PT64720A - Broad-spectrum cephalosporin antibiotics resistant to beta-lactamase - 7-(alpha-(4pethyl-2,3-dioxo-piperazinocarbonylamino)-para-hydroxy- phenylacetamido)-ceph-3-em-4-carboxylic acids - Google Patents
Broad-spectrum cephalosporin antibiotics resistant to beta-lactamase - 7-(alpha-(4pethyl-2,3-dioxo-piperazinocarbonylamino)-para-hydroxy- phenylacetamido)-ceph-3-em-4-carboxylic acidsInfo
- Publication number
- PT64720A PT64720A PT6472076A PT6472076A PT64720A PT 64720 A PT64720 A PT 64720A PT 6472076 A PT6472076 A PT 6472076A PT 6472076 A PT6472076 A PT 6472076A PT 64720 A PT64720 A PT 64720A
- Authority
- PT
- Portugal
- Prior art keywords
- lactamase
- cpd
- beta
- broad
- 4pethyl
- Prior art date
Links
- 229930186147 Cephalosporin Natural products 0.000 title abstract 2
- 108090000204 Dipeptidase 1 Proteins 0.000 title abstract 2
- 239000003242 anti bacterial agent Substances 0.000 title abstract 2
- 229940088710 antibiotic agent Drugs 0.000 title abstract 2
- 102000006635 beta-lactamase Human genes 0.000 title abstract 2
- 229940124587 cephalosporin Drugs 0.000 title abstract 2
- 150000001780 cephalosporins Chemical class 0.000 title abstract 2
- -1 1-methyl-1,2,3,4-tetrazol-5-ylthio Chemical group 0.000 abstract 1
- 241000894006 Bacteria Species 0.000 abstract 1
- 241000588747 Klebsiella pneumoniae Species 0.000 abstract 1
- 241000588769 Proteus <enterobacteria> Species 0.000 abstract 1
- 241000589517 Pseudomonas aeruginosa Species 0.000 abstract 1
- 125000003668 acetyloxy group Chemical group [H]C([H])([H])C(=O)O[*] 0.000 abstract 1
- 230000001580 bacterial effect Effects 0.000 abstract 1
- 230000000903 blocking effect Effects 0.000 abstract 1
- 230000036765 blood level Effects 0.000 abstract 1
- 150000001768 cations Chemical class 0.000 abstract 1
- 230000002949 hemolytic effect Effects 0.000 abstract 1
- 231100000053 low toxicity Toxicity 0.000 abstract 1
Landscapes
- Cephalosporin Compounds (AREA)
Abstract
Cephalosporins of formula (I): (where R1 = H, a cation or a blocking group and R2 = acetoxy (cpd. C) carbamyloxy (cpd. D), 5-methyl-1,3,4-thiazol-2-ylthio (cpd. B) or 1-methyl-1,2,3,4-tetrazol-5-ylthio (cpd. A)), are broad spectrum antibiotics effective against Gram-positive and Gram-negative bacteria (partic. Pseudomonas aeruginosa, Klebsiella pneumoniae and Proteus species) and stable to bacterial beta-lactamase. The cpds. have low toxicity, are well absorbed to give high blood levels and do not show hemolytic activity.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PT6472076A PT64720B (en) | 1976-01-20 | 1976-01-20 | PROCESS FOR THE PREPARATION OF NEW CEFALOSPORINS |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PT6472076A PT64720B (en) | 1976-01-20 | 1976-01-20 | PROCESS FOR THE PREPARATION OF NEW CEFALOSPORINS |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| PT64720A true PT64720A (en) | 1976-02-01 |
| PT64720B PT64720B (en) | 1977-06-03 |
Family
ID=20081839
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT6472076A PT64720B (en) | 1976-01-20 | 1976-01-20 | PROCESS FOR THE PREPARATION OF NEW CEFALOSPORINS |
Country Status (1)
| Country | Link |
|---|---|
| PT (1) | PT64720B (en) |
-
1976
- 1976-01-20 PT PT6472076A patent/PT64720B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| PT64720B (en) | 1977-06-03 |
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