PT3660073T - Poli-(lactídeo-co-glicolídeo) de libertação imediata reduzida - Google Patents

Poli-(lactídeo-co-glicolídeo) de libertação imediata reduzida

Info

Publication number: PT3660073T
Authority: PT; Portugal
Prior art keywords: polymers; methods; low; burst; produce
Prior art date: 2007-02-15

Application number

PT192030716T

Other languages

English (en)

Original Assignee

Tolmar International Ltd

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2007-02-15

Filing date

2008-02-13

Publication date

2023-08-31

2008-02-13 Application filed by Tolmar International Ltd filed Critical Tolmar International Ltd

2023-08-31 Publication of PT3660073T publication Critical patent/PT3660073T/pt

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/34—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyesters, polyamino acids, polysiloxanes, polyphosphazines, copolymers of polyalkylene glycol or poloxamers
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/18—Feminine contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P5/00—Drugs for disorders of the endocrine system
- A61P5/06—Drugs for disorders of the endocrine system of the anterior pituitary hormones, e.g. TSH, ACTH, FSH, LH, PRL, GH
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
- C08G63/02—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds
- C08G63/06—Polyesters derived from hydroxycarboxylic acids or from polycarboxylic acids and polyhydroxy compounds derived from hydroxycarboxylic acids
- C08G63/08—Lactones or lactides
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G63/00—Macromolecular compounds obtained by reactions forming a carboxylic ester link in the main chain of the macromolecule
- C08G63/88—Post-polymerisation treatment
- C08G63/90—Purification; Drying
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
- A61K38/08—Peptides having 5 to 11 amino acids

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
General Health & Medical Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Chemical Kinetics & Catalysis (AREA)
Organic Chemistry (AREA)
Engineering & Computer Science (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Endocrinology (AREA)
Immunology (AREA)
Polymers & Plastics (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Reproductive Health (AREA)
Gastroenterology & Hepatology (AREA)
Pain & Pain Management (AREA)
Communicable Diseases (AREA)
Ophthalmology & Optometry (AREA)
Oncology (AREA)
Inorganic Chemistry (AREA)
Dermatology (AREA)
Neurology (AREA)
Rheumatology (AREA)
Gynecology & Obstetrics (AREA)
Diabetes (AREA)
Virology (AREA)
Psychiatry (AREA)
Tropical Medicine & Parasitology (AREA)
Urology & Nephrology (AREA)
Pregnancy & Childbirth (AREA)
Physical Education & Sports Medicine (AREA)

PT192030716T 2007-02-15 2008-02-13 Poli-(lactídeo-co-glicolídeo) de libertação imediata reduzida PT3660073T (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US90143507P	2007-02-15	2007-02-15

Publications (1)

Publication Number	Publication Date
PT3660073T true PT3660073T (pt)	2023-08-31

Family

ID=39504385

Family Applications (3)

Application Number	Title	Priority Date	Filing Date
PT151852183T PT3202814T (pt)	2007-02-15	2008-02-13	Poli-(lactido/glicolido) de libertação imediata reduzida e métodos de produção de polímeros
PT87255113T PT2115029E (pt)	2007-02-15	2008-02-13	Poli-(lactido/glicolido) de efeito de libertação imediata reduzido e métodos de produção de polímeros
PT192030716T PT3660073T (pt)	2007-02-15	2008-02-13	Poli-(lactídeo-co-glicolídeo) de libertação imediata reduzida

Family Applications Before (2)

Application Number	Title	Priority Date	Filing Date
PT151852183T PT3202814T (pt)	2007-02-15	2008-02-13	Poli-(lactido/glicolido) de libertação imediata reduzida e métodos de produção de polímeros
PT87255113T PT2115029E (pt)	2007-02-15	2008-02-13	Poli-(lactido/glicolido) de efeito de libertação imediata reduzido e métodos de produção de polímeros

Country Status (15)

Country	Link
US (7)	US9187593B2 (pt)
EP (3)	EP3202814B1 (pt)
JP (3)	JP5342459B2 (pt)
CA (1)	CA2678350C (pt)
CY (2)	CY1116785T1 (pt)
DK (3)	DK2115029T3 (pt)
ES (3)	ES2755374T3 (pt)
FI (1)	FI3660073T3 (pt)
HR (3)	HRP20150997T1 (pt)
HU (3)	HUE047775T2 (pt)
LT (2)	LT3202814T (pt)
PL (3)	PL3202814T3 (pt)
PT (3)	PT3202814T (pt)
SI (3)	SI3660073T1 (pt)
WO (1)	WO2008100532A1 (pt)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US8313763B2 (en)	2004-10-04	2012-11-20	Tolmar Therapeutics, Inc.	Sustained delivery formulations of rapamycin compounds
US8852638B2 (en)	2005-09-30	2014-10-07	Durect Corporation	Sustained release small molecule drug formulation
ES2397712T3 (es)	2006-01-18	2013-03-08	Qps, Llc	Composiciones farmacéuticas con estabilidad reforzada
EP3202814B1 (en)	2007-02-15	2019-10-16	Tolmar Therapeutics, Inc.	Low burst poly-(lactide/glycolide) and methods to produce polymers
WO2008153611A2 (en) *	2007-05-25	2008-12-18	Qlt Usa, Inc.	Sustained delivery formulations of risperidone compounds
CA2726763A1 (en)	2008-06-03	2009-12-10	Tolmar Therapeutics, Inc.	Controlled release copolymer formulation with improved release kinetics
US10335366B2 (en)	2010-05-31	2019-07-02	Laboratorios Farmacéuticos Rovi, S.A.	Risperidone or paliperidone implant formulation
US10285936B2 (en)	2010-05-31	2019-05-14	Laboratorios Farmacéuticos Rovi, S.A.	Injectable composition with aromatase inhibitor
US10350159B2 (en)	2010-05-31	2019-07-16	Laboratories Farmacéuticos Rovi, S.A.	Paliperidone implant formulation
US10881605B2 (en)	2010-05-31	2021-01-05	Laboratorios Farmaceuticos Rovi, S.A.	Methods for the preparation of injectable depot compositions
HUE029895T2 (en)	2010-05-31	2017-04-28	Farm Rovi Lab Sa	Antipsychotic injectable depot composition
LT2394663T (lt)	2010-05-31	2022-02-10	Laboratorios Farmaceuticos Rovi, S.A.	Kompozicijos, skirtos įšvirkščiamiems in situ biologiškai skaidiems implantams
US10463607B2 (en)	2010-05-31	2019-11-05	Laboratorios Farmaceutics Rofi S.A.	Antipsychotic Injectable Depot Composition
US9272044B2 (en)	2010-06-08	2016-03-01	Indivior Uk Limited	Injectable flowable composition buprenorphine
GB2481017B (en)	2010-06-08	2015-01-07	Rb Pharmaceuticals Ltd	Microparticle buprenorphine suspension
GB2513267B (en)	2010-06-08	2015-03-18	Rb Pharmaceuticals Ltd	Injectable flowable composition comprising buprenorphine
CN103421172B (zh) *	2012-05-23	2016-01-20	上海现代药物制剂工程研究中心有限公司	一种生物可降解聚酯的纯化工艺
AU2014249008B2 (en)	2013-03-11	2018-12-06	Durect Corporation	Injectable controlled release composition comprising high viscosity liquid carrier
US20140308352A1 (en)	2013-03-11	2014-10-16	Zogenix Inc.	Compositions and methods involving polymer, solvent, and high viscosity liquid carrier material
JP5959728B2 (ja) *	2013-04-11	2016-08-02	三井化学株式会社	乳酸―グリコール酸共重合体の製造法またはその塩の製造法
CN106132397A (zh) *	2013-12-06	2016-11-16	恩维希亚治疗股份有限公司	用于治疗眼部疾病的前房内植入物
GB201404139D0 (en)	2014-03-10	2014-04-23	Rb Pharmaceuticals Ltd	Sustained release buprenorphine solution formulations
US20160106804A1 (en) *	2014-10-15	2016-04-21	Yuhua Li	Pharmaceutical composition with improved stability
CA3015557C (en)	2014-11-07	2019-07-16	Indivior Uk Limited	The use of sustained-release buprenorphine formulations for the treatment of pain or opioid use disorders
US11458041B2 (en)	2015-10-08	2022-10-04	Ocular Therapeutix, Inc.	Punctal plug and bioadhesives
US10646484B2 (en)	2017-06-16	2020-05-12	Indivior Uk Limited	Methods to treat opioid use disorder
CN108498456B (zh) *	2018-05-16	2021-01-01	丽珠医药集团股份有限公司	一种阿立哌唑缓释微球及其制备方法
PE20210047A1 (es)	2018-06-12	2021-01-08	Farm Rovi Lab Sa	Composicion inyectable
KR20220041782A (ko) *	2019-05-27	2022-04-01	톨마 인터내셔날 리미티드	루프롤라이드 아세테이트 조성물 및 유방암 치료에 이용하는 방법
US20210251893A1 (en)	2020-02-06	2021-08-19	Ocular Therapeutix, Inc.	Compositions and Methods for Treating Ocular Diseases
EP4142664A4 (en)	2020-04-27	2024-05-29	Ocular Therapeutix, Inc.	METHODS FOR TREATING ALLERGIC CONJUNCTIVITIS
JP2023544311A (ja)	2020-09-30	2023-10-23	トルマーインターナショナルリミテッド	テストステロンの延長送達のための生分解性ポリマー送達システム
US12318387B2 (en)	2021-07-16	2025-06-03	Laboratorios Farmaceuticos Rovi, S.A.	Method of treating acute exacerbation of schizophrenia with long-acting injectable depot composition
WO2023027559A1 (ko) *	2021-08-27	2023-03-02	주식회사 엘지화학	블록 공중합체 및 이의 제조 방법
WO2024168022A2 (en)	2023-02-10	2024-08-15	Tolmar, Inc.	Degarelix polymeric formulations
AU2024291054A1 (en)	2023-07-05	2025-11-27	Tolmar International Limited	Polymeric leuprolide acetate formulations

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP2551756B2 (ja)	1985-05-07	1996-11-06	武田薬品工業株式会社	ポリオキシカルボン酸エステルおよびその製造法
DE3641692A1 (de)	1986-12-06	1988-06-09	Boehringer Ingelheim Kg	Katalysatorfreie resorbierbare homopolymere und copolymere
DE3708916A1 (de)	1987-03-19	1988-09-29	Boehringer Ingelheim Kg	Verfahren zur reinigung resorbierbarer polyester
US4938763B1 (en)	1988-10-03	1995-07-04	Atrix Lab Inc	Biodegradable in-situ forming implants and method of producing the same
US5702716A (en)	1988-10-03	1997-12-30	Atrix Laboratories, Inc.	Polymeric compositions useful as controlled release implants
US5324519A (en)	1989-07-24	1994-06-28	Atrix Laboratories, Inc.	Biodegradable polymer composition
US5487897A (en)	1989-07-24	1996-01-30	Atrix Laboratories, Inc.	Biodegradable implant precursor
ATE168391T1 (de)	1990-04-13	1998-08-15	Takeda Chemical Industries Ltd	Biologisch abbaubare hochmolekulare polymere, ihre herstellung und ihre verwendung
USRE37950E1 (en)	1990-04-24	2002-12-31	Atrix Laboratories	Biogradable in-situ forming implants and methods of producing the same
US6353030B1 (en) *	1990-08-01	2002-03-05	Novartis Ag	Relating to organic compounds
AU2605592A (en)	1991-10-15	1993-04-22	Atrix Laboratories, Inc.	Polymeric compositions useful as controlled release implants
EP0560014A1 (en)	1992-03-12	1993-09-15	Atrix Laboratories, Inc.	Biodegradable film dressing and method for its formation
US5681873A (en)	1993-10-14	1997-10-28	Atrix Laboratories, Inc.	Biodegradable polymeric composition
DE69524398T2 (de)	1994-04-08	2002-07-18	Atrix Laboratories, Inc.	Flüssige mittel zur wirkstoffabgabe
JP4979843B2 (ja)	1995-03-10	2012-07-18	ロッシュディアグノスティクスゲゼルシャフトミットベシュレンクテルハフツング	微粒子の形のポリペプチド含有投薬形
US5736152A (en)	1995-10-27	1998-04-07	Atrix Laboratories, Inc.	Non-polymeric sustained release delivery system
US6264970B1 (en)	1996-06-26	2001-07-24	Takeda Chemical Industries, Ltd.	Sustained-release preparation
JP4317599B2 (ja) *	1996-06-26	2009-08-19	武田薬品工業株式会社	徐放性製剤
CN1195788C (zh) *	1997-10-03	2005-04-06	麦克罗梅德公司	具有可逆热胶凝性质的可生物降解低分子量三嵌段聚(丙交酯－共聚－乙交酯)聚乙二醇共聚物
US6261583B1 (en)	1998-07-28	2001-07-17	Atrix Laboratories, Inc.	Moldable solid delivery system
US6143314A (en)	1998-10-28	2000-11-07	Atrix Laboratories, Inc.	Controlled release liquid delivery compositions with low initial drug burst
US6565874B1 (en)	1998-10-28	2003-05-20	Atrix Laboratories	Polymeric delivery formulations of leuprolide with improved efficacy
US6355657B1 (en)	1998-12-30	2002-03-12	Atrix Laboratories, Inc.	System for percutaneous delivery of opioid analgesics
US6461631B1 (en)	1999-11-16	2002-10-08	Atrix Laboratories, Inc.	Biodegradable polymer composition
ES2577389T3 (es)	2000-08-07	2016-07-14	Wako Pure Chemical Industries, Ltd.	Polímero de ácido láctico y procedimiento para su producción
JP5188670B2 (ja) *	2001-06-29	2013-04-24	武田薬品工業株式会社	徐放性組成物およびその製造法
TWI225416B (en)	2001-06-29	2004-12-21	Takeda Chemical Industries Ltd	Sustained-release composition and process for producing the same
US20060034889A1 (en) *	2004-08-16	2006-02-16	Macromed, Inc.	Biodegradable diblock copolymers having reverse thermal gelation properties and methods of use thereof
MX2007003789A (es) *	2004-10-04	2007-07-20	Qlt Usa Inc	Suministro ocular de formulaciones polimericas para suministro.
ES2528720T3 (es) *	2004-11-10	2015-02-12	Tolmar Therapeutics, Inc.	Sistema de suministro de polímero estabilizado
DK2079767T3 (da) *	2006-10-11	2014-10-27	Tolmar Therapeutics Inc	Fremstilling af bionedbrydelige polyestere med lave burst-egenskaber ved ekstraktion med et superkritisk fluid
EP3202814B1 (en)	2007-02-15	2019-10-16	Tolmar Therapeutics, Inc.	Low burst poly-(lactide/glycolide) and methods to produce polymers

2008
- 2008-02-13 EP EP15185218.3A patent/EP3202814B1/en active Active
- 2008-02-13 PL PL15185218T patent/PL3202814T3/pl unknown
- 2008-02-13 HR HRP20150997TT patent/HRP20150997T1/hr unknown
- 2008-02-13 FI FIEP19203071.6T patent/FI3660073T3/fi active
- 2008-02-13 PT PT151852183T patent/PT3202814T/pt unknown
- 2008-02-13 PL PL19203071.6T patent/PL3660073T3/pl unknown
- 2008-02-13 EP EP08725511.3A patent/EP2115029B1/en active Active
- 2008-02-13 CA CA2678350A patent/CA2678350C/en not_active Expired - Fee Related
- 2008-02-13 HU HUE15185218A patent/HUE047775T2/hu unknown
- 2008-02-13 SI SI200832213T patent/SI3660073T1/sl unknown
- 2008-02-13 DK DK08725511.3T patent/DK2115029T3/en active
- 2008-02-13 HU HUE08725511A patent/HUE025842T2/en unknown
- 2008-02-13 EP EP19203071.6A patent/EP3660073B1/en active Active
- 2008-02-13 WO PCT/US2008/001887 patent/WO2008100532A1/en not_active Ceased
- 2008-02-13 US US12/527,377 patent/US9187593B2/en not_active Expired - Fee Related
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Also Published As

Publication number	Publication date
PT2115029E (pt)	2015-10-26
WO2008100532A1 (en)	2008-08-21
HRP20192055T1 (hr)	2020-02-21
EP3660073B1 (en)	2023-07-12
US9187593B2 (en)	2015-11-17
US20160106847A1 (en)	2016-04-21
US20170095560A1 (en)	2017-04-06
CA2678350C (en)	2015-11-17
ES2755374T3 (es)	2020-04-22
PL2115029T3 (pl)	2016-01-29
US20100292195A1 (en)	2010-11-18
HUE047775T2 (hu)	2020-05-28
SI3660073T1 (sl)	2023-10-30
US11717572B2 (en)	2023-08-08
JP5848290B2 (ja)	2016-01-27
EP2115029B1 (en)	2015-09-16
JP5342459B2 (ja)	2013-11-13
PL3202814T3 (pl)	2020-01-31
DK2115029T3 (en)	2015-10-05
FI3660073T3 (fi)	2023-09-11
JP2010519218A (ja)	2010-06-03
JP2013224339A (ja)	2013-10-31
HK1138303A1 (en)	2010-08-20
HRP20150997T1 (hr)	2015-12-18
US10206970B2 (en)	2019-02-19
LT3202814T (lt)	2019-12-10
US20170216395A1 (en)	2017-08-03
PT3202814T (pt)	2019-11-26
ES2550014T3 (es)	2015-11-03
HRP20231117T3 (hr)	2023-12-22
SI2115029T1 (sl)	2016-01-29
EP3660073A1 (en)	2020-06-03
US9561282B2 (en)	2017-02-07
JP2015127351A (ja)	2015-07-09
DK3660073T3 (da)	2023-09-18
EP2115029A1 (en)	2009-11-11
HUE025842T2 (en)	2016-04-28
EP3202814B1 (en)	2019-10-16
US9655970B2 (en)	2017-05-23
US20220202941A1 (en)	2022-06-30
US9974824B2 (en)	2018-05-22
US11147880B2 (en)	2021-10-19
EP3202814A1 (en)	2017-08-09
US20190209643A1 (en)	2019-07-11
CY1122304T1 (el)	2021-01-27
HUE063170T2 (hu)	2024-01-28
CA2678350A1 (en)	2008-08-21
DK3202814T3 (da)	2019-11-25
PL3660073T3 (pl)	2023-12-27
ES2956244T3 (es)	2023-12-15
CY1116785T1 (el)	2017-03-15
JP6195587B2 (ja)	2017-09-13
LT3660073T (lt)	2023-10-10
SI3202814T1 (sl)	2019-12-31
US20180311305A1 (en)	2018-11-01

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