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PT78427B - Process for preparing novel pyrimidine derivatives and of phar-maceutical compositions containing the same - Google Patents

Process for preparing novel pyrimidine derivatives and of phar-maceutical compositions containing the same

Info

Publication number
PT78427B
PT78427B PT78427A PT7842784A PT78427B PT 78427 B PT78427 B PT 78427B PT 78427 A PT78427 A PT 78427A PT 7842784 A PT7842784 A PT 7842784A PT 78427 B PT78427 B PT 78427B
Authority
PT
Portugal
Prior art keywords
pyrimidine derivatives
phar
same
compositions containing
preparing novel
Prior art date
Application number
PT78427A
Other languages
English (en)
Other versions
PT78427A (en
Inventor
Ivan Kompis
Rita Locher
Hans Maag
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of PT78427A publication Critical patent/PT78427A/pt
Publication of PT78427B publication Critical patent/PT78427B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/70—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D211/74—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/68—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D211/72—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D211/78—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Compositions Of Macromolecular Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
PT78427A 1983-04-14 1984-04-13 Process for preparing novel pyrimidine derivatives and of phar-maceutical compositions containing the same PT78427B (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CH200383 1983-04-14
CH63384 1984-02-10

Publications (2)

Publication Number Publication Date
PT78427A PT78427A (en) 1984-05-01
PT78427B true PT78427B (en) 1986-08-22

Family

ID=25685195

Family Applications (1)

Application Number Title Priority Date Filing Date
PT78427A PT78427B (en) 1983-04-14 1984-04-13 Process for preparing novel pyrimidine derivatives and of phar-maceutical compositions containing the same

Country Status (19)

Country Link
US (2) US4590270A (pt)
EP (1) EP0122580B1 (pt)
KR (1) KR840008352A (pt)
AT (1) ATE30423T1 (pt)
AU (1) AU567731B2 (pt)
CA (1) CA1244028A (pt)
DE (1) DE3466988D1 (pt)
DK (1) DK169984A (pt)
ES (3) ES8602751A1 (pt)
FI (1) FI841429A7 (pt)
GR (1) GR81833B (pt)
HU (1) HU193923B (pt)
IE (1) IE57201B1 (pt)
IL (1) IL71478A (pt)
MC (1) MC1599A1 (pt)
NO (1) NO158420C (pt)
NZ (1) NZ207761A (pt)
PH (1) PH20484A (pt)
PT (1) PT78427B (pt)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1244028A (en) * 1983-04-14 1988-11-01 Hans Maag Pyrimidine derivatives
NZ227684A (en) * 1988-01-30 1991-07-26 Merck Sharp & Dohme Pyrazine, pyridazine, and pyrimidine derivatives and pharmaceutical compositions
US5260293A (en) * 1988-01-30 1993-11-09 Merck Sharp & Dohme Limited Pyrazines, pyrimidines and pyridazines useful in the treatment of senile dementia
PT99514B (pt) * 1990-11-14 1999-04-30 Chiron Corp Processo de preparacao de compostos para o tratamento de infeccoes fungicas
GB9510459D0 (en) 1995-05-24 1995-07-19 Zeneca Ltd Bicyclic amines
DE69728531T2 (de) * 1996-05-13 2004-09-30 Syngenta Ltd., Guildford Bicyclische amine als insektizide
GB9623944D0 (en) * 1996-11-15 1997-01-08 Zeneca Ltd Bicyclic amine derivatives
GB9624114D0 (en) * 1996-11-20 1997-01-08 Zeneca Ltd Pesticidal bicyclic amine derivatives
ES2216131T3 (es) * 1996-11-26 2004-10-16 Syngenta Limited Derivados de 8-azabiciclo 3,2,1 )octano-,8- azabiciclo 3,2.1) oct-6- eno- 9-azabiciclo 3.3.1) nonano-, 9-aza -3- oxabiciclo 3.3.1) nonano - y 9 -aza-3- tiabiciclo 3.3.1) nonano, su preparacion y su uso como insecticidas.
GB9624611D0 (en) * 1996-11-26 1997-01-15 Zeneca Ltd Bicyclic amine compounds
CZ298824B6 (cs) 1997-05-30 2008-02-20 Neurosearch A/S Deriváty 8-azabicyklo[3.2.1]okt-2-enu, zpusob jejich prípravy a jejich použití
KR20100110378A (ko) * 2002-05-24 2010-10-12 안지오테크 인터내셔날 아게 의료용 임플란트를 피복하기 위한 조성물 및 방법
US8313760B2 (en) * 2002-05-24 2012-11-20 Angiotech International Ag Compositions and methods for coating medical implants
CN102649786B (zh) * 2011-02-28 2014-08-27 郑州福源动物药业有限公司 一种2，4-二氨基-5-(8-二甲氨基-7-甲基-5-喹啉基甲基)-2，4-(1h，3h)嘧啶的制备方法
EP3411367A4 (en) 2016-02-05 2019-07-10 Vyera Pharmaceuticals, LLC COMPOSITIONS AND METHOD FOR THE TREATMENT OF INFECTIONS
AU2018312985A1 (en) * 2017-08-07 2020-02-27 Vyera Pharmaceuticals, LLC DHFR inhibitors, compositions, and methods related thereto
US11472295B2 (en) 2018-12-27 2022-10-18 Msns, Llc Regenerative braking energy dissipater and system and method of using same

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB762256A (en) * 1953-09-17 1956-11-28 Sterling Drug Inc Tertiary-amino-substituted compounds of the tropane and granatanine series
US3133073A (en) * 1959-12-10 1964-05-12 Sterling Drug Inc 3-aryl-1, 5-iminocycloalkanes and preparation thereof
JPS4911710A (pt) * 1972-05-15 1974-02-01
US4053475A (en) * 1975-03-07 1977-10-11 Sterling Drug Inc. N-[2-(Pyridinyl)-4-pyrimidinyl]ureas preparation
US4008235A (en) * 1975-03-07 1977-02-15 Sterling Drug Inc. N-[2-(pyridinyl)-4-pyrimidinyl]ureas
US4109092A (en) * 1976-10-07 1978-08-22 Sterling Drug Inc. Preparation of 2-(pyridinyl)-4-pyrimidinamines
FR2476088A2 (fr) * 1979-01-16 1981-08-21 Delalande Sa Nouveaux derives du nor-tropane, leur procede de preparation et leur application en therapeutique
FR2493848B2 (fr) * 1980-11-07 1986-05-16 Delalande Sa Nouveaux derives des nor-tropane et granatane, leur procede de preparation et leur application en therapeutique
US4438267A (en) * 1980-11-11 1984-03-20 Daluge Susan M Monoheteroring compounds and their use
CA1244028A (en) * 1983-04-14 1988-11-01 Hans Maag Pyrimidine derivatives

Also Published As

Publication number Publication date
KR840008352A (ko) 1984-12-14
NO158420C (no) 1988-09-07
ES531578A0 (es) 1985-12-01
ES8602751A1 (es) 1985-12-01
HU193923B (en) 1987-12-28
ATE30423T1 (de) 1987-11-15
FI841429L (fi) 1984-10-15
IE57201B1 (en) 1992-06-03
AU2664284A (en) 1984-10-18
IL71478A0 (en) 1984-07-31
EP0122580A1 (de) 1984-10-24
IE840919L (en) 1984-10-14
NZ207761A (en) 1987-01-23
CA1244028A (en) 1988-11-01
FI841429A7 (fi) 1984-10-15
AU567731B2 (en) 1987-12-03
GR81833B (pt) 1984-12-12
US4590270A (en) 1986-05-20
MC1599A1 (fr) 1985-05-09
HUT34017A (en) 1985-01-28
ES539537A0 (es) 1985-11-01
DK169984A (da) 1984-10-15
DK169984D0 (da) 1984-03-27
PH20484A (en) 1987-01-16
ES8601184A1 (es) 1985-11-01
US4774249A (en) 1988-09-27
IL71478A (en) 1987-07-31
NO841508L (no) 1984-10-15
ES539536A0 (es) 1985-11-16
FI841429A0 (fi) 1984-04-11
NO158420B (no) 1988-05-30
EP0122580B1 (de) 1987-10-28
DE3466988D1 (en) 1987-12-03
ES8601925A1 (es) 1985-11-16
PT78427A (en) 1984-05-01

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