PT2710013T - Compostos novos como inibidores de diacilglicerol aciltransferas - Google Patents
Compostos novos como inibidores de diacilglicerol aciltransferasInfo
- Publication number
- PT2710013T PT2710013T PT127899318T PT12789931T PT2710013T PT 2710013 T PT2710013 T PT 2710013T PT 127899318 T PT127899318 T PT 127899318T PT 12789931 T PT12789931 T PT 12789931T PT 2710013 T PT2710013 T PT 2710013T
- Authority
- PT
- Portugal
- Prior art keywords
- novel compounds
- diacylglycerol acyltransferase
- acyltransferase inhibitors
- inhibitors
- diacylglycerol
- Prior art date
Links
- 102000002148 Diacylglycerol O-acyltransferase Human genes 0.000 title 1
- 108010001348 Diacylglycerol O-acyltransferase Proteins 0.000 title 1
- 239000002404 acyltransferase inhibitor Substances 0.000 title 1
- 150000001875 compounds Chemical class 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
- A61K31/553—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having at least one nitrogen and one oxygen as ring hetero atoms, e.g. loxapine, staurosporine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Child & Adolescent Psychology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN1452DE2011 | 2011-05-20 | ||
| US201161503728P | 2011-07-01 | 2011-07-01 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| PT2710013T true PT2710013T (pt) | 2016-09-28 |
Family
ID=47217645
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PT127899318T PT2710013T (pt) | 2011-05-20 | 2012-05-18 | Compostos novos como inibidores de diacilglicerol aciltransferas |
Country Status (34)
| Country | Link |
|---|---|
| US (4) | US8859536B2 (pt) |
| EP (1) | EP2710013B1 (pt) |
| JP (1) | JP5844456B2 (pt) |
| KR (1) | KR101919080B1 (pt) |
| CN (1) | CN103703009B (pt) |
| AU (1) | AU2012259044B2 (pt) |
| BR (1) | BR112013029935B1 (pt) |
| CA (1) | CA2836669C (pt) |
| CO (1) | CO6811855A2 (pt) |
| CR (1) | CR20130602A (pt) |
| CY (1) | CY1118188T1 (pt) |
| DK (1) | DK2710013T3 (pt) |
| DO (1) | DOP2013000272A (pt) |
| EA (1) | EA023030B1 (pt) |
| ES (1) | ES2588748T3 (pt) |
| HR (1) | HRP20161089T1 (pt) |
| HU (1) | HUE028870T2 (pt) |
| IL (1) | IL229488A (pt) |
| LT (1) | LT2710013T (pt) |
| MA (1) | MA35185B1 (pt) |
| ME (1) | ME02479B (pt) |
| MX (1) | MX346494B (pt) |
| MY (1) | MY184553A (pt) |
| PE (1) | PE20141204A1 (pt) |
| PH (1) | PH12013502401A1 (pt) |
| PL (1) | PL2710013T3 (pt) |
| PT (1) | PT2710013T (pt) |
| RS (1) | RS55006B1 (pt) |
| SG (1) | SG195044A1 (pt) |
| SI (1) | SI2710013T1 (pt) |
| SM (1) | SMT201600328B (pt) |
| UA (1) | UA111360C2 (pt) |
| WO (1) | WO2012162129A1 (pt) |
| ZA (1) | ZA201308664B (pt) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EA023030B1 (ru) | 2011-05-20 | 2016-04-29 | Глэксосмитклайн Интеллекчуал Проперти (No.2) Лимитед | Новые соединения в качестве ингибиторов диацилглицеролацилтрансферазы |
| WO2014081996A1 (en) * | 2012-11-23 | 2014-05-30 | Glaxosmithkline Llc | Novel compounds as diacylglycerol acyltransferase inhibitors |
| SI2922551T1 (sl) | 2012-11-23 | 2019-05-31 | Glaxosmithkline Llc | Nove spojine kot inhibitorji diacilglicerol aciltransferaze |
| US9796729B2 (en) | 2012-11-23 | 2017-10-24 | Glaxosmithkline Llc | Compounds as diacylglycerol acyltransferase inhibitors |
| CN103524431B (zh) * | 2013-09-24 | 2016-01-13 | 西安交通大学 | 3-苄基-4-喹唑啉酮类化合物及其合成方法和应用 |
| WO2015049668A1 (en) | 2013-10-03 | 2015-04-09 | Glaxosmithkline Intellectual Property (No.2) Limited | Novel compound as a diacylglycerol acyltransferase inhibitor |
| WO2015049667A1 (en) | 2013-10-03 | 2015-04-09 | Glaxosmithkline Intellectual Property (No.2) Limited | Novel compound as a diacylglycerol acyltransferase inhibitor |
| CN103880757B (zh) * | 2014-04-15 | 2016-02-24 | 上海毕得医药科技有限公司 | 一种5-羟基嘧啶-2-羧酸的合成方法 |
| US20180125816A1 (en) | 2015-05-11 | 2018-05-10 | Cadila Healthcare Limited | Saroglitazar magnesium for the treatment of chylomicronemia syndrome |
| US10385017B2 (en) | 2015-10-14 | 2019-08-20 | Cadila Healthcare Limited | Pyrrole compound, compositions and process for preparation thereof |
| CN105732461A (zh) * | 2016-02-03 | 2016-07-06 | 常州工程职业技术学院 | 5-甲氧基-6-卤代吲哚的制备方法 |
| CN106083707B (zh) * | 2016-06-01 | 2018-10-26 | 温州大学 | 一种非对称杂芳基硫醚的合成方法 |
| CN107619932B (zh) * | 2016-07-15 | 2020-08-07 | 中国科学院上海有机化学研究所 | 一种萃取组合物、萃取体系及其应用 |
| CN107619928B (zh) * | 2016-07-15 | 2020-08-07 | 中国科学院上海有机化学研究所 | 一种萃取组合物、萃取体系及其应用 |
| RU2706655C1 (ru) * | 2019-01-28 | 2019-11-19 | Акционерное общество "Гознак" (АО "Гознак") | Полимерсодержащее композиционное защищенное изделие |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20090036425A1 (en) * | 2007-08-02 | 2009-02-05 | Pfizer Inc | Substituted bicyclolactam compounds |
| NZ593537A (en) * | 2008-12-19 | 2013-07-26 | Genentech Inc | Isoquinoline derivatives and methods of use |
| WO2010086820A1 (en) | 2009-02-02 | 2010-08-05 | Pfizer Inc. | 4-amino-5-oxo-7, 8-dihydropyrimido [5,4-f] [1,4] oxazepin-6 (5h) -yl) phenyl derivatives, pharmaceutical compositions and uses thereof |
| AU2010226826A1 (en) * | 2009-03-18 | 2011-10-13 | Merck Sharp & Dohme Corp. | Bicyclic compounds as inhibitors of diacylglycerol acyltransferase |
| ES2513915T3 (es) * | 2009-04-24 | 2014-10-27 | F. Hoffmann-La Roche Ag | Inhibidores de la tirosina quinasa de Bruton |
| EA023030B1 (ru) | 2011-05-20 | 2016-04-29 | Глэксосмитклайн Интеллекчуал Проперти (No.2) Лимитед | Новые соединения в качестве ингибиторов диацилглицеролацилтрансферазы |
| US9796729B2 (en) | 2012-11-23 | 2017-10-24 | Glaxosmithkline Llc | Compounds as diacylglycerol acyltransferase inhibitors |
-
2012
- 2012-05-18 EA EA201391737A patent/EA023030B1/ru unknown
- 2012-05-18 PT PT127899318T patent/PT2710013T/pt unknown
- 2012-05-18 PL PL12789931T patent/PL2710013T3/pl unknown
- 2012-05-18 PH PH1/2013/502401A patent/PH12013502401A1/en unknown
- 2012-05-18 HR HRP20161089TT patent/HRP20161089T1/hr unknown
- 2012-05-18 HU HUE12789931A patent/HUE028870T2/en unknown
- 2012-05-18 EP EP12789931.8A patent/EP2710013B1/en active Active
- 2012-05-18 RS RS20160648A patent/RS55006B1/sr unknown
- 2012-05-18 KR KR1020137033509A patent/KR101919080B1/ko not_active Expired - Fee Related
- 2012-05-18 MY MYPI2013702195A patent/MY184553A/en unknown
- 2012-05-18 LT LTEP12789931.8T patent/LT2710013T/lt unknown
- 2012-05-18 US US14/118,976 patent/US8859536B2/en not_active Expired - Fee Related
- 2012-05-18 JP JP2014511575A patent/JP5844456B2/ja not_active Expired - Fee Related
- 2012-05-18 BR BR112013029935-5A patent/BR112013029935B1/pt not_active IP Right Cessation
- 2012-05-18 UA UAA201314878A patent/UA111360C2/uk unknown
- 2012-05-18 AU AU2012259044A patent/AU2012259044B2/en not_active Ceased
- 2012-05-18 SG SG2013085501A patent/SG195044A1/en unknown
- 2012-05-18 ES ES12789931.8T patent/ES2588748T3/es active Active
- 2012-05-18 WO PCT/US2012/038523 patent/WO2012162129A1/en not_active Ceased
- 2012-05-18 CA CA2836669A patent/CA2836669C/en not_active Expired - Fee Related
- 2012-05-18 SI SI201230689A patent/SI2710013T1/sl unknown
- 2012-05-18 MX MX2013013566A patent/MX346494B/es active IP Right Grant
- 2012-05-18 ME MEP-2016-159A patent/ME02479B/me unknown
- 2012-05-18 CN CN201280035792.5A patent/CN103703009B/zh not_active Expired - Fee Related
- 2012-05-18 PE PE2013002531A patent/PE20141204A1/es active IP Right Grant
- 2012-05-18 DK DK12789931.8T patent/DK2710013T3/en active
-
2013
- 2013-11-18 IL IL229488A patent/IL229488A/en active IP Right Grant
- 2013-11-19 ZA ZA2013/08664A patent/ZA201308664B/en unknown
- 2013-11-20 DO DO2013000272A patent/DOP2013000272A/es unknown
- 2013-11-20 CR CR20130602A patent/CR20130602A/es unknown
- 2013-11-20 CO CO13273126A patent/CO6811855A2/es active IP Right Grant
- 2013-12-13 MA MA36566A patent/MA35185B1/fr unknown
-
2014
- 2014-09-05 US US14/478,309 patent/US9040517B2/en not_active Expired - Fee Related
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2015
- 2015-04-24 US US14/695,206 patent/US9273069B2/en not_active Expired - Fee Related
-
2016
- 2016-01-15 US US14/996,318 patent/US9540400B2/en not_active Expired - Fee Related
- 2016-09-19 CY CY20161100926T patent/CY1118188T1/el unknown
- 2016-09-20 SM SM201600328T patent/SMT201600328B/it unknown
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