PT827964E - Complexos de s-(+)-adenosilmetionina e 3'-azido-2',3'-didesoxinucleosido como inibidores potentes da replicacao de hiv - Google Patents
Complexos de s-(+)-adenosilmetionina e 3'-azido-2',3'-didesoxinucleosido como inibidores potentes da replicacao de hivInfo
- Publication number
- PT827964E PT827964E PT97114113T PT97114113T PT827964E PT 827964 E PT827964 E PT 827964E PT 97114113 T PT97114113 T PT 97114113T PT 97114113 T PT97114113 T PT 97114113T PT 827964 E PT827964 E PT 827964E
- Authority
- PT
- Portugal
- Prior art keywords
- azido
- complexes
- didesoxinucleosido
- adenosylmetionin
- hiv replication
- Prior art date
Links
- 230000010076 replication Effects 0.000 title abstract 2
- 239000003112 inhibitor Substances 0.000 title 1
- 241000713772 Human immunodeficiency virus 1 Species 0.000 abstract 1
- 102100034343 Integrase Human genes 0.000 abstract 1
- 108010092799 RNA-directed DNA polymerase Proteins 0.000 abstract 1
- MEFKEPWMEQBLKI-AIRLBKTGSA-N S-adenosyl-L-methioninate Chemical compound O[C@@H]1[C@H](O)[C@@H](C[S+](CC[C@H](N)C([O-])=O)C)O[C@H]1N1C2=NC=NC(N)=C2N=C1 MEFKEPWMEQBLKI-AIRLBKTGSA-N 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 239000002777 nucleoside Substances 0.000 abstract 1
- 125000003835 nucleoside group Chemical group 0.000 abstract 1
- 230000002195 synergetic effect Effects 0.000 abstract 1
- 231100001274 therapeutic index Toxicity 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Veterinary Medicine (AREA)
- Virology (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Immunology (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Tropical Medicine & Parasitology (AREA)
- AIDS & HIV (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19632823A DE19632823C1 (de) | 1996-08-14 | 1996-08-14 | Komplexe zwischen S-(+)-Adenosylmethionin und 3'-Azido-2',3'-didesoxynucleosid als potente Inhibitoren der HIV-Replikation |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT827964E true PT827964E (pt) | 2003-04-30 |
Family
ID=7802653
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT97114113T PT827964E (pt) | 1996-08-14 | 1997-08-14 | Complexos de s-(+)-adenosilmetionina e 3'-azido-2',3'-didesoxinucleosido como inibidores potentes da replicacao de hiv |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6117849A (pt) |
| EP (1) | EP0827964B1 (pt) |
| JP (1) | JP3202179B2 (pt) |
| AT (1) | ATE229030T1 (pt) |
| CA (1) | CA2213099C (pt) |
| DE (2) | DE19632823C1 (pt) |
| DK (1) | DK0827964T3 (pt) |
| ES (1) | ES2188828T3 (pt) |
| PT (1) | PT827964E (pt) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6759395B2 (en) * | 2000-12-18 | 2004-07-06 | Orchid Chemicals & Pharmaceuticals, Ltd. | Soft-gelatin capsule comprising S-adenosylmethionine and a method for producing the same |
| WO2002074910A2 (en) | 2001-03-15 | 2002-09-26 | Trustees Of Boston College, The | Selective anti-viral nucleoside chain terminators |
| ITMI20012462A1 (it) * | 2001-11-22 | 2003-05-22 | Gnosis Srl | Processo per la preparazione di compresse comprendenti s-adenosilmetionina |
| DK1325740T3 (da) * | 2001-12-12 | 2004-08-16 | Chemistry & Health Int Bv | Stabile granulater indeholdende s-adenosylmethionin og fremgangsmåde til fremstilling deraf |
| US20050272687A1 (en) * | 2004-06-08 | 2005-12-08 | Hebert Rolland F | Stable S-adenosyl-l-methionine |
| US20090012036A1 (en) * | 2005-05-24 | 2009-01-08 | Hebert Rolland F | Stable S-adenosyl-L-methionine |
| NZ609146A (en) * | 2005-09-26 | 2014-08-29 | Gilead Pharmasset Llc | Modified 4’-nucleosides as antiviral agents |
| US20100004191A1 (en) * | 2008-07-01 | 2010-01-07 | Rolland F Hebert | Compositions of S-adenosyl-L-methionine. |
| EP2945959B1 (en) | 2013-01-16 | 2020-05-13 | Hebert Sam-E LLC | Stable indole-3-propionate salts of s-adenosyl-l-methionine |
| JP2020164521A (ja) * | 2019-03-29 | 2020-10-08 | 国立大学法人 長崎大学 | 抗ウィルス薬 |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB2001976B (en) * | 1977-08-03 | 1982-03-10 | Yamasa Shoyu Kk | S-adenosyl-l-methionine compositions and production thereof |
| US4724232A (en) * | 1985-03-16 | 1988-02-09 | Burroughs Wellcome Co. | Treatment of human viral infections |
| US4880782A (en) * | 1986-11-21 | 1989-11-14 | Max-Planck-Gesellschaft Zur Foederung Der Wissenschaften E.V. | Method of treating viral infections in humans and compositions therefor |
| DE4005275A1 (de) * | 1990-02-20 | 1991-08-22 | Grundmann Ewald | Verwendung von s-adenosylmethionin als mittel gegen virale infektionen durch retroviren |
| IT1243859B (it) * | 1990-10-23 | 1994-06-28 | Bioresearch Spa | Composizioni farmaceutiche comprendenti associazioni fra sali di s-adenosil-l-metionina e acido 5-metil (o 5-formil)-tetraidrofolico per la terapia di complicanze neurologiche negli ammalati di aids. |
| DE19628514C1 (de) * | 1996-07-05 | 1997-09-25 | E Dr Grundmann | Kombination von S-Adenosylmethionin und Azidothymidin zur Hemmung der HIV-Replikation |
-
1996
- 1996-08-14 DE DE19632823A patent/DE19632823C1/de not_active Expired - Fee Related
-
1997
- 1997-08-14 US US08/911,516 patent/US6117849A/en not_active Expired - Lifetime
- 1997-08-14 JP JP21965197A patent/JP3202179B2/ja not_active Expired - Fee Related
- 1997-08-14 AT AT97114113T patent/ATE229030T1/de active
- 1997-08-14 PT PT97114113T patent/PT827964E/pt unknown
- 1997-08-14 EP EP97114113A patent/EP0827964B1/en not_active Expired - Lifetime
- 1997-08-14 DK DK97114113T patent/DK0827964T3/da active
- 1997-08-14 DE DE69717568T patent/DE69717568T2/de not_active Expired - Lifetime
- 1997-08-14 ES ES97114113T patent/ES2188828T3/es not_active Expired - Lifetime
- 1997-08-14 CA CA002213099A patent/CA2213099C/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| JPH10139795A (ja) | 1998-05-26 |
| CA2213099C (en) | 2003-10-28 |
| DE69717568D1 (de) | 2003-01-16 |
| US6117849A (en) | 2000-09-12 |
| ATE229030T1 (de) | 2002-12-15 |
| DK0827964T3 (da) | 2003-03-17 |
| JP3202179B2 (ja) | 2001-08-27 |
| CA2213099A1 (en) | 1998-02-14 |
| ES2188828T3 (es) | 2003-07-01 |
| DE19632823C1 (de) | 1997-11-20 |
| DE69717568T2 (de) | 2003-09-04 |
| EP0827964B1 (en) | 2002-12-04 |
| EP0827964A3 (en) | 1998-07-29 |
| EP0827964A2 (en) | 1998-03-11 |
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