PT3160978T - Profármacos de gemcitabina - Google Patents

Profármacos de gemcitabina

Info

Publication number: PT3160978T
Authority: PT; Portugal
Prior art keywords: gemcitabine prodrugs; gemcitabine; prodrugs
Prior art date: 2014-06-25

Application number

PT157334970T

Other languages

English (en)

Original Assignee

NuCana plc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2014-06-25

Filing date

2015-06-25

Publication date

2020-08-24

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=53499027&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=PT3160978(T) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2014-06-25 Priority claimed from GBGB1411253.6A external-priority patent/GB201411253D0/en

2015-06-25 Application filed by NuCana plc filed Critical NuCana plc

2020-08-24 Publication of PT3160978T publication Critical patent/PT3160978T/pt

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/10—Drugs for disorders of the urinary system of the bladder
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Molecular Biology (AREA)
Urology & Nephrology (AREA)
Biotechnology (AREA)
Biochemistry (AREA)
Genetics & Genomics (AREA)
Hematology (AREA)
Epidemiology (AREA)
Pulmonology (AREA)
Reproductive Health (AREA)
Endocrinology (AREA)
Diabetes (AREA)
Gastroenterology & Hepatology (AREA)
Oncology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)
Medicinal Preparation (AREA)
Nutrition Science (AREA)
Physiology (AREA)

PT157334970T 2014-06-25 2015-06-25 Profármacos de gemcitabina PT3160978T (pt)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
IN2050MU2014		2014-06-25
GBGB1411253.6A GB201411253D0 (en)	2014-06-25	2014-06-25	Prodrug

Publications (1)

Publication Number	Publication Date
PT3160978T true PT3160978T (pt)	2020-08-24

Family

ID=53499027

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT157334970T PT3160978T (pt)	2014-06-25	2015-06-25	Profármacos de gemcitabina

Country Status (29)

Country	Link
US (2)	US10662213B2 (pt)
EP (2)	EP3757112B1 (pt)
JP (2)	JP6982957B2 (pt)
KR (2)	KR102563040B1 (pt)
CN (2)	CN111214480A (pt)
AU (2)	AU2015278899B2 (pt)
CA (1)	CA2945938C (pt)
CL (1)	CL2016003260A1 (pt)
CY (1)	CY1123389T1 (pt)
DK (1)	DK3160978T3 (pt)
EA (1)	EA034890B1 (pt)
ES (2)	ES2811268T3 (pt)
HR (2)	HRP20230584T1 (pt)
HU (2)	HUE062474T2 (pt)
IL (2)	IL248642B (pt)
LT (1)	LT3160978T (pt)
ME (1)	ME03817B (pt)
MX (2)	MX2016015628A (pt)
MY (1)	MY183198A (pt)
NZ (2)	NZ765508A (pt)
PH (1)	PH12016502553B1 (pt)
PL (1)	PL3160978T3 (pt)
PT (1)	PT3160978T (pt)
RS (1)	RS60968B1 (pt)
SG (2)	SG11201608808TA (pt)
SI (1)	SI3160978T1 (pt)
SM (1)	SMT202000564T1 (pt)
TW (2)	TWI695718B (pt)
WO (1)	WO2015198058A1 (pt)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
RS58849B1 (sr)	2012-11-16	2019-07-31	Univ College Cardiff Consultants Ltd	Smeša rp/sp gemcitabin-[fenil-(benziloksi-l-alaninil)]-fosfata
KR102563040B1 (ko)	2014-06-25	2023-08-02	뉴카나 피엘씨	젬시타빈 전구 약물
TWI674097B (zh)	2014-06-25	2019-10-11	英商努卡那公眾有限公司	磷酸酯衍生物之調配物
GB201417644D0 (en)	2014-10-06	2014-11-19	Nucana Biomed Ltd	Method of separating phosphate diastereoisomers
CN106543220A (zh)	2015-09-16	2017-03-29	博瑞生物医药（苏州）股份有限公司	氨基磷酸酯化合物及其制备方法和晶体
CN106539810B (zh)	2015-09-16	2021-03-09	济南高合医疗科技有限公司	一种富集了nuc-1031单一异构体的组合物及其制备方法和用途
CN106543252A (zh)	2015-09-16	2017-03-29	博瑞生物医药（苏州）股份有限公司	核苷氨基磷酸酯类前药的制备方法及其中间体
JP7038653B2 (ja)	2015-10-05	2022-03-18	ニューカナパブリックリミテッドカンパニー	併用療法
HRP20211812T1 (hr)	2015-12-11	2022-03-04	NuCana plc	Dijastereoselektivna sinteza derivata fosfata i prolijeka gemcitabina nuc-1031
GB201522771D0 (en)	2015-12-23	2016-02-03	Nucana Biomed Ltd	Crystalline form of a phosphate derivative
GB201609600D0 (en) *	2016-06-01	2016-07-13	Nucuna Biomed Ltd	Cancer treatments
WO2018019188A1 (zh) *	2016-07-23	2018-02-01	博瑞生物医药（苏州）股份有限公司	核苷氨基磷酸酯类前药的多晶型及其制备方法
CN106946960A (zh) *	2017-03-29	2017-07-14	郑州泰基鸿诺医药股份有限公司	一种吉西他滨前药的晶型、制备方法、用途和药物组合物
GB201709471D0 (en)	2017-06-14	2017-07-26	Nucana Biomed Ltd	Diastereoselective synthesis of hosphate derivatives
CN110806454A (zh) *	2018-08-06	2020-02-18	江苏正大清江制药有限公司	一种盐酸吉西他滨中手性异构体的检测方法
CN110215469B (zh) *	2019-07-08	2021-11-30	绍兴市人民医院	一种治疗胆管癌的药物组合物

Family Cites Families (30)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5728575A (en)	1990-02-01	1998-03-17	Emory University	Method of resolution of 1,3-oxathiolane nucleoside enantiomers
US6703396B1 (en)	1990-02-01	2004-03-09	Emory University	Method of resolution and antiviral activity of 1,3-oxathiolane nuclesoside enantiomers
JP2002500880A (ja)	1998-01-23	2002-01-15	ニューバイオティックスインコーポレイテッド	酵素に触媒される治療剤
US7462605B2 (en)	1998-01-23	2008-12-09	Celmed Oncology (Usa), Inc.	Phosphoramidate compounds and methods of use
EP1200455B1 (en)	1999-07-22	2009-04-22	Celmed Oncology (USA), Inc.	Enzyme catalyzed therapeutic activation
GB0317009D0 (en) *	2003-07-21	2003-08-27	Univ Cardiff	Chemical compounds
MX2007009033A (es)	2005-01-27	2008-01-16	Erimos Pharmaceuticals Llc	Formulaciones orales para lsuministro de butanos catecolicos incluyendo compuestos ndga.
EP1928475B1 (en)	2005-08-15	2018-05-23	Riboscience LLC	Antiviral phosphoramidates of 4'-c-azido-substituted pronucleotides
WO2007092620A2 (en)	2006-02-09	2007-08-16	Macusight, Inc.	Stable formulations, and methods of their preparation and use
GB0821994D0 (en) *	2008-12-02	2009-01-07	Ge Healthcare Ltd	In viva imaging method
KR20110120886A (ko)	2009-01-09	2011-11-04	유니버시티 칼리지 오브 카디프 컨설턴트 리미티드	바이러스 감염 치료용 구아노신 뉴클레오사이드 화합물의 포스포라미데이트 유도체
TWI576352B (zh)	2009-05-20	2017-04-01	基利法瑪席特有限責任公司	核苷磷醯胺
KR20120086729A (ko)	2009-11-20	2012-08-03	클라비스 파마 에이에스에이	젬시타빈 유도체의 비경구적 제제
BR112013005872A2 (pt)	2010-09-22	2019-09-24	Alios Biopharma Inc	compostos, composição farmacêutica e respectivos usos
SI2681227T1 (sl)	2011-03-01	2016-04-29	Nucana Biomed Limited	Fosforamidatni derivati 5-fluoro-2'-deoksiuridina za uporabo pri zdravljenju raka
CA2863500A1 (en)	2012-01-20	2013-07-25	Aratana Therapeutics Nv	Eye drop composition
RS58849B1 (sr) *	2012-11-16	2019-07-31	Univ College Cardiff Consultants Ltd	Smeša rp/sp gemcitabin-[fenil-(benziloksi-l-alaninil)]-fosfata
GB2517988A (en) *	2013-09-09	2015-03-11	Redx Pharma Ltd	Compounds
SI3043803T1 (sl)	2013-09-11	2022-09-30	Emory University	Nukleotidne in nukleozidne sestave in njihova uporaba
JP2017504572A (ja) *	2013-11-27	2017-02-09	アイデニクス・ファーマシューティカルズ・エルエルシー	肝臓癌治療のためのヌクレオチド類
TWI674097B (zh)	2014-06-25	2019-10-11	英商努卡那公眾有限公司	磷酸酯衍生物之調配物
KR102563040B1 (ko)	2014-06-25	2023-08-02	뉴카나 피엘씨	젬시타빈 전구 약물
EP3172218B1 (en)	2014-07-22	2020-10-21	NuCana plc	Process for the preparation of gemcitabine-[phenyl(benzoxy-l-alaninyl)] phosphate
GB201417644D0 (en)	2014-10-06	2014-11-19	Nucana Biomed Ltd	Method of separating phosphate diastereoisomers
EP3197456B2 (en)	2015-05-14	2023-10-11	NuCana plc	Cancer treatments
JP7038653B2 (ja)	2015-10-05	2022-03-18	ニューカナパブリックリミテッドカンパニー	併用療法
HRP20211812T1 (hr)	2015-12-11	2022-03-04	NuCana plc	Dijastereoselektivna sinteza derivata fosfata i prolijeka gemcitabina nuc-1031
PL3393478T3 (pl)	2015-12-23	2020-07-13	NuCana plc	Terapia skojarzona
GB201522771D0 (en)	2015-12-23	2016-02-03	Nucana Biomed Ltd	Crystalline form of a phosphate derivative
WO2017109444A1 (en)	2015-12-23	2017-06-29	Nucana Biomed Limited	Combination therapy

2015
- 2015-06-25 KR KR1020227019095A patent/KR102563040B1/ko active Active
- 2015-06-25 HR HRP20230584TT patent/HRP20230584T1/hr unknown
- 2015-06-25 SG SG11201608808TA patent/SG11201608808TA/en unknown
- 2015-06-25 CN CN202010140546.2A patent/CN111214480A/zh active Pending
- 2015-06-25 TW TW104120671A patent/TWI695718B/zh not_active IP Right Cessation
- 2015-06-25 MX MX2016015628A patent/MX2016015628A/es unknown
- 2015-06-25 US US15/308,491 patent/US10662213B2/en active Active
- 2015-06-25 ES ES15733497T patent/ES2811268T3/es active Active
- 2015-06-25 PT PT157334970T patent/PT3160978T/pt unknown
- 2015-06-25 RS RS20200953A patent/RS60968B1/sr unknown
- 2015-06-25 NZ NZ765508A patent/NZ765508A/en unknown
- 2015-06-25 EA EA201692312A patent/EA034890B1/ru unknown
- 2015-06-25 JP JP2016573536A patent/JP6982957B2/ja not_active Expired - Fee Related
- 2015-06-25 NZ NZ725205A patent/NZ725205A/en unknown
- 2015-06-25 AU AU2015278899A patent/AU2015278899B2/en not_active Ceased
- 2015-06-25 ES ES20187951T patent/ES2948660T3/es active Active
- 2015-06-25 SG SG10201907898SA patent/SG10201907898SA/en unknown
- 2015-06-25 MX MX2021001140A patent/MX391758B/es unknown
- 2015-06-25 CA CA2945938A patent/CA2945938C/en active Active
- 2015-06-25 HU HUE20187951A patent/HUE062474T2/hu unknown
- 2015-06-25 ME MEP-2020-171A patent/ME03817B/me unknown
- 2015-06-25 SI SI201531314T patent/SI3160978T1/sl unknown
- 2015-06-25 SM SM20200564T patent/SMT202000564T1/it unknown
- 2015-06-25 LT LTEP15733497.0T patent/LT3160978T/lt unknown
- 2015-06-25 MY MYPI2016002193A patent/MY183198A/en unknown
- 2015-06-25 TW TW109115415A patent/TWI758728B/zh not_active IP Right Cessation
- 2015-06-25 HU HUE15733497A patent/HUE053240T2/hu unknown
- 2015-06-25 KR KR1020167033632A patent/KR102407935B1/ko active Active
- 2015-06-25 EP EP20187951.7A patent/EP3757112B1/en active Active
- 2015-06-25 WO PCT/GB2015/051857 patent/WO2015198058A1/en not_active Ceased
- 2015-06-25 CN CN201580034740.XA patent/CN106459129B/zh active Active
- 2015-06-25 EP EP15733497.0A patent/EP3160978B1/en active Active
- 2015-06-25 HR HRP20201264TT patent/HRP20201264T1/hr unknown
- 2015-06-25 DK DK15733497.0T patent/DK3160978T3/da active
- 2015-06-25 PL PL15733497T patent/PL3160978T3/pl unknown
2016
- 2016-10-31 IL IL248642A patent/IL248642B/en active IP Right Grant
- 2016-12-20 PH PH12016502553A patent/PH12016502553B1/en unknown
- 2016-12-20 CL CL2016003260A patent/CL2016003260A1/es unknown
2019
- 2019-08-13 AU AU2019216626A patent/AU2019216626B2/en not_active Ceased
2020
- 2020-02-17 IL IL272724A patent/IL272724B/en active IP Right Grant
- 2020-04-22 JP JP2020076384A patent/JP6970236B2/ja not_active Expired - Fee Related
- 2020-05-04 US US16/865,527 patent/US11629164B2/en active Active
- 2020-08-10 CY CY20201100745T patent/CY1123389T1/el unknown

Also Published As

Publication number	Publication date
HRP20201264T1 (hr)	2021-02-05
IL248642B (en)	2020-03-31
NZ725205A (en)	2023-12-22
HRP20230584T1 (hr)	2023-09-15
CY1123389T1 (el)	2021-12-31
US11629164B2 (en)	2023-04-18
MX391758B (es)	2025-03-21
LT3160978T (lt)	2020-08-25
AU2019216626B2 (en)	2020-07-23
EP3757112A1 (en)	2020-12-30
TWI695718B (zh)	2020-06-11
EA034890B1 (ru)	2020-04-02
US20200262861A1 (en)	2020-08-20
MY183198A (en)	2021-02-18
EP3160978A1 (en)	2017-05-03
AU2015278899B2 (en)	2019-07-18
DK3160978T3 (da)	2020-08-17
SI3160978T1 (sl)	2020-11-30
KR102407935B1 (ko)	2022-06-10
EP3757112C0 (en)	2023-06-07
HUE053240T2 (hu)	2021-06-28
MX2016015628A (es)	2017-07-04
KR20220080220A (ko)	2022-06-14
KR102563040B1 (ko)	2023-08-02
US10662213B2 (en)	2020-05-26
CA2945938C (en)	2023-04-18
PH12016502553A1 (en)	2017-04-10
PH12016502553B1 (en)	2021-10-29
NZ765508A (en)	2023-12-22
JP6970236B2 (ja)	2021-11-24
SG10201907898SA (en)	2019-09-27
PL3160978T3 (pl)	2020-11-30
IL272724A (en)	2020-04-30
ES2811268T3 (es)	2021-03-11
EA201692312A1 (ru)	2017-04-28
US20170107246A1 (en)	2017-04-20
AU2019216626A1 (en)	2019-09-05
IL248642A0 (en)	2017-01-31
TWI758728B (zh)	2022-03-21
TW201613614A (en)	2016-04-16
ME03817B (me)	2021-04-20
JP6982957B2 (ja)	2021-12-17
IL272724B (en)	2021-06-30
CN111214480A (zh)	2020-06-02
KR20170043479A (ko)	2017-04-21
CL2016003260A1 (es)	2017-10-06
TW202033204A (zh)	2020-09-16
SMT202000564T1 (it)	2020-11-10
AU2015278899A1 (en)	2016-11-03
WO2015198058A1 (en)	2015-12-30
JP2020152725A (ja)	2020-09-24
CA2945938A1 (en)	2015-12-30
JP2017519014A (ja)	2017-07-13
MX2021001140A (es)	2022-04-21
RS60968B1 (sr)	2020-11-30
SG11201608808TA (en)	2016-11-29
EP3757112B1 (en)	2023-06-07
ES2948660T3 (es)	2023-09-15
CN106459129B (zh)	2020-03-31
HUE062474T2 (hu)	2023-11-28
CN106459129A (zh)	2017-02-22
EP3160978B1 (en)	2020-07-29

Publication	Publication Date	Title
IL248642B (en)	2020-03-31	Gemcitabine drug inhibitors
AU361515S (en)	2015-04-30	Dishrack
AU362944S (en)	2015-07-28	Lapboard
EP3119795A4 (en)	2018-03-14	Gemcitabine analogs
IL255516B (en)	2020-02-27	Oxabicycloheptane prodrugs
GB2541867B (en)	2021-08-04	Polytunnel arrangement
GB2545956B (en)	2018-03-07	Vibro-polishing arrangement
GB2540412B (en)	2021-07-28	Polytunnel arrangement
GB2544388B (en)	2021-06-09	Polytunnel Arrangement
ZA201604337B (en)	2017-07-26	Container-drum structural arrangement
AU5585P (en)	2015-03-05	Lanutah Mandevilla sanderi
AU5583P (en)	2015-03-05	Lanminnesota Mandevilla sanderi
AU5584P (en)	2015-03-05	Laniowa Mandevilla sanderi
AU5285P (en)	2016-11-11	FLOMANRER Mandevilla sanderi
AU5286P (en)	2016-11-11	FLOMANWHW Mandevilla sanderi
AU5289P (en)	2016-11-18	FLOMANFOP Mandevilla sanderi
AU5288P (en)	2016-11-18	FLOMANTOG Mandevilla sanderi
AU5287P (en)	2016-11-18	FLOMANPIW Mandevilla sanderi
AU2014299V (en)	2015-01-08	WonderScreen Pittosporum tenuifolium
GB201417348D0 (en)	2014-11-12	Prodrugs of lxazomib
GB201417347D0 (en)	2014-11-12	Prodrugs of delanzomib
SG10201404628TA (en)	2016-03-30	Ball-bond arrangement
GB201411253D0 (en)	2014-08-06	Prodrug
HU4401U (en)	2014-07-28	Panel-safety arrangement
GB201409826D0 (en)	2014-07-16	Project X