1 (en) * | 2005-04-09 | 2006-10-19 | Vuab Pharma A.S. | A process for the preparation of an oxaliplatin preparation |
| RU2447889C2 (ru) * | 2005-07-18 | 2012-04-20 | Бипар Сайенсиз, Инк. | Способ лечения рака (варианты) |
| CA2640621A1 (en) | 2006-01-30 | 2007-08-02 | Platco Technologies (Proprietary) Limited | Preparation of platinum (ii) complexes |
| AR060635A1 (es) | 2006-04-27 | 2008-07-02 | Banyu Pharma Co Ltd | Derivados de 1,2-dihidro-3h-pirazolo[3,4-d]pirimidin-3-ona, composiciones farmaceuticas que los comprenden y su uso en el tratamiento del cancer |
| JP2008081492A (ja) | 2006-08-31 | 2008-04-10 | Banyu Pharmaceut Co Ltd | オーロラa選択的阻害作用を有する新規アミノピリジン誘導体 |
| CA2662517A1 (en) | 2006-09-05 | 2008-03-13 | Jerome Moore | Treatment of cancer |
| CA2662337A1 (en) | 2006-09-05 | 2008-03-13 | Bipar Sciences, Inc. | Inhibition of fatty acid synthesis by parp inhibitors and methods of treatment thereof |
| US7977336B2 (en) | 2006-12-28 | 2011-07-12 | Banyu Pharmaceutical Co. Ltd | Aminopyrimidine derivatives as PLK1 inhibitors |
| CN101903025A (zh) * | 2007-10-19 | 2010-12-01 | 彼帕科学公司 | 利用苯并吡喃酮-型parp抑制剂治疗癌症的方法和组合物 |
| EP2213673B1 (en) | 2007-10-23 | 2013-06-05 | Msd K.K. | Pyridone-substituted-dihydropyrazolopyrimidinone derivative |
| SG185952A1 (en) | 2007-11-12 | 2012-12-28 | Bipar Sciences Inc | Treatment of breast cancer with 4-iodo-3-nitrobenzamide in combination with anti-tumor agents |
| WO2010098367A1 (en) | 2009-02-25 | 2010-09-02 | Banyu Pharmaceutical Co.,Ltd. | Pyrimidopyrimidoindazole derivative |
| EP2403339B1 (en) | 2009-03-06 | 2017-01-18 | Merck Sharp & Dohme Corp. | Combination cancer therapy with an akt inhibitor and other anticancer agents |
| EP2208731B1 (en) | 2009-06-26 | 2012-08-15 | Umicore AG & Co. KG | Process for preparation of 1,2-diamino-cyclohexane-platinum(II) complexes |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CH605550A5 (pt) * | 1972-06-08 | 1978-09-29 | Research Corp | |
| US4115418A (en) * | 1976-09-02 | 1978-09-19 | Government Of The United States Of America | 1,2-diaminocyclohexane platinum (ii) complexes having antineoplastic activity |
| JPS6041077B2 (ja) * | 1976-09-06 | 1985-09-13 | 喜徳 喜谷 | 1,2‐ジアミノシクロヘキサン異性体のシス白金(2)錯体 |
| US4175133A (en) | 1977-02-18 | 1979-11-20 | United States Of America | 1,2-Diaminocyclohexane platinum (II) complexes having antineoplastic activity against L1210 leukemia |
| GR75598B (pt) * | 1980-04-29 | 1984-08-01 | Sanofi Sa | |
| IL74449A (en) * | 1984-03-01 | 1988-07-31 | Us Commerce | Tetrahalo-1,2-cyclohexane-diamino platinum complexes and anti-neoplastic compositions comprising them |
| US4550187A (en) * | 1984-04-12 | 1985-10-29 | The Research Foundation Of State University Of New York | Synthesis of platinum (IV) antineoplastic agents |
| US4665210A (en) * | 1984-12-17 | 1987-05-12 | American Cyanamid Company | Platinum complexes of aliphatic tricarboxylic acids |
| US4710557A (en) * | 1985-02-01 | 1987-12-01 | Eastman Kodak Company | Polymers of thiophenyl thioacrylate and thiomethacrylate monomers |
| US4680308A (en) * | 1985-12-26 | 1987-07-14 | Andrulis Research Corporation | Stable soluble 1,2-diaminocyclohexane platinum complexes |
| US5011959A (en) * | 1986-11-17 | 1991-04-30 | The Board Of Regents, The University Of Texas System | 1,2-diaminocyclohexane-platinum complexes with antitumor activity |
| JPH02256690A (ja) * | 1988-12-27 | 1990-10-17 | Ss Pharmaceut Co Ltd | 新規白金錯体 |
| EP0376076A1 (en) * | 1988-12-27 | 1990-07-04 | Ss Pharmaceutical Co., Ltd. | Novel platinum complex |
| JP2673331B2 (ja) * | 1993-01-12 | 1997-11-05 | 田中貴金属工業 株式会社 | 光学的に高純度なシス―オキザラート(トランス―1―1,2―シクロヘキサンジアミン)白金(▲ii▼) |
| JPH06287021A (ja) * | 1992-04-22 | 1994-10-11 | Tanaka Kikinzoku Kogyo Kk | 光学活性な白金錯化合物の光学的分割方法 |
| JPH05301884A (ja) * | 1992-04-22 | 1993-11-16 | Tanaka Kikinzoku Kogyo Kk | 白金錯化合物の製造方法 |
| JP3025602B2 (ja) * | 1993-05-21 | 2000-03-27 | デビオファーム エス.アー. | 光学的に高純度なシス−オキザラート(トランス−l−1,2−シクロヘキサンジアミン)白金(II)錯体の製造方法 |
| JPH0725890A (ja) * | 1993-07-09 | 1995-01-27 | Tanaka Kikinzoku Kogyo Kk | 白金錯体の製造方法 |
-
1996
- 1996-07-04 JP JP17478896A patent/JP3154399B2/ja not_active Expired - Lifetime
-
1997
- 1997-07-04 WO PCT/JP1997/002332 patent/WO1998001454A1/ja not_active Ceased
- 1997-07-04 ES ES97929532T patent/ES2210543T3/es not_active Expired - Lifetime
- 1997-07-04 PT PT97929532T patent/PT881226E/pt unknown
- 1997-07-04 DE DE69726408T patent/DE69726408T2/de not_active Expired - Lifetime
- 1997-07-04 EP EP97929532A patent/EP0881226B1/en not_active Expired - Lifetime
- 1997-07-04 US US09/029,682 patent/US5959133A/en not_active Expired - Lifetime
- 1997-07-04 DK DK97929532T patent/DK0881226T3/da active
- 1997-07-04 AT AT97929532T patent/ATE255118T1/de active
-
2003
- 2003-11-11 HK HK03108144A patent/HK1055746A1/xx unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DK0881226T3 (da) | 2004-03-29 |
| US5959133A (en) | 1999-09-28 |
| JPH1017587A (ja) | 1998-01-20 |
| HK1055746A1 (en) | 2004-01-21 |
| JP3154399B2 (ja) | 2001-04-09 |
| EP0881226B1 (en) | 2003-11-26 |
| DE69726408T2 (de) | 2004-05-19 |
| DE69726408D1 (de) | 2004-01-08 |
| WO1998001454A1 (fr) | 1998-01-15 |
| ATE255118T1 (de) | 2003-12-15 |
| EP0881226A4 (en) | 2000-03-15 |
| EP0881226A1 (en) | 1998-12-02 |
| ES2210543T3 (es) | 2004-07-01 |
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