PT4012035T - Adeno-associated viral vectors for treating myocilin (myoc) glaucoma - Google Patents
Adeno-associated viral vectors for treating myocilin (myoc) glaucomaInfo
- Publication number
- PT4012035T PT4012035T PT212042576T PT21204257T PT4012035T PT 4012035 T PT4012035 T PT 4012035T PT 212042576 T PT212042576 T PT 212042576T PT 21204257 T PT21204257 T PT 21204257T PT 4012035 T PT4012035 T PT 4012035T
- Authority
- PT
- Portugal
- Prior art keywords
- myoc
- adeno
- glaucoma
- viral vectors
- associated viral
- Prior art date
Links
- 208000010412 Glaucoma Diseases 0.000 title 1
- 101150104791 MYOC gene Proteins 0.000 title 1
- 102100029839 Myocilin Human genes 0.000 title 1
- 101710196550 Myocilin Proteins 0.000 title 1
- 239000013603 viral vector Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14141—Use of virus, viral particle or viral elements as a vector
- C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Biophysics (AREA)
- Wood Science & Technology (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Gastroenterology & Hepatology (AREA)
- Physics & Mathematics (AREA)
- Toxicology (AREA)
- Virology (AREA)
- Plant Pathology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462051229P | 2014-09-16 | 2014-09-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT4012035T true PT4012035T (en) | 2025-02-11 |
Family
ID=54238590
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT212042576T PT4012035T (en) | 2014-09-16 | 2015-09-16 | Adeno-associated viral vectors for treating myocilin (myoc) glaucoma |
Country Status (5)
| Country | Link |
|---|---|
| ES (1) | ES3011359T3 (en) |
| HU (1) | HUE070278T2 (en) |
| PL (1) | PL4012035T3 (en) |
| PT (1) | PT4012035T (en) |
| WO (1) | WO2016044478A1 (en) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3033125A1 (en) * | 2016-08-16 | 2018-02-22 | The University Of North Carolina At Chapel Hill | Methods and compositions for targeted gene transfer |
| MX2022012493A (en) * | 2020-04-06 | 2022-10-27 | Alnylam Pharmaceuticals Inc | Compositions and methods for silencing myoc expression. |
| IL301647A (en) * | 2020-10-07 | 2023-05-01 | Regenxbio Inc | Adeno-associated viruses for ocular delivery of gene therapy |
| JP2024520740A (en) * | 2021-06-03 | 2024-05-24 | ダイノ セラピューティクス インコーポレイテッド | Capsid variants and methods of using same |
| JP2024526234A (en) * | 2021-06-28 | 2024-07-17 | アルナイラム ファーマシューティカルズ， インコーポレイテッド | Compositions and methods for silencing myoc expression |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6225291B1 (en) | 1997-04-21 | 2001-05-01 | University Of Florida | Rod opsin mRNA-specific ribozyme compositions and methods for the treatment of retinal diseases |
| US6566118B1 (en) | 1997-09-05 | 2003-05-20 | Targeted Genetics Corporation | Methods for generating high titer helper-free preparations of released recombinant AAV vectors |
| US6995006B2 (en) | 1997-09-05 | 2006-02-07 | Targeted Genetics Corporation | Methods for generating high titer helper-free preparations of released recombinant AAV vectors |
| EP2369002A1 (en) | 1999-08-09 | 2011-09-28 | Targeted Genetics Corporation | Enhancement of expression of a single-stranded, heterologous nucleotide sequence from recombinant viral vectors by designing the sequence such that it forms intrastrand base pairs |
| ES2256265T3 (en) | 2000-06-01 | 2006-07-16 | University Of North Carolina At Chapel Hill | DUVICATED PARVOVIRUS VECTORS. |
| CA2406745C (en) | 2001-11-13 | 2006-01-10 | The Trustees Of The University Of Pennsylvania | A method of detecting and/or identifying adeno-associated virus (aav) sequences and isolating novel sequences identified thereby |
| GB0403600D0 (en) * | 2004-02-18 | 2004-03-24 | Trinity College Dublin | Methods and reagents for treating disease |
| WO2005117938A2 (en) * | 2004-04-13 | 2005-12-15 | Regents Of The University Of Minnesota | Methods of treating ocular conditions |
| US7765583B2 (en) | 2005-02-28 | 2010-07-27 | France Telecom | System and method for managing virtual user domains |
| US8283151B2 (en) | 2005-04-29 | 2012-10-09 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | Isolation, cloning and characterization of new adeno-associated virus (AAV) serotypes |
| EP2007795B1 (en) | 2006-03-30 | 2016-11-16 | The Board Of Trustees Of The Leland Stanford Junior University | Aav capsid proteins |
| EP2192926A1 (en) * | 2007-10-01 | 2010-06-09 | Alcon Research, Ltd. | Self complementary aav-mediated delivery of interfering rna molecules to treat or prevent ocular disorders |
| WO2009105690A2 (en) | 2008-02-21 | 2009-08-27 | Targeted Genetics Corporation | Devices and methods for delivering polynucleotides into retinal cells of the macula and fovea |
| US8663624B2 (en) | 2010-10-06 | 2014-03-04 | The Regents Of The University Of California | Adeno-associated virus virions with variant capsid and methods of use thereof |
| KR101956885B1 (en) | 2011-02-17 | 2019-03-12 | 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 | Compositions and methods for altering tissue specificity and improving aav9-mediated gene transfer |
-
2015
- 2015-09-16 PT PT212042576T patent/PT4012035T/en unknown
- 2015-09-16 PL PL21204257.6T patent/PL4012035T3/en unknown
- 2015-09-16 ES ES21204257T patent/ES3011359T3/en active Active
- 2015-09-16 WO PCT/US2015/050515 patent/WO2016044478A1/en not_active Ceased
- 2015-09-16 HU HUE21204257A patent/HUE070278T2/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| WO2016044478A1 (en) | 2016-03-24 |
| PL4012035T3 (en) | 2025-03-24 |
| HUE070278T2 (en) | 2025-05-28 |
| CA2961523A1 (en) | 2016-03-24 |
| ES3011359T3 (en) | 2025-04-07 |
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