PT83007B - Processo para a preparacao de proantocianidina a2 , e de composicoes farmaceuticas que a contem - Google Patents
Processo para a preparacao de proantocianidina a2 , e de composicoes farmaceuticas que a contemInfo
- Publication number
- PT83007B PT83007B PT83007A PT8300786A PT83007B PT 83007 B PT83007 B PT 83007B PT 83007 A PT83007 A PT 83007A PT 8300786 A PT8300786 A PT 8300786A PT 83007 B PT83007 B PT 83007B
- Authority
- PT
- Portugal
- Prior art keywords
- proanthocyanidin
- preparation
- same
- pharmaceutical compositions
- compositions containing
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title abstract 2
- NSEWTSAADLNHNH-TXZJYACMSA-N Proanthocyanidin A-2 Natural products C1([C@H]2OC3=C4[C@H]5C6=C(O)C=C(O)C=C6O[C@]([C@@H]5O)(OC4=CC(O)=C3C[C@@H]2O)C=2C=C(O)C(O)=CC=2)=CC=C(O)C(O)=C1 NSEWTSAADLNHNH-TXZJYACMSA-N 0.000 title 1
- 229920002982 Procyanidin A2 Polymers 0.000 title 1
- NSEWTSAADLNHNH-UHFFFAOYSA-N pavetannin A-2 Natural products OC1CC2=C(O)C=C3OC(C4O)(C=5C=C(O)C(O)=CC=5)OC5=CC(O)=CC(O)=C5C4C3=C2OC1C1=CC=C(O)C(O)=C1 NSEWTSAADLNHNH-UHFFFAOYSA-N 0.000 title 1
- NSEWTSAADLNHNH-LSBOWGMISA-N proanthocyanidin A2 Chemical compound C1([C@H]2OC3=C4[C@H]5C6=C(O)C=C(O)C=C6O[C@]([C@@H]5O)(OC4=CC(O)=C3C[C@H]2O)C=2C=C(O)C(O)=CC=2)=CC=C(O)C(O)=C1 NSEWTSAADLNHNH-LSBOWGMISA-N 0.000 title 1
- 230000000694 effects Effects 0.000 abstract 2
- 230000035876 healing Effects 0.000 abstract 2
- 241000157280 Aesculus hippocastanum Species 0.000 abstract 1
- 208000007107 Stomach Ulcer Diseases 0.000 abstract 1
- 208000027418 Wounds and injury Diseases 0.000 abstract 1
- 230000004856 capillary permeability Effects 0.000 abstract 1
- 208000000718 duodenal ulcer Diseases 0.000 abstract 1
- 235000013399 edible fruits Nutrition 0.000 abstract 1
- 238000000605 extraction Methods 0.000 abstract 1
- 230000002496 gastric effect Effects 0.000 abstract 1
- 235000010181 horse chestnut Nutrition 0.000 abstract 1
- 230000001771 impaired effect Effects 0.000 abstract 1
- 238000004519 manufacturing process Methods 0.000 abstract 1
- 238000005502 peroxidation Methods 0.000 abstract 1
- 241000894007 species Species 0.000 abstract 1
- 230000004936 stimulating effect Effects 0.000 abstract 1
- 230000009885 systemic effect Effects 0.000 abstract 1
- 230000000699 topical effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/12—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains three hetero rings
- C07D493/18—Bridged systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/77—Sapindaceae (Soapberry family), e.g. lychee or soapberry
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Organic Chemistry (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Alternative & Traditional Medicine (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Vascular Medicine (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Plant Substances (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB858518289A GB8518289D0 (en) | 1985-07-19 | 1985-07-19 | Obtaining proanthocyanidine a2 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PT83007A PT83007A (en) | 1986-08-01 |
| PT83007B true PT83007B (pt) | 1988-07-01 |
Family
ID=10582551
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT83007A PT83007B (pt) | 1985-07-19 | 1986-07-17 | Processo para a preparacao de proantocianidina a2 , e de composicoes farmaceuticas que a contem |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US4863956A (pt) |
| EP (1) | EP0210785B1 (pt) |
| JP (1) | JPS6277390A (pt) |
| KR (1) | KR870000927A (pt) |
| AT (1) | ATE56868T1 (pt) |
| DE (1) | DE3674500D1 (pt) |
| ES (1) | ES2000532A6 (pt) |
| GB (1) | GB8518289D0 (pt) |
| GR (1) | GR861847B (pt) |
| PT (1) | PT83007B (pt) |
Families Citing this family (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB8917323D0 (en) * | 1989-07-28 | 1989-09-13 | Inverni Della Beffa Spa | Methods and pharmaceutical compositions for the treatment of ophthalmic diseases |
| IT1231725B (it) * | 1989-08-11 | 1991-12-21 | Inverni Della Beffa Spa | Procedimento per la preparazione di estratti ad alto contenuto in antocianosidi. |
| US5211944A (en) * | 1990-10-12 | 1993-05-18 | Shaman Pharmaceuticals, Inc. | Proanthocyanidin polymers having antiviral activity and methods of obtaining same |
| IT1270602B (it) * | 1994-07-12 | 1997-05-07 | Indena Spa | Formulazioni a base di esculoside e loro uso in campo farmaceutico e cosmetico |
| IT1270999B (it) * | 1994-07-26 | 1997-05-26 | Indena Spa | Formulazioni a base di cumarine e loro uso in campo farmaceutico e cosmetico |
| US5470874A (en) * | 1994-10-14 | 1995-11-28 | Lerner; Sheldon | Ascorbic acid and proanthocyanidine composition for topical application to human skin |
| FI955691A7 (fi) * | 1994-11-28 | 1996-05-29 | Suntory Ltd | Lipoproteiini(a):ta alentava aine, kolesterolia alentava aine ja näitä aineita sisältävät lääkkeet |
| US5683678A (en) * | 1995-03-09 | 1997-11-04 | The Procter & Gamble Company | Oral compositions |
| PL329325A1 (en) * | 1996-04-02 | 1999-03-29 | Mars Inc | Cocoa extract compounds, method of obtaining them and their application |
| JPH1059846A (ja) * | 1996-06-10 | 1998-03-03 | Kikkoman Corp | 白内障の予防または治療薬剤 |
| FR2770228B1 (fr) * | 1997-10-27 | 1999-12-10 | Greentech Sa | Procede d'obtention d'oligomeres de proanthocyanidines par biofermentation et leur utilisation dans des compositions cosmetiques, dietetiques, pharmaceutiques, chimiques et alimentaires |
| IT1304183B1 (it) * | 1998-12-18 | 2001-03-08 | Indena Spa | Complessi di proantocianidina a2 con fosfolipidi come agentiantiaterosclerotici. |
| US6245336B1 (en) | 1999-03-11 | 2001-06-12 | Dry Creek Nutrition, Inc. | Prevention and treatment of acetaminophen toxicity with grape seed proanthocyanidin extract |
| US6291517B1 (en) | 1999-11-19 | 2001-09-18 | Dry Creek Nutrition, Inc | Method for preventing or reducing stress-induced gastric injury using grape seed proanthocyanidin extract |
| US6228387B1 (en) | 2000-01-27 | 2001-05-08 | Murray Borod | Integrated comprehensive hemorrhoid treatment compositions and regimen |
| CA2421109C (en) * | 2000-08-31 | 2011-05-03 | Hauser, Inc. | Efficient method for producing compositions enriched in anthocyanins |
| US6960360B2 (en) * | 2000-08-31 | 2005-11-01 | Phenolics, Llc | Efficient method for producing compositions enriched in total phenols |
| US7306815B2 (en) * | 2000-08-31 | 2007-12-11 | Phenolics, Llc | Compositions enriched in phenolic compounds and methods for producing the same |
| US6706756B1 (en) | 2001-11-16 | 2004-03-16 | University Of South Florida | Vasodilating compound and method of use |
| DE50308279D1 (de) * | 2003-06-24 | 2007-11-08 | Cognis Ip Man Gmbh | Extrakte von Litchi sinensis enthaltend oligomere Proanthocyanidine |
| TWI279231B (en) * | 2003-10-02 | 2007-04-21 | Asahi Breweries Ltd | Neutralization agent of vacuolization toxin |
| US9675630B2 (en) * | 2004-01-28 | 2017-06-13 | Mars, Incorporated | Compositions and methods of use of A-type procyanidins |
| US20060073220A1 (en) * | 2004-07-08 | 2006-04-06 | Daugherty F J | Cinnamon extract enriched for polyphenols and methods of preparing same |
| TWI273911B (en) * | 2005-01-18 | 2007-02-21 | Univ Nat Chiao Tung | Prevention and amelioration of acetaminophen toxicity with tea melanin |
| US20060293258A1 (en) * | 2005-06-23 | 2006-12-28 | Peter Rohdewald | Method and composition to treat skin ulcers |
| EP2061327B1 (en) | 2006-05-01 | 2016-10-05 | Napo Pharmaceuticals, Inc. | Compositions for treating or preventing inflammatory bowel disease |
| DE102009005201A1 (de) * | 2009-01-20 | 2010-07-22 | Universität Rostock | Verwendung von Polyphenol-haltigen Pflanzenextrakten zur Behandlung von Adipositas und Diabetes mellitus Typ 2 |
| IT1398624B1 (it) | 2009-02-02 | 2013-03-08 | Dermogyn S R L | Uso cosmetico della proantocianidina a2 |
| JP5459699B2 (ja) * | 2009-03-27 | 2014-04-02 | キッコーマン株式会社 | クランベリー抽出物及びその製造方法 |
| ITMI20111671A1 (it) | 2011-09-16 | 2013-03-17 | Indena Spa | Composizioni per il trattamento di ulcere periferiche di varia origine |
| CN102924466A (zh) * | 2012-11-28 | 2013-02-13 | 华东理工大学 | 一种简便的合成[3.3.1]-双环缩酮及其衍生物的新方法 |
| CN103467477B (zh) * | 2013-07-24 | 2015-07-29 | 中国科学院华南植物园 | 原花青素a2及其制备方法和应用 |
| EP2829277A1 (en) | 2013-07-26 | 2015-01-28 | Natac Biotech, S.L. | Use of a-type proanthocyanidins in treating a mineralocorticoid receptor related disease |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR1584725A (pt) * | 1968-01-30 | 1970-01-02 | ||
| GB1589294A (en) * | 1976-09-08 | 1981-05-13 | Inverni Della Beffa Spa | Pharmaceutical compositions containing anthocyanidines |
| FR2480601A1 (fr) * | 1980-04-22 | 1981-10-23 | Science Union & Cie | Nouveau medicament a base de biflavanone |
| US4443472A (en) * | 1982-03-15 | 1984-04-17 | Richter Gedeon Vegyeszeti Gyar R.T. | Method of treating mammals for effects of neuro- and cardiovascular toxins |
-
1985
- 1985-07-19 GB GB858518289A patent/GB8518289D0/en active Pending
-
1986
- 1986-07-16 DE DE8686305461T patent/DE3674500D1/de not_active Expired - Fee Related
- 1986-07-16 EP EP86305461A patent/EP0210785B1/en not_active Expired - Lifetime
- 1986-07-16 GR GR861847A patent/GR861847B/el unknown
- 1986-07-16 AT AT86305461T patent/ATE56868T1/de not_active IP Right Cessation
- 1986-07-17 PT PT83007A patent/PT83007B/pt not_active IP Right Cessation
- 1986-07-18 ES ES8600403A patent/ES2000532A6/es not_active Expired
- 1986-07-18 JP JP61169669A patent/JPS6277390A/ja active Pending
- 1986-07-18 US US06/886,790 patent/US4863956A/en not_active Expired - Fee Related
- 1986-07-19 KR KR1019860005869A patent/KR870000927A/ko not_active Ceased
-
1989
- 1989-05-25 US US07/356,896 patent/US4925871A/en not_active Expired - Fee Related
- 1989-05-25 US US07/356,895 patent/US4925870A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| PT83007A (en) | 1986-08-01 |
| EP0210785B1 (en) | 1990-09-26 |
| EP0210785A1 (en) | 1987-02-04 |
| US4925871A (en) | 1990-05-15 |
| JPS6277390A (ja) | 1987-04-09 |
| GR861847B (en) | 1986-09-17 |
| ATE56868T1 (de) | 1990-10-15 |
| ES2000532A6 (es) | 1988-03-01 |
| GB8518289D0 (en) | 1985-08-29 |
| KR870000927A (ko) | 1987-03-10 |
| US4925870A (en) | 1990-05-15 |
| US4863956A (en) | 1989-09-05 |
| DE3674500D1 (de) | 1990-10-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM3A | Annulment or lapse |
Free format text: LAPSE DUE TO NON-PAYMENT OF FEES Effective date: 19930630 |