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PT83613B - Process for the selective chemical removal of a protein amino-terminal residue - Google Patents

Process for the selective chemical removal of a protein amino-terminal residue

Info

Publication number
PT83613B
PT83613B PT83613A PT8361386A PT83613B PT 83613 B PT83613 B PT 83613B PT 83613 A PT83613 A PT 83613A PT 8361386 A PT8361386 A PT 8361386A PT 83613 B PT83613 B PT 83613B
Authority
PT
Portugal
Prior art keywords
terminal residue
protein amino
selective chemical
chemical removal
removal
Prior art date
Application number
PT83613A
Other languages
English (en)
Other versions
PT83613A (en
Inventor
Richard Dennis Dimarchi
Gerald Stephen Brooke
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Publication of PT83613A publication Critical patent/PT83613A/pt
Publication of PT83613B publication Critical patent/PT83613B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/61—Growth hormone [GH], i.e. somatotropin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
PT83613A 1985-10-28 1986-10-24 Process for the selective chemical removal of a protein amino-terminal residue PT83613B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US79183785A 1985-10-28 1985-10-28

Publications (2)

Publication Number Publication Date
PT83613A PT83613A (en) 1986-11-01
PT83613B true PT83613B (en) 1988-11-21

Family

ID=25154940

Family Applications (1)

Application Number Title Priority Date Filing Date
PT83613A PT83613B (en) 1985-10-28 1986-10-24 Process for the selective chemical removal of a protein amino-terminal residue

Country Status (12)

Country Link
EP (1) EP0220958A3 (pt)
JP (1) JPS62106100A (pt)
KR (1) KR890004352B1 (pt)
CN (1) CN86107569A (pt)
AU (1) AU6441486A (pt)
DK (1) DK512286A (pt)
HU (1) HUT41811A (pt)
IL (1) IL80422A0 (pt)
NZ (1) NZ218088A (pt)
PT (1) PT83613B (pt)
SU (1) SU1531858A3 (pt)
ZA (1) ZA868168B (pt)

Families Citing this family (83)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5648254A (en) * 1988-01-15 1997-07-15 Zymogenetics, Inc. Co-expression in eukaryotic cells
WO1990005185A1 (fr) * 1988-11-07 1990-05-17 L'universite De L'etat A Liege Hormone de croissance humaine modifiee
US5126249A (en) * 1989-05-09 1992-06-30 Eli Lilly And Company Enzymatic removal of a protein amino-terminal sequence
US5756458A (en) * 1989-06-16 1998-05-26 Pharmacia & Upjohn Company Stabilized potent GRF analogs
IL97885A0 (en) 1990-04-24 1992-06-21 Lilly Co Eli Growth hormone releasing factor analogs
WO1992009691A1 (fr) * 1990-11-29 1992-06-11 Institut National De La Recherche Agronomique - I.N.R.A. Nouveaux variants derives des interferons de type i, leur procede de production, et leurs applications
FR2669931B1 (fr) * 1990-11-29 1995-03-31 Transgene Nouveaux variants derives des interferons-alpha et leur procede de production.
US6428771B1 (en) 1995-05-15 2002-08-06 Pharmaceutical Discovery Corporation Method for drug delivery to the pulmonary system
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RU2161501C1 (ru) * 2000-06-29 2001-01-10 Санкт-Петербургская Общественная Организация "Санкт-Петербургский Институт Биорегуляции И Геронтологии Сзо Рамн" Способ получения пептидов, обладающих тканеспецифической активностью, и фармацевтические композиции на их основе
WO2002011676A2 (en) 2000-08-04 2002-02-14 Dmi Biosciences, Inc. Method of using diketopiperazines and composition containing them
ES2300568T3 (es) 2002-03-20 2008-06-16 Mannkind Corporation Aparato de inhalacion.
ES2572975T3 (es) 2003-05-15 2016-06-03 Ampio Pharmaceuticals, Inc. Tratamiento de enfermedades mediadas por los linfocitos T
US20080090753A1 (en) 2004-03-12 2008-04-17 Biodel, Inc. Rapid Acting Injectable Insulin Compositions
ES2385934T3 (es) 2004-08-20 2012-08-03 Mannkind Corporation Catálisis de la síntesis de dicetopiperazina.
ES2540886T3 (es) 2004-08-23 2015-07-14 Mannkind Corporation Sales de dicetopiperazina para la administración de fármacos
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US7713929B2 (en) 2006-04-12 2010-05-11 Biodel Inc. Rapid acting and long acting insulin combination formulations
US8084420B2 (en) 2005-09-29 2011-12-27 Biodel Inc. Rapid acting and long acting insulin combination formulations
CA2628241C (en) 2005-11-07 2016-02-02 Indiana University Research And Technology Corporation Glucagon analogs exhibiting physiological solubility and stability
CN101389348A (zh) 2006-02-22 2009-03-18 曼金德公司 用于改善包含二酮哌嗪和活性剂的微粒的药物性质的方法
JP2009533471A (ja) 2006-04-12 2009-09-17 バイオデル， インコーポレイテッド 即効型および長時間作用型組合せインスリン製剤
AU2008205229B2 (en) 2007-01-05 2014-03-27 Indiana University Research And Technology Corporation Glucagon analogs exhibiting enhanced solubility in physiological pH buffers
EP2487184A1 (en) 2007-02-15 2012-08-15 Indiana University Research and Technology Corporation Glucagon/GLP-1 receptor co-agonists
RU2506273C2 (ru) * 2007-07-09 2014-02-10 Импиэриэл Инноувейшнс Лимитид Аналог панкреатического полипептида человека (варианты), фармацевтическая композиция на его основе, способ лечения ожирения или диабета, способ снижения аппетита, уменьшения поглощения пищи или снижения потребления калорий и способ косметического снижения массы посредством указанного аналога
JP5669582B2 (ja) 2007-10-30 2015-02-12 インディアナ ユニバーシティー リサーチ アンド テクノロジー コーポレーションＩｎｄｉａｎａ Ｕｎｉｖｅｒｓｉｔｙ Ｒｅｓｅａｒｃｈ Ａｎｄ Ｔｅｃｈｎｏｌｏｇｙ Ｃｏｒｐｏｒａｔｉｏｎ グルカゴンアンタゴニスト
EP2214691B1 (en) 2007-10-30 2015-09-30 Indiana University Research and Technology Corporation Compounds exhibiting glucagon antagonist and glp-1 agonist activity
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EP2300011A4 (en) 2008-05-27 2012-06-20 Dmi Life Sciences Inc THERAPEUTIC PROCESSES AND COMPOUNDS
WO2009152477A2 (en) 2008-06-13 2009-12-17 Mannkind Corporation A dry powder inhaler and system for drug delivery
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US9060927B2 (en) 2009-03-03 2015-06-23 Biodel Inc. Insulin formulations for rapid uptake
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WO2010144785A2 (en) 2009-06-12 2010-12-16 Mannkind Corporation Diketopiperazine microparticles with defined isomer contents
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JP6723222B2 (ja) 2014-08-18 2020-07-15 アンピオ ファーマシューティカルズ，インコーポレイテッド 関節病態の治療
JP6701208B2 (ja) 2014-09-24 2020-05-27 インディアナ ユニヴァーシティ リサーチ アンド テクノロジー コーポレイション 脂質化アミド系インスリンプロドラッグ
ES2822994T3 (es) 2014-09-24 2021-05-05 Univ Indiana Res & Tech Corp Conjugados de incretina-insulina
US10561806B2 (en) 2014-10-02 2020-02-18 Mannkind Corporation Mouthpiece cover for an inhaler
EP3310375A4 (en) 2015-06-22 2019-02-20 Ampio Pharmaceuticals, Inc. USE OF LOW-MOLECULAR FRACTIONS OF HUMAN SERUMALBUMINE IN THE TREATMENT OF ILLNESSES
CN106855477A (zh) * 2015-12-09 2017-06-16 中国科学院大连化学物理研究所 基于埃德曼降解的蛋白质c-末端肽富集方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2921216A1 (de) * 1979-05-25 1980-12-04 Teschemacher Hansjoerg Pharmakologisch aktive peptide
IL60184A (en) * 1979-05-31 1984-05-31 Schering Ag Process for the specific cleavage of protein sequences from proteins
WO1986007380A1 (fr) * 1985-06-04 1986-12-18 Takeda Chemical Industries, Ltd. Procede de preparation de polypeptides

Also Published As

Publication number Publication date
AU6441486A (en) 1987-04-30
IL80422A0 (en) 1987-01-30
DK512286A (da) 1987-04-29
NZ218088A (en) 1989-01-27
HUT41811A (en) 1987-05-28
JPS62106100A (ja) 1987-05-16
EP0220958A2 (en) 1987-05-06
KR870004056A (ko) 1987-05-07
KR890004352B1 (ko) 1989-10-31
ZA868168B (en) 1988-06-29
CN86107569A (zh) 1987-07-08
PT83613A (en) 1986-11-01
EP0220958A3 (en) 1989-01-25
DK512286D0 (da) 1986-10-27
SU1531858A3 (ru) 1989-12-23

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