PT84229B - Processo para a preparacao de novos tioeteres fenolicos uteis como inibidores de 5-lipoxigenase - Google Patents
Processo para a preparacao de novos tioeteres fenolicos uteis como inibidores de 5-lipoxigenaseInfo
- Publication number
- PT84229B PT84229B PT84229A PT8422987A PT84229B PT 84229 B PT84229 B PT 84229B PT 84229 A PT84229 A PT 84229A PT 8422987 A PT8422987 A PT 8422987A PT 84229 B PT84229 B PT 84229B
- Authority
- PT
- Portugal
- Prior art keywords
- substituted
- alkyl
- methylene
- phenyl
- lipoxygenase
- Prior art date
Links
- 239000000867 Lipoxygenase Inhibitor Substances 0.000 title 1
- 150000002989 phenols Chemical class 0.000 title 1
- 125000000325 methylidene group Chemical group [H]C([H])=* 0.000 abstract 4
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- -1 phenolic thioethers Chemical class 0.000 abstract 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- 102000001381 Arachidonate 5-Lipoxygenase Human genes 0.000 abstract 2
- 108010093579 Arachidonate 5-lipoxygenase Proteins 0.000 abstract 2
- 206010020751 Hypersensitivity Diseases 0.000 abstract 2
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 2
- 150000001875 compounds Chemical class 0.000 abstract 2
- 206010061218 Inflammation Diseases 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 208000026935 allergic disease Diseases 0.000 abstract 1
- 230000007815 allergy Effects 0.000 abstract 1
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 208000035475 disorder Diseases 0.000 abstract 1
- 125000005842 heteroatom Chemical group 0.000 abstract 1
- 125000004356 hydroxy functional group Chemical group O* 0.000 abstract 1
- 230000004054 inflammatory process Effects 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 230000037353 metabolic pathway Effects 0.000 abstract 1
- 229910052757 nitrogen Inorganic materials 0.000 abstract 1
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
- 229910052760 oxygen Inorganic materials 0.000 abstract 1
- 239000001301 oxygen Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 150000003457 sulfones Chemical group 0.000 abstract 1
- 150000003462 sulfoxides Chemical group 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 239000011593 sulfur Substances 0.000 abstract 1
- 230000009885 systemic effect Effects 0.000 abstract 1
- 125000003831 tetrazolyl group Chemical group 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/10—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C323/18—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton
- C07C323/20—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and singly-bound oxygen atoms bound to the same carbon skeleton having the sulfur atom of at least one of the thio groups bound to a carbon atom of a six-membered aromatic ring of the carbon skeleton with singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/22—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and doubly-bound oxygen atoms bound to the same carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/23—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
- C07C323/24—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/25—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
- C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
- C07C323/52—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
- C07C323/64—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton
- C07C323/65—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and sulfur atoms, not being part of thio groups, bound to the same carbon skeleton containing sulfur atoms of sulfone or sulfoxide groups bound to the carbon skeleton
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C327/00—Thiocarboxylic acids
- C07C327/20—Esters of monothiocarboxylic acids
- C07C327/22—Esters of monothiocarboxylic acids having carbon atoms of esterified thiocarboxyl groups bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C327/00—Thiocarboxylic acids
- C07C327/36—Esters of dithiocarboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C331/00—Derivatives of thiocyanic acid or of isothiocyanic acid
- C07C331/02—Thiocyanates
- C07C331/10—Thiocyanates having sulfur atoms of thiocyanate groups bound to carbon atoms of hydrocarbon radicals substituted by singly-bound oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Production Of Liquid Hydrocarbon Mixture For Refining Petroleum (AREA)
- Polymerisation Methods In General (AREA)
- Lubricants (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US06/824,984 US4711903A (en) | 1986-01-31 | 1986-01-31 | Phenolic thioethers as inhibitors of 5-lipoxygenase |
| US07/001,259 US4755524A (en) | 1986-01-31 | 1987-01-15 | Novel phenolic thioethers as inhibitors of 5-lipoxygenase |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PT84229A PT84229A (en) | 1987-02-01 |
| PT84229B true PT84229B (pt) | 1989-03-30 |
Family
ID=26668781
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT84229A PT84229B (pt) | 1986-01-31 | 1987-01-30 | Processo para a preparacao de novos tioeteres fenolicos uteis como inibidores de 5-lipoxigenase |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US4755524A (pt) |
| EP (1) | EP0235575B1 (pt) |
| JP (1) | JPH085852B2 (pt) |
| KR (1) | KR910002948B1 (pt) |
| AT (1) | ATE56702T1 (pt) |
| AU (1) | AU593606B2 (pt) |
| CA (1) | CA1302424C (pt) |
| DE (1) | DE3764976D1 (pt) |
| DK (1) | DK50487A (pt) |
| ES (1) | ES2017647B3 (pt) |
| FI (1) | FI87922C (pt) |
| GR (1) | GR3000864T3 (pt) |
| IL (1) | IL81420A (pt) |
| NO (1) | NO165191C (pt) |
| NZ (1) | NZ219104A (pt) |
| PH (1) | PH24624A (pt) |
| PT (1) | PT84229B (pt) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8320943D0 (en) * | 1983-08-03 | 1983-09-07 | Lilly Industries Ltd | Organic compounds |
| DE3674014D1 (de) * | 1985-02-04 | 1990-10-18 | Searle & Co | Disubstituierte 4-hydroxyphenylthio-anilide. |
| US5157053A (en) * | 1985-02-04 | 1992-10-20 | G. D. Searle & Co. | Bicycloalky, tricycloalkyl, azabicycloalkyl, and azatricycloalkyl thio amides used to treat inflammation, allergy, asthma and skin disorders |
| US4847305A (en) * | 1987-06-05 | 1989-07-11 | G. D. Searle & Co. | Phenolic thioethers as inhibitors of 5-lipoxygenase |
| CA1327050C (en) * | 1987-06-05 | 1994-02-15 | Richard August Mueller | Phenolic thioethers, sulfoxides, and disulfides as inhibitors of 5-lipoxygenase |
| US5002967A (en) * | 1987-06-05 | 1991-03-26 | G. D. Searle & Co. | Phenolic thioethers, sulfoxides, and disulfides as inhibitors of 5-lipoxygenase |
| AU610528B2 (en) * | 1987-10-29 | 1991-05-23 | Smithkline Beckman Corporation | Leukotriene antagonists |
| US5066822A (en) * | 1987-11-13 | 1991-11-19 | Riker Laboratories, Inc | Di-t-butylphenols substituted by an alkoxy or benzyloxy group or a benzylthio group |
| US4968710A (en) * | 1987-11-13 | 1990-11-06 | Riker Laboratories, Inc. | Substituted di-t-butylphenols and anti-allergic use thereof |
| NZ226621A (en) * | 1987-11-13 | 1991-12-23 | Riker Laboratories Inc | Di-tert butyl phenols substituted by alkoxy, benzyloxy, or benzylthio groups; pharmaceutical compositions containing them |
| US4959383A (en) * | 1988-10-31 | 1990-09-25 | E. R. Squibb & Sons, Inc. | Phenylsulfone alkenoic acids, derivatives thereof, compositions containing same and method of use |
| US5006542A (en) * | 1988-10-31 | 1991-04-09 | E. R. Squibb & Sons, Inc. | Arylthioalkylphenyl carboxylic acids, derivatives thereof, compositions containing same and method of use |
| US5070099A (en) * | 1988-10-31 | 1991-12-03 | E. R. Squibb & Sons, Inc. | Arylthioalkylphenyl carboxylic acids, derivatives thereof, compositions containing same method of use |
| JP2627003B2 (ja) * | 1989-01-25 | 1997-07-02 | 塩野義製薬株式会社 | ジーｔｅｒｔ―ブチルヒドロキシフェニルチオ誘導体 |
| US4952724A (en) * | 1989-12-08 | 1990-08-28 | G. D. Searle & Co. | Process for preparation of alpha-aryloxy acetic acids and their salts |
| US5013864A (en) * | 1989-12-08 | 1991-05-07 | G. D. Searle & Co. | Process for preparation of α-alkoxy acetic acids and their salts |
| JPH0629236B2 (ja) * | 1990-05-02 | 1994-04-20 | ナショナル サイエンス カウンシル | ２，６―ジメトキシヒドロキノン―３―メルカプトプロピオン酸および２，６―ジメトキシヒドロキノン―３―メルカプト酢酸およびその抗癌用途 |
| US5064860A (en) * | 1990-09-07 | 1991-11-12 | G. D. Searle & Co. | Method of inhibiting superoxide generation |
| DE69107851T2 (de) * | 1990-09-07 | 1995-08-03 | Searle & Co | Phenolische thioetheramide als 5-lipoxygenase-inhibitoren. |
| CA2051229A1 (en) * | 1990-09-14 | 1992-03-15 | Sing-Yuen Sit | Hypocholesterolemic unsymmetrical dithiol ketals |
| US5145992A (en) * | 1991-05-06 | 1992-09-08 | G. D. Searle & Co. | Process and preparation of α-alkoxy acetic acids and their salts |
| US5147893A (en) * | 1991-05-09 | 1992-09-15 | G. D. Searle & Co. | Cyclic phenolic thioethers |
| US5250567A (en) * | 1991-05-09 | 1993-10-05 | G. D. Searle & Co. | Cyclic phenolic thioethers |
| US5442111A (en) * | 1991-05-24 | 1995-08-15 | Warner-Lambert Company | 3,5-di-tetriary-4-butyl-4-hydroxyphenyloxy- or tioalkylene N-hydroxyamides, N-hydroxythioamides, N-hydroxyureas, and N-hydroxythioureas as 5-lipoxygenase inhibitors |
| US5272178A (en) * | 1991-11-18 | 1993-12-21 | G. D. Searle & Co. | Compounds of cyclic phenolic thioethers which are useful in stimulating and inhibiting superoxide generation |
| US5476944A (en) * | 1991-11-18 | 1995-12-19 | G. D. Searle & Co. | Derivatives of cyclic phenolic thioethers |
| US5326907A (en) * | 1992-12-18 | 1994-07-05 | G. D. Searle & Co. | 2-aminoethanesulfonic acid derivatives of 3,5-disubstituted-4-hydroxyphenolic thioethers |
| ES2087019B1 (es) * | 1994-02-08 | 1997-03-16 | Bobel246 S L | Uso de derivados de fenoles 2,4-disubstituidos como inhibidores de la 5-lipoxigenasa. |
| US5420343A (en) * | 1994-08-31 | 1995-05-30 | G. D. Searle & Co. | Derivatives of aromatic cyclic alkylethers |
| US6670398B2 (en) * | 1997-05-14 | 2003-12-30 | Atherogenics, Inc. | Compounds and methods for treating transplant rejection |
| AU2006202461B2 (en) * | 1997-05-14 | 2009-12-03 | Atherogenics, Inc. | Compositions and methods for the inhibition of the expression of VCAM-1 |
| BR9809819A (pt) * | 1997-05-14 | 2001-09-18 | Atherogenics Inc | Compostos e métodos para a inibição da expressão de vcam-1 |
| EP1695959A1 (en) * | 1997-05-14 | 2006-08-30 | Atherogenics, Inc. | Compouds and methods for the inhibition of the expression of VCAM-1 |
| US6852878B2 (en) * | 1998-05-14 | 2005-02-08 | Atherogenics, Inc. | Thioketals and thioethers for inhibiting the expression of VCAM-1 |
| CA2349476A1 (en) * | 1998-11-03 | 2000-05-11 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Imidazonaphthyridines |
| AU2002320025A1 (en) * | 2001-04-11 | 2002-11-11 | Atherogenics, Inc. | Probucol monoesters and their use to increase plasma hdl cholesterol levels and improve hdl functionality |
| US7479507B2 (en) * | 2003-01-14 | 2009-01-20 | Adam Heller | Anti-inflammatory substituted phenols and elastomeric compositions for oral delivery of drugs |
| WO2005051900A1 (en) * | 2003-11-25 | 2005-06-09 | Novo Nordisk A/S | Novel compounds for the treatment of obesity |
| US7294737B2 (en) | 2004-04-20 | 2007-11-13 | Atherogenics, Inc. | Process of preparing esters and ethers of probucol and derivatives thereof |
| BRPI0809423A2 (pt) * | 2007-03-26 | 2014-09-09 | Salutria Pharmaceuticals Llc | Usos e composições de derivados de probucol para o tratamento de diabetes |
| WO2008118946A1 (en) * | 2007-03-27 | 2008-10-02 | Atherogenics, Inc. | Methods and compositions using certain phenolic derivatives for the treatment of diabetes |
| MY205872A (en) | 2009-04-29 | 2024-11-18 | Amarin Pharmaceuticals Ie Ltd | Pharmaceutical compositions comprising omega-3 fatty acids |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1936463A1 (de) * | 1969-07-17 | 1971-02-04 | Boehringer Sohn Ingelheim | Substituierte Phenole |
| US3674857A (en) * | 1970-03-02 | 1972-07-04 | Dow Chemical Co | (((alkylthio) alkyl)thio)phenols |
| CA1037964A (en) * | 1973-02-14 | 1978-09-05 | Eugene R. Wagner | 2-((3,5-di-tert-buryl-4-hydroxyphenyl)thio)alkanoic acids and derivatives and esters |
| AT353776B (de) * | 1973-12-27 | 1979-12-10 | Siegfried Ag | Verfahren zur herstellung von neuen alkan- saeuren, deren estern und salzen |
| US4029812A (en) * | 1976-02-18 | 1977-06-14 | The Dow Chemical Company | Novel hypolipidemic 2-(3,5-di-tert-butyl-4-hydroxyphenyl)thio carboxamides |
| EP0079855A1 (de) * | 1981-11-12 | 1983-05-25 | Ciba-Geigy Ag | Alkylierte Hydroxyphenylthioalkansäureester |
| DE3324916A1 (de) * | 1983-07-09 | 1985-01-17 | Boehringer Mannheim Gmbh, 6800 Mannheim | Thioether, verfahren zu deren herstellung sowie diese verbindungen enthaltende arzneimittel |
| US4551279A (en) | 1984-01-09 | 1985-11-05 | G. D. Searle & Co. | Protease inhibitors |
| EP0190684B1 (en) * | 1985-02-04 | 1990-07-25 | G.D. Searle & Co. | Bicycloalkyl, tricycloalkyl, azabicycloalkyl and azatricycloalkyl amides |
-
1987
- 1987-01-15 US US07/001,259 patent/US4755524A/en not_active Expired - Lifetime
- 1987-01-29 AT AT87101222T patent/ATE56702T1/de not_active IP Right Cessation
- 1987-01-29 IL IL8781420A patent/IL81420A/xx not_active IP Right Cessation
- 1987-01-29 AU AU68103/87A patent/AU593606B2/en not_active Ceased
- 1987-01-29 CA CA000528522A patent/CA1302424C/en not_active Expired - Lifetime
- 1987-01-29 NZ NZ219104A patent/NZ219104A/xx unknown
- 1987-01-29 ES ES87101222T patent/ES2017647B3/es not_active Expired - Lifetime
- 1987-01-29 EP EP87101222A patent/EP0235575B1/en not_active Expired - Lifetime
- 1987-01-29 DE DE8787101222T patent/DE3764976D1/de not_active Expired - Fee Related
- 1987-01-29 PH PH34787A patent/PH24624A/en unknown
- 1987-01-30 DK DK050487A patent/DK50487A/da not_active Application Discontinuation
- 1987-01-30 FI FI870417A patent/FI87922C/fi not_active IP Right Cessation
- 1987-01-30 PT PT84229A patent/PT84229B/pt not_active IP Right Cessation
- 1987-01-30 JP JP62020326A patent/JPH085852B2/ja not_active Expired - Lifetime
- 1987-01-30 KR KR1019870000741A patent/KR910002948B1/ko not_active Expired
- 1987-01-30 NO NO870384A patent/NO165191C/no unknown
-
1990
- 1990-09-25 GR GR90400412T patent/GR3000864T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA1302424C (en) | 1992-06-02 |
| US4755524A (en) | 1988-07-05 |
| NO870384D0 (no) | 1987-01-30 |
| IL81420A (en) | 1991-11-21 |
| DK50487D0 (da) | 1987-01-30 |
| DK50487A (da) | 1987-08-01 |
| NO165191C (no) | 1991-01-09 |
| FI87922C (fi) | 1993-03-10 |
| PH24624A (en) | 1990-08-17 |
| KR910002948B1 (ko) | 1991-05-11 |
| GR3000864T3 (en) | 1991-11-15 |
| JPH085852B2 (ja) | 1996-01-24 |
| AU6810387A (en) | 1987-08-06 |
| AU593606B2 (en) | 1990-02-15 |
| NZ219104A (en) | 1989-09-27 |
| IL81420A0 (en) | 1987-08-31 |
| FI87922B (fi) | 1992-11-30 |
| KR870007113A (ko) | 1987-08-14 |
| ATE56702T1 (de) | 1990-10-15 |
| PT84229A (en) | 1987-02-01 |
| NO165191B (no) | 1990-10-01 |
| DE3764976D1 (en) | 1990-10-25 |
| ES2017647B3 (es) | 1991-03-01 |
| JPS62228054A (ja) | 1987-10-06 |
| NO870384L (no) | 1987-08-03 |
| EP0235575B1 (en) | 1990-09-19 |
| EP0235575A1 (en) | 1987-09-09 |
| FI870417A7 (fi) | 1987-08-01 |
| FI870417A0 (fi) | 1987-01-30 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PT84229B (pt) | Processo para a preparacao de novos tioeteres fenolicos uteis como inibidores de 5-lipoxigenase | |
| IE870249L (en) | Phenolic thioethers as inhibitors of 5-lipoxygenase | |
| PT90805A (pt) | Processo para a preparacao de 1-indolilalquil-4-(piridinil substituido)-piperazinas e de composicoes farmaceuticas que as contem | |
| ES2111288T3 (es) | Nuevos 3,4-diaril tiofenos y analogos de los mismos utiles como agentes antiinflamatorios. | |
| PT91231A (pt) | Processo de preparacao de derivados substituidos purinona e de composicoes farmaceuticas que os contem | |
| BR9914696A (pt) | Composto, processo para tratamento de distúrbio mediado por ciclo-oxigenase-2 em um indivìduo, e, composição farmacêutica | |
| PT81637B (pt) | Processo para a preparacao de novos compostos de indol acidicos e de composicoes farmaceuticas que os contem | |
| ES553043A1 (es) | Un procedimiento para la preparacion de composiciones lubricantes constituidas esencialmente por un aceite de viscosidad lubricante. | |
| ES2036259T3 (es) | Un procedimientos para la preparacion de agentes antiinflamatorios. | |
| PT96030A (pt) | Processo para a preparacao de aminocarbonilcarbamatos relacionados com fisoestigmina e de composicoes farmaceuticas que os contem | |
| PT98773A (pt) | Processo para a preparacao de di-hidropirido/4,3-d/pirimidinas substituidas na posicao 4 e de composicoes farmaceuticas analgesicas e antiinflamatorias que as contem | |
| ES538903A0 (es) | Procedimiento para la preparacion de agentes anti-psoriaticos del tipo naftalenico | |
| PT81576B (pt) | Processo para a preparacao de derivados de mercaptano e de composicoes faramceuticas que os contem | |
| ES523226A0 (es) | "procedimiento para la fabricacion de derivados de la tetrahidro-5.6.7.7. 4h-tieno (3, 2-c) piridinona-2 | |
| PT82814B (pt) | Processo de preparacao de derivados de 5-oxo-1-imidazolidinoacetimida, dos seus sais farmaceuticamente aceitaveis e das composicoes farmaceuticas que os contem | |
| PT81933B (pt) | Processo para a preparacao de composicoes aperfeicoadas anti-inflamatorias contendo piroxicamo e inositol | |
| PT81206B (pt) | Processo para a preparacao de derivados de furo {3,2-c} piridinas e de composicoes farmaceuticas que os contem | |
| IT1205640B (it) | Nuovi composti ad attivita' antiinfiammatoria,procedimento per la loro preparazione e composizioni farmaceutiche che li contengono | |
| PT98911A (pt) | Processo para a preparacao de 3-(1h-indazol-3-il)-4-piridinaminas, seus intermediarios e composicoes farmaceuticas que os contem | |
| ES2075137T3 (es) | Compuestos sustituidos de piridina; su produccion y composiciones farmaceuticas que los contienen. | |
| PT83929B (pt) | Processo de preparacao de 3-benzazepinas substituidas por sulfinilo e sulfonilo e das composicoes farmaceuticas que as contem | |
| DE69535475D1 (de) | Guanidinomethylcyclohexancarbonsäure-Ester Derivate | |
| BR9402149A (pt) | Processo para a preparação da forma cristalina monohidratada de um composto | |
| PT98186A (pt) | Processo para a preparacao de purinil- e de pirimidinil-tetra-hidrofuranos e de composicoes farmaceuticas que os contem | |
| ES2033322T3 (es) | Procedimiento para preparar antagonistas de leucotrieno. |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM3A | Annulment or lapse |
Free format text: LAPSE DUE TO NON-PAYMENT OF FEES Effective date: 19950331 |